Is reverse bonesmashing possible

[Deleted member 9670]

I need to lose bone how to?

 

[Baldingman1998]

Don't put any pressure on that bone for many years and don't use it in your daily life or put any muscle tension or environmental stress on it. That's the only thing you can do outside of surgery. And also retin a. It works in cartilage and less so on bone but should still affect bone very long term.

 

[Deleted member 9670]

I'm a pathetic human who deformed himself bonesmashing please help

 

[Deleted member 9670]

Don't put any pressure on that bone for many years and don't use it in your daily life or out any muscle tension or environmental stress on it. That's the only thing you can do outside if surgery. And also retin a. It works in cartilage and less so on bone but should still affect bone very long term.

I use retin a

it does not break down cartliage it did that in bovine cartilage not human it wont shrink nose tip there's no evidence it does

 

[mug]

Don't put any pressure on that bone for many years and don't use it in your daily life or put any muscle tension or environmental stress on it. That's the only thing you can do outside of surgery. And also retin a. It works in cartilage and less so on bone but should still affect bone very long term.

Retinarhinoplasty?

 

[Baldingman1998]

I use retin a

it does not break down cartliage it did that in bovine cartilage not human it wont shrink nose tip there's no evidence it does

 

[Deleted member 9670]

View attachment 1805660

Retinoic acid and oncostatin M combine to promote cartilage degradation via matrix metalloproteinase-13 expression in bovine but not human chondrocytes

Abstract. Objectives. Retinoic acid (RetA) and oncostatin M (OSM) have both been shown to mediate potent effects with respect to extracellular matrix integ

academic.oup.com

 

[GandyIsNormie]

Wtf

How?

 

[Deleted member 9670]

Wtf

How?

My chin is too big now

 

[GandyIsNormie]

My chin is too big now

Is good

 

[Deleted member 15827]

View attachment 1805660

WOW SHE BECOMES BANGABLE IN THE SECOND BUT STILL HAS ACNE SCARS WTF WHAT DID TRET DO?

 

[Baldingman1998]

Retinoic acid and oncostatin M combine to promote cartilage degradation via matrix metalloproteinase-13 expression in bovine but not human chondrocytes

Abstract. Objectives. Retinoic acid (RetA) and oncostatin M (OSM) have both been shown to mediate potent effects with respect to extracellular matrix integ

academic.oup.com

403 Forbidden
Request forbidden by administrative rules.

 

[Deleted member 9670]

Is good

no it look retarded

403 Forbidden
Request forbidden by administrative rules.

Abstract​

Objectives. Retinoic acid (RetA) and oncostatin M (OSM) have both been shown to mediate potent effects with respect to extracellular matrix integrity. This study assesses the effects of a RetA + OSM combination on cartilage catabolism.

Methods. Animal and human cartilage samples were used to assess the ability of RetA + OSM to promote the release of collagen and proteoglycan fragments, which was determined by measuring glycosaminoglycan and hydroxyproline, respectively. Total collagenolytic and tissue inhibitor of metalloproteinases (TIMP) inhibitory activities were determined by bioassay, whilst gene expression of matrix metalloproteinases (MMPs) and TIMP-1 were determined by northern blotting. Immunohistochemistry was used to assess the presence of MMP-1 and -13 in resorbing cartilage explants.

Results. Both agents alone induced proteoglycan release from bovine cartilage, whilst RetA-induced collagen release was variable. Reproducible and synergistic collagenolysis was observed with RetA + OSM, which appeared to be due to MMP-13. Similar collagen release was observed from porcine cartilage. Conversely, no collagen release was seen with human articular cartilage. In primary human chondrocytes, RetA + OSM failed to induce MMP-1 or -13 but caused a significant increase in TIMP-1 expression.

Conclusions. These novel observations show that the combination of RetA + OSM has profound effects on cartilage matrix turnover, but these effects are species-specific. A better understanding of the mechanism by which this combination differentially regulates MMP and TIMP expression in human chondrocytes could provide valuable insight into new therapeutic strategies aimed at the prevention of cartilage destruction.

 

[Deleted member 9670]

Wait, does it really work?

yes but you shouldn't try

 

[Baldingman1998]

no it look retarded

Abstract​

Objectives. Retinoic acid (RetA) and oncostatin M (OSM) have both been shown to mediate potent effects with respect to extracellular matrix integrity. This study assesses the effects of a RetA + OSM combination on cartilage catabolism.

