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God make my neurotransmitters great inc
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One of the major components of the skin is collagen (Ottani et al, 2001, 2002). Mutations in collagen genes resulting in abnormalities in collagen synthesis, deposition and/or degradation have been associated with a variety of human diseases (Myllyharju and Kivirikko, 2001). The skin of patients affected with scleroderma (Jimenez et al, 1996) and stiff skin syndrome (Esterly and McKusick, 1971;Jablonska et al, 1989) contains abnormally high amounts of collagen, and lacks the pliability and elasticity of normal skin. We have been investigating the features of Tight skin mice (Tsk and Tsk2) which, because of their increased deposition of collagen in the skin, have served as models for these diseases
