Inducing Longitudinal Bone Growth via IGF-1 production - HGH + AI [FULL USAGE GUIDE]

[Aㅤㅤㅤ]

Spoiler: Disclaimer

This guide is provided solely for educational and informational purposes. It is not medical advice and does not recommend or encourage the use of HGH, aromatase inhibitors, or any other medication. Discuss this with a qualified healthcare professional.

[IGF-1 induced production]
Human Growth Hormone (HGH) + Aromatase Inhibitors (AIs)
[FULL USAGE GUIDE]
The induction of longitudinal bone growth

​

Introduction The science and requirements behind the stack​

Pre-requisites The exact tools, syringes, water, and sterilizing gear you need​

Reconstitution The step-by-step math and process of mixing HGH without destroying the protein​

HGH Injection How to draw, prep, and subcutaneously inject HGH​

AI (Dosing, Timing, Etc...) Oral dosing, timing, and choosing between Arimidex, Aromasin, and Letrozole​

Mitigation Strategies Controlling insulin resistance, thyroid, blood pressure, and lipids​

Bone Mineral Density Support The specific compounds to prevent your bones from turning brittle while estrogen is suppressed​

Spoiler: Note

Before we go any further with the guide below, I do want to emphasize that this entire guide is written under the assumption that you are a complete beginner on HGH, AI, or you've just never even seen a vial of HGH or a syringe in real life.

Introduction

This guide solely focuses on maximizing your linear height. Hence why I'll be focusing on how to use two specific compounds combined:

- Human Growth Hormone (HGH)
- Aromatase Inhibitors (AIs)

During puberty, your balls produce massive amounts of testosterone. Some of this testosterone aromatizes (converts) into estrogen. Estrogen is the exact hormone responsible for fusing your growth plates (the epiphyseal plates at the ends of your long bones). Once estrogen fuses those plates, your bones cannot grow any longer.

By combining HGH with an Aromatase Inhibitor (AI):

HGH:
Stimulates your liver to produce IGF-1, which then directly forces your bones to grow longer.

AI:
Prevents puberty-induced fusion. This would just mean that your testosterone is blocked from converting into estrogen, which keeps your growth plates open for years longer than normal.

Spoiler: Studies

Spoiler: Mauras et al., J Clin Endocrinol Metab (2016), RCT, 76 pubertal boys, ISS

GH + AI vs. GH alone vs. AI alone, 24 months. Groups: AI alone (n=25, anastrozole or letrozole), GH alone (n=25), combination (n=26).

At 24 months: adult height was increased more in the combination group (+18.8 cm) compared with the GH alone group (+17 cm) and aromatase inhibitor alone group (14.2 cm; P = .0002).

Spoiler: ANSWER Program study (Norditropin real-world data), PMC7537098, males with GHD or ISS

n=142 GH-naïve patients, GHD (n=115) or ISS (n=27), mean baseline age 12.10 ± 3.00 (GHD) and 10.76 ± 3.07 (ISS).

Mean HSDS improved from −1.94 ± 0.77 at baseline to −0.92 ± 0.89 at AIT initiation, then further improved to −0.62 ± 0.95 after 1 year of concomitant GH plus AIT.

Spoiler: Hou et al., J Clin Endocrinol Metab (2025), boys with ISS, bone age ≥13

Now, there are only about three criteria you have to meet in order to touch these drugs, and if you don't meet them, just don't bother.

Spoiler: 1. Open growth plates (non-negotiable)

You must get a prescription for a left-wrist and hand X-ray to determine your bone age. If the radiologist's report says your epiphyseal plates are fused or closing, then I'm sad to say that this protocol will be utterly useless and will only cause side effects.

Spoiler: 2. Idiopathic Short Stature (ISS) or GH Deficiency (GHD)

HGH + AI is typically used for males diagnosed with ISS (which just means that you're abnormally short for your age with no known medical cause) or true Growth Hormone Deficiency (GHD).

Spoiler: 3. Active puberty

It is quite literally a MUST that you're in active puberty (typically Tanner Stage 2 to 4). If you haven't even started puberty yet, blocking estrogen would just be utterly useless and could fuck up your development. If you are past puberty, it just means your plates are already closed.

Pre-requisites

If you do not have every single item that I will be listing below sitting somewhere on your table before you pop the plastic caps off your vials, don't even consider starting. You'll just end up with a disgusting bacterial abscess or ruined peptides.
​

HGH & AI​

1. HGH (Lyophilized Powder)

This must be kept in a cool, dark place. Unopened vials can sit at room temperature for a bit, but keeping them in the fridge is always safer.​

2. AI (Oral Tablets)

You can choose from the following sources: Arimidex, Aromasin, or Letrozole. Keep these in their original blister packs or prescription bottles.​

​

Liquids​

1. Bacteriostatic Water (BAC Water)

This is sterile water containing 0.9% benzyl alcohol. The alcohol is what stops bacteria from growing inside the vial once you puncture the rubber stopper.
Do not use plain sterile water unless you plan on injecting the entire vial of HGH within 24 hours. If you leave plain water sitting in a vial, it will turn into a breeding ground for bacteria.​

​

Needles and syringes​

1. The Mixing Syringe (Reconstitution)

You need a standard 3 mL syringe with a 21-gauge to 25-gauge needle (1 inch or 1.5 inch length). This is a thicker needle used to quickly draw the BAC water out of its bottle and transfer it into the HGH vial.​

2. The Injection Syringe (Insulin Syringe)

You need U-100 insulin syringes. The ideal size is 1 mL (100 units) or 0.5 mL (50 units) with a 29-gauge to 31-gauge needle (either 0.5-inch or 5/16-inch length). These needles are incredibly thin, meaning you barely feel them when injecting into stomach fat.​

​

Sanitization and disposal​

1. 70% Isopropyl Alcohol Prep Pads

Buy a box of 100 or 200. You will use at least two pads every single time you mix or inject. ​

2. Sharps Disposal Container

Buy a proper red biohazard sharps bin, or at the very least, use an empty, thick-walled plastic laundry detergent bottle. Do not be a piece of shit and throw loose needles directly into the household trash where a family member or waste worker can get stuck.​

​

Storage​

1. Refrigerator

Once you mix BAC water with your HGH powder, it MUST live in the refrigerator. Reconstituted HGH degrades and loses its potency within hours if left at room temperature. If you do not have a reliable fridge, do not buy HGH.​

Reconstitution

Because this guide assumes you're a complete beginner, I'm basically going to use the easiest mixing math possible. If you, somehow, after reading the instructions, fuck up the math, you will either inject too little and waste your time, or inject too much and cause severe joint swelling.

With that said, follow these exact steps to mix your HGH.
​

Step 1: Prep your workspace​

Clear off a clean table. Wash your hands with soap. Set out your lyophilized HGH vial, your BAC water, one mixing syringe (the larger 3 mL one), and two alcohol prep pads.​

​

Step 2: Sterilize the vials​

Pop the plastic flip-caps off both the HGH vial and the BAC water vial. Use an alcohol prep pad to firmly wipe the rubber stopper on top of both vials. Let the alcohol air-dry for 30 seconds. Do not blow on them to dry the, because you'll just blow bacteria back onto the sterile rubber.​

​

Step 3: Draw the BAC water​

Open your mixing syringe. Pull the plunger back to draw 1 mL of air. Stab the needle straight down through the rubber stopper of the BAC water. Push the air into the vial (this creates pressure so the water draws out easily). Flip the BAC water vial upside down, pull the plunger back, and draw exactly 1 mL (which is the "1.0 mL" or "1cc" mark on the syringe) of water. Pull the needle out.​

​

Step 4: Mix the HGH (Gently)​

Stab the needle of your mixing syringe through the rubber stopper of your HGH vial. Aim the needle tip at the glass side wall of the vial. Do not spray the water directly onto the white powder. Slowly depress the plunger, letting the water drip down the side of the glass. HGH is a fragile protein; if you squirt the water in like a water gun, you will destroy the peptide.​

​

Step 5: Dissolve the powder​

Pull the mixing syringe out and throw it in your sharps container. Gently roll the HGH vial between your palms. Do not shake the vial. Shaking it will fuck up the HGH and create a layer of foam. Let it sit on the table for 5 to 10 minutes until the liquid is 100% clear with no floating powder left.​

Beginner Reconstitution Math (10 IU Vial)
Almost all standard HGH vials contain 10 IU of powder.

