FBl
Federal Bureau of Investigation
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D-CHIRO INOSITOL HAS BEEN SHOWN TO INCREASE TESTOSTERONE IN ELDERLY HYPOGONADAL MEN. MYO INOSITOL HAS BEEN SHOWN TO IMPROVE BLOOD GLUCOSE AND BLOOD LIPIDS.
There are two important versions of inositol:
Inositols effects on testosterone in men:
Hypogonadism and insulin resistance:
Inositol deficiency:
Increasing age, antibiotic use, sugar and refined carbohydrate intake, sodium deficiency, insulin resistance, and type 1 and type 2 diabetes all increase the need for myo-inositol.
Inositols effects on fertility:
Inositols relation to metabolism:
This is very important for long term health
There are two important versions of inositol:
- Myo inositol (often abbreviated MYO or MI)
- d-chiro inositol (often abbreviated DCI)
Inositols effects on testosterone in men:
This study show that [d-chiro inositol] treatment improved the levels of testosterone and androstenedione at the expense of oestrogens in elder men with low basal levels of these hormones without adverse effects./
Hypogonadism and insulin resistance:
male hypogonadism is associated with insulin resistance (IR) [which] very often leads to metabolic syndrome [which is the precursor to diabetes type 2]
Inositol deficiency:
Increasing age, antibiotic use, sugar and refined carbohydrate intake, sodium deficiency, insulin resistance, and type 1 and type 2 diabetes all increase the need for myo-inositol.
Inositols effects on fertility:
- These data show that myo inositol increases sperm motility and the number of spermatozoa retrieved after swim-up in both normozoospermic men and patients with abnormal sperm parameters.
- Results showed that the ratio of MI-DCI dropped from 100:1 in healthy participants to 0.2:1 in [women] with polycystic ovarian syndrome who additionally displayed significantly higher levels of insulin resistance, hyperinsulinemia, and luteinizing hormone.
- [Metabolites of inositol act as] (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896029/) secondary messengers for insulin, follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH)
Inositols relation to metabolism:
- Myo-inositol is also important for insulin signalling as it makes up many secondary messengers in response to insulin. Elevated glucose levels decrease the absorption and biosynthesis of myo-inositol and increase its degradation and urinary excretion. Insulin resistance and elevated glucose levels reduce inositol uptake into tissues. Myo-inositol levels are higher in tissues that use large amounts of glucose, such as the brain, heart and ovaries. D-chiro-inositol (DCI) is higher in tissues requiring glucose storage, such as liver and muscles. Insulin resistance impairs the conversion of myo-inositol to DCI in muscles, fat and liver. Increased urinary losses of myo-inositol have been consistently found in those with type 1 and type 2 diabetes.
- Inositol supplementation may result in reduction in triglycerides, total- and LDL-cholesterol levels, but did not affect HDL-cholesterol levels
This is very important for long term health
with all of this is mind, inositol supplementation is very likely to be able to improve metabolic, and sex hormone, function men who suffer with metabolic health, hypogonadism included.
