mcmentalonthemic
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Anyone who comments "Water" or "DNR" will be Blocked, Deleted, and also, BACKTRACED.
If I put a number next to a statement [example¹] it means I provide supporting information on it all the way at the bottom to act as proof or so if you want to read further on it.
This Guide goes more in-depth that the "average" .org guide. If you failed to pass Highschool Biology I suggest you keep ChatGPT on the next tab to quickly dumb down any Bio terms I use whilst reading.
The info I put in my guides are ALWAYS out there. As goes for EVERY other guide on this site. What my guide does is save you hours of research and experience and puts all the information you would have learned into a 5-10 minute read [20 if you do a bit of research and ChatGPTing whilst reading] Never trust anyone if they are telling you they are giving you secrets, whether in a looksmaxxing influencer's course or .org guide. The only secrets that ever get revealed are the ones that come from REAL studies.
They are either saving you time or money you would've put into trying out ways to look better, or they are selling you complete snake oil and SCAMMING you.
Anyone who comments "Water" or "DNR" will be Blocked, Deleted, and also, BACKTRACED.
If I put a number next to a statement [example¹] it means I provide supporting information on it all the way at the bottom to act as proof or so if you want to read further on it.
This Guide goes more in-depth that the "average" .org guide. If you failed to pass Highschool Biology I suggest you keep ChatGPT on the next tab to quickly dumb down any Bio terms I use whilst reading.
The info I put in my guides are ALWAYS out there. As goes for EVERY other guide on this site. What my guide does is save you hours of research and experience and puts all the information you would have learned into a 5-10 minute read [20 if you do a bit of research and ChatGPTing whilst reading] Never trust anyone if they are telling you they are giving you secrets, whether in a looksmaxxing influencer's course or .org guide. The only secrets that ever get revealed are the ones that come from REAL studies.
They are either saving you time or money you would've put into trying out ways to look better, or they are selling you complete snake oil and SCAMMING you.
-------------------------------------------------------------
What is Hyaluronic Acid? [HA]:
Hyaluronic Acid is a carbohydrate, specifically a GlycosAminoGlycan (GAG) that regulates extracellular matrix homeostasis, mediate cell proliferation
Jk you niggas aren't that smart
Hyaluronic Acid is a sugar molecule that your body produces and uses to hold onto water, helping your body retain and lock in moisture. It's used in your joints, eyes and ofcourse skin. Because of it's function it basically helps your skin stay hydrated. It's Literally your body's natural moisturizer.
Just like Collagen, as you get older your body produces less of this. I know Collagen production being lost overtime is the main reason people start looking older and less youthful, but this is definitely a close second.
Graph I made showing Hyaluronic Acid production decline over time [from 18-68 in 5 year increments]
(starts at 18 because your Hyaluronic Acid production actually peaks at 17-18, it's all downhill from there)
Why should I care? [Why it's Important]:
Unless you've already done research on HA and have heard of this before, this is going to blow your mind.
Skincare brand L'Oreal [no I am not going to provide a link of the product with a referral link at the end
Don't worry] paid independent research institutes to run clinical trials on their HA solution. The results?14% reduction in wrinkles after 2 weeks.
31% reduction after 4 weeks.
47% reduction after 6 weeks. [AVERAGE]
60% reduction in fine lines after 6 weeks.¹
Now no shit this was done on post-menopause women but the results are still insane. [And I don't want to hear anything about how the studies were done on women and not men like Females and Males are different species with completely different skin structure. The part I was focusing on is the post-menopause part as I'm sure 90% of the people reading this are 16-24]
RETINOL IS GLAZED ON THIS SITE yet the greatest piece of evidence supporting it's anti aging effects was a landmark study showing UP TO 30-40% wrinkle improvements after 24 weeks.² Now no shit if you care at all about anti aging you should be using retinol but just for a comparison:
According to studies..
Collagen Creams:
Average solutions: On average, 10–20% wrinkle reduction over 8 to 12 weeks
(and even then the other ingredients in the cream are doing 90% of the legwork.)
