Kj’s diary

[MugzLePew]

Reminder Quando Rondo is only 5'7 and he still slays.

 

[Deleted member 6403]

I thank God every day I'm med

 

[Deleted member 6403]

Do I have bdd or am I just really attuned to my body?

Cause if i eat some bad/have a bad lifestyle choice, my face turns ugly and vice versa

 

[Deleted member 6403]

I forgot how to eat

 

[Deleted member 6403]

Remember when mirin literally turned anorexic and everyone shrugged it off, acted like it was normal and just called it muh leanmaxxing?

@moonblunt @looksmaxxer234 @Adriana Lima @volcelfatcel @Monk @FastBananaCEO @AlwaysHaveQuestions

 

[volcelfatcel]

Remember when mirin literally turned anorexic and everyone shrugged it off, acted like it was normal and just called it muh leanmaxxing?

@moonblunt @looksmaxxer234 @Adriana Lima @volcelfatcel @Monk @FastBananaCEO @AlwaysHaveQuestions

currently becoming anorexic to leanmax tbh

 

[Deleted member 6403]

Had this wild dream where this theory of people that went to Walmart, never left Walmart

But before that I was about to get mauled by a pittbull but I used a screwdriver, and stabbed it up in the neck even though I had a knife on my pocket

Then I was at school and I seen bronem that died a minute ago, he just asked me sum and looked out for us cause these niggas was in the showers making all of the water come out of one pipe, so ift looked like a firefighter hose

Then I had to walk home and I got jumped by my rl opp w 3 other niggas, niggas stabbed me

 

[Deleted member 6403]

My dad's genes lowkey strong af cause my half bro looks exactly like me/us, that's them strong genes even tho we got different moms

 

[Deleted member 6403]

damn this brings back crazy memories, i remember the exact momeny when this album dropped,

it was midnight, i didn't have a bed, i was sleeping on the floor and listening to this

while thinking about my ex cause i had cut her off around this time, i had piped her like the week before

 

[Deleted member 5189]

Remember when mirin literally turned anorexic and everyone shrugged it off, acted like it was normal and just called it muh leanmaxxing?

@moonblunt @looksmaxxer234 @Adriana Lima @volcelfatcel @Monk @FastBananaCEO @AlwaysHaveQuestions

i dont even know who that is ngl

 

[Deleted member 6403]

 

[Deleted member 6403]

ill go dig up my old rods, aint think about buying no new guns

 

[Deleted member 6403]

Stuck in the hood, this where my niggas died, kinda hard for me to move on

 

[Deleted member 6403]

what movie that one called where dad tries to kill family movie, took place during winter, the hotel was haunted i think

 

[Deleted member 6403]

what movie that one called where dad tries to kill family movie, took place during winter, the hotel was haunted i think

the shining, just remembered

 

[MugzLePew]

latinos doesn't matter for height.

 

[Deleted member 6403]

why the hell am i getting darker? i liked being med coloring but I WONT STOP GETTING DARKER NOW!!!!

how do i stop melanin production

 

[Deleted member 6403]

i thought i was gonna die this morning ngl

 

[Deleted member 6403]

what did i say? i hope yall niggas @rm3d in gta 5

@ToursOverBoyo2020 @Chadlite Rutherford @Adriana Lima

 

[Deleted member 6403]

what did i say? i hope yall niggas @rm3d in gta 5

@ToursOverBoyo2020 @Chadlite Rutherford @Adriana Lima

^^ @lutte @WadlowMaxxing @Yellow_fever_cel

 

[Deleted member 6403]

@FastBananaCEO @LondonVillie @MakinItHappen

 

[Deleted member 6403]

 

[Adriana Lima]

TAKE LE GOVERMENT PROTECTION JUICE GOYIM

 

[Deleted member 6403]

drank too much coffee againm my hear is beating ot of its chest

 

[Deleted member 6403]

ahhhh fucc

finna go buss out some reps, chest n tri day, real nigga shit

 

[Deleted member 6403]

 

[Deleted member 6403]

lmfao

 

[Deleted member 6403]

lmfao

id pipe 3 n 5

 

[Deleted member 6403]

id pipe 3 n 5

5 can get it frfr

 

[Deleted member 6403]

Effect of aspirin on semen quality: A review​

According to the PubMed data base, there are at least fifty published articles that link between aspirin and semen quality. However, such link has yet to be comprehensively discussed and summarised.

This work reviews and summarises the effect of aspirin on semen quality and sperm fertility characteristics, and hence on semen fertilising ability. To achieve this contribution, an electronic search of PubMed and Scopus databases was conducted for original manuscripts, presented from January 1974 through September 2019, via the keywords "aspirin" and "acetylsalicylic acid" versus "sperm" and "semen."