By adding exactly 1 mL (100 units on an insulin syringe) of BAC water:

10 units on your insulin syringe = 1 IU of HGH
20 units on your insulin syringe = 2 IU of HGH
30 units on your insulin syringe = 3 IU of HGH
40 units on your insulin syringe = 40 units on the syringe = 4 IU of HGH
​

Step 6: Store in the fridge​

Place the mixed HGH vial in the refrigerator immediately. Do not freeze it, and do not put it in the door of the fridge where the temperature fluctuates. Keep it in the main body of the fridge.​

HGH Injection

HGH is injected into the fat layer right under your skin (a subcutaneous injection). Do not go deep into the muscle. The stomach fat is the easiest and least painful spot for a beginner.
​

Step 1: Prep your syringe and vial​

Get your cold HGH vial out of the fridge. Take one fresh, sterile insulin syringe (29G to 31G) and two alcohol prep pads. Wipe the rubber stopper of the HGH vial with an alcohol pad. ​

​

Step 2: Draw your dose​

Remove the caps from your insulin syringe. We will use a standard daily height-maximization dose of 3 IU (which is the 30 units mark on your syringe) for this particular example:

1. Pull the plunger back to draw 30 units of air into the syringe.
2. Stab the needle straight down through the rubber stopper of the HGH vial.
3. Push the air into the vial.
4. Flip the vial and syringe completely upside down.
5. Slowly pull the plunger down past the 30 units mark (go to about 35 units).
6. Flick the side of the syringe with your finger to force any tiny air bubbles to the top.
7. Push the plunger back up to exactly the 30 units mark, forcing the air bubbles back into the vial. Pull the needle straight out.​

​

Step 3: Choose and prep the injection site​

The best spot is the fat around your lower stomach.

(1) Location:
Stay at least two inches away from your belly button.

(2) Rotate:
Rotate your injection sites daily. Inject on the left side of your belly button one day, and the right side the next day. If you inject in the exact same spot every day, you will develop hard lumps of scar tissue under your skin.

(3) Sanitize:
Wipe the chosen skin area with a fresh alcohol pad. Let it air-dry completely. If the skin is still wet with alcohol when you inject, it will sting.
​

​

Step 4: Inject the HGH​

Many people find visual demonstrations easier to follow than written instructions. If you're one of them, I recommend watching the video below.


Probably the best general SubQ injection tutorial.

If you'd rather follow written instructions, use the steps below.

1. Pinch a one-inch fold of your sanitized stomach fat with your non-dominant hand.
2. Hold the syringe like a pencil in your dominant hand.
3. Stab the needle straight into the pinched fat at a 90-degree angle. Push the needle all the way in (it is only half an inch long, so it is perfectly safe).
4. Slowly push the plunger all the way down to inject the liquid.
5. Hold the needle in place for 5 seconds. If you pull it out too fast, some of the HGH will leak out of the skin.
6. Pull the needle straight out and let go of the skin fold. Do not rub the injection site. ​

Step 5: Clean up​

Throw the dirty syringe straight into your sharps container. Put your HGH vial back into the refrigerator immediately.​

AI (Dosing, Timing, Etc...)

As I've already stated before, the purpose of the Aromatase Inhibitor (AI) is to systematically suppress estrogen to zero or near-zero levels. This delays the calcification and fusion of your epiphyseal plates.

AIs are oral tablets. You swallow them with water. You do not inject them.
​

Choosing your AI​

​

Letrozole (Femara) This is the strongest AI on the market. It blocks up to 98% of your body's estrogen conversion. Because it is so potent, it is the standard choice in clinical trials for short boys.​

Anastrozole (Arimidex) This is slightly milder, blocking about 80% to 85% of estrogen. It is used if Letrozole is too hard to acquire, or if Letrozole's side effects are too brutal for you to tolerate.​

​

Dosing​

​

Letrozole​	Anastrozole​
2.5 mg (usually one full tablet)​	1 mg (usually one full tablet)​

These are both taken once daily.​

​

Timing & administration​

Because AIs have incredibly long half-lives (Letrozole has a half-life of 2 to 4 days; Anastrozole has a half-life of 48 hours), the exact time of day you take the pill really doesn't matter.

1. Take the pill at the exact same time every day to keep your hormone levels completely flat.
2. You can take it with or without food.
3. If you miss a dose, do not take a double dose the next day. Just take your regular single pill and keep going.
​

Side-effects​

You need to understand that crushing your estrogen to zero to keep your growth plates open has side effects. Estrogen is still important for joint lubrication and brain function. If you're on this protocol, you will likely experience:

1. Dry, creaky, or aching joints (especially in your knees and elbows)
2. Mild fatigue or brain fog
3. Lower HDL (good cholesterol) levels

Mitigation Strategies

When you run this stack, you have to understand that you are fundamentally altering your biochemistry. You are forcing your body to grow while simultaneously taking it of a vital protective hormone (estrogen).

If you do not run a mitigation stack alongside this stack, you will end up with things like insulin resistance, a fucked thyroid, high blood pressure, and shitty cholesterol levels.
​

Glucose​

HGH makes your cells highly resistant to insulin. It prevents them from absorbing glucose, leaving your blood sugar constantly elevated. If you ignore this, you can give yourself type-2 diabetes.
​

1. Metformin (500 mg/daily) Take it with my largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

2. Berberine (500 mg/daily) Take it with your largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

​

Thyroid​

HGH speeds up the conversion of T4 into T3. Yes, this may sound great for burning fat, but it quickly drains your body's T4 storage. Once your T4 is depleted, your thyroid output stalls. You will feel absolutely exhausted, freezing cold, and you will start holding fat.
​

1. T4, Levothyroxine (50 mcg/daily) Take this every single morning. You must take this on an empty stomach, at least 30 minutes before eating or drinking anything else, or your body won't absorb it. DO NOT BY T3. You only need T4 because the HGH is already handling the conversion.​

​

Cardiovascular​

Because you are taking Letrozole or Anastrozole to crush your estrogen, your liver will stop producing healthy amounts of HDL (good cholesterol), and your LDL (bad cholesterol) will skyrocket like fucking crazy. At the same time, HGH causes you to hold onto sodium and water, which volume-loads your heart and spikes your blood pressure.

​

1. Get a blood pressure monitor and use it every morning.​

1. Telmisartan (40mg/daily) Use this if your pressure climbs above 130/80. It lowers blood pressure, protects your kidneys, and actually helps with insulin sensitivity.​

2. Citrus Bergamot ((1000 mg/daily) + Omega-3 Fish Oil (4g/daily) These keep your lipids from turning into absolute sludge while your estrogen is suppressed.​

Bone Mineral Density Support

Estrogen is the primary hormone that basically tells your bones to absorb calcium and maintain their density. Without it, you develop osteopenia (the medical term for weak bones) which leads directly to fractures. If your bones are weak, they cannot support the rapid linear growth that the HGH is trying to force.

You must run this specific support protocol to keep your skeleton strong while your growth plates remain open.

