list supplements/interventions that can delay puberty , menopause , or when applied during youth , extend lifespan

[Youㅤ]

most anti ageing supps are cope . even if they arent complete cope , they probably are when ur young . maybe they restore a biomarker so oldcels fare better , but this doesnt mean they actually slow ageing . therefore if they dont slow ageing , it would not be worth takeing in youth .

• melatonin can delay puberty in mice and potentially in humans . also can delay fecundity decline in mice and potentially menopause in humans . delaying things associated with ageing (puberty , menopause) is IMO more reason to think it delays ageing than something extending lifespan in mice . but melatonin has been shown to increase maximum lifespan in mice and fruit flies , so even better . melatonin actually starts to decline very early , peaking in early childhood , with a pronounced decline coincideing with puberty . and perhaps the further decline throughout adulthood contributes to the onset of menopause .

• lithium ? need more data on this but in fruit flies at least it increased lifespan mildly at 10 mM and insignificantly at 1 mM (in their food , yeast) when only given the first 1/4th of their lifespan . this means it couldnt have simply helped old flies cope with oldceldom and consequently extend lifespan , instead it probably slowed ageing . this is fly data but lithium did increase healthspan in mice and is associated with improved survival in humans . it is possible that lithium in early life impacted development somehow to extend lifespan later , and thus doesnt have to truly slow-ageing , but given the data in humans and mice , i think it likely does slow some aspects of ageing .

• resveratrol . this one has much hype for anti ageing and also much research . much controversy on whether it extends lifespan , but it has been shown to have many anti ageing effects , even if perhaps not strong enough to increase lifespan by much . one of these effects is it delays growth plate fusion (according to paper title , i didnt know rabbits growth plates fused) in female rabbits . im too lazy to do more reading on resveratrol but would be interesting to see how it affects fecundity decline in mice .

• rapamycin . rapamycin for only 3 months in 20 month old male mice extended remaining lifespan by over 50% and maximum lifespan by slightly under 200 days , at a very high dose of 8 mg/kg per day (injection) . but in female counterparts at this dose it slightly reduced survival , perhaps due to increased haematopoietic tumorigenesis . although at 128pmm in chow it increased survival both male and females when used for 3 months . the mice overall lived longer after treatment , implying that ageing was slowed . this was in old mice tho , and i want to know if rapamycin slows ageing in youth . well i couldnt find study on rapamycin in early adulthood , but it does delay puberty in female mice and it does extend lifespan when given the first 45 days of life in mice .

• ethanol (alcohol) . delayed puberty in mice . unfortunately behind a paywal so i cant know the dosage .https://www.sciencedirect.com/science/article/abs/pii/0890623889900440ethanol also increase mouse lifespan , and drinking alcohol (but not too much) associated with better survival in humans . since it delay mouse puberty , hopefully it actually slows ageing instead of simply gives oldcels some extra stress tolerance or something .

please list more things that show promise on actually slowing ageing , not things for oldcels to cope with oldceldom but things to actually delay oldceldom . if anyone has any info on how NAD+ precursors could affect ageing in youth , mechanistically or with evidence such as puberty timeing or transient application in mice , please let me know about it .

 

[Youㅤ]

rapamycin . rapamycin for only 3 months in 20 month old male mice extended remaining lifespan by over 50% and maximum lifespan by slightly under 200 days , at a very high dose of 8 mg/kg per day (injection) . but in female counterparts at this dose it slightly reduced survival , perhaps due to increased haematopoietic tumorigenesis . although at 128pmm in chow it increased survival both male and females when used for 3 months . the mice overall lived longer after treatment , implying that ageing was slowed . this was in old mice tho , and i want to know if rapamycin slows ageing in youth . well i couldnt find study on rapamycin in early adulthood , but it does delay puberty in female mice and it does extend lifespan when given the first 45 days of life in mice .

another study on transient early life rapamycin administration shows that the first 30 days but not day 30-60 extend lifespan significantly . but rapamycin from day 30-60 did extend extend lifespan , just below statistical significance . and remember rapamycin has extended lifespan in middle age and old age in mice , but it seems early is required for the imprint , whereas after that critical developmental stage , it slows ageing while in application but not after . this does not detract from the evidence that rapamycin will slow ageing in young adults .

 

[Deleted member 71172]

Brutal 0 reply pill + bump

 

[_looksmaxxer_]

im 14.5 rn, do you think it would be smart for me to take melatonin or not

 

[_looksmaxxer_]

Brutal 0 reply pill + bump

it has only been a minute, chill bro

 

[Youㅤ]

im 14.5 rn, do you think it would be smart for me to take melatonin or not

the only thing thats truly smart would be to learn about it urself and come to a conclusion

i dont give advice , but im willing to discuss science . i am not aware of any concerns with melatonin , as long as u buy a legit supplement , apart from potentially delayed puberty , which IMO is a good thing . i dont know how melatonin would impact puberty if ur already in the middle of it though , plus im not even sure how effective it is at delaying puberty or the exact nature of it .

