DrTony
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- Oct 4, 2018
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thing is, there isn't such thing as a "tall gene". HMGA2 is the only real gene that has has been discovered to impact height dependent on it's encoding, and that's by like 0.3 of an inch, crazy shit. Height is completely and utterly random for the most part, your parents being tall doesn't mean anything, nor does your parents being short mean you're going to also end up short, I know many people who are all over 6ft with parents in the 5'5-5'8 range. BMP's and GDF's are growth factors that greatly impact bone growth in a particular sequence, cartilage tissue (the precursor to bone) primarily made up of chondrogenic cells are effected by growth factors, the growth factors cause the chondrocytes to proliferate, hypertrophy and eventually differentiate into bone tissue, then the osteoblastic and osteoclastic activity within the newly formed bone tissue upregulate due to the high abundance of growth factors such as BMP's GDF's FGF's and IGF's influencing ossification of the bone, all growth factors, and their respective receptors are encoded by genes, genes in which aren't always influenced by your father and mother. It's completely random, diet and sleep doesn't have much of an influence on height (albeit it would if you were starved and sleep-deprived).
There are *HUNDREDS* of genes that control height not ONE, each with a tiny effect size on the overall final phenotype (in that case adult height). Read that again. NOT ONE. HUNDREDS. How do we know? GWAS and Mendelian randomization. Case closed. / end thread
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