Methods. Animal and human cartilage samples were used to assess the ability of RetA + OSM to promote the release of collagen and proteoglycan fragments, which was determined by measuring glycosaminoglycan and hydroxyproline, respectively. Total collagenolytic and tissue inhibitor of metalloproteinases (TIMP) inhibitory activities were determined by bioassay, whilst gene expression of matrix metalloproteinases (MMPs) and TIMP-1 were determined by northern blotting. Immunohistochemistry was used to assess the presence of MMP-1 and -13 in resorbing cartilage explants.

Results. Both agents alone induced proteoglycan release from bovine cartilage, whilst RetA-induced collagen release was variable. Reproducible and synergistic collagenolysis was observed with RetA + OSM, which appeared to be due to MMP-13. Similar collagen release was observed from porcine cartilage. Conversely, no collagen release was seen with human articular cartilage. In primary human chondrocytes, RetA + OSM failed to induce MMP-1 or -13 but caused a significant increase in TIMP-1 expression.

Conclusions. These novel observations show that the combination of RetA + OSM has profound effects on cartilage matrix turnover, but these effects are species-specific. A better understanding of the mechanism by which this combination differentially regulates MMP and TIMP expression in human chondrocytes could provide valuable insight into new therapeutic strategies aimed at the prevention of cartilage destruction.

Nigga who cares about this cope. They say "species specific" well if it works in rats then it will most probably work in humans. Maybe it will take longer to affect cartilage formation, since the study time is limited. Or maybe humans don't absorb as much as other animals they tested on and so it's not because of what they think but different absorption levels? There could be a thousand excuses and things we don't know. Bottom line is we know that to some extent it affects cartilage formation in humans and animals. Saying muh we don't know cuz we wanna sell retin a(real reason) is cope. The picture abivr is enough evidence. Unless it's photoshopped or she had surgery (which is very unlikely)

 

[Deleted member 9670]

Nigga who cares about this cope. They say "species specific" well if it works in rats then emit will work in humans. Maybe it will take longer to affect cartilage formation, since the study time is limited. Or maybe humans don't absorb as much as other animals they tested on and so it's not because of what they thing but different absorption levels? There could be a thousand excuses and things we don't know. Bottom line is we know that to some extent it affects cartilage formation in humans and animals. Saying muh we don't know cuz we wanna sell retin a(real reason) is cope. The picture about is enough evidence. Unless it's photoshopped or she had surgery (which is very unlikely)

i just think it's cope

I still use high strength retin a on my nose just in case it works cause I have a huge bulbous nose tip

 

[Baldingman1998]

i just think it's cope

I still use high strength retin a on my nose just in case it works cause I have a huge bulbous nose tip

It takes years. Not months

 

[Deleted member 9670]

Nigga who cares about this cope. They say "species specific" well if it works in rats then emit will work in humans. Maybe it will take longer to affect cartilage formation, since the study time is limited. Or maybe humans don't absorb as much as other animals they tested on and so it's not because of what they think but different absorption levels? There could be a thousand excuses and things we don't know. Bottom line is we know that to some extent it affects cartilage formation in humans and animals. Saying muh we don't know cuz we wanna sell retin a(real reason) is cope. The picture abivr is enough evidence. Unless it's photoshopped or she had surgery (which is very unlikely)

there's a guy on here who used corticosteroids on his nose and shrunk the cartilage but that's much higher risk but he seemed okay

 

[Baldingman1998]

there's a guy on here who used corticosteroids on his nose and shrunk the cartilage but that's much higher risk but he seemed okay

Also take pictures. If it's slowly working you will unironically not be able to see a difference because you see your face everyday. You need to have a reference point because our memory is limited and eventually you will forget what you used to look like and only remember your current self.

 

[Deleted member 9670]

Also take pictures. If it's slowly working you will unironically not be able to see a difference because you see your face everyday. You need to have a reference point because our memory is limited and eventually you will forget what you used to look like and only remember your current self.

