literal heightpills

[Sachlichkeit]

infigratinib is a cancer medication that inhibits FGFR1‑FGFR4 signaling.

Infigratinib was studied in the Phase 2 PROPEL 2 trial (NCT04265651), involving 72 children aged 3–11 with achondroplasia. The key findings:

• Dosages: daily oral doses escalating across cohorts: 0.016, 0.032, 0.064, 0.128, and 0.25 mg/kg. The 0.25 mg/kg/day dose (Cohort 5) was selected for extended treatment reddit.com+10nejm.org+102minutemedicine.com+10.
• Efficacy: In Cohort 5, the mean increase in annualized height velocity reached +3.03 to +3.38 cm/year at 6 months, stabilizing at +2.50 cm/year by month 18; height z‑scores improved by +0.54 and body proportions also enhanced investors.com+9gimopen.org+9globenewswire.com+9.
• Side Effects: All participants experienced ≥1 treatment-emergent adverse event (TEAE), mostly mild-to-moderate. The most common included:
  • Common Cold (~40% of children) gimopen.org+62minutemedicine.com+6reddit.com+6
  • Other frequent issues: general infections (often upper respiratory), headaches, gastrointestinal discomfort (dyspepsia, flatulence), reduced appetite, hypercholesterolemia, hyperphosphatemia, and decreased vitamin D levels. No serious adverse events, no dose reductions or discontinuations due to AEs investor.bridgebio.com+8pmc.ncbi.nlm.nih.gov+8investor.bridgebio.com+8.

Study has shown it is more effective at height increase than vosoritide, which is the go-to for treating achondroplasia. It is also an oral, whereas vosoritide is subq (needle.) It is also cheaper, and easier to get a hold of.

The downside?

• Infection (who cares.)
• Diarrhea, constipation
• Appetite loss
• Headache
• Theoretical Alopecia
• Theoretical Dry eye, blurred vision, REVERSIBLE RETINAL DETACHMENT
• Theoretical 32% chance of serious adverse effects
• Theoretical permanent blindness

Theoretical meaning, well, theoretical. So these side effects haven't been observed in trials. Still retarded to risk permanent blindness for height so I will not be using it but interesting nontheless.