So clearly you’re pissed because I called out that you were factually incorrect and contradicting
tret also ups collagen production
should i get ceramide heavy 1
no they do not
Isotret breaks down into tretinoin in the body so whilst isotret doesnt bind to the RAR-y receptor itself its metabolites do the main one being tretinoin. Itself is a prodrug, they both reduce sebum production isotret just does it in the entire body. Just becuase they are prescribed to different people dont mean they dont work the same pathways
They share the RAR-γ pathway because of the prodrug conversion, but if you actually took the time to read the study you linked:
how about we read into the context of this post or does everyone have the same reaction/ genes as eachother? He says he has been on isotret for 4 months and is asking will taking tret help him now I ask you what will he get from using tret which he wont get from iso tret as the main pathway in tret is already in isotret or did you not read the start of the thread and think my post is more important (thank you if that is the case)
So clearly you’re pissed because I called out that you were factually incorrect and contradicting
You are completely right and I apolagise for my previous comments. He should 100% go on a combo of accutane and tretSo clearly you’re pissed because I called out that you were factually incorrect and contradicting
With regards to the context of the post, topical application would allow the pharmacokinetic delivery gradient to saturate the surface epidermis from the outside of the skin.
Application of topical Tretinoin during Isotretinoin therapy forces a high concentration of active retinoic acid directly into the follicular epithelium, resulting in significantly accelerated comedolysis (the rapid clearing of existing clogged pores) as compared to Isotretinoin therapy alone.
Furthermore, and most importantly, the direct topical application initiates aggressive dermal remodeling by communicating with fibroblasts to stimulate procollagen synthesis, leading to vastly superior and faster improvement in skin texture, post-inflammatory hyperpigmentation, and atrophic scarring compared to relying on the oral medication alone.
You clearly don’t understand the mechanistic properties of either of these drugs. You need to understand that Isotretinoin has to travel through the bloodstream, partition into the dermis, and then diffuse upward into the epidermis and sebaceous glands. And while it aggressively targets the sebaceous gland (triggering that unique apoptotic ), the actual concentration of retinoid metabolites that reaches the uppermost epidermal layers is limited by systemic distribution.
Therefore you cannot expect the same effects of topical Tretinoin by taking systemic Isotretinoin alone. And the combination would in fact be synergistic.
Again, nice try.
will def be using after this , thanks for ur effortSo clearly you’re pissed because I called out that you were factually incorrect and contradicting
With regards to the context of the post, topical application would allow the pharmacokinetic delivery gradient to saturate the surface epidermis from the outside of the skin.
Application of topical Tretinoin during Isotretinoin therapy forces a high concentration of active retinoic acid directly into the follicular epithelium, resulting in significantly accelerated comedolysis (the rapid clearing of existing clogged pores) as compared to Isotretinoin therapy alone.
Furthermore, and most importantly, the direct topical application initiates aggressive dermal remodeling by communicating with fibroblasts to stimulate procollagen synthesis, leading to vastly superior and faster improvement in skin texture, post-inflammatory hyperpigmentation, and atrophic scarring compared to relying on the oral medication alone.
You clearly don’t understand the mechanistic properties of either of these drugs. You need to understand that Isotretinoin has to travel through the bloodstream, partition into the dermis, and then diffuse upward into the epidermis and sebaceous glands. And while it aggressively targets the sebaceous gland (triggering that unique apoptotic ), the actual concentration of retinoid metabolites that reaches the uppermost epidermal layers is limited by systemic distribution.
Therefore you cannot expect the same effects of topical Tretinoin by taking systemic Isotretinoin alone. And the combination would in fact be synergistic.
Again, nice try.