1. 5000 IU Vitamin D3 and 100 mcg Vitamin K2

Take it every single morning. The D3 pulls the calcium into your body, and the K2 acts as a traffic cop that forces that calcium straight into your bone matrix. Do not take Vitamin D3 by itself. If you take high doses of D3 without K2, your body will absorb calcium but will not know where to put it.​

2. 1000 mg of Calcium Citrate

You must split this into two separate 500 mg doses (one in the morning, one at night) because your gut cannot physically absorb more than 500 mg of calcium at one time. Do not buy cheap calcium carbonate, which is the garbage form found in cheap antacids. Your stomach cannot absorb it efficiently.​

3. Heavy Axial Loading (Weightlifting)

You must perform heavy compound lifts that compress your spine and long bones. This includes exercises like barbell squats, deadlifts, and overhead presses. Lift heavy relative to your strength level at least three times a week.​

​

---

Thanks for reading ​

 

[Aㅤㅤㅤ]

Spoiler: Tags

@illusion @Genio @Chazza.cl @Sayori

 

[Aㅤㅤㅤ]

Spoiler: Tags

@DrMd @htncel @Revan @mohito @Navity

 

[GoErOnFoids]

First and before botb

 

[jotunnr]

View attachment 5332942

Spoiler: Disclaimer

This guide is provided solely for educational and informational purposes. It is not medical advice and does not recommend or encourage the use of HGH, aromatase inhibitors, or any other medication. Discuss this with a qualified healthcare professional.

[IGF-1 induced production]
Human Growth Hormone (HGH) + Aromatase Inhibitors (AIs)
[FULL USAGE GUIDE]
The induction of longitudinal bone growth
View attachment 5332434
​

Introduction The science and requirements behind the stack​

Pre-requisites The exact tools, syringes, water, and sterilizing gear you need​

Reconstitution The step-by-step math and process of mixing HGH without destroying the protein​

HGH Injection How to draw, prep, and subcutaneously inject HGH​

AI (Dosing, Timing, Etc...) Oral dosing, timing, and choosing between Arimidex, Aromasin, and Letrozole​

Mitigation Strategies Controlling insulin resistance, thyroid, blood pressure, and lipids​

Bone Mineral Density Support The specific compounds to prevent your bones from turning brittle while estrogen is suppressed​

Spoiler: Note

Before we go any further with the guide below, I do want to emphasize that this entire guide is written under the assumption that you are a complete beginner on HGH, AI, or you've just never even seen a vial of HGH or a syringe in real life.

Introduction

This guide solely focuses on maximizing your linear height. Hence why I'll be focusing on how to use two specific compounds combined:

- Human Growth Hormone (HGH)
- Aromatase Inhibitors (AIs)

During puberty, your balls produce massive amounts of testosterone. Some of this testosterone aromatizes (converts) into estrogen. Estrogen is the exact hormone responsible for fusing your growth plates (the epiphyseal plates at the ends of your long bones). Once estrogen fuses those plates, your bones cannot grow any longer.

By combining HGH with an Aromatase Inhibitor (AI):

HGH:
Stimulates your liver to produce IGF-1, which then directly forces your bones to grow longer.

AI:
Prevents puberty-induced fusion. This would just mean that your testosterone is blocked from converting into estrogen, which keeps your growth plates open for years longer than normal.

Spoiler: Studies

Spoiler: Mauras et al., J Clin Endocrinol Metab (2016), RCT, 76 pubertal boys, ISS

GH + AI vs. GH alone vs. AI alone, 24 months. Groups: AI alone (n=25, anastrozole or letrozole), GH alone (n=25), combination (n=26).

At 24 months: adult height was increased more in the combination group (+18.8 cm) compared with the GH alone group (+17 cm) and aromatase inhibitor alone group (14.2 cm; P = .0002).
View attachment 5332531

Spoiler: ANSWER Program study (Norditropin real-world data), PMC7537098, males with GHD or ISS

n=142 GH-naïve patients, GHD (n=115) or ISS (n=27), mean baseline age 12.10 ± 3.00 (GHD) and 10.76 ± 3.07 (ISS).

Mean HSDS improved from −1.94 ± 0.77 at baseline to −0.92 ± 0.89 at AIT initiation, then further improved to −0.62 ± 0.95 after 1 year of concomitant GH plus AIT.
View attachment 5332561

Spoiler: Hou et al., J Clin Endocrinol Metab (2025), boys with ISS, bone age ≥13

View attachment 5332577

Now, there are only about three criteria you have to meet in order to touch these drugs, and if you don't meet them, just don't bother.

Spoiler: 1. Open growth plates (non-negotiable)

You must get a prescription for a left-wrist and hand X-ray to determine your bone age. If the radiologist's report says your epiphyseal plates are fused or closing, then I'm sad to say that this protocol will be utterly useless and will only cause side effects.

Spoiler: 2. Idiopathic Short Stature (ISS) or GH Deficiency (GHD)

HGH + AI is typically used for males diagnosed with ISS (which just means that you're abnormally short for your age with no known medical cause) or true Growth Hormone Deficiency (GHD).

Spoiler: 3. Active puberty

It is quite literally a MUST that you're in active puberty (typically Tanner Stage 2 to 4). If you haven't even started puberty yet, blocking estrogen would just be utterly useless and could fuck up your development. If you are past puberty, it just means your plates are already closed.

Pre-requisites

If you do not have every single item that I will be listing below sitting somewhere on your table before you pop the plastic caps off your vials, don't even consider starting. You'll just end up with a disgusting bacterial abscess or ruined peptides.
​

HGH & AI​

1. HGH (Lyophilized Powder)
View attachment 5327063


2. AI (Oral Tablets)
View attachment 5326769

​

Liquids​

1. Bacteriostatic Water (BAC Water)
View attachment 5327104

​

Needles and syringes​

1. The Mixing Syringe (Reconstitution)
View attachment 5327151


2. The Injection Syringe (Insulin Syringe)
View attachment 5327172

​

Sanitization and disposal​

1. 70% Isopropyl Alcohol Prep Pads
View attachment 5327312


2. Sharps Disposal Container
View attachment 5327315

​

Storage​

1. Refrigerator
View attachment 5327200


Reconstitution

Because this guide assumes you're a complete beginner, I'm basically going to use the easiest mixing math possible. If you, somehow, after reading the instructions, fuck up the math, you will either inject too little and waste your time, or inject too much and cause severe joint swelling.

With that said, follow these exact steps to mix your HGH.
​

Step 1: Prep your workspace​

​

Step 2: Sterilize the vials​

​

Step 3: Draw the BAC water​

​

Step 4: Mix the HGH (Gently)​

​

Step 5: Dissolve the powder​

Beginner Reconstitution Math (10 IU Vial)
Almost all standard HGH vials contain 10 IU of powder.

By adding exactly 1 mL (100 units on an insulin syringe) of BAC water:

10 units on your insulin syringe = 1 IU of HGH
20 units on your insulin syringe = 2 IU of HGH
30 units on your insulin syringe = 3 IU of HGH
40 units on your insulin syringe = 40 units on the syringe = 4 IU of HGH
​

Step 6: Store in the fridge​

HGH Injection

HGH is injected into the fat layer right under your skin (a subcutaneous injection). Do not go deep into the muscle. The stomach fat is the easiest and least painful spot for a beginner.
​

Step 1: Prep your syringe and vial​

​

Step 2: Draw your dose​

​

Step 3: Choose and prep the injection site​

​

Step 4: Inject the HGH​

Step 5: Clean up​

AI (Dosing, Timing, Etc...)

As I've already stated before, the purpose of the Aromatase Inhibitor (AI) is to systematically suppress estrogen to zero or near-zero levels. This delays the calcification and fusion of your epiphyseal plates.