Enhanced formulations [with peptides/antoxidents/whatever]: UP TO 20–30% wrinkle reduction over 8 to 16 weeks
(and even then the peptides and shit are doing most of the legwork. I have a thread on why 99% of collagen products are cope³ which I will link at the bottom)
Retinol Creams:
Average solutions: On average, 20–35% wrinkle reduction over 12 to 24 weeks
Enhanced formulations [with peptides/antoxidents/whatever]: UP TO 30–40% wrinkle reduction over 12 to 24 weeks
Hyaluronic Acid solution:
Average solutions: On average, 47% reduction after 6 weeks
Enhanced formulations [with peptides/antoxidents/whatever]: DOES NOT EVEN NEED THEM. As long as the solution has lipid disruptors to bypass the lipid matrix of the stratum corneum it's in the clear. [which if it doesn't you might aswell put rat piss on your face for anti-aging since that HA is NOT even reaching your epidermis]
[Please focus on whether it says "On average" or "UP TO"]
Btw, I will be using L'Oreal's solution as an example from now on since it is the brand of HA I use and I can't be bothered using others like Ordinary or Cerave since no reason to gallop between them, though if you, through personal preference, research or just familiarity feel like another brand's is right for you go ahead.
But my moisturizer already has Hyaluronic Acid in it. [Why get seperate solution]:
I gaurantee if you are using moisturizer, that moisturizer has HA in it, and I will tell you why that does not matter.
There are 2 main differences between the HA you might find in the moisturizer you are using right now, and the one you might find in a solution where HA is the main ingredient, and that is that the HA solution will have something that the hyaluronic acid in those moisturizers usually don't and that is
1: The 3 variants of Hyaluronic Acid [Macro HA, Micro HA, & Micro-Epidermic HA] and not just the 1, and
2: Lipid disruptors [which I will talk about in the next section]
Another thing to note. Hyaluronic Acid is not it's own stand alone molecule. Hyaluronic acid is made up of long chains of 2 sugars, D-glucuronic acid N-acetyl-D-glucosamine [don't need to know their names, trust me I'll forget them right after posting this thread]. How long the chains are determines it's molecular weight.
Macro Hyaluronic Acid:
The molecular size of Macro HA is over 1,000,000-2,000,000 daltons. This is lower than Natural HA that the body produces which is 4,000,000 daltons. It's purpose is to hydrate the top area of the skin to act as a humectant, attracting moisture to the skin's surface. This type of HA stays ontop the Intact Stratum Corneum layer of the Epidermis [to skip you the ChatGPT search, the epidermis is the upper-most layer of the skin. and the stratum corneum is the uppermost level of the epidermis. Look at your skin right now. What you are seeing is the stratum corneum layer. - look at the next image for a diagram] and even when it bypasses the top of the stratum corneum using passive transport thru lipids [due to the lipid disruptors in HA solution] it does not go past under the stratum corneum.
[If you have never done research into topical solutions and don't know what daltons are, it's just the atomic mass of all the atoms in a molecule added together. If you've ever done middle-school biology you should know this. Just add up the amount of Protons and Neutrons in all the atoms of a molecule together. That will be that molecule's weight in daltons. (Protons and Neutrons are both 1 dalton each respectively. electrons are 0.0005 daltons each so don't bother adding them up)]
Micro Hyaluronic Acid:
The molecular size of Micro HA is 10,000-500,000 daltons. Its purpose is to hydrate deeper layers of the skin by penetrating below the surface, providing longer-lasting moisture and plumping from within. This type of HA reaches beneath the stratum corneum and resides primarily in the Stratum Granulosum layer of the Epidermis
Studies comparing HA of lower molecular weight [20,000 daltons to 50,000 daltons aka Micro HA] penetrated into the skin deeper compared to "Hyaluronic acid of higher molecular weights" aka Macro HA⁴, proving what I am saying.
Micro-Epidermic Hyaluronic Acid:
Usually [99% of the time] sodium acetylated, this type of HA is 3,000–50,000 daltons. Its purpose is to penetrate even deeper into the skin to deliver hydration at the base of the epidermis, supporting skin structure and promoting regeneration. This type of HA reaches past the upper layers and resides primarily in the Stratum Basale layer of the Epidermis.
Studies comparing Acetylated HA vs non-acetylated HA of similiar molecular weights found the acetylated version had better epidermal penetration due to the chemical modificaiton⁵, proving what I'm saying, once again.
THAT MOISTURIZER YOU'RE USING DOES NOT HAVE ALL 3 TYPES.
Infact, it does not even have 2. The Hyaluronic acid in your moisturizer, unless it explicitly says otherwise (which I highly doubt), will only have Macro HA. Why? Because whilst Micro-HA and Micro-epidermic HA will have a stronger and longer lasting result on skin quality than Macro HA will have standalone, Macro HA will have stronger immediate affects since it mostly acts on the intact statum corneum. Maybe after 100 days of applying Micro and Micro-epidermic HA you will see more of a result than you would only applying Macro HA. But after first use you will see MORE of a result with MACRO HA. And that is what the skincare brand you are buying from wants. You will notice that 1st time glow from the Macro HA in your moisturizer and continue to buy their product. It's cheaper and still gives visible results by softening and smoothing. Ofcourse the single weight HA in your moisturizer is still useful so they're not completely fucking you but it's much more superficial.