I have 1000s of pictures

my nose use to look smaller I think I get water retention in it from minoxidil

 

[Baldingman1998]

I have 1000s of pictures

my nose use to look smaller I think I get water retention in it from minoxidil

Minoxidil fucked up my skin tbh. It's jew poison. Made me have wrinkly scaly rough skin on my forehead

 

[Deleted member 17791]

facial feminisation surgery

 

[Deleted member 9670]

facial feminisation surgery

bone shaving I'll go to korea

how much this cost

 

[Deleted member 9670]

Minoxidil fucked up my skin tbh. It's jew poison. Made me have wrinkly scaly rough skin on my forehead

gave me forehead wrinkles and bad skin texture

I actually looked at old pics and my nose looks a little better tbh

 

[Deleted member 17791]

bone shaving I'll go to korea

how much this cost

I don't know boyo.

 

[Deleted member 9670]

I don't know boyo.

it's over

 

[Deleted member 17791]

it's over

Why do you not like your bones? You might have body dysmorphia.

 

[Deleted member 9670]

Why do you not like your bones? You might have body dysmorphia.

no I bonesmashed my chin it's too big now I sent you pms yesterday

 

[Deleted member 17791]

no I bonesmashed my chin it's too big now I sent you pms yesterday

It's not a disaster, having a too big chin is far better than a small one. Relax homie, it'll all be alright.

 

[Deleted member 17735]

perhaps swelling, chill for a few weeks if you bonesmashed intensely

 

[Deleted member 9670]

perhaps swelling, chill for a few weeks if you bonesmashed intensely

it's not swelling it's bone I stopped months ago

 

[Deleted member 9670]

It's not a disaster, having a too big chin is far better than a small one. Relax homie, it'll all be alright.

cope small chins are cutee

 

[Deleted member 17791]

cope small chins are cutee

If you wanna be a woman. Sure, it's ideal.

 

[Deleted member 9670]

If you wanna be a woman. Sure, it's ideal.

no small angular chins mog

it depends white people can have very big chins tbh

 

[Deleted member 17735]

it's not swelling it's bone I stopped months ago

mirin then, well done, are u white?

 

[germanlooks]

I'm a pathetic human who deformed himself bonesmashing please help

Post before after of your chin. You probably are just imagining things which aren’t there in reality

 

[Deleted member 17791]

no small angular chins mog

it depends white people can have very big chins tbh

Do I have cute chin?

 

[Deleted member 17791]

Post before after of your chin. You probably are just imagining things which aren’t there in reality

No, he changed his whole faceshape. It used to be heart shaped but now more squared.

 

[Deleted member 9670]

Post before after of your chin. You probably are just imagining things which aren’t there in reality

I am not imagining

u dont think it works cuz you haven't tried its really easy to gain bone if you do it properly

No, he changed his whole faceshape. It used to be heart shaped but now more squared.

Tell him bro

These copers

 

[Deleted member 9670]

Do I have cute chin?

Yes

 

[Deleted member 17791]

I am not imagining

u dont think it works cuz you haven't tried its really easy to gain bone if you do it properly

Tell him bro

These copers

I'm gonna ice my eyes. Need to get better hooding

 

[Deleted member 17791]

Yes

thank you! So you think it's androgynous?

 

[Deleted member 9670]

Post before after of your chin. You probably are just imagining things which aren’t there in reality

Happy?
You can see how I deformed myself

 

[Deleted member 9670]

thank you! So you think it's androgynous?

Avg Anglo girl has 3x chin mass of you tbh

 

[Deleted member 17791]

View attachment 1805693View attachment 1805694
Happy?
You can see how I deformed myself

doesn't look that bad here.

 

[Deleted member 17791]

Avg Anglo girl has 3x chin mass of you tbh

great news.

 

[Deleted member 9670]

doesn't look that bad here.

It looks better there tbh but full face it's very noticeable

 

[Deleted member 17791]

It looks better there tbh but full face it's very noticeable

Jaw seemed to get wider as well. Did you bone mash that too?

 

[Deleted member 9670]

Jaw seemed to get wider as well. Did you bone mash that too?

no i chewed a lot I think my masseters are just bigger

i dont chew anymore but they just retained a lot of their size that's why my jaw looks so rounded

 

[Deleted member 17791]

no i chewed a lot I think my masseters are just bigger

i dont chew anymore but they just retained a lot of their size that's why my jaw looks so rounded

Do you think I should get my masseters to atrophy to get a cuter look?