Isotretinion: Common Myth DEBUNKED - Prematured plate closure

[Fleisch]

This is a common misconspection about Isotretion

It mainly originates of a study done on kids. It showed an 1.38% chance of pre matured close plates ( 3/216 )

Spoiler: Study in question -

https://onlinelibrary.wiley.com/doi/10.1002/pbc.28236

It is true. It's a FACT -
These kids did get it.... But it just doesn't apply to people like us --
Most people can't interpert study's -
They didn't read it,
They just copy what other people say,
They're retarded and blind,
Or they're only reading ''conclusion''


Here are the facts onto why the study is USELESS -


1. Almost ALL patients were <5-10 years old
76% being <5y old
19% being 5-10y old
6% being 10y or older
Do I even have to comment anything on this???

2. The dosing of Isotret in question
The standard dosing here was 160 mg/m^2/day - The dosing was divided into 2 administrations.
Example -
Average 5 year old - 110cm-18kg-5y = 120mg PER DAY
Average 10 year old - 138cm - 32kg-10y = 180mg PER DAY

3. Why its diffrent for YOU and ME
1- Most likely you are not between the ages of 2 and 12 years old
2- You are not planning on going anywhere NEAR 120-200mg Isotret DAILY
3- You are already FAR more developed (GP wise ) than a 5 year old kid
4- Lets be honest here, even if it had a 1.38% change, having chronic acne is far worse




Accutane is a miracle drug
Worthy of your money and time.
If you have active acne, Accutane is the drug for you

Hope this thread could help a few gremlins out

Tags
- @Volksstaffel
- @turkcelfatcel
- @KanyeEast
- @Micrognathic
- @Sub5kang

 

[Lenko]

This is a common misconspection about Isotretion

It mainly originates of a study done on kids. It showed an 1.38% chance of pre matured close plates ( 3/216 )

Spoiler: Study in question -

https://onlinelibrary.wiley.com/doi/10.1002/pbc.28236

It is true. It's a FACT -
These kids did get it.... But it just doesn't apply to people like us --
Most people can't interpert study's -
They didn't read it,
They just copy what other people say,
They're retarded and blind,
Or they're only reading ''conclusion''


Here are the facts onto why the study is USELESS -


1. Almost ALL patients were <5-10 years old
76% being <5y old
19% being 5-10y old
6% being 10y or older
Do I even have to comment anything on this???

2. The dosing of Isotret in question
The standard dosing here was 160 mg/m^2/day - The dosing was divided into 2 administrations.
Example -
Average 5 year old - 110cm-18kg-5y = 120mg PER DAY
Average 10 year old - 138cm - 32kg-10y = 180mg PER DAY

3. Why its diffrent for YOU and ME
1- Most likely you are not between the ages of 2 and 12 years old
2- You are not planning on going anywhere NEAR 120-200mg Isotret DAILY
3- You are already FAR more developed (GP wise ) than a 5 year old kid
4- Lets be honest here, even if it had a 1.38% change, having chronic acne is far worse




Accutane is a miracle drug
Worthy of your money and time.
If you have active acne, Accutane is the drug for you

Hope this thread could help a few gremlins out

Tags
- @Volksstaffel
- @turkcelfatcel
- @KanyeEast
- @Micrognathic
- @Sub5kang

tretinoin even in it's topical form is a true lifesaver
retinoids r law

 

[Fleisch]

tretinoin even in it's topical form is a true lifesaver
retinoids r law

Agree, the only sad thing about Isotret is that it doesn’t help post inflammatory hyperpigmentation, which is a shame, so if u got bad old acne marks still there and takes extremely long to heal naturally without retinols

Therefore I use both at same time, will be using Isotret forever

 

[badorb]

Still not worth the over 50% dht loss during puberty

 

[moggin]

Still not worth the over 50% dht loss during puberty

dht is essentially worthless after you turn 15-16. All it does is grow your dick

 

[badorb]

dht is essentially worthless after you turn 15-16. All it does is grow your dick

more than that iqlet

 

[Fleisch]

Still not worth the over 50% dht loss during puberty

Is this ragebait or what, show evidence lil bro

 

[badorb]

Is this ragebait or what, show evidence lil bro

Holy shit bro ur retarded. This is a well known fact

The effect of low-dose isotretinoin therapy on serum androgen levels in women with acne vulgaris - PMC