Ofcourse, it goes without say, using only Macro HA without the other 2 types will do nothing for anti-aging, only for at the moment moisturizing. ONTOP of this Micro HA lasts 13x longer in the skin than Macro HA⁶.
Lipid Disruptors. [Why HA is useless without them]:
Your moisturizer will not have these. And if (IF) they do, they are just molecules that coincidentally act as lipid disruptors, and the company behind your moisturizer would've put them in for completely different reasons.
What they even are:
Just saying before I continue, this is where the "smart niggas only" part of the title will really shine. Unless you've passed Highschool Biology with a B or higher, open ChatGPT up right now because you are not understanding this.
And yes passing Highschool Biology with a B is the qualifier to being smart on .org
The Lipid Matrix of the Stratum Corneum [concerning Macro HA]
ALL YOU NEED TO FOCUS ON IS NO.3. THE LIPID LAYER.
Imagine Lipids as Stacy. All she's been given are the 5/10 normies [fat soluble molecules] at her school. Then imagine Lipid Disruptors as the High Tier Normie who just moved to the Highschool [Stratum Corneum]. High Tier Normie loosens stacy up allowing Stacy [Lipids] to recieve his HTNCock and Sperm [Macro Hyaluronic Acid], Deep enough to be accepted by Stacy [Lipids] on the surface level but not deep enough to impregnate her [go past the Corneum].
The Phospholipid Bilayer of the Stratum Granulosum [concerning Micro HA]
This will be a breath of fresh air to you if you've done HS bio as you've probably done alot of studying in the past on the phospholipid bilayer.
ALL YOU NEED TO FOCUS ON IS THE RED STUFF. THOSE ARE LIPIDS.
Imagine Lipids as Stacy again. She's a bit more grown up and is now in College [Stratum Granulosum]. But now.. she's surrounded by sub5s/studycels. Fortunately for her, because of the bigger sample size compared to her school, a new Lipid Disruptor as the CHADLITE that mogs the old HTN appears. Chadlite loosens Stacy even more than HTN did, allowing Stacy [Lipid] to recieve his Lightningcock and Sperm [Micro Hyaluronic Acid]. His Sperm [Micro Hyaluronic Acid] goes even deeper inside of Stacy's pussy [Layer of the epidermis] than HTN's but unfortunately, Stacy's vagina was made for ChadCock so she does not get fully impregnated.
The Phospholipid Bilayer of the Stratum Basale [concerning Micro-Epidermic HA]
Yes both the Stratum Basale and the Stratum Granulosum's phospholipid bilayer has the exact same structure, just using a different diagram so you guys don't get confused and think they're the same place.
ALL YOU NEED TO FOCUS ON IS THE BLUEISH-YELLOW STUFF. THOSE ARE LIPIDS [again].
Our recurring character Stacy [Lipids] is back, and she's out of college. She now has a job and money to "find herself" [we all know what that means]. She goes to Hanava, Cuba [Stratum Basale] and she sees him. finally, Chad [Lipid Disruptor]. which is on a completely different level to the old HTN and Chadlite that had her way with her back in the day. One thing leads to another, Chad loosens her up quickly, and finally uses his THUNDERCOCK. His Sperm [Micro-Epidermic Hyaluronic Acid] reaches her womb, and she is finally impregnated [HA has reached the bottom laters of the Epidermis]. Now Stacy is a single mom [Epidermis-wide hydratation has been achieved].
Ofcourse, the more HTNS, Chadlites and Chads [Lipid Disruptors] added to an environment aka schools [aka skin], the more it messes up the sexual market place of that environment [will cause skin irritation].
So skincare companies only put enough lipid disruptors required for the ingredients in that solution and only the amount of lipid disruptors required by the ingredients in that solution. Don't expect putting molecules that have over 500 dalton molecular weight [for example topical dutasteride] onto your skinafter using a solution that has lipid disruptors will magically make those molecules pass through.
L'Oreal does use lipid disruptors (Pentylene Glycol which is a mild lipid disruptor, though I am sure it's only there as a humectant and it's function as a lipid disruptor is coincidence, and PEG-60 Hydrogenated Castor Oil which is the main lipid and intended lipid disruptor.)
Studies show lipid disruptors do greatly help HA penetration through the epidermis⁷ which again, again again again proves my point.
Why not take when older?
(Why not take it when I'm older since HA development reduction accelerates only at around 43, compared to collagen's which is at 30?)
