K2-MK4 source (UK)

[Fiqh]

Thoughts? @Napoleon1800

Thorne Vitamin K2

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[HighTierNormie]

k2 mk4 is a meme

 

[Fiqh]

k2 mk4 is a meme

What makes you come to this conclusion?

 

[HighTierNormie]

What makes you come to this conclusion?

i havent seen any convincing studies on efficacy of mk4 and people here over hype it, is good for calcium reabsorption but high T and growth hormone will do more for bones I dont really understand why mk4 over mk7 either

 

[coispet]

NOW Foods, Vitamin K-2, 100 mcg, 100 Veg Capsules

uk.iherb.com

I ordered this yday alongside D3

 

[Fiqh]

i havent seen any convincing studies on efficacy of mk4 and people here over hype it, is good for calcium reabsorption but high T and growth hormone will do more for bones I dont really understand

Not everyone is willing to do the latter.

mk4 over mk7 either

The large scale clinical trials are mostly with MK-4. The Japanese also have access to MK-7 and can produce it a lot more cheaply than MK-4 by using nato. Yet, they still went with MK-4. Most of the MK-7 trials so far are sponsored by either cheese or nato industry groups. There is notable lack of studies comparing MK-7 and MK-4. Probably because MK-4 will be found superior or at least as good as MK-7. The trials so far on MK-7 focus on comparisons with K1, which we know is inferior to the menaquinones. MK-4 is also the form used by the humans for functions such as electron transport carrier and co-factor for the carboxylation of osteocalcin. MK-7 is at best a surrogate for MK-4.


MK-4 has effects on gene expression in bone tissue that MK-7 doesn't have.
"The investigators found that MK-4 strongly activates transcription of two specific genes in osteoblast cells. Osteoblasts are cells that create bone tissue. The genes are GDF15 and STC2 and they're involved in bone and cartilage formation. They tested K1 and MK-7, and in contrast to MK-4, they did not activate transcription of the genes in the slightest. This shows that MK-4 has effects on gene expression in bone tissue that MK-7 doesn't have."
MK-7 has also less interaction with enzymes that would bring it into the cells (due to a longer side-chain, more lipophile)

Mk4 is preferably used by body
“Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells”
T Ichikawa1, K Horie-Inoue1, K Ikeda1, B Blumberg2 and S Inoue1,3 1

K2 Mk4 Or Mk7?

So which of the two forms hel with vitamin d3 and calcium deposting? The video below specifically claims the artery protective benefits are from mk7

raypeatforum.com

 

[Fiqh]

NOW Foods, Vitamin K-2, 100 mcg, 100 Veg Capsules

uk.iherb.com

I ordered this yday alongside D3

Couldn’t find mk4 in high enough dose that shipped to the UK

Why didn't you buy the one I linked? It's mk-4 with a good enough dosage.

 

[coispet]

Why didn't you buy the one I linked? It's mk-4 with a good enough dosage.

Send it again, I’ll buy it now

 

[coispet]

Send it again, I’ll buy it now

Wait nvm I’m stupid it’s in this thread

 

[Roge]

Vitamin D3 in MCT oil 5000 i.u. 1 ounce

healthnatura.com

This site also has k2 mk4 and less pricey than thorne