Lowering T3/T4 can make you taller?

[topology]

This is me spitballing, I haven't heard this discussed anywhere and I'm curious about other perspectives. The common myth is to actually TAKE more T4.

As we know, gigantism mostly occurs when a tumor forms on the pituitary gland, causing massive amounts of growth hormone to be released continuously. This skyrockets the baseline, making people dramatically taller among other things. A fair question is whether pulses would be superior to a constant baseline elevation. For normal people, yes, pulses are more efficient. But gigantism shows that if the baseline is high enough and sustained long enough, it overrides that advantage entirely. That distinction matters for what I'm about to argue.

From here on I'll refer to growth hormone as GH.

GH drives the production of new cartilage and bone material while thyroid hormone drives its conversion and maturation into actual bone. Think of GH as the person making sandwiches and thyroid hormone as the person selling them. The making is the harder and more limiting job, so allocating equal resources to both is inefficient. The bottleneck is on the production side.

Now, the chondrocyte "exhaustion timer" is commonly cited as the hard limit on height, roughly 40 replications before the cells wear out. I'd argue this is not the primary constraint. The bigger factor is simply time. Chondrocytes are mostly exhausted by how long they live and operate, not by hitting a replication ceiling. Gigantism actually demonstrates this. It forces growth to happen so rapidly that it functionally bypasses the exhaustion argument. If replication limit was the real ceiling, gigantism wouldn't work, nothing would.

So why doesn't more thyroid hormone make you taller? It should promote growth on the surface. The problem is you're deploying all your resources into selling when there isn't enough being made to keep up. Worse, research has only looked at extreme thyroid deficiency combined with GH administration in rodents. Nobody has studied the subtle range. Excess thyroid hormone accelerates growth plate ossification and closes the window faster, which is why it can actually make you shorter.

The key observation is this: a child injecting supraphysiological HGH doesn't get meaningfully taller. The growth plates are open, the GH is available, and the effect is smaller than it should be. That tells you the GH axis is not the rate-limiting step under normal physiological conditions. The only way GH overcomes this is at the extreme sustained levels seen in gigantism. Via elimination, the bottleneck sits at the chondrocyte level, and thyroid signaling is the primary driver of chondrocyte maturation and ossification rate.

Reducing thyroid signaling also reduces GH receptor sensitivity and IGF-1 production, so it can't be dropped significantly. The solution is modest suppression of thyroid activity -- whether through T4, T3, or both depending on the individual -- enough to slow ossification rate without meaningfully impairing the GH axis. The exact degree would vary by individual due to differences in thyroid sensitivity, and the window only matters while growth plates are still open. But The takeaway is that nobody actually reaches their true genetic height potential, and gigantism shows this. The ceiling isn't fixed, it's a timing problem. I don't think anyone has seriously explored this specific angle before, which is part of why I'm nervous I'm wrong or oversimplifying everything down to these three hormones. This also assumes estrogen is in check, since estrogen is its own major driver of growth plate closure and that variable needs to be controlled for any of this to hold.

Note that I simplified a lot and didn't go deep on many of the mechanisms, so there are likely gaps in how this is presented. If something seems off or underexplained, leave a comment. Any "Dnr" commentors will be promptly put on ignored.

--------------

TLDR: Chondrocytes are time-limited, not replication-limited. Thyroid signaling is the primary driver of how fast that window closes -- for everyone, including gigantism cases where GH simply overwhelms the bottleneck rather than removes it. A modest reduction in thyroid activity slows ossification rate, preserves more of the growth window, and means most people never reach their true genetic height potential.

Inb4 BOTB.

@iblamexyz @Fridx @Scandicel @polonaecel @StyIix

 

[topology]

@Jason Voorhees @Verdam @whitecelcoper @lowtiersubhuman @Deroga

 

[Fridx]

And they say
muhhh ur here only to troll
Mirin thread g

 

[looksmaxer321]

This is me spitballing, I haven't heard this discussed anywhere and I'm curious about other perspectives. The common myth is to actually TAKE more T4.

As we know, gigantism mostly occurs when a tumor forms on the pituitary gland, causing massive amounts of growth hormone to be released continuously. This skyrockets the baseline, making people dramatically taller among other things. A fair question is whether pulses would be superior to a constant baseline elevation. For normal people, yes, pulses are more efficient. But gigantism shows that if the baseline is high enough and sustained long enough, it overrides that advantage entirely. That distinction matters for what I'm about to argue.

From here on I'll refer to growth hormone as GH.

GH drives the production of new cartilage and bone material while thyroid hormone drives its conversion and maturation into actual bone. Think of GH as the person making sandwiches and thyroid hormone as the person selling them. The making is the harder and more limiting job, so allocating equal resources to both is inefficient. The bottleneck is on the production side.