AIs are oral tablets. You swallow them with water. You do not inject them.
​

Choosing your AI​

​

Letrozole (Femara) View attachment 5331910 This is the strongest AI on the market. It blocks up to 98% of your body's estrogen conversion. Because it is so potent, it is the standard choice in clinical trials for short boys.​

Anastrozole (Arimidex) View attachment 5331926 This is slightly milder, blocking about 80% to 85% of estrogen. It is used if Letrozole is too hard to acquire, or if Letrozole's side effects are too brutal for you to tolerate.​

​

Dosing​

​

Letrozole​	Anastrozole​
2.5 mg (usually one full tablet)​	1 mg (usually one full tablet)​

These are both taken once daily.​

​

Timing & administration​

Because AIs have incredibly long half-lives (Letrozole has a half-life of 2 to 4 days; Anastrozole has a half-life of 48 hours), the exact time of day you take the pill really doesn't matter.

1. Take the pill at the exact same time every day to keep your hormone levels completely flat.
2. You can take it with or without food.
3. If you miss a dose, do not take a double dose the next day. Just take your regular single pill and keep going.
​

Side-effects​

You need to understand that crushing your estrogen to zero to keep your growth plates open has side effects. Estrogen is still important for joint lubrication and brain function. If you're on this protocol, you will likely experience:

1. Dry, creaky, or aching joints (especially in your knees and elbows)
2. Mild fatigue or brain fog
3. Lower HDL (good cholesterol) levels

Mitigation Strategies

When you run this stack, you have to understand that you are fundamentally altering your biochemistry. You are forcing your body to grow while simultaneously taking it of a vital protective hormone (estrogen).

If you do not run a mitigation stack alongside this stack, you will end up with things like insulin resistance, a fucked thyroid, high blood pressure, and shitty cholesterol levels.
​

Glucose​

HGH makes your cells highly resistant to insulin. It prevents them from absorbing glucose, leaving your blood sugar constantly elevated. If you ignore this, you can give yourself type-2 diabetes.
​

1. Metformin (500 mg/daily) View attachment 5332065 Take it with my largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

2. Berberine (500 mg/daily) View attachment 5332077 Take it with your largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

​

Thyroid​

HGH speeds up the conversion of T4 into T3. Yes, this may sound great for burning fat, but it quickly drains your body's T4 storage. Once your T4 is depleted, your thyroid output stalls. You will feel absolutely exhausted, freezing cold, and you will start holding fat.
​

1. T4, Levothyroxine (50 mcg/daily) View attachment 5332205 Take this every single morning. You must take this on an empty stomach, at least 30 minutes before eating or drinking anything else, or your body won't absorb it. DO NOT BY T3. You only need T4 because the HGH is already handling the conversion.​

​

Cardiovascular​

Because you are taking Letrozole or Anastrozole to crush your estrogen, your liver will stop producing healthy amounts of HDL (good cholesterol), and your LDL (bad cholesterol) will skyrocket like fucking crazy. At the same time, HGH causes you to hold onto sodium and water, which volume-loads your heart and spikes your blood pressure.

​

1. Get a blood pressure monitor and use it every morning.​

1. Telmisartan (40mg/daily) View attachment 5332274 Use this if your pressure climbs above 130/80. It lowers blood pressure, protects your kidneys, and actually helps with insulin sensitivity.​

2. Citrus Bergamot ((1000 mg/daily) + Omega-3 Fish Oil (4g/daily) View attachment 5332291 These keep your lipids from turning into absolute sludge while your estrogen is suppressed.​

Bone Mineral Density Support

Estrogen is the primary hormone that basically tells your bones to absorb calcium and maintain their density. Without it, you develop osteopenia (the medical term for weak bones) which leads directly to fractures. If your bones are weak, they cannot support the rapid linear growth that the HGH is trying to force.

You must run this specific support protocol to keep your skeleton strong while your growth plates remain open.

1. 5000 IU Vitamin D3 and 100 mcg Vitamin K2
View attachment 5332382


2. 1000 mg of Calcium Citrate
View attachment 5332384


3. Heavy Axial Loading (Weightlifting)
View attachment 5332416

​

---

Thanks for reading ​

Bump.

 

[DrMd]

incredible, what do you think about bone weakening with letrozole?

 

[mtn_dude_193]

dnr

 

[2s2f]

dnr, I can't get my hands on hgh it's over

 

[Dolorous]

Bump. I'll read for later

 

[2s2f]

too many words...

 

[anthony267]

View attachment 5332942

Spoiler: Disclaimer

This guide is provided solely for educational and informational purposes. It is not medical advice and does not recommend or encourage the use of HGH, aromatase inhibitors, or any other medication. Discuss this with a qualified healthcare professional.

[IGF-1 induced production]
Human Growth Hormone (HGH) + Aromatase Inhibitors (AIs)
[FULL USAGE GUIDE]
The induction of longitudinal bone growth
View attachment 5332434
​

Introduction The science and requirements behind the stack​

Pre-requisites The exact tools, syringes, water, and sterilizing gear you need​

Reconstitution The step-by-step math and process of mixing HGH without destroying the protein​

HGH Injection How to draw, prep, and subcutaneously inject HGH​

AI (Dosing, Timing, Etc...) Oral dosing, timing, and choosing between Arimidex, Aromasin, and Letrozole​

Mitigation Strategies Controlling insulin resistance, thyroid, blood pressure, and lipids​

Bone Mineral Density Support The specific compounds to prevent your bones from turning brittle while estrogen is suppressed​

Spoiler: Note

Before we go any further with the guide below, I do want to emphasize that this entire guide is written under the assumption that you are a complete beginner on HGH, AI, or you've just never even seen a vial of HGH or a syringe in real life.

Introduction

This guide solely focuses on maximizing your linear height. Hence why I'll be focusing on how to use two specific compounds combined:

- Human Growth Hormone (HGH)
- Aromatase Inhibitors (AIs)

During puberty, your balls produce massive amounts of testosterone. Some of this testosterone aromatizes (converts) into estrogen. Estrogen is the exact hormone responsible for fusing your growth plates (the epiphyseal plates at the ends of your long bones). Once estrogen fuses those plates, your bones cannot grow any longer.

By combining HGH with an Aromatase Inhibitor (AI):

HGH:
Stimulates your liver to produce IGF-1, which then directly forces your bones to grow longer.

AI:
Prevents puberty-induced fusion. This would just mean that your testosterone is blocked from converting into estrogen, which keeps your growth plates open for years longer than normal.

Spoiler: Studies

Spoiler: Mauras et al., J Clin Endocrinol Metab (2016), RCT, 76 pubertal boys, ISS

GH + AI vs. GH alone vs. AI alone, 24 months. Groups: AI alone (n=25, anastrozole or letrozole), GH alone (n=25), combination (n=26).

At 24 months: adult height was increased more in the combination group (+18.8 cm) compared with the GH alone group (+17 cm) and aromatase inhibitor alone group (14.2 cm; P = .0002).
View attachment 5332531

Spoiler: ANSWER Program study (Norditropin real-world data), PMC7537098, males with GHD or ISS

n=142 GH-naïve patients, GHD (n=115) or ISS (n=27), mean baseline age 12.10 ± 3.00 (GHD) and 10.76 ± 3.07 (ISS).

Mean HSDS improved from −1.94 ± 0.77 at baseline to −0.92 ± 0.89 at AIT initiation, then further improved to −0.62 ± 0.95 after 1 year of concomitant GH plus AIT.
View attachment 5332561

Spoiler: Hou et al., J Clin Endocrinol Metab (2025), boys with ISS, bone age ≥13

View attachment 5332577

Now, there are only about three criteria you have to meet in order to touch these drugs, and if you don't meet them, just don't bother.

