Local estrogen in the growth plates

[pizda]

I bought fucking chatgpt 5 because i use it alot for school n shit and it told me something very intresting, ive never heard this concept anywhere and it tells me its true. Basicly i was asking chat gpt about all this pharmacology shit and it told me that aromasin or ai in general is cope for heightmaxxing because ur growth plates produce estrogen localy and you cant inhibit it with stuff like ai? Is this actually true?

 

[Mwtkhs92]

A Little late but wanted to give my opinion. theoretically, lowering serum e2 reduces the substrate for local estrogen in growth plates, so in that case Its not cope. However some people say shit like "I'll take 500mg test for height but with an ai I'm fine" and that's where the problem comes because with testosterone present, an ai won't be able to reduce estrogen produced by the aromatase in growth plates as long as T is there.
Long story short don't take test at doses higher that 200mg if you care about height and use DHT derivatives instead.

 

[pizda]

A Little late but wanted to give my opinion. theoretically, lowering serum e2 reduces the substrate for local estrogen in growth plates, so in that case Its not cope. However some people say shit like "I'll take 500mg test for height but with an ai I'm fine" and that's where the problem comes because with testosterone present, an ai won't be able to reduce estrogen produced by the aromatase in growth plates as long as T is there.
Long story short don't take test at doses higher that 200mg if you care about height and use DHT derivatives instead.

What about jt activating the androgen receptors in ur growth plates?

 

[Mwtkhs92]

What about jt activating the androgen receptors in ur growth plates?

If you're asking if AR activation causes growth plates closure, unless you're running copious amounts of androgens, it's usually no big deal at all. May cause some very slight bone age advancement, (but still, at low-mid doses, it's no problem), but it doesn't mean bone closure.
Some studies show that compounds that activate AR a lot. (Tren) May slightly upregulated ER activity in bone independently of E2 levels, but that's in extreme case and not a certainty.

 

[PharmaPhaggot]

an ai won't be able to reduce estrogen produced by the aromatase in growth plates as long as T is there.

 

[Zagro]

A Little late but wanted to give my opinion. theoretically, lowering serum e2 reduces the substrate for local estrogen in growth plates, so in that case Its not cope. However some people say shit like "I'll take 500mg test for height but with an ai I'm fine" and that's where the problem comes because with testosterone present, an ai won't be able to reduce estrogen produced by the aromatase in growth plates as long as T is there.
Long story short don't take test at doses higher that 200mg if you care about height and use DHT derivatives instead.

You know that aromatase inhibitors work intracellularly right

That means that it also works in the growth plates thus the chondrocytes