Now, the chondrocyte "exhaustion timer" is commonly cited as the hard limit on height, roughly 40 replications before the cells wear out. I'd argue this is not the primary constraint. The bigger factor is simply time. Chondrocytes are mostly exhausted by how long they live and operate, not by hitting a replication ceiling. Gigantism actually demonstrates this. It forces growth to happen so rapidly that it functionally bypasses the exhaustion argument. If replication limit was the real ceiling, gigantism wouldn't work, nothing would.

So why doesn't more thyroid hormone make you taller? It should promote growth on the surface. The problem is you're deploying all your resources into selling when there isn't enough being made to keep up. Worse, research has only looked at extreme thyroid deficiency combined with GH administration in rodents. Nobody has studied the subtle range. Excess thyroid hormone accelerates growth plate ossification and closes the window faster, which is why it can actually make you shorter.

The key observation is this: a child injecting supraphysiological HGH doesn't get meaningfully taller. The growth plates are open, the GH is available, and the effect is smaller than it should be. That tells you the GH axis is not the rate-limiting step under normal physiological conditions. The only way GH overcomes this is at the extreme sustained levels seen in gigantism. Via elimination, the bottleneck sits at the chondrocyte level, and thyroid signaling is the primary driver of chondrocyte maturation and ossification rate.

Reducing thyroid signaling also reduces GH receptor sensitivity and IGF-1 production, so it can't be dropped significantly. The solution is modest suppression of thyroid activity -- whether through T4, T3, or both depending on the individual -- enough to slow ossification rate without meaningfully impairing the GH axis. The exact degree would vary by individual due to differences in thyroid sensitivity, and the window only matters while growth plates are still open. But The takeaway is that nobody actually reaches their true genetic height potential, and gigantism shows this. The ceiling isn't fixed, it's a timing problem. I don't think anyone has seriously explored this specific angle before, which is part of why I'm nervous I'm wrong or oversimplifying everything down to these three hormones. This also assumes estrogen is in check, since estrogen is its own major driver of growth plate closure and that variable needs to be controlled for any of this to hold.

Note that I simplified a lot and didn't go deep on many of the mechanisms, so there are likely gaps in how this is presented. If something seems off or underexplained, leave a comment. Any "Dnr" commentors will be promptly put on ignored.

--------------

TLDR: Chondrocytes are time-limited, not replication-limited. Thyroid signaling is the primary driver of how fast that window closes -- for everyone, including gigantism cases where GH simply overwhelms the bottleneck rather than removes it. A modest reduction in thyroid activity slows ossification rate, preserves more of the growth window, and means most people never reach their true genetic height potential.

Inb4 BOTB.

@iblamexyz @Fridx @Scandicel @polonaecel @StyIix

Iqlet

 

[iqletandrew73]

may read later on, looks good thread to me g

 

[jizargo]

Everybody tell this nigger shut up

 

[topology]

And they say
muhhh ur here only to troll
Mirin thread g

When will they learn...

 

[topology]

Iqlet

Didn't even read what I said.

Everybody tell this nigger shut up

Get a grip.

You people tell me to contribute and STILL try to be funny and clown me once I do. No winning with you people.

 

[topology]

@Ghost Philosophy I've contributed to this site. Can I have my reaction permissions back yet?

 

[lowtiersubhuman]

This is me spitballing, I haven't heard this discussed anywhere and I'm curious about other perspectives. The common myth is to actually TAKE more T4.

As we know, gigantism mostly occurs when a tumor forms on the pituitary gland, causing massive amounts of growth hormone to be released continuously. This skyrockets the baseline, making people dramatically taller among other things. A fair question is whether pulses would be superior to a constant baseline elevation. For normal people, yes, pulses are more efficient. But gigantism shows that if the baseline is high enough and sustained long enough, it overrides that advantage entirely. That distinction matters for what I'm about to argue.

From here on I'll refer to growth hormone as GH.

GH drives the production of new cartilage and bone material while thyroid hormone drives its conversion and maturation into actual bone. Think of GH as the person making sandwiches and thyroid hormone as the person selling them. The making is the harder and more limiting job, so allocating equal resources to both is inefficient. The bottleneck is on the production side.

Now, the chondrocyte "exhaustion timer" is commonly cited as the hard limit on height, roughly 40 replications before the cells wear out. I'd argue this is not the primary constraint. The bigger factor is simply time. Chondrocytes are mostly exhausted by how long they live and operate, not by hitting a replication ceiling. Gigantism actually demonstrates this. It forces growth to happen so rapidly that it functionally bypasses the exhaustion argument. If replication limit was the real ceiling, gigantism wouldn't work, nothing would.

So why doesn't more thyroid hormone make you taller? It should promote growth on the surface. The problem is you're deploying all your resources into selling when there isn't enough being made to keep up. Worse, research has only looked at extreme thyroid deficiency combined with GH administration in rodents. Nobody has studied the subtle range. Excess thyroid hormone accelerates growth plate ossification and closes the window faster, which is why it can actually make you shorter.