Spoiler: 1. Open growth plates (non-negotiable)

You must get a prescription for a left-wrist and hand X-ray to determine your bone age. If the radiologist's report says your epiphyseal plates are fused or closing, then I'm sad to say that this protocol will be utterly useless and will only cause side effects.

Spoiler: 2. Idiopathic Short Stature (ISS) or GH Deficiency (GHD)

HGH + AI is typically used for males diagnosed with ISS (which just means that you're abnormally short for your age with no known medical cause) or true Growth Hormone Deficiency (GHD).

Spoiler: 3. Active puberty

It is quite literally a MUST that you're in active puberty (typically Tanner Stage 2 to 4). If you haven't even started puberty yet, blocking estrogen would just be utterly useless and could fuck up your development. If you are past puberty, it just means your plates are already closed.

Pre-requisites

If you do not have every single item that I will be listing below sitting somewhere on your table before you pop the plastic caps off your vials, don't even consider starting. You'll just end up with a disgusting bacterial abscess or ruined peptides.
​

HGH & AI​

1. HGH (Lyophilized Powder)
View attachment 5327063


2. AI (Oral Tablets)
View attachment 5326769

​

Liquids​

1. Bacteriostatic Water (BAC Water)
View attachment 5327104

​

Needles and syringes​

1. The Mixing Syringe (Reconstitution)
View attachment 5327151


2. The Injection Syringe (Insulin Syringe)
View attachment 5327172

​

Sanitization and disposal​

1. 70% Isopropyl Alcohol Prep Pads
View attachment 5327312


2. Sharps Disposal Container
View attachment 5327315

​

Storage​

1. Refrigerator
View attachment 5327200


Reconstitution

Because this guide assumes you're a complete beginner, I'm basically going to use the easiest mixing math possible. If you, somehow, after reading the instructions, fuck up the math, you will either inject too little and waste your time, or inject too much and cause severe joint swelling.

With that said, follow these exact steps to mix your HGH.
​

Step 1: Prep your workspace​

​

Step 2: Sterilize the vials​

​

Step 3: Draw the BAC water​

​

Step 4: Mix the HGH (Gently)​

​

Step 5: Dissolve the powder​

Beginner Reconstitution Math (10 IU Vial)
Almost all standard HGH vials contain 10 IU of powder.

By adding exactly 1 mL (100 units on an insulin syringe) of BAC water:

10 units on your insulin syringe = 1 IU of HGH
20 units on your insulin syringe = 2 IU of HGH
30 units on your insulin syringe = 3 IU of HGH
40 units on your insulin syringe = 40 units on the syringe = 4 IU of HGH
​

Step 6: Store in the fridge​

HGH Injection

HGH is injected into the fat layer right under your skin (a subcutaneous injection). Do not go deep into the muscle. The stomach fat is the easiest and least painful spot for a beginner.
​

Step 1: Prep your syringe and vial​

​

Step 2: Draw your dose​

​

Step 3: Choose and prep the injection site​

​

Step 4: Inject the HGH​

Step 5: Clean up​

AI (Dosing, Timing, Etc...)

As I've already stated before, the purpose of the Aromatase Inhibitor (AI) is to systematically suppress estrogen to zero or near-zero levels. This delays the calcification and fusion of your epiphyseal plates.

AIs are oral tablets. You swallow them with water. You do not inject them.
​

Choosing your AI​

​

Letrozole (Femara) View attachment 5331910 This is the strongest AI on the market. It blocks up to 98% of your body's estrogen conversion. Because it is so potent, it is the standard choice in clinical trials for short boys.​

Anastrozole (Arimidex) View attachment 5331926 This is slightly milder, blocking about 80% to 85% of estrogen. It is used if Letrozole is too hard to acquire, or if Letrozole's side effects are too brutal for you to tolerate.​

​

Dosing​

​

Letrozole​	Anastrozole​
2.5 mg (usually one full tablet)​	1 mg (usually one full tablet)​

These are both taken once daily.​

​

Timing & administration​

Because AIs have incredibly long half-lives (Letrozole has a half-life of 2 to 4 days; Anastrozole has a half-life of 48 hours), the exact time of day you take the pill really doesn't matter.

1. Take the pill at the exact same time every day to keep your hormone levels completely flat.
2. You can take it with or without food.
3. If you miss a dose, do not take a double dose the next day. Just take your regular single pill and keep going.
​

Side-effects​

You need to understand that crushing your estrogen to zero to keep your growth plates open has side effects. Estrogen is still important for joint lubrication and brain function. If you're on this protocol, you will likely experience:

1. Dry, creaky, or aching joints (especially in your knees and elbows)
2. Mild fatigue or brain fog
3. Lower HDL (good cholesterol) levels

Mitigation Strategies

When you run this stack, you have to understand that you are fundamentally altering your biochemistry. You are forcing your body to grow while simultaneously taking it of a vital protective hormone (estrogen).

If you do not run a mitigation stack alongside this stack, you will end up with things like insulin resistance, a fucked thyroid, high blood pressure, and shitty cholesterol levels.
​

Glucose​

HGH makes your cells highly resistant to insulin. It prevents them from absorbing glucose, leaving your blood sugar constantly elevated. If you ignore this, you can give yourself type-2 diabetes.
​

1. Metformin (500 mg/daily) View attachment 5332065 Take it with my largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

2. Berberine (500 mg/daily) View attachment 5332077 Take it with your largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

​

Thyroid​

HGH speeds up the conversion of T4 into T3. Yes, this may sound great for burning fat, but it quickly drains your body's T4 storage. Once your T4 is depleted, your thyroid output stalls. You will feel absolutely exhausted, freezing cold, and you will start holding fat.
​

1. T4, Levothyroxine (50 mcg/daily) View attachment 5332205 Take this every single morning. You must take this on an empty stomach, at least 30 minutes before eating or drinking anything else, or your body won't absorb it. DO NOT BY T3. You only need T4 because the HGH is already handling the conversion.​

​

Cardiovascular​

Because you are taking Letrozole or Anastrozole to crush your estrogen, your liver will stop producing healthy amounts of HDL (good cholesterol), and your LDL (bad cholesterol) will skyrocket like fucking crazy. At the same time, HGH causes you to hold onto sodium and water, which volume-loads your heart and spikes your blood pressure.

​

1. Get a blood pressure monitor and use it every morning.​

1. Telmisartan (40mg/daily) View attachment 5332274 Use this if your pressure climbs above 130/80. It lowers blood pressure, protects your kidneys, and actually helps with insulin sensitivity.​

2. Citrus Bergamot ((1000 mg/daily) + Omega-3 Fish Oil (4g/daily) View attachment 5332291 These keep your lipids from turning into absolute sludge while your estrogen is suppressed.​

Bone Mineral Density Support

Estrogen is the primary hormone that basically tells your bones to absorb calcium and maintain their density. Without it, you develop osteopenia (the medical term for weak bones) which leads directly to fractures. If your bones are weak, they cannot support the rapid linear growth that the HGH is trying to force.

You must run this specific support protocol to keep your skeleton strong while your growth plates remain open.

1. 5000 IU Vitamin D3 and 100 mcg Vitamin K2
View attachment 5332382


2. 1000 mg of Calcium Citrate
View attachment 5332384


3. Heavy Axial Loading (Weightlifting)
View attachment 5332416

​

---

Thanks for reading ​

Wow bhai I skimmed but botb worthy good shi looking forward to more guides

 

[Aㅤㅤㅤ]

incredible, what do you think about bone weakening with letrozole?

There's a reason I included the last section

 

[DrMd]

There's a reason I included the last section

shit mb, didnt read it completly

 

[Stacyslayerᛉ]

The style is great, but the thread is just water tbh.

Mirin the colors

 

[Meant To Be]

incredible, what do you think about bone weakening with letrozole?