 

[Youㅤ]

im 14.5 rn, do you think it would be smart for me to take melatonin or not

"Melatonin can impact TET proteins via the regulation of α-ketoglutarate level, thus promoting active DNA demethylation. Moreover, melatonin may also regulate DNMT, resulting in DNA methylation inhibition."

DNA methylation overall increases with age , perhaps melatonin delays puberty onset by slowing the methylation that induces puberty , and perhaps melatonin decreases during puberty to promote faster methylation to help drive puberty development .

in mice it can rejuvenate the thymus gland , which begins the process of involution (atrophy and replacement with fat) before puberty . perhaps it rejuvenates the thymus gland in mice by demethylateing the areas of the chromosomes responsible for promoteing thymus function .

 

[Deleted member 71172]

it has only been a minute, chill bro

Posted 3hrs ago

 

[Deleted member 23558]

youth hormones pregnenolone, progesterone, dhea

 

[Clavicular]

another study on transient early life rapamycin administration shows that the first 30 days but not day 30-60 extend lifespan significantly . but rapamycin from day 30-60 did extend extend lifespan , just below statistical significance . and remember rapamycin has extended lifespan in middle age and old age in mice , but it seems early is required for the imprint , whereas after that critical developmental stage , it slows ageing while in application but not after . this does not detract from the evidence that rapamycin will slow ageing in young adults .
View attachment 2925913

Bump

 

[Codeinlover]

most anti ageing supps are cope . even if they arent complete cope , they probably are when ur young . maybe they restore a biomarker so oldcels fare better , but this doesnt mean they actually slow ageing . therefore if they dont slow ageing , it would not be worth takeing in youth .

• melatonin can delay puberty in mice and potentially in humans . also can delay fecundity decline in mice and potentially menopause in humans . delaying things associated with ageing (puberty , menopause) is IMO more reason to think it delays ageing than something extending lifespan in mice . but melatonin has been shown to increase maximum lifespan in mice and fruit flies , so even better . melatonin actually starts to decline very early , peaking in early childhood , with a pronounced decline coincideing with puberty . and perhaps the further decline throughout adulthood contributes to the onset of menopause .

• lithium ? need more data on this but in fruit flies at least it increased lifespan mildly at 10 mM and insignificantly at 1 mM (in their food , yeast) when only given the first 1/4th of their lifespan . this means it couldnt have simply helped old flies cope with oldceldom and consequently extend lifespan , instead it probably slowed ageing . this is fly data but lithium did increase healthspan in mice and is associated with improved survival in humans . it is possible that lithium in early life impacted development somehow to extend lifespan later , and thus doesnt have to truly slow-ageing , but given the data in humans and mice , i think it likely does slow some aspects of ageing .

• resveratrol . this one has much hype for anti ageing and also much research . much controversy on whether it extends lifespan , but it has been shown to have many anti ageing effects , even if perhaps not strong enough to increase lifespan by much . one of these effects is it delays growth plate fusion (according to paper title , i didnt know rabbits growth plates fused) in female rabbits . im too lazy to do more reading on resveratrol but would be interesting to see how it affects fecundity decline in mice .

• rapamycin . rapamycin for only 3 months in 20 month old male mice extended remaining lifespan by over 50% and maximum lifespan by slightly under 200 days , at a very high dose of 8 mg/kg per day (injection) . but in female counterparts at this dose it slightly reduced survival , perhaps due to increased haematopoietic tumorigenesis . although at 128pmm in chow it increased survival both male and females when used for 3 months . the mice overall lived longer after treatment , implying that ageing was slowed . this was in old mice tho , and i want to know if rapamycin slows ageing in youth . well i couldnt find study on rapamycin in early adulthood , but it does delay puberty in female mice and it does extend lifespan when given the first 45 days of life in mice .

• ethanol (alcohol) . delayed puberty in mice . unfortunately behind a paywal so i cant know the dosage .https://www.sciencedirect.com/science/article/abs/pii/0890623889900440ethanol also increase mouse lifespan , and drinking alcohol (but not too much) associated with better survival in humans . since it delay mouse puberty , hopefully it actually slows ageing instead of simply gives oldcels some extra stress tolerance or something .

please list more things that show promise on actually slowing ageing , not things for oldcels to cope with oldceldom but things to actually delay oldceldom . if anyone has any info on how NAD+ precursors could affect ageing in youth , mechanistically or with evidence such as puberty timeing or transient application in mice , please let me know about it .

Just wear sunscrrren and eat raw primal

 

[Youㅤ]

youth hormones pregnenolone, progesterone, dhea

do those peak in childhood ?

 

[Deleted member 23558]

do those peak in childhood ?

right before puberty