Lifespan vs Health span

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Inhibiting CD38 protein can significantly increase NAD and sirt1 activity, because CD38 is a mayor consumer of NAD and other factors

https://onlinelibrary.wiley.com/doi/10.1111/acel.13589

Apigenin inhibits CD38 & increases NAD+

Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome - PubMed

Metabolic syndrome is a growing health problem worldwide. It is therefore imperative to develop new strategies to treat this pathology. In the past years, the manipulation of NAD(+) metabolism has emerged as a plausible strategy to ameliorate metabolic syndrome. In particular, an increase in...

pubmed.ncbi.nlm.nih.gov

lack of physical activity decreases CD38