I personally think letrozole is too powerful and crashing ur estrogen levels near zero/zero is just.. not worth it.
It's used primarily for breast cancer patients BTW.

 

[Dolorous]

C

View attachment 5332942

Spoiler: Disclaimer

This guide is provided solely for educational and informational purposes. It is not medical advice and does not recommend or encourage the use of HGH, aromatase inhibitors, or any other medication. Discuss this with a qualified healthcare professional.

[IGF-1 induced production]
Human Growth Hormone (HGH) + Aromatase Inhibitors (AIs)
[FULL USAGE GUIDE]
The induction of longitudinal bone growth
View attachment 5332434
​

Introduction The science and requirements behind the stack​

Pre-requisites The exact tools, syringes, water, and sterilizing gear you need​

Reconstitution The step-by-step math and process of mixing HGH without destroying the protein​

HGH Injection How to draw, prep, and subcutaneously inject HGH​

AI (Dosing, Timing, Etc...) Oral dosing, timing, and choosing between Arimidex, Aromasin, and Letrozole​

Mitigation Strategies Controlling insulin resistance, thyroid, blood pressure, and lipids​

Bone Mineral Density Support The specific compounds to prevent your bones from turning brittle while estrogen is suppressed​

Spoiler: Note

Before we go any further with the guide below, I do want to emphasize that this entire guide is written under the assumption that you are a complete beginner on HGH, AI, or you've just never even seen a vial of HGH or a syringe in real life.

Introduction

This guide solely focuses on maximizing your linear height. Hence why I'll be focusing on how to use two specific compounds combined:

- Human Growth Hormone (HGH)
- Aromatase Inhibitors (AIs)

During puberty, your balls produce massive amounts of testosterone. Some of this testosterone aromatizes (converts) into estrogen. Estrogen is the exact hormone responsible for fusing your growth plates (the epiphyseal plates at the ends of your long bones). Once estrogen fuses those plates, your bones cannot grow any longer.

By combining HGH with an Aromatase Inhibitor (AI):

HGH:
Stimulates your liver to produce IGF-1, which then directly forces your bones to grow longer.

AI:
Prevents puberty-induced fusion. This would just mean that your testosterone is blocked from converting into estrogen, which keeps your growth plates open for years longer than normal.

Spoiler: Studies

Spoiler: Mauras et al., J Clin Endocrinol Metab (2016), RCT, 76 pubertal boys, ISS

GH + AI vs. GH alone vs. AI alone, 24 months. Groups: AI alone (n=25, anastrozole or letrozole), GH alone (n=25), combination (n=26).

At 24 months: adult height was increased more in the combination group (+18.8 cm) compared with the GH alone group (+17 cm) and aromatase inhibitor alone group (14.2 cm; P = .0002).
View attachment 5332531

Spoiler: ANSWER Program study (Norditropin real-world data), PMC7537098, males with GHD or ISS

n=142 GH-naïve patients, GHD (n=115) or ISS (n=27), mean baseline age 12.10 ± 3.00 (GHD) and 10.76 ± 3.07 (ISS).

Mean HSDS improved from −1.94 ± 0.77 at baseline to −0.92 ± 0.89 at AIT initiation, then further improved to −0.62 ± 0.95 after 1 year of concomitant GH plus AIT.
View attachment 5332561

Spoiler: Hou et al., J Clin Endocrinol Metab (2025), boys with ISS, bone age ≥13

View attachment 5332577

Now, there are only about three criteria you have to meet in order to touch these drugs, and if you don't meet them, just don't bother.

Spoiler: 1. Open growth plates (non-negotiable)

You must get a prescription for a left-wrist and hand X-ray to determine your bone age. If the radiologist's report says your epiphyseal plates are fused or closing, then I'm sad to say that this protocol will be utterly useless and will only cause side effects.

Spoiler: 2. Idiopathic Short Stature (ISS) or GH Deficiency (GHD)

HGH + AI is typically used for males diagnosed with ISS (which just means that you're abnormally short for your age with no known medical cause) or true Growth Hormone Deficiency (GHD).

Spoiler: 3. Active puberty

It is quite literally a MUST that you're in active puberty (typically Tanner Stage 2 to 4). If you haven't even started puberty yet, blocking estrogen would just be utterly useless and could fuck up your development. If you are past puberty, it just means your plates are already closed.

Pre-requisites

If you do not have every single item that I will be listing below sitting somewhere on your table before you pop the plastic caps off your vials, don't even consider starting. You'll just end up with a disgusting bacterial abscess or ruined peptides.
​

HGH & AI​

1. HGH (Lyophilized Powder)
View attachment 5327063


2. AI (Oral Tablets)
View attachment 5326769

​

Liquids​

1. Bacteriostatic Water (BAC Water)
View attachment 5327104

​

Needles and syringes​

1. The Mixing Syringe (Reconstitution)
View attachment 5327151


2. The Injection Syringe (Insulin Syringe)
View attachment 5327172

​

Sanitization and disposal​

1. 70% Isopropyl Alcohol Prep Pads
View attachment 5327312


2. Sharps Disposal Container
View attachment 5327315

​

Storage​

1. Refrigerator
View attachment 5327200


Reconstitution

Because this guide assumes you're a complete beginner, I'm basically going to use the easiest mixing math possible. If you, somehow, after reading the instructions, fuck up the math, you will either inject too little and waste your time, or inject too much and cause severe joint swelling.

With that said, follow these exact steps to mix your HGH.
​

Step 1: Prep your workspace​

​

Step 2: Sterilize the vials​

​

Step 3: Draw the BAC water​

​

Step 4: Mix the HGH (Gently)​

​

Step 5: Dissolve the powder​

Beginner Reconstitution Math (10 IU Vial)
Almost all standard HGH vials contain 10 IU of powder.

By adding exactly 1 mL (100 units on an insulin syringe) of BAC water:

10 units on your insulin syringe = 1 IU of HGH
20 units on your insulin syringe = 2 IU of HGH
30 units on your insulin syringe = 3 IU of HGH
40 units on your insulin syringe = 40 units on the syringe = 4 IU of HGH
​

Step 6: Store in the fridge​

HGH Injection

HGH is injected into the fat layer right under your skin (a subcutaneous injection). Do not go deep into the muscle. The stomach fat is the easiest and least painful spot for a beginner.
​

Step 1: Prep your syringe and vial​

​

Step 2: Draw your dose​

​

Step 3: Choose and prep the injection site​

​

Step 4: Inject the HGH​

Step 5: Clean up​

AI (Dosing, Timing, Etc...)

As I've already stated before, the purpose of the Aromatase Inhibitor (AI) is to systematically suppress estrogen to zero or near-zero levels. This delays the calcification and fusion of your epiphyseal plates.

AIs are oral tablets. You swallow them with water. You do not inject them.
​

Choosing your AI​

​

Letrozole (Femara) View attachment 5331910 This is the strongest AI on the market. It blocks up to 98% of your body's estrogen conversion. Because it is so potent, it is the standard choice in clinical trials for short boys.​

Anastrozole (Arimidex) View attachment 5331926 This is slightly milder, blocking about 80% to 85% of estrogen. It is used if Letrozole is too hard to acquire, or if Letrozole's side effects are too brutal for you to tolerate.​

​

Dosing​

​

Letrozole​	Anastrozole​
2.5 mg (usually one full tablet)​	1 mg (usually one full tablet)​

These are both taken once daily.​

​

Timing & administration​

Because AIs have incredibly long half-lives (Letrozole has a half-life of 2 to 4 days; Anastrozole has a half-life of 48 hours), the exact time of day you take the pill really doesn't matter.