In summary, there is a scientific research consensus that reveals negative effects of aspirin on semen quality.

Still, clinical studies that directly examine the effect of aspirin on the main semen quality parameters are needed to support this conclusion.

Mechanistically, the negative documented effect of aspirin on semen quality parameters may be attributable to decreased synthesis of testosterone, reduced function of nuclear factor kappa-light-chain-enhancer of activated B cells, decreased formation of testicular prostaglandins, reduced production of seminal nitric oxide and increased oxidative injury to sperm.

 

[Deleted member 6403]

Aspirin inhibits androgen response to chorionic gonadotropin in humans​

Eicosanoids play an important role in the regulation of the hypothalamic-pituitary axis; less clear is their role in testicular steroidogenesis. To evaluate the involvement of cyclooxygenase metabolites, such as prostaglandins, in the regulation of human testicular steroidogenesis, we examined the effects of a prostaglandin-blocker, aspirin, on plasma testosterone, pregnenolone, progesterone, 17OH-progesterone, androstenedione, dehydroepiandrosterone, and 17beta-estradiol response to human chorionic gonadotropin (hCG) in normal male volunteers in a placebo-controlled, single-blinded study.

To test the efficacy of aspirin, seminal prostaglandin E(2) levels were also determined. hCG stimulation increased peripheral levels of testosterone, 17OH-progesterone, androstenedione, dehydroepiandrosterone, and 17beta-estradiol, without affecting circulating pregnenolone and progesterone values.

Aspirin significantly lowered seminal prostaglandin E(2) levels, whereas it did not modify steroid concentrations not exposed to exogenous hCG. Moreover, the drug significantly reduced the response of testosterone, 17OH-progesterone, androstenedione, and dehydroepiandrosterone to hCG, as assessed by the mean integrated area under the curve, whereas it did not influence 17beta-estradiol response. In conclusion, aspirin treatment inhibits androgen response to chorionic gonadotropin stimulation in normal humans. The action of aspirin is probably mediated via an effective arachidonate cyclooxygenase block.

 

[Deleted member 6403]

Paracetamol, aspirin and indomethacin display endocrine disrupting properties in the adult human testis in vitro​

Study question: Do mild analgesics affect the endocrine system of the human adult testis?

Summary answer: Mild analgesics induce multiple endocrine disturbances in the human adult testis in vitro.

What is known already: Mild analgesics have recently been incriminated as potential endocrine disruptors. Studies of the effects of these widely used molecules on the androgenic status of men are limited and somewhat contradictory. This prompted us to investigate whether these compounds could alter the adult human testicular function. We therefore assessed in parallel the effects of paracetamol, aspirin and indomethacin on organo-cultured adult human testis and on the NCI-H295R steroid-producing human cell line.

Study design, size, duration: Adult human testis explants or NCI-H295R adrenocortical human cells were cultured with 10(-4) or 10(-5) M paracetamol, aspirin or indomethacin for 24-48 h. The effect of 10(-5) M ketoconazole, used as an anti-androgenic reference molecule, was also assessed.

Participants/materials, setting, methods: Testes were obtained from prostate cancer patients, who had not received any hormone therapy. The protocol was approved by the local ethics committee of Rennes, France and informed consent was given by the donors. Only testes displaying spermatogenesis, as assessed by transillumination, were used in this study. Hormone levels in the culture media were determined by radioimmunoassay (testosterone, insulin-like factor 3), Enzyme-Linked Immunosorbent Assay (inhibin B) or Enzyme Immunosorbent Assay [prostaglandin (PG) D2, and PGE2]. Tissues were observed and cells counted using classical immunohistochemical methods.

Main results and the role of chance: The three mild analgesics caused multiple endocrine disturbances in the adult human testis. This was particularly apparent in the interstitial compartment. Effective doses were in the same range as those measured in blood plasma following standard analgesic treatment. The production of testosterone and insulin-like factor 3 by Leydig cells was altered by exposure to all these drugs. Inhibin B production by Sertoli cells was marginally affected by aspirin only. Our experiments also revealed that mild analgesics display direct anti-PG activity, which varied depending on the drug used, the dose and the duration of exposure. Nevertheless, associations between the alteration of the PG and testosterone profiles were not systematically observed, suggesting that a combination of mechanisms of endocrine disruption is at play.

Limitations, reasons for caution: Our studies were performed in vitro.

Wider implications of the findings: We provide the first evidence that direct exposure to mild analgesics can result in multiple endocrine disturbances in the human adult testis. Caution, concerning the consumption of mild analgesics by men, should be strengthened, particularly in high-risk population subgroups such as elite athletes.

 

[Deleted member 6403]

Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis​

More than half the pregnant women in the Western world report taking mild analgesics. These pharmaceutical compounds have been associated with congenital cryptorchidism in humans, the best-known risk factor for low semen quality and testicular germ cell cancer.

