S
samskeyti
Iron
- Joined
- Mar 29, 2020
- Posts
- 95
- Reputation
- 136
https://www.ncbi.nlm.nih.gov/pubmed/29893293(The corpus cavernosum after treatment with finasteride or dutasteride)
https://www.issm.info/news/research...n-rat-after-discontinuation-of-5a/(Incomplete recovery of Erectile Function In Rats After Cessation of The 5ARI)
''The current results suggest that some of the changes in CCSM function are persistent and may be irreversible. More studies are warranted, as men of various ages take 5ARIs for a variety of conditions.''
https://www.ncbi.nlm.nih.gov/pubmed/31429633(Effects of dutasteride and sildenafil(Viagra) Association In The Penile Tissue)
''Treatment with dutasteride promoted morphological changes in the corpus cavernous of this BPH model. Concomitant treatment with sildenafil DID NOT prevent the morphological changes caused by dutasteride; on the contrary, it also promoted a further increase in elastic fibers.''
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479083/(Persistent Erectile Dysfunction After Discontinuation 5ARI Treatment)
''Dutasteride administration for 4 and 8 weeks significantly decreased erectile parameters compared with the control group. Reduced erectile responses were recovered during 2 weeks of drug-free time in the 4-week treatment group, but WERE NOT in the 8-week group''
''Dutasteride markedly decreased smooth muscle content and increased collagen after 4 and 8 weeks of use, but no nuclear size changes; however, neither group showed significant improvement in the smooth muscle to collagen ratio after the rest period.''
''Our study showed that recovery from ED depended on the duration of medication, and administration of dutasteride for more than 8-weeks in rats could result in irreversible ED even after discontinuation of medication. ''
JFL at those who are going to say ''muh rat studies don't reflect the reality'' Experimental things with drugs are done on animals to gather information since it's thought that doing experiments on humans is unethical.It's not exclusive to fin-dut.
https://www.issm.info/news/research...n-rat-after-discontinuation-of-5a/(Incomplete recovery of Erectile Function In Rats After Cessation of The 5ARI)
''The current results suggest that some of the changes in CCSM function are persistent and may be irreversible. More studies are warranted, as men of various ages take 5ARIs for a variety of conditions.''
https://www.ncbi.nlm.nih.gov/pubmed/31429633(Effects of dutasteride and sildenafil(Viagra) Association In The Penile Tissue)
''Treatment with dutasteride promoted morphological changes in the corpus cavernous of this BPH model. Concomitant treatment with sildenafil DID NOT prevent the morphological changes caused by dutasteride; on the contrary, it also promoted a further increase in elastic fibers.''
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479083/(Persistent Erectile Dysfunction After Discontinuation 5ARI Treatment)
''Dutasteride administration for 4 and 8 weeks significantly decreased erectile parameters compared with the control group. Reduced erectile responses were recovered during 2 weeks of drug-free time in the 4-week treatment group, but WERE NOT in the 8-week group''
''Dutasteride markedly decreased smooth muscle content and increased collagen after 4 and 8 weeks of use, but no nuclear size changes; however, neither group showed significant improvement in the smooth muscle to collagen ratio after the rest period.''
''Our study showed that recovery from ED depended on the duration of medication, and administration of dutasteride for more than 8-weeks in rats could result in irreversible ED even after discontinuation of medication. ''
JFL at those who are going to say ''muh rat studies don't reflect the reality'' Experimental things with drugs are done on animals to gather information since it's thought that doing experiments on humans is unethical.It's not exclusive to fin-dut.