1. Take the pill at the exact same time every day to keep your hormone levels completely flat.
2. You can take it with or without food.
3. If you miss a dose, do not take a double dose the next day. Just take your regular single pill and keep going.
​

Side-effects​

You need to understand that crushing your estrogen to zero to keep your growth plates open has side effects. Estrogen is still important for joint lubrication and brain function. If you're on this protocol, you will likely experience:

1. Dry, creaky, or aching joints (especially in your knees and elbows)
2. Mild fatigue or brain fog
3. Lower HDL (good cholesterol) levels

Mitigation Strategies

When you run this stack, you have to understand that you are fundamentally altering your biochemistry. You are forcing your body to grow while simultaneously taking it of a vital protective hormone (estrogen).

If you do not run a mitigation stack alongside this stack, you will end up with things like insulin resistance, a fucked thyroid, high blood pressure, and shitty cholesterol levels.
​

Glucose​

HGH makes your cells highly resistant to insulin. It prevents them from absorbing glucose, leaving your blood sugar constantly elevated. If you ignore this, you can give yourself type-2 diabetes.
​

1. Metformin (500 mg/daily) View attachment 5332065 Take it with my largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

2. Berberine (500 mg/daily) View attachment 5332077 Take it with your largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

​

Thyroid​

HGH speeds up the conversion of T4 into T3. Yes, this may sound great for burning fat, but it quickly drains your body's T4 storage. Once your T4 is depleted, your thyroid output stalls. You will feel absolutely exhausted, freezing cold, and you will start holding fat.
​

1. T4, Levothyroxine (50 mcg/daily) View attachment 5332205 Take this every single morning. You must take this on an empty stomach, at least 30 minutes before eating or drinking anything else, or your body won't absorb it. DO NOT BY T3. You only need T4 because the HGH is already handling the conversion.​

​

Cardiovascular​

Because you are taking Letrozole or Anastrozole to crush your estrogen, your liver will stop producing healthy amounts of HDL (good cholesterol), and your LDL (bad cholesterol) will skyrocket like fucking crazy. At the same time, HGH causes you to hold onto sodium and water, which volume-loads your heart and spikes your blood pressure.

​

1. Get a blood pressure monitor and use it every morning.​

1. Telmisartan (40mg/daily) View attachment 5332274 Use this if your pressure climbs above 130/80. It lowers blood pressure, protects your kidneys, and actually helps with insulin sensitivity.​

2. Citrus Bergamot ((1000 mg/daily) + Omega-3 Fish Oil (4g/daily) View attachment 5332291 These keep your lipids from turning into absolute sludge while your estrogen is suppressed.​

Bone Mineral Density Support

Estrogen is the primary hormone that basically tells your bones to absorb calcium and maintain their density. Without it, you develop osteopenia (the medical term for weak bones) which leads directly to fractures. If your bones are weak, they cannot support the rapid linear growth that the HGH is trying to force.

You must run this specific support protocol to keep your skeleton strong while your growth plates remain open.

1. 5000 IU Vitamin D3 and 100 mcg Vitamin K2
View attachment 5332382


2. 1000 mg of Calcium Citrate
View attachment 5332384


3. Heavy Axial Loading (Weightlifting)
View attachment 5332416

​

---

Thanks for reading ​

Please correct me if I'm wrong, since I haven't read this in detail yet, but I don't think you included the scheduling for the HGH injections. I've seen before that people inject once in the morning and once at night, and it would also be convenient for readers to mention briefly how to get the proper bloodwork done and how one should determine dosage of HGH.

Also, what is the point of the weightlifting? I thought it negatively affected growth plate senescence because of the Heuter-Volkmann principle.

 

[D02]

View attachment 5332942

Spoiler: Disclaimer

This guide is provided solely for educational and informational purposes. It is not medical advice and does not recommend or encourage the use of HGH, aromatase inhibitors, or any other medication. Discuss this with a qualified healthcare professional.

[IGF-1 induced production]
Human Growth Hormone (HGH) + Aromatase Inhibitors (AIs)
[FULL USAGE GUIDE]
The induction of longitudinal bone growth
View attachment 5332434
​

Introduction The science and requirements behind the stack​

Pre-requisites The exact tools, syringes, water, and sterilizing gear you need​

Reconstitution The step-by-step math and process of mixing HGH without destroying the protein​

HGH Injection How to draw, prep, and subcutaneously inject HGH​

AI (Dosing, Timing, Etc...) Oral dosing, timing, and choosing between Arimidex, Aromasin, and Letrozole​

Mitigation Strategies Controlling insulin resistance, thyroid, blood pressure, and lipids​

Bone Mineral Density Support The specific compounds to prevent your bones from turning brittle while estrogen is suppressed​

Spoiler: Note

Before we go any further with the guide below, I do want to emphasize that this entire guide is written under the assumption that you are a complete beginner on HGH, AI, or you've just never even seen a vial of HGH or a syringe in real life.

Introduction

This guide solely focuses on maximizing your linear height. Hence why I'll be focusing on how to use two specific compounds combined:

- Human Growth Hormone (HGH)
- Aromatase Inhibitors (AIs)

During puberty, your balls produce massive amounts of testosterone. Some of this testosterone aromatizes (converts) into estrogen. Estrogen is the exact hormone responsible for fusing your growth plates (the epiphyseal plates at the ends of your long bones). Once estrogen fuses those plates, your bones cannot grow any longer.

By combining HGH with an Aromatase Inhibitor (AI):

HGH:
Stimulates your liver to produce IGF-1, which then directly forces your bones to grow longer.

AI:
Prevents puberty-induced fusion. This would just mean that your testosterone is blocked from converting into estrogen, which keeps your growth plates open for years longer than normal.

Spoiler: Studies

Spoiler: Mauras et al., J Clin Endocrinol Metab (2016), RCT, 76 pubertal boys, ISS

GH + AI vs. GH alone vs. AI alone, 24 months. Groups: AI alone (n=25, anastrozole or letrozole), GH alone (n=25), combination (n=26).

At 24 months: adult height was increased more in the combination group (+18.8 cm) compared with the GH alone group (+17 cm) and aromatase inhibitor alone group (14.2 cm; P = .0002).
View attachment 5332531

Spoiler: ANSWER Program study (Norditropin real-world data), PMC7537098, males with GHD or ISS

n=142 GH-naïve patients, GHD (n=115) or ISS (n=27), mean baseline age 12.10 ± 3.00 (GHD) and 10.76 ± 3.07 (ISS).

Mean HSDS improved from −1.94 ± 0.77 at baseline to −0.92 ± 0.89 at AIT initiation, then further improved to −0.62 ± 0.95 after 1 year of concomitant GH plus AIT.
View attachment 5332561

Spoiler: Hou et al., J Clin Endocrinol Metab (2025), boys with ISS, bone age ≥13

View attachment 5332577

Now, there are only about three criteria you have to meet in order to touch these drugs, and if you don't meet them, just don't bother.

Spoiler: 1. Open growth plates (non-negotiable)

You must get a prescription for a left-wrist and hand X-ray to determine your bone age. If the radiologist's report says your epiphyseal plates are fused or closing, then I'm sad to say that this protocol will be utterly useless and will only cause side effects.

Spoiler: 2. Idiopathic Short Stature (ISS) or GH Deficiency (GHD)

HGH + AI is typically used for males diagnosed with ISS (which just means that you're abnormally short for your age with no known medical cause) or true Growth Hormone Deficiency (GHD).

Spoiler: 3. Active puberty

It is quite literally a MUST that you're in active puberty (typically Tanner Stage 2 to 4). If you haven't even started puberty yet, blocking estrogen would just be utterly useless and could fuck up your development. If you are past puberty, it just means your plates are already closed.