Furthermore, some of these mild analgesics exert potent anti-androgenic effects in the male rat and several endocrine-disrupting compounds, known to alter masculinization, have also been shown to be potent inhibitors of prostaglandin (PG) synthesis similar to mild analgesics.

Using a 3-day ex vivo organotypic model system based on gestational day 14.5 rat testes, we herein show that testosterone production was inhibited by paracetamol, at doses of 0.1 μm to 100 μm. Similar results were obtained for aspirin (1-100 μm) and indomethacin (10 μm). The production of the other Leydig cell hormone, Insl3, was not disrupted by exposure to paracetamol. Investigations of the gross anatomy of the testis as well as Leydig cells number and rate of gonocyte apoptosis after the 3 days of ex vivo differentiation showed no significant effect of the analgesics tested compared with controls.

These data indicate therefore that mild analgesics specifically inhibit testosterone production in rat foetal testes in vitro and that these compounds had no effect on gonocyte survival. Parallel determinations of prostaglandin D2 (PGD2) production indicated that the effects of paracetamol and aspirin on PGD2 and testosterone were not connected, whereas the effects of indomethacin were correlated.

We conclude that mild analgesics exert direct and specific anti-androgenic effects in rat foetal testis in our experimental setup and that the mechanism of action is probably uncoupled from the inhibition of PG synthesis.

 

[Deleted member 6403]

 

[Deleted member 6403]

Effect of Different Garlic Preparations on Testosterone, Thyroid Hormones, and Some Serum Trace Elements in Rats​

Garlic is a house-available vegetable which is widely used for its spicy and medicinal benefits. Impact of different preparations on testosterone, thyroid hormones, and blood micro and trace elements were studied. Eight groups of male albino rats were selected including control group and other seven groups administered different doses of different garlic preparations by oral gavages for 1 month. At the end of the experiment, blood samples were collected for determination of serum hormones by radioimmunoassay, serum micro and trace elements by inductively coupled plasma-optical emission spectrometry (ICP-OES), and testes tissues for histological examination.

All treated groups with different garlic preparations revealed a highly significant decrease of testosterone level in rats as compared to control which confirmed with histological changes. Increase of thyroid hormones in some groups was seen. Hypokalemia and hypernatremia effect was recorded due to garlic treatments. Calcium, magnesium, selenium, zinc, manganese, iron, cadmium, lead, silicon, molybdenum, germanium, barium, boron, niobium, and aluminum levels showed alterations in different preparations groups. On the other hand, insignificant changes of strontium, chromium, cesium, and the nickel serum levels were noted.

Interestingly, although all garlic preparations have negative effects on serum testosterone level and testicular tissues, some garlic preparations have different effects on blood elements. Consequently, it infers that the usage of different garlic preparations must abide benefit/risk assessment to avoid unexpected health issues.

 

[Deleted member 6403]

RELATIONSHIP BETWEEN THE CONTENT OF ANDROGENIC STEROIDS IN THE TESTES AND THE SECRETORY ACTIVITY OF THE SEMINAL VESICLES IN THE BULL (Sucrose Levels and T)​

Testosterone and androstenedione were determined chemically in testes of bulls ranging in age from 28 days to 17½ years. The earliest age at which it was possible to detect both steroids was 39 days. Their combined contents in the testes varied from 4·7 to 61 μg at 39–90 days, from 31 to 475 μg at 3½–5½ months, and from 155 to 3450 μg at 10½ months-17½ years of age.

The ratio androstenedione/testosterone decreased with age. In immature bull calves, less than 4 months old, it exceeded 1:1, in animals above 9 months of age it was less than 1:10.

The appearance of chemically demonstrable amounts of testosterone and androstenedione in the testes of young bull calves coincided with the onset of an active process of fructose and citric-acid production by the seminal vesicles. Between the 2nd and 6th month of life, the weight, fructose level and citric-acid level of the seminal vesicles increased at an exponential rate, and this sharp increase in the activity of the seminal vesicles was accompanied by a similarly sharp increase in the testosterone content of the testes. In adult bulls, differing widely in age and breed, the testicular content of testosterone was significantly correlated with the weight, fructose content and citric-acid content of the seminal vesicles.

