MPMD has said this. DHT is 2-5x more potent than testosterone after all and DHT is strong AF for raping the follicles.
That's assuming they actually bind to androgen receptors in the scalp and cause follicles to turn dormant just as DHT does.
respond to my profile post boyo
Well I found out the hard way. It took me 4 fucking months to go from NW2 to NW1, now I need to buy ky19382.
There is a lack of evidence for it.
It’s not as linear as I make it sound but MPMD used 1mg Dut ED which is like ~63% scalp suppression (not known, based of calculations, linked below) and had ~2000ngdl Test levels off the top of my head. If prone to loss and with supraphysological levels i’m not too surprised someone would continue progressing on that. Coming to the conclusion that his loss was because of scalp T however doesn’t sound logical to me.
github.com
Valid what you're saying, though I'm not saying his hair loss was from testosterone, I meant that he mentioned how with dutasteride there is still supraphysiological levels of testosterone binding to scalp AR that cause miniaturisation.There is a lack of evidence for it.
The people born with 5AR deficiency have higher test levels than the average person and have no signs of hair loss what so ever.
The increase in scalp test from 2.5mg Dut vs 5mg Fin is drastically different (don’t remember the numbers off the top of my head). Dut still showed the greatest improvement compared to Fin, despite how much higher scalp test levels were on Dut.
Obv this is at physiological test levels.
I think T would still cause miniaturisation, just at a much slower rate. Then again like I said there is a lack of evidence for that.
I don’t think the distinction really matters anyway. Dut and RU and you’ll cover your bases anyway, regardless of it T is a concern or not.
It’s not as linear as I make it sound but MPMD used 1mg Dut ED which is like ~63% scalp suppression (not known, based of calculations, linked below) and had ~2000ngdl Test levels off the top of my head. If prone to loss and with supraphysological levels i’m not too surprised someone would continue progressing. Coming to the conclusion that his loss was because of scalp T however, doesn’t sound logical to me.
GitHub - FuzzyCat444/Dutasteride-Pharmacokinetics-Pharmacodynamics: A powerful predictor of the pharmacokinetics and pharmacodynamics of dutasteride by dose, based on papers by Per Olsson Gisleskog, David Hermann, Margareta Hammarlund-Udenaes, Mats O
A powerful predictor of the pharmacokinetics and pharmacodynamics of dutasteride by dose, based on papers by Per Olsson Gisleskog, David Hermann, Margareta Hammarlund-Udenaes, Mats O. Karlsson. Pre...
It obviously binds and transcribes androgenic signalling and thus hairloss
That’s what MPMD said himself with the logic that his serum DHT levels were crushed to the point where they were undetectable on blood tests, which isn’t a valid justification for associating his loss to testosterone.
I’m aware. I personally agree but we don’t have the evidence to back that claim up as far as i’m aware.
What dutasteride do you use? Is it pharma?Do not fucking touch them without a topical anti androgen, not even with SARMS
I'm on 2.5mg dutasteride and 500 testosterone and I went from NW1 to NW2 in one month. Testosterone also binds to scalp AR
Pharmaceutical grade (rafuster or dastidem) 2.5mg ed
Ok then the theory I was about to propose is not valid.