This is fucking retarded but I'm on .org so I can only expect retarded replies.
If 6 weeks of Hyaluronic Acid solution on the surface of your skin reduces wrinkles by -47% on average post menopause by deepness, imagine taking it since you're a teenager/early 20s/EVEN in your 30s.
"Ehh I'll be 55 when it matters, I can't be bothered buying and taking something as a teen that'll only mattter when I'm soo old"
Ignoring the fact that it's still a great moisturizer and skin hydrator, and ignoring the fact that taking HA from let's say from 18 till 25 will still provide great benefit ignoring natural HA production recession overtime, there are legitimately people in this community and in the BP in general who believe the Blackpill/Lookism stops existing once you're old
.I've heard stories of GRANDPAS getting hair transplants and noticing insane difference in how they're treated. Do not worsen your life quality out of retardation.
The best way to increase HA penetration through the skin:
I do believe just using HA solution twice a day will be better than doing this on it's own, but doing that and the thing I'm about to tell you together will unironically be better than taking accutane.
And that is taking Hyaluronic acid directly before and after MICRONEEDLING.
Will not say anymore Because I am planning on releasing a complete guide like this one on microneedling and either I write the information here and do not include it in the microneedling guide, or I provide the same information in both which is stupid, since this guide will be a precursor to the Microneedling one and there is no need to putting the same information in both. You are not missing out on any information on hyaluronic acid by me not including that information here, just know HA on skin, then microneedling, then HA on skin again (directly before and after) = profit
(Reply to this thread telling me to @ you when I release the microneedling guide. You get notification, I get this thread bumped. Win-win.)
Sources/proof I'm not bullshitting:
Retards guide:
⁶ = go to source 6
¹ = go to source 1
Source 1: https://www.loreal-paris.co.uk/revitalift/filler-renew/hyaluronic-acid-anti-wrinkle-serum
"Our most advanced serum to visibly plump skin & reduce wrinkles by 47%* after 6 weeks." - directly from L'Oreal
(wouldn't recommend buying from this link [proves i'm not using refferal] this vendor is a bit expensive]
Source 2: https://pmc.ncbi.nlm.nih.gov/articles/PMC6540032/
"Retinols also increase the amount of collagen present in the skin and decrease the amount of enzymes, including collagenases that threaten to break down collagen fibers. The study found that fine lines and wrinkles were reduced by about 33 percent after 12 weeks of using a product with retinol and alpha hydroxy acid, a type of exfoliant"
Source 3: https://looksmax.org/threads/why-90-of-collagen-products-are-cope-smart-niggas-only.1450039/
Source 4: https://pubmed.ncbi.nlm.nih.gov/25877232/
Source 5: https://onlinelibrary.wiley.com/doi/10.1111/jocd.14539
Compared acetylated vs. non-acetylated HA of similar molecular weights (15 kDa); found the acetylated version had better epidermal penetration due to chemical modification.
(Can't quote because the official summary of the study uses too much big smarty biology words that us looksmaxxers don't care about)
Source 6: https://www.lorealparis.co.in/hyaluronic-acid
"The micro epidermic Hyaluronic Acid that L’Oréal Paris has been tested and the study showed it was 13x long lasting in the skin."
Source 7:
Oscillational motion properties of bacteria and polystyrene particles on a positively polarized substrate surface
The oscillational motion of bacteria and non-biological particles on a positively polarized substrate surface were investigated in this study using se…
Hyaluronic acid and HA-modified cationic liposomes for promoting skin penetration and retention
Hyaluronic acid (HA) has been widely used in cosmetics and topical preparations owing to its favorable moisturizing property and potential in enhancin…
A new insight into protein-protein interactions and the effect of conformational alterations in PCNA
The sliding clamp proteins are present in almost all forms of life and participate in various fundamental processes. Many of these proteins accommodat…
I'm not providing quotes to all these studies tbh can't be bothered, if you care so much read the studies yourself
The number symbols so you can Ctrl+F and find what statement I made that required me to show proof:
¹ ² ³ ⁴ ⁵ ⁶ ⁷
Thread over. Hope if you've made it this far you've learnt atleast 1 thing new.
Honourable mention to the thread that gave me inspiration. When I read it, I was so shocked at it's genius.
Collagen Hyaluronic Acid takviyesi
Collagen Hyaluronic Acid takviyesi almak bir işe yararmi yararsa neye yarar yardımcı olursanız sevinirim birkaç yerde bu kolojen hakkında birşeyler görüldüğümü hatırlıyorum ama ne işe yardığını hatırlamıyorum
looksmax.org
I actually made this joke not realising it was turkish. I thought it was gibberish
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