importance of E2 in puberty

[hyomaxxer]

i'm having a pretty hard time deceting how much i should nuke my estradiol during puberty to maximize height without completely screwing myself cognitively or increasing my risk of osteoporosis. i was reading this study suggesting that 2.5 mg letrozole ED isn't particularly neurotoxic, but i'm not really sure what to make of it.

my main concern is finding the balance between delaying growth plate fusion and not ending up with terrible cognition, mood, memory, bone mineral density, or other developmental issues from crushing estrogen too hard. please help

 

[hyomaxxer]

b

 

[hyomaxxer]

b