IF you really wanna try antidepressants or can not live without them: THERE ARE ONLY 2 OPTIONS

[Yusu]

Never under any circumstances take SSRI, look at my thread about why too much ssri and serotonin will turn you into a zombie and cuck. (Lowering testosterone, increasing prolactin, estrogen...) I am still tapering them off since 2020.​

There is wellbutrin for dopamine, yeah. But if you have anxiety then this is also not a good choice because wellbutrin main effect is the elevation of nordadrenaline. You would destroy your body over time because your nervous system will be activated too much and your anxiety probably will incraese.

Now here comes the interesting part: What else can you take if no SSRI, Wellbutrin or MAOI?

Trazodone​

Trazodone is an mixed agonist and antagonist of various serotonin receptors, antagonist of adrenergic receptors, weak histamine H1 receptor antagonist, and weak serotonin reuptake inhibitor.
IT is not only specially a (weak) SSRI, it also inhibits serotonin in some ares and that is fucking important because too much serotonin makes you a cuck. It also is an antagonist of adrenergic receptors which is great for anxiety and stress (but bad if you have 0 energy - thats why wellbutrin gives you energy)
Some reviews says that their libido rises up after Trazodone

DEFINE_ME

3.5–19.2-mg extended-release (XR) TRZ daily (bioequivalent to 1.2–6.4-mg immediate-release [IR] TRZ 3 times a day) is estimated to be the minimum effective dose for improving sexual desire and arousal; 75 mg (25-mg IR) appears to be the threshold dose for CNS depression.

Two sexual side effects associated with trazodone have been reported: priapism in men and increased libido in women. This report describes three depressed men who had increased libido while receiving trazodone. Possible mechanisms are suggested. Research is needed to explore trazodone's usefulness in treating disorders of sexual desire.​

IT CAN EVEN FUCKING CAUSE PRIAPISM
IT IS THE LITERALLY OPPOSITE OF SSRI
IT IS A MEDICATION THAT HELPS WITH DEPRESSION ANXIETY AND WILL MAKE YOUR DICK BIGGER

But there is one problem, it is still sediating

Trazodone's propensity to cause sedation is a dual-edged sword. For many patients, the relief from agitation, anxiety, and insomnia can be rapid; for other patients, including those individuals with considerable psychomotor retardation and feelings of low energy, therapeutic doses of trazodone may not be tolerable because of sedation.

So try it and if it does not take your energy you probably will be a low inhib high sex drive monster.

Tianeptine​

this one is even more complex than the first one

Tianeptine has antidepressant and anxiolytic effects[9] with a relative lack of sedative, anticholinergic, and cardiovascular side effects.[7][10]

It is an AD and helps with anxiety without the sedative effects, which is very nice. Just like some ssri.
But it acts in fact as a serotonin reuptake enhancer - So it will reduce serotonin!

Tianeptine is no longer labelled a Selective Serotonin Reuptake Enhancer (SSRE) antidepressant.[40][41][42][43][10][14] Tianeptine has been found to bind to the same allosteric site on the serotonin transporter (SERT) as conventional TCAs.[44] However, whereas conventional TCAs inhibit serotonin reuptake by the SERT, tianeptine appears to enhance it.[44] This seems to be because of the unique C3 amino heptanoic acid side chain of tianeptine, which, in contrast to other TCAs, is thought to lock the SERT in a conformation that increases affinity for and reuptake (Vmax) of serotonin.[44] As such, tianeptine acts as a positive allosteric modulator of the SERT, or as a "serotonin reuptake enhancer".[44]

Isn't that bad? No. SSRI does not work because of higher serotonin. They work probably because they increase BNDF to grow new braincells and the high serotonin will just MASK your emotions.
In fact: SSRI will cause more anxiety and probably just mask them (Very very fucked up pills)

They found that serotonin produced by these cells is a signal to other neurons in the circuit, leading to an increase in anxiety.

Giving mice an SSRI has the same effect on this brain circuit as putting the animals in a fearful situation: Serotonin levels rise and anxiety-like behaviors increase.

Serotonin Triggers Anxiety Through Newly Discovered Brain Circuit | Brain & Behavior Research Foundation

Serotonin, a neurotransmitter whose levels are boosted by certain antidepressant medications, is best known for its role in regulating mood in a positive way. But the same neurotransmitter can also induce distressing emotions when it acts on a newly discovered anxiety-regulating circuit in the...

www.bbrfoundation.org

Previous studies have led researchers to believe that individuals with social anxiety disorder or social phobia have too low levels of the neurotransmitter serotonin. A new study, however, shows that the situation is exactly the opposite. Individuals with social phobia make too much serotonin. The more serotonin they produce, the more anxious they are in social situations.

Individuals with social phobia have too much serotonin -- not too little

Previous studies have led researchers to believe that individuals with social anxiety disorder or social phobia have too low levels of the neurotransmitter serotonin. A new study, however, shows that the situation is exactly the opposite. Individuals with social phobia make too much serotonin...

www.sciencedaily.com

Increased libido in three men treated with trazodone - PubMed

Two sexual side effects associated with trazodone have been reported: priapism in men and increased libido in women. This report describes three depressed men who had increased libido while receiving trazodone. Possible mechanisms are suggested. Research is needed to explore trazodone's...

pubmed.ncbi.nlm.nih.gov

Now that is the effect you want

Research suggests that tianeptine produces its antidepressant effects through indirect alteration and inhibition of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.[40][41][42][43][10][14] Some researchers hypothesize that tianeptine has a protective effect against stress induced neuronal remodeling.[40][10] There is also action on the NMDA and AMPA receptors.[40][10] I

And now comes the probably most improtant part: Dopamine D2

Tianeptine modestly enhances the mesolimbic release of dopamine[48] and potentiates CNS D2 and D3 receptors.