 

[Deleted member 6403]

Nah I fr thought I was gonna die this morning, I was on the verge of writing my will over Instagram DM's to this honduran bitch, out of all people, I was finna tell her where my Magnus opus and shit was located at

 

[Deleted member 6403]

free me

 

[Adriana Lima]

@kjsbdfiusdf @looksmaxxer234 @moonblunt

 

[BrendioEEE]

 

[Deleted member 6403]

I wanna start an ice cream selling business

but i don't want to run it publicly/work in it , I don't wanna ruin my street cred, I need to hire an illegal

how tho

 

[Deleted member 6403]

how do i hire someone to sell my ice cream

 

[Deleted member 6403]

Wtf is wrong w niggers

 

[Deleted member 6403]

a diet that is low iron and PUFA, contains the fat soluble vitamins, roughly equal or more calcium than phophorous (not necessarily very high amounts though), sufficient amounts of high quality protein, and overall very digestible. None of this is controversial. The mainstream fully accepts all of this.

But lifestyle and environment are the most important after that. Some concentric exercise, lots of sunlight and bright light, close positive social bonds, ample time for creative pursuits.
For cancer prevention your best bet is to keep the dopamine/serotonin ratio high through these general diet and lifestyle guidelines and keep your mitochondria healthy through an appropriate amount of exercise and enough magnesium and B vitamins.
Extremes aren't necessary.

 

[Deleted member 6403]

how do i find women that look exactly like this?

 

[Deleted member 6403]

...The simulacrum is never that which conceals the truth—it is the truth which conceals that there is none. The simulacrum is true.[3]
— The quote is credited to Ecclesiastes, but the words do not occur there. It can be seen as an addition,[4] a paraphrase and an endorsement of Ecclesiastes' condemnation[5] of the pursuit of wisdom as folly and a 'chasing after wind'—see for example Ecclesiastes 1.17.

Simulacra and Simulation is most known for its discussion of symbols, signs, and how they relate to contemporaneity (simultaneous existences).[6] Baudrillard claims that our current society has replaced all reality and meaning with symbols and signs, and that human experience is a simulation of reality.[7] Moreover, these simulacra are not merely mediations of reality, nor even deceptive mediations of reality; they are not based in a reality nor do they hide a reality, they simply hide that nothing like reality is relevant to our current understanding of our lives.[citation needed] The simulacra that Baudrillard refers to are the significations and symbolism of culture and media that construct perceived reality, the acquired understanding by which our lives and shared existence are rendered legible. Baudrillard believed that society had become so saturated with these simulacra and our lives so saturated with the constructs of society that all meaning was becoming meaningless by being infinitely mutable; he called this phenomenon the "precession of simulacra".[8]

Simulacra and Simulation delineates the sign-order into four stages:

1. The first stage is a faithful image/copy, where we believe, and it may even be correct, that a sign is a "reflection of a profound reality" (pg 6), this is a good appearance, in what Baudrillard called "the sacramental order".
2. The second stage is perversion of reality, this is where we come to believe the sign to be an unfaithful copy, which "masks and denatures" reality as an "evil appearance—it is of the order of maleficence". Here, signs and images do not faithfully reveal reality to us, but can hint at the existence of an obscure reality which the sign itself is incapable of encapsulating.
3. The third stage masks the absence of a profound reality, where the sign pretends to be a faithful copy, but it is a copy with no original. Signs and images claim to represent something real, but no representation is taking place and arbitrary images are merely suggested as things which they have no relationship to. Baudrillard calls this the "order of sorcery", a regime of semantic algebra where all human meaning is conjured artificially to appear as a reference to the (increasingly) hermetic truth.
4. The fourth stage is pure simulacrum, in which the simulacrum has no relationship to any reality whatsoever. Here, signs merely reflect other signs and any claim to reality on the part of images or signs is only of the order of other such claims. This is a regime of total equivalency, where cultural products need no longer even pretend to be real in a naïve sense, because the experiences of consumers' lives are so predominantly artificial that even claims to reality are expected to be phrased in artificial, "hyperreal" terms. Any naïve pretension to reality as such is perceived as bereft of critical self-awareness, and thus as oversentimental.

Simulacra and Simulation identifies three types of simulacra and identifies each with a historical period:

1. First order, associated with the premodern period, where representation is clearly an artificial placemarker for the real item. The uniqueness of objects and situations marks them as irreproducibly real and signification obviously gropes towards this reality.
2. Second order, associated with the modernity of the Industrial Revolution, where distinctions between representation and reality break down due to the proliferation of mass-reproducible copies of items, turning them into commodities. The commodity's ability to imitate reality threatens to replace the authority of the original version, because the copy is just as "real" as its prototype.
3. Third order, associated with the postmodernity of Late Capitalism, where the simulacrum precedes the original and the distinction between reality and representation vanishes. There is only the simulation, and originality becomes a totally meaningless concept.[9]

 

[lutte]

drank too much coffee againm my hear is beating ot of its chest

weak

 

[lutte]

@delusionalretard var det du som inte dricker kaffe?

 

[Deleted member 6403]

 

[Deleted member 6403]

checking up on my bitches...making sure they aint get the vaxx