MyDreamIsToBe183CM
8'10 or death
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Disclaimer: This is purely experimental and hypothetical only, so don't come crying to me when you retardedly start blasting these substances with no research and get testicular cancer
There are hundreds to even thousands of different pathways that contribute to height directly or indirectly, but most of them aren't worth looking into as optimizing them would barely give any height growth. We should be looking into what are the most important signaling pathways that contribute the most to height or longitudinal bone growth.
After the growth hormone signaling pathway, it seems the Wnt/B-catenin signaling pathway is the second most important pathway in regulating chondrocyte profileration within the growth plate, which can significantly impact bone growth and height
Basically what the Wnt/B-catenin signaling pathway does is coordinate and control chondrocyte profileration and differentation
pmc.ncbi.nlm.nih.gov
Studies have demonstrated that Wnt signaling pathway plays an important role in cartilage development and homeostasis by regulating the growth, differentiation, and proliferation of chondrocytes
Specifically, the canonical Wnt/β-catenin signaling pathway plays a significant role in regulating chondrocyte phenotype, maturation, and function during the cartilage development process, which is crucial for cartilage defining cartilage boundaries and endochondral ossification
Genetic defects impacting the Wnt/B-catening signaling pathway can lead to some serious skeletal disorders and impaired bone growth
CXXC5 impact on the Wnt/B-Catenin signaling pathway
CXXC finger protein 5 (CXXC5) is a negative regulator of the Wnt/B-Catenin signaling pathway. As you progress further in puberty, CXXC5 expresison also progressively increases, and studies have shown that CXXC5 contributes to growth plate senesence at puberty, so we want to inhibit the CXXC5 gene. Inhibiting this gene can also lead to activation of the Wnt/B-Catenin pathway
"Collectively, our findings reveal an important role for CXXC5 as a suppressor of longitudinal bone growth involving growth plate activity."
"In summary, CXXC5, a protein induced with pubertal progression in the growth plate chondrocytes, is characterized as a key factor mediating termination of longitudinal bone growth by promoting growth plate senescence."
It has also been shown that estrogen, the main hormone contributing to growth plate closure induces CXXc5 expression, while also decreasing chondrocyte profileration.
pmc.ncbi.nlm.nih.gov
In this study, we found that CXXC5 expression progressively increased in the resting, proliferative, and hypertrophic chondrocytes undergoing growth plate senescence. We also found that estrogen, a sex hormone that is elevated during the pubertal period, induced CXXC5 expression followed by decrement of β-catenin in chondrocytes.
Inhibiting this gene enhanced chondrocyte profileration and differentation
Now although there are many other negative regulators of the Wnt/B-catenin signaling pathway, it seems the CXXC5 gene has the most detrimental effect. So, we will focus on this for now.
Inhibition of the GSK-3B gene, which destablizies B-catenine, also resulted in tibial elongation through activaiton of Wnt/B-catenin signaling
My theory on how to optimize the Wnt/B-catenin signaling pathway:
This is where the substance, KY-19382 comes into play. If you are a true heightmaxxer then you have probably heard of this drug atleast once during your research. It was originally used by some redditors as a potential cure to hair loss, but our goal is longitudinal bone growth so I will not talk about all the other potential positive effects of KY besides potential increased height
KY-19382 activates WNT/B-catening signaling via inhibition of CXXC5 and GSK-3B activity.
Through this action, studies show KY-19382 has shown drastic increase in chondrocyte profileration and differentation, which induced increased longitudinal bone growth while also delaying growth plate senesence
KY-19382 effects on chondrocytes and growth plate height:
"The total growth plate height, monitored by COL2A1 immunostaining, was significantly increased by KY19382 treatment. This effect was confirmed by increased numbers of both proliferative and hypertrophic chondrocytes per column,"
"nuclear β-catenin was dramatically increased in the growth plate chondrocytes by KY19382 treatment"
"These functional and structural changes demonstrate the ability of KY19382 in delaying growth plate senescence."
