Keicht IGF1 spitballing 1

[Sachlichkeit]

Welcome back lads

We call it IGF spitballing 1 because there will probably be a 2. I do research, come to conclusions, some correct, some not, and adjust cycle/posts accordingly.

We are 147 days on cycle as of today.

I have 2 write more on tazmetostat, hdac inhibitors, blablabla, but today? GH.

This is a good thread and you should skim it if not read it

Will 12 IUs of Human Growth Hormone cause Acromegaly? Extensive Study.

Will 12 IUs of Human Growth Hormone cause Acromegaly? Multiple manlets on this Website will tell u that a Dosage like 10 to 15 IUs of HGH will cause Acromegaly, Few Examples pertain to; acromegaly speedrun Develop acromegaly For tards that think HGH is a superpower Now there are multiple...

looksmax.org

Acromegaly and abnormally large growth are not the same thing. Acromegaly warps proportions, causes soft tissue growth, organ growth, etc. As stated in the thread above, acromegaly comes from CHRONICALLY high GH and thus IGF-1, not the artificial spike exogenous GH causes, or even the tiktok cope GH secretagogue peptides & orals.

GH since 2003 has been approved for being short. not even a joke, its called idopathic short stature, medical term for being short for no reason. If you, as a teenager, go to a doctor and say, "doc, im short." theres a chance he writes you a script for GH.

So the org/tiktok fearmongering about the "drug" human growth hormone, (I put drug in parentheses because rHGH and endogenous GH are effectively the same thing,) is largely unfounded when approached from a medical perspective. Though between endogenous GH and exogenous obviously if we could go the natural route we would prefer to.

The effectiveness of GH varies in teens from bunch of retarded factors we don't care about. If you have idiopathic short stature 1-3inches should be expected for a standard (not looksmax.org 12-18iu, lmao) dose.

most important IGFBP igf binding proteins for bone growth is IGFBP 3 and 5. IGFBPs bind and shuttle IGF-1 to bones where their effects are released locally.

https://pubmed.ncbi.nlm.nih.gov/29130588/. This is korean study on Astralagus extract supplemental mix administered to little korean kids. the SUPPLEMENT raised IGFBP3 by 10-11% which is a significant margin (compared to exogenous HGH which is something like 10-30%.) You can probably source the supplement split easily and self compound. My stack is already large, I would rather streamline/do more drugs then tack on ancillaries. My primary constraints are diet, time and mechanical loading rn, not more drugs/supps. A bottle sourced from SK is in the hundreds of dollars (ebay.)

I am STILL a fan of metformin and spamming sugar for spiking insulin and reasonably controlling "background" IGF1 and am @ 500mg PM dose along with a neuroprotective dose of melatonin. Sugar to spike insulin, allowing for growth and easy carbs, metformin & blood glucose for blood sugar and as an organomegaly guardrail

How do we increase transcription/sensitivity? Tren. Test is base androgen, has all necessary downstreams, so its not just a big strong androgen, its basically hub for all male hormones. Tren? not so much, non aromatizing, just hardness and no significant neurosteroid downstreams/metabolites. So its just sheer androgen pressure

This isn't really good for growth, and dimorphism only goes so far. The reason it's mentioned is because of its unique localized IGF-1 enhancement in muscle and skeleton. As well as satellite cell upregulation. if person A does CJC+dac and person B does CJC+dac+tren B will have more growth specifically in skeleton and muscle tissue but moreso muscle.

What drives skeletal growth is low troughs and high peaks, more than the chronic elevation present in acromegaly. This is what makes the downstream amplification so good, because the natural rhythm which plays a significant part in the type of growth we want is preserved and enhanced.

Supplementing with tiktok drugs does not work. mk677 maybe but the more selective medically approved (in japan) anamorelin is preferred if you have appetite issues, though if you can't find the strength to bulk heavy im not sure you should be cycling

My primary constraints are diet, time and mechanical loading rn

We get heavy on this, maybe 6d/wk then optimize ancillaries, up dosages, and run bodybuilder panels for 2 years. just a little longer and I can leave this place forever. It was more than I bargained for lads. sometimes I wish I could go back to being ignorant

next threads are on the gene drugs, maybe experimental alternatives to mechanical tension, and full AAS attempted mitigation longterm
o7

 

[o_Owtf]

Good post overall, and you’re right that acromegaly != size increase. Classic acromegaly comes from chronically elevated GH/IGF-1, not pulsatile exposure, and the fearmongering around moderate exogenous GH is mostly exaggerated. That said, rHGH being "identical" to endogenous GH doesn’t mean it’s physiologically equivalent, exogenous use still bypasses feedback loops, so long-term average IGF-1 and individual sensitivity matter more than IU numbers alone.

IGFBP-3/5 are indeed the real levers for skeletal effects, but translating pediatric or supplement data to adult structural growth is still speculative. Same with tren: strong evidence for muscle IGF-1 amplification, much weaker for meaningful adult skeletal remodeling. Peaks > chronic elevation helps avoid acromegaloid changes, but it doesn’t guarantee growth by itself. And as you said, mechanical loading, diet, and time are still the true bottlenecks, drugs just amplify whatever signal is already there. 13 year olds just start pinning tren and do nothing which just gives you the risks with significantly reduced benefits.