Acne vulgaris is a common dermatologic disease that causes significant social and psychological morbidity. Isotretinoin, as a vitamin A derivative, is the most effective agent in the treatment of acne. Evidence suggests that isotretinoin’s ...

pmc.ncbi.nlm.nih.gov

 

[Fleisch]

Holy shit bro ur retarded. This is a well known fact

The effect of low-dose isotretinoin therapy on serum androgen levels in women with acne vulgaris - PMC

Acne vulgaris is a common dermatologic disease that causes significant social and psychological morbidity. Isotretinoin, as a vitamin A derivative, is the most effective agent in the treatment of acne. Evidence suggests that isotretinoin’s ...

pmc.ncbi.nlm.nih.gov

Lemme guess, u didn’t read the study

 

[badorb]

Lemme guess, u didn’t read the study

Together, these reports suggest that isotretinoin therapy decreases total testosterone, prolactin, and DHT, while increasing free testosterone and DHEA. Although the mechanism of these changes is not well understood, we hypothesize that isotretinoin induces the separation of testosterone from sex hormone-binding globulin, thereby increasing free testosterone levels and inhibiting the transformation of testosterone to DHT.

read the conclusion

 

[iblamebones000101]

Agree, the only sad thing about Isotret is that it doesn’t help post inflammatory hyperpigmentation, which is a shame, so if u got bad old acne marks still there and takes extremely long to heal naturally without retinols

Therefore I use both at same time, will be using Isotret forever

how do i get rid of spots then i am hoppig on free accutane at jan 14 i was wondering what do i do for spots

 

[karmacitathugmaxx]

i knew the jews were just trying to fear monger people into staying chopped

 

[Gandy'sOrbitalVecto]

This is a common misconspection about Isotretion

It mainly originates of a study done on kids. It showed an 1.38% chance of pre matured close plates ( 3/216 )

Spoiler: Study in question -

https://onlinelibrary.wiley.com/doi/10.1002/pbc.28236

It is true. It's a FACT -
These kids did get it.... But it just doesn't apply to people like us --
Most people can't interpert study's -
They didn't read it,
They just copy what other people say,
They're retarded and blind,
Or they're only reading ''conclusion''


Here are the facts onto why the study is USELESS -


1. Almost ALL patients were <5-10 years old
76% being <5y old
19% being 5-10y old
6% being 10y or older
Do I even have to comment anything on this???

2. The dosing of Isotret in question
The standard dosing here was 160 mg/m^2/day - The dosing was divided into 2 administrations.
Example -
Average 5 year old - 110cm-18kg-5y = 120mg PER DAY
Average 10 year old - 138cm - 32kg-10y = 180mg PER DAY

3. Why its diffrent for YOU and ME
1- Most likely you are not between the ages of 2 and 12 years old
2- You are not planning on going anywhere NEAR 120-200mg Isotret DAILY
3- You are already FAR more developed (GP wise ) than a 5 year old kid
4- Lets be honest here, even if it had a 1.38% change, having chronic acne is far worse




Accutane is a miracle drug
Worthy of your money and time.
If you have active acne, Accutane is the drug for you

Hope this thread could help a few gremlins out

Tags
- @Volksstaffel
- @turkcelfatcel
- @KanyeEast
- @Micrognathic
- @Sub5kang

Good thread bro

 

[Fleisch]

how do i get rid of spots then i am hoppig on free accutane at jan 14 i was wondering what do i do for spots

What kind of spots are you talking about brother,

 

[iblamebones000101]

What kind of spots are you talking about brother,

post inflametory spots brother like smll red dots after acne is gone aswell or somethimes dark brown

 

[Fleisch]

post inflametory spots brother like smll red dots after acne is gone aswell or somethimes dark brown

Use tretinion cream, I had that problem aswell, tret got rid of it pretty quick. I use tret+ Isotret it’s not a problem, just don’t do 80mg & 0.1% I do 20mg and .025%

 

[killuacel]

nice thread

 

[HighPerformer]

What do you think about normal retinol? Can it compete with tretinoin or is tret just so much better?

 

[Fleisch]

What do you think about normal retinol? Can it compete with tretinoin or is tret just so much better?