"These results demonstrate that KY19382 promotes chondrocyte proliferation and differentiation via specific activation of the Wnt/β-catenin pathway."
TL;DR: Ideal optimization of the Wnt/B-catenin has some crazy potential for heightmaxxing, it is the second most important pathway after the growth hormone signaling pathway for height in my opinio.
KY-19382 also achieves increased chondrocyte profileration and delayed growth plate senesence through different methods and pathways then HGH and AI, so just imagine pairing up KY-19382 with HGH and AI
we could actually keep grow until fucking age 25 if we find a way to properly optimize this pathway. (sadly the only studies of ky-19382 affecting growth plates were done on rats)
Ky-19382 side effects aren't revealed yet, but according to redditors who used it for hair loss they reported 0 sides. It is also expensive as shit, dosage is around 0.1 mg/kg per bw every single day. But some people were able to get a way cheaper source. And you need to larp your way on being a researcher and shit... but i already found my way around it (not allowed to leak jfl so dont ask)
I already have a source for ky-19382 at a semi-reasonable price. Problem is im still trying to figure out how to mix the powder into an injectable solution.
Anyways my bad for the poor formatating and text, I made this whole thing in a rush out of boredom. But still, an interesting topic.
Tagging heightmaxxers/educated members:
@org3cel.RR @The Homelander @Cyrus @enchanted_elixir @Corpuscula
@
There are hundreds to even thousands of different pathways that contribute to height directly or indirectly, but most of them aren't worth looking into as optimizing them would barely give any height growth. We should be looking into what are the most important signaling pathways that contribute the most to height or longitudinal bone growth.
After the growth hormone signaling pathway, it seems the Wnt/B-catenin signaling pathway is the second most important pathway in regulating chondrocyte profileration within the growth plate, which can significantly impact bone growth and height
Basically what the Wnt/B-catenin signaling pathway does is coordinate and control chondrocyte profileration and differentation
Role of Wnt signaling pathway in joint development and cartilage degeneration - PMC
Osteoarthritis (OA) is a prevalent musculoskeletal disease that affects approximately 500 million people worldwide. Unfortunately, there is currently no effective treatment available to stop or delay the degenerative progression of joint disease. ...
pmc.ncbi.nlm.nih.gov
Studies have demonstrated that Wnt signaling pathway plays an important role in cartilage development and homeostasis by regulating the growth, differentiation, and proliferation of chondrocytes
Specifically, the canonical Wnt/β-catenin signaling pathway plays a significant role in regulating chondrocyte phenotype, maturation, and function during the cartilage development process, which is crucial for cartilage defining cartilage boundaries and endochondral ossification
Genetic defects impacting the Wnt/B-catening signaling pathway can lead to some serious skeletal disorders and impaired bone growth
CXXC5 impact on the Wnt/B-Catenin signaling pathway
CXXC finger protein 5 (CXXC5) is a negative regulator of the Wnt/B-Catenin signaling pathway. As you progress further in puberty, CXXC5 expresison also progressively increases, and studies have shown that CXXC5 contributes to growth plate senesence at puberty, so we want to inhibit the CXXC5 gene. Inhibiting this gene can also lead to activation of the Wnt/B-Catenin pathway
"Collectively, our findings reveal an important role for CXXC5 as a suppressor of longitudinal bone growth involving growth plate activity."
"In summary, CXXC5, a protein induced with pubertal progression in the growth plate chondrocytes, is characterized as a key factor mediating termination of longitudinal bone growth by promoting growth plate senescence."
It has also been shown that estrogen, the main hormone contributing to growth plate closure induces CXXc5 expression, while also decreasing chondrocyte profileration.
CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth - PMC
Inhibition of the CXXC5–DVL interaction is a potential therapeutic strategy for height enhancement of children with growth retardation.
pmc.ncbi.nlm.nih.gov
Inhibiting this gene enhanced chondrocyte profileration and differentation
Furthermore, Cxxc5−/− mice displayed enhanced chondrocyte proliferation and differentiation in the late pubertal growth plate as well as longer tibiae at adulthood
Cxxc5-/- means the CXXC5 gene has been inhibited btw
Cxxc5-/- means the CXXC5 gene has been inhibited btw
Now although there are many other negative regulators of the Wnt/B-catenin signaling pathway, it seems the CXXC5 gene has the most detrimental effect. So, we will focus on this for now.
In summary, CXXC5, a protein induced with pubertal progression in the growth plate chondrocytes, is characterized as a key factor mediating termination of longitudinal bone growth by promoting growth plate senescence
Inhibition of the GSK-3B gene, which destablizies B-catenine, also resulted in tibial elongation through activaiton of Wnt/B-catenin signaling
In addition, treatment with an inhibitor of glycogen synthase kinase 3β (GSK3β), a serine/threonine kinase that destabilizes β-catenin resulted in tibial elongation in the ex vivo culture system
My theory on how to optimize the Wnt/B-catenin signaling pathway:
This is where the substance, KY-19382 comes into play. If you are a true heightmaxxer then you have probably heard of this drug atleast once during your research. It was originally used by some redditors as a potential cure to hair loss, but our goal is longitudinal bone growth so I will not talk about all the other potential positive effects of KY besides potential increased height
KY-19382 activates WNT/B-catening signaling via inhibition of CXXC5 and GSK-3B activity.
Through this action, studies show KY-19382 has shown drastic increase in chondrocyte profileration and differentation, which induced increased longitudinal bone growth while also delaying growth plate senesence
We further demonstrated that KY19382 markedly enhanced proliferation and differentiation of chondrocytes and induced longitudinal tibiae growth in adolescent mice by delaying growth plate senescence
pmc.ncbi.nlm.nih.gov
CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth - PMC
Inhibition of the CXXC5–DVL interaction is a potential therapeutic strategy for height enhancement of children with growth retardation.
pmc.ncbi.nlm.nih.gov
KY-19382 effects on chondrocytes and growth plate height:
"The total growth plate height, monitored by COL2A1 immunostaining, was significantly increased by KY19382 treatment. This effect was confirmed by increased numbers of both proliferative and hypertrophic chondrocytes per column,"
"nuclear β-catenin was dramatically increased in the growth plate chondrocytes by KY19382 treatment"
"These functional and structural changes demonstrate the ability of KY19382 in delaying growth plate senescence."
"These results demonstrate that KY19382 promotes chondrocyte proliferation and differentiation via specific activation of the Wnt/β-catenin pathway."
TL;DR: Ideal optimization of the Wnt/B-catenin has some crazy potential for heightmaxxing, it is the second most important pathway after the growth hormone signaling pathway for height in my opinio.
KY-19382 also achieves increased chondrocyte profileration and delayed growth plate senesence through different methods and pathways then HGH and AI, so just imagine pairing up KY-19382 with HGH and AI
we could actually keep grow until fucking age 25 if we find a way to properly optimize this pathway. (sadly the only studies of ky-19382 affecting growth plates were done on rats)Ky-19382 side effects aren't revealed yet, but according to redditors who used it for hair loss they reported 0 sides. It is also expensive as shit, dosage is around 0.1 mg/kg per bw every single day. But some people were able to get a way cheaper source. And you need to larp your way on being a researcher and shit... but i already found my way around it (not allowed to leak jfl so dont ask)
I already have a source for ky-19382 at a semi-reasonable price. Problem is im still trying to figure out how to mix the powder into an injectable solution.
Anyways my bad for the poor formatating and text, I made this whole thing in a rush out of boredom. But still, an interesting topic.
Tagging heightmaxxers/educated members:
@org3cel.RR @The Homelander @Cyrus @enchanted_elixir @Corpuscula
@