Yeah it is modestly (Like wellbutrin) but it seems to have no libido side effects like ssri

Tianeptine Can Be Effective in Men with Depression and Erectile Dysfunction | Request PDF

Request PDF | Tianeptine Can Be Effective in Men with Depression and Erectile Dysfunction | Introduction. Erectile dysfunction (ED) and depression are highly prevalent medical disorders affecting men of diverse cultures throughout the... | Find, read and cite all the research you need on...

www.researchgate.net

Switching to tianeptine in patients with antidepressant-induced sexual dysfunction | Request PDF

Request PDF | Switching to tianeptine in patients with antidepressant-induced sexual dysfunction | Sexual side effects are frequent and are recently being considered as effects of antidepressant treatment. One method to improve the sexual... | Find, read and cite all the research you need on...

www.researchgate.net

However what seems weird is that still some people describe low libido on it

Probably because it also is an opiod agonist. It could reduce testosterone / androgens. There need to be more research.

But just look at the studies above

Unlike SSRIs and other "serotonergic" antidepressants, tianeptine does not dampen libido or sexual performance. Indeed sexual function may even be enhanced.

TL;DR
NO SSRI FOR YOU
NO WELLBUTRIN IF YOU HAVE ANXIETY

Trazodone: SSRI but also serotonin inhibitor. Antianxiety. Probably high libido or no side effect / ED. Maybe low energy because of sediative effect.​

Tianeptine: Anti serotonin. Effect is much more complex. However probably Libido enhancing. But maybe lowering androgends because of opiod agonist.​

Helps with anxiety and depression. No sediative effects. Maybe even increasing Dopamine D2 in low ranges.​

TL;DR:TL;DR Try trazodone first. If it does not help, reduces libido or energy than try tianeptine but be cautious because of potentially low testosterone (like other ssri)

 

[Yusu]

Edit:
Trazodone seems to increase androgens but cause damage to sperm (Every fucking thing causes damage to sperm, just like your mobile phone)

Additionally, serum FSH, LH, and testosterone levels were elevated in the trazodone-administered groups

Thus, we concluded that trazodone induced reproductive toxicity in male rats; this reproductive toxicity was accompanied by oxidative stress and hormonal changes, which are considered as important causes of reproductive disorders.

Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress

Depression and anxiety are recognized as public health problems. Epidemiological studies have shown that depression and anxiety often occur during reproductive ages between 20 and 60 years of age in males. Trazodone is one of the most frequently prescribed drugs in the treatment of depression...

www.hindawi.com

 

[Yusu]

Edit 2:
Found another potential good AD but I would be cautious

Agomelatine​

One review found that it is as effective as other antidepressants with similar discontinuation rates overall but less discontinuations due to side effects.

It works by stimulating melatonin receptors and blocking serotonin receptors.[10]

It blocks serotonin, increases melatonin for deep sleep and even can increase dopamine and noradrenaline

Agomelatine resynchronizes circadian rhythms in animal models of delayed sleep phase syndrome.[27] By antagonizing 5-HT2C, it disinhibits/increases noradrenaline and dopamine release specifically in the frontal cortex. Therefore, it is sometimes classified as a norepinephrine–dopamine disinhibitor. It has no influence on the extracellular levels of serotonin.

However melatonin can reduce testosterone. I found 2 studies: In one testosterone increased after agomelatine, in the other one it decreased.

(PDF) Effects of Paroxetine, Bupropion and Agomelatine on Reproduction Hormones and Sperm Parameters in Male Rats

PDF | AIM: Antidepressants are drugs commonly used in the treatment of many psychiatric disorders. There is limited edition study about effects of... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

Caution: Melatonin supplementation should not be done over long times. I am wondering why they are using such an AD. I think long term use can be even more dangerous than SSRI.

 

[Yusu]

Trazodone seems to be the one, because the other one has some opiod effects and it can reduce T (although it is mild so maybe it will have no effect on it)

Trazodone seems to even reduce PRL

The effect of i.v. trazpdone on PRL and GH was studied in normal subjects and in patients with hypophyseal adenoma coupled with amenorrhoea and galactorrhoea or acromegaly. PRL levels were reduced

[Action of trazodone on the secretion of pituitary hormones. Behavior of prolactin and somatotropin] - PubMed

The effect of i.v. trazpdone on PRL and GH was studied in normal subjects and in patients with hypophyseal adenoma coupled with amenorrhoea and galactorrhoea or acromegaly. PRL levels were reduced, whereas the behaviour of GH was paradoxical. These results suggest that the dopaminergic and...

pubmed.ncbi.nlm.nih.gov

However every study in this context must be seen critical.

 

[Yusu]

I myself will try one of these, probably Trazodone
I hate my zoloft, I have to taper it off for some months. Maybe I will take traz while tapering off or after that. But If I will stay fine I would not take anything

 

[Deleted member 11414]

honestly your better off shooting up heroin than taking ssris

 

[Yusu]

Okay hands down all three are shit, did more research

/close

 

[Bobelbrah]

@Yusa What about this claim that SSRI affect testosterone? I am on them myself and took a blood test recently. It showed that I have even higher levels of test than the normal range.