Pre-requisites

If you do not have every single item that I will be listing below sitting somewhere on your table before you pop the plastic caps off your vials, don't even consider starting. You'll just end up with a disgusting bacterial abscess or ruined peptides.
​

HGH & AI​

1. HGH (Lyophilized Powder)
View attachment 5327063


2. AI (Oral Tablets)
View attachment 5326769

​

Liquids​

1. Bacteriostatic Water (BAC Water)
View attachment 5327104

​

Needles and syringes​

1. The Mixing Syringe (Reconstitution)
View attachment 5327151


2. The Injection Syringe (Insulin Syringe)
View attachment 5327172

​

Sanitization and disposal​

1. 70% Isopropyl Alcohol Prep Pads
View attachment 5327312


2. Sharps Disposal Container
View attachment 5327315

​

Storage​

1. Refrigerator
View attachment 5327200


Reconstitution

Because this guide assumes you're a complete beginner, I'm basically going to use the easiest mixing math possible. If you, somehow, after reading the instructions, fuck up the math, you will either inject too little and waste your time, or inject too much and cause severe joint swelling.

With that said, follow these exact steps to mix your HGH.
​

Step 1: Prep your workspace​

​

Step 2: Sterilize the vials​

​

Step 3: Draw the BAC water​

​

Step 4: Mix the HGH (Gently)​

​

Step 5: Dissolve the powder​

Beginner Reconstitution Math (10 IU Vial)
Almost all standard HGH vials contain 10 IU of powder.

By adding exactly 1 mL (100 units on an insulin syringe) of BAC water:

10 units on your insulin syringe = 1 IU of HGH
20 units on your insulin syringe = 2 IU of HGH
30 units on your insulin syringe = 3 IU of HGH
40 units on your insulin syringe = 40 units on the syringe = 4 IU of HGH
​

Step 6: Store in the fridge​

HGH Injection

HGH is injected into the fat layer right under your skin (a subcutaneous injection). Do not go deep into the muscle. The stomach fat is the easiest and least painful spot for a beginner.
​

Step 1: Prep your syringe and vial​

​

Step 2: Draw your dose​

​

Step 3: Choose and prep the injection site​

​

Step 4: Inject the HGH​

Step 5: Clean up​

AI (Dosing, Timing, Etc...)

As I've already stated before, the purpose of the Aromatase Inhibitor (AI) is to systematically suppress estrogen to zero or near-zero levels. This delays the calcification and fusion of your epiphyseal plates.

AIs are oral tablets. You swallow them with water. You do not inject them.
​

Choosing your AI​

​

Letrozole (Femara) View attachment 5331910 This is the strongest AI on the market. It blocks up to 98% of your body's estrogen conversion. Because it is so potent, it is the standard choice in clinical trials for short boys.​

Anastrozole (Arimidex) View attachment 5331926 This is slightly milder, blocking about 80% to 85% of estrogen. It is used if Letrozole is too hard to acquire, or if Letrozole's side effects are too brutal for you to tolerate.​

​

Dosing​

​

Letrozole​	Anastrozole​
2.5 mg (usually one full tablet)​	1 mg (usually one full tablet)​

These are both taken once daily.​

​

Timing & administration​

Because AIs have incredibly long half-lives (Letrozole has a half-life of 2 to 4 days; Anastrozole has a half-life of 48 hours), the exact time of day you take the pill really doesn't matter.

1. Take the pill at the exact same time every day to keep your hormone levels completely flat.
2. You can take it with or without food.
3. If you miss a dose, do not take a double dose the next day. Just take your regular single pill and keep going.
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Side-effects​

You need to understand that crushing your estrogen to zero to keep your growth plates open has side effects. Estrogen is still important for joint lubrication and brain function. If you're on this protocol, you will likely experience:

1. Dry, creaky, or aching joints (especially in your knees and elbows)
2. Mild fatigue or brain fog
3. Lower HDL (good cholesterol) levels

Mitigation Strategies

When you run this stack, you have to understand that you are fundamentally altering your biochemistry. You are forcing your body to grow while simultaneously taking it of a vital protective hormone (estrogen).

If you do not run a mitigation stack alongside this stack, you will end up with things like insulin resistance, a fucked thyroid, high blood pressure, and shitty cholesterol levels.
​

Glucose​

HGH makes your cells highly resistant to insulin. It prevents them from absorbing glucose, leaving your blood sugar constantly elevated. If you ignore this, you can give yourself type-2 diabetes.
​

1. Metformin (500 mg/daily) View attachment 5332065 Take it with my largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

2. Berberine (500 mg/daily) View attachment 5332077 Take it with your largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

​

Thyroid​

HGH speeds up the conversion of T4 into T3. Yes, this may sound great for burning fat, but it quickly drains your body's T4 storage. Once your T4 is depleted, your thyroid output stalls. You will feel absolutely exhausted, freezing cold, and you will start holding fat.
​

1. T4, Levothyroxine (50 mcg/daily) View attachment 5332205 Take this every single morning. You must take this on an empty stomach, at least 30 minutes before eating or drinking anything else, or your body won't absorb it. DO NOT BY T3. You only need T4 because the HGH is already handling the conversion.​

​

Cardiovascular​

Because you are taking Letrozole or Anastrozole to crush your estrogen, your liver will stop producing healthy amounts of HDL (good cholesterol), and your LDL (bad cholesterol) will skyrocket like fucking crazy. At the same time, HGH causes you to hold onto sodium and water, which volume-loads your heart and spikes your blood pressure.

​

1. Get a blood pressure monitor and use it every morning.​

1. Telmisartan (40mg/daily) View attachment 5332274 Use this if your pressure climbs above 130/80. It lowers blood pressure, protects your kidneys, and actually helps with insulin sensitivity.​

2. Citrus Bergamot ((1000 mg/daily) + Omega-3 Fish Oil (4g/daily) View attachment 5332291 These keep your lipids from turning into absolute sludge while your estrogen is suppressed.​

Bone Mineral Density Support

Estrogen is the primary hormone that basically tells your bones to absorb calcium and maintain their density. Without it, you develop osteopenia (the medical term for weak bones) which leads directly to fractures. If your bones are weak, they cannot support the rapid linear growth that the HGH is trying to force.

You must run this specific support protocol to keep your skeleton strong while your growth plates remain open.

1. 5000 IU Vitamin D3 and 100 mcg Vitamin K2
View attachment 5332382


2. 1000 mg of Calcium Citrate
View attachment 5332384


3. Heavy Axial Loading (Weightlifting)
View attachment 5332416

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Thanks for reading ​

Good thread despite me disagreeing with the thesis

 

[Aㅤㅤㅤ]

I don't think you included the scheduling for the HGH injections.

You inject your entire dose exactly once daily, right before bed.

how one should determine dosage of HGH.

Start at 2 IU daily. If your blood glucose stays under 90 mg/dL and you have no joint swelling after a month, you can move up to 3 IU or 4 IU daily.

Anything over 4 IU daily is completely useless for height, and you will just end up with bloated feet, carpal tunnel syndrome, etc.

how to get the proper bloodwork done

You can use an online private lab service to order these tests every three months:
1. IGF-1 (obviously)
2. E2
3. HbA1c and Fasting Glucose

Also, what is the point of the weightlifting? I thought it negatively affected growth plate senescence because of the Heuter-Volkmann principle.

You're overthinking basic physics.

This principle only applies to constant, pathological pressure (e.g., a big physical deformity or a bone fracture that heals wrong). It does not apply to a 45 min weightlifting session.

Gravity and your own body weight exert way more compression on your spine throughout the day than a few sets of squats.
In fact, lifting weights actually spikes your natural GH release and keeps your bone mineral density high.

You need that extra bone density so your skeleton can physically support the rapid height growth without fracturing.

You only need proper form. If you were to, say, drop a barbell on your leg and literally fracture your epiphyseal plate, that would stunt your growth. Not this.

 

[Aㅤㅤㅤ]

@Gengar’s Ghost Pin, please?