Normal retinol is trash bro

Don’t use that shit

 

[HighPerformer]

Normal retinol is trash bro

Don’t use that shit

Alright. I had some nice results from 1% retinol. But it probably doesn't come close to the effects of tretinoin. Beginners start with 0.025% right?

 

[Fleisch]

Alright. I had some nice results from 1% retinol. But it probably doesn't come close to the effects of tretinoin. Beginners start with 0.025% right?

If u already did 1% retinol just start at .05% tret bro

 

[iblamebones000101]

Use tretinion cream, I had that problem aswell, tret got rid of it pretty quick. I use tret+ Isotret it’s not a problem, just don’t do 80mg & 0.1% I do 20mg and .025%

cheers idk what doseage i will get for accutane but i will get tret cream since i heard accutane dont help anything in terms of post inflametory spots

 

[Fleisch]

cheers idk what doseage i will get for accutane but i will get tret cream since i heard accutane dont help anything in terms of post inflametory spots

Depends, use it if u got active acne rn

 

[iblamebones000101]

Depends, use it if u got active acne rn

ayee but it aint much acne i just made some bullshit about mental and confidence to get it i targeted accutane mostly for nose since i was planing on ehno or fake a condition for sypto also you think getting my trt from made in china a good idea or na

 

[Itsnotover77]

This is a common misconspection about Isotretion

It mainly originates of a study done on kids. It showed an 1.38% chance of pre matured close plates ( 3/216 )

Spoiler: Study in question -

https://onlinelibrary.wiley.com/doi/10.1002/pbc.28236

It is true. It's a FACT -
These kids did get it.... But it just doesn't apply to people like us --
Most people can't interpert study's -
They didn't read it,
They just copy what other people say,
They're retarded and blind,
Or they're only reading ''conclusion''


Here are the facts onto why the study is USELESS -


1. Almost ALL patients were <5-10 years old
76% being <5y old
19% being 5-10y old
6% being 10y or older
Do I even have to comment anything on this???

2. The dosing of Isotret in question
The standard dosing here was 160 mg/m^2/day - The dosing was divided into 2 administrations.
Example -
Average 5 year old - 110cm-18kg-5y = 120mg PER DAY
Average 10 year old - 138cm - 32kg-10y = 180mg PER DAY

3. Why its diffrent for YOU and ME
1- Most likely you are not between the ages of 2 and 12 years old
2- You are not planning on going anywhere NEAR 120-200mg Isotret DAILY
3- You are already FAR more developed (GP wise ) than a 5 year old kid
4- Lets be honest here, even if it had a 1.38% change, having chronic acne is far worse




Accutane is a miracle drug
Worthy of your money and time.
If you have active acne, Accutane is the drug for you

Hope this thread could help a few gremlins out

Tags
- @Volksstaffel
- @turkcelfatcel
- @KanyeEast
- @Micrognathic
- @Sub5kang

Thanks buddy. what I am asking me is: "How could a persn handle doses of 120-200mg?" I mean isnt that a damage, whcih was done to the participans??? I was using it for months and my nose began to bleed at 40mg at about 72kg.

 

[Fleisch]

Thanks buddy. what I am asking me is: "How could a persn handle doses of 120-200mg?" I mean isnt that a damage, whcih was done to the participans??? I was using it for months and my nose began to bleed at 40mg at about 72kg.

Since at a certain point blocking for example 95% of oil production at 60mg not superior over blocking 99% oil production at 200mg. They use it for the other effect being cancer tumor growth. So after a certain point it doesn’t matter THAT much anymore and is just money wise

 

[Fleisch]

If u use trt or any hormone or you’re young it’s always good to take Accutane tbh. It’s never bad, just stay on low doses and you’ll be fine

ayee but it aint much acne i just made some bullshit about mental and confidence to get it i targeted accutane mostly for nose since i was planing on ehno or fake a condition for sypto also you think getting my trt from made in china a good idea or na

 

[iblamebones000101]

If u use trt or any hormone or you’re young it’s always good to take Accutane tbh. It’s never bad, just stay on low doses and you’ll be fine

i meant tret bhai sorry for my mispells

 

[Fleisch]

i meant tret bhai sorry for my mispells

Than it’s a no brainer, but I would say Accutane is far better bc the acne from sebum upregulation is systematic from the trt so it would be smarter to also block it systematically with pills

 

[Kevla]

@Zagro