The key observation is this: a child injecting supraphysiological HGH doesn't get meaningfully taller. The growth plates are open, the GH is available, and the effect is smaller than it should be. That tells you the GH axis is not the rate-limiting step under normal physiological conditions. The only way GH overcomes this is at the extreme sustained levels seen in gigantism. Via elimination, the bottleneck sits at the chondrocyte level, and thyroid signaling is the primary driver of chondrocyte maturation and ossification rate.

Reducing thyroid signaling also reduces GH receptor sensitivity and IGF-1 production, so it can't be dropped significantly. The solution is modest suppression of thyroid activity -- whether through T4, T3, or both depending on the individual -- enough to slow ossification rate without meaningfully impairing the GH axis. The exact degree would vary by individual due to differences in thyroid sensitivity, and the window only matters while growth plates are still open. But The takeaway is that nobody actually reaches their true genetic height potential, and gigantism shows this. The ceiling isn't fixed, it's a timing problem. I don't think anyone has seriously explored this specific angle before, which is part of why I'm nervous I'm wrong or oversimplifying everything down to these three hormones. This also assumes estrogen is in check, since estrogen is its own major driver of growth plate closure and that variable needs to be controlled for any of this to hold.

Note that I simplified a lot and didn't go deep on many of the mechanisms, so there are likely gaps in how this is presented. If something seems off or underexplained, leave a comment. Any "Dnr" commentors will be promptly put on ignored.

--------------

TLDR: Chondrocytes are time-limited, not replication-limited. Thyroid signaling is the primary driver of how fast that window closes -- for everyone, including gigantism cases where GH simply overwhelms the bottleneck rather than removes it. A modest reduction in thyroid activity slows ossification rate, preserves more of the growth window, and means most people never reach their true genetic height potential.

Inb4 BOTB.

@iblamexyz @Fridx @Scandicel @polonaecel @StyIix

Piggybacking off your sandwhich analogy So basically your saying you leave the top bun off so you can make double the burgers with the extra buns you have then when you get a buyer you now have the ability to put the top buns on all the burgers

 

[Ghost Philosophy]

@Ghost Philosophy I've contributed to this site. Can I have my reaction permissions back yet?

Sure, it’s been long enough. Kindly don’t do it again, otherwise I’ll have to take them away again, and for a longer period of time.

I’ll give them back after I’m done with the dishes and showering.

 

[topology]

So basically your saying you leave the top bun off so you can make double the burgers with the extra buns you have then when you get a buyer you now have the ability to put the top buns on all the burgers

No, the analogy would be like this: you get more people making burgers while fewer sell, until it's at the optimal ratio for sales (height). This is because there's basically an infinite queue of people waiting to buy. People would be differentiated mostly by how long they waited rather than how many others bought.

 

[topology]

Sure, it’s been long enough. Kindly don’t do it again, otherwise I’ll have to take them away again, and for a longer period of time.

I’ll give them back after I’m done with the dishes and showering.

Thanks.

 

[topology]

Piggybacking off your sandwhich analogy So basically your saying you leave the top bun off so you can make double the burgers with the extra buns you have then when you get a buyer you now have the ability to put the top buns on all the burgers

No, the analogy would be like this: you get more people making burgers while fewer sell, until it's at the optimal ratio for sales (height). This is because there's basically an infinite queue of people waiting to buy. People would be differentiated mostly by how long they waited rather than how many others bought.

This is kind of like a quadratic situation where it's like "500 people attend for $50 tickets, the number of attendees goes down by 5 every $5 increase. What is the optimal price?"

 

[lowtiersubhuman]

No, the analogy would be like this: you get more people making burgers while fewer sell, until it's at the optimal ratio for sales (height). This is because there's basically an infinite queue of people waiting to buy. People would be differentiated mostly by how long they waited rather than how many others bought.

if im understanding correctly the people selling are the thyroid hormone, they mature the bone and make the sale(bone growth but this also slightly closes the plate
The ppl making burgers are the gh making the cartilage so you basically you want to keep a stockpile of cartilage so that the plate cant close because your cashiers(thyroid cant leave work until they sold all the burgers so we keep making burgers

 

[Deroga]

@Jason Voorhees @Verdam @whitecelcoper @lowtiersubhuman @Deroga

Nice threasd

 

[lowtiersubhuman]

This is kind of like a quadratic situation where it's like "500 people attend for $50 tickets, the number of attendees goes down by 5 every $5 increase. What is the optimal price?"

This makes more sense you want to equalize both things that make bones

 

[topology]

if im understanding correctly the people selling are the thyroid hormone, they mature the bone and make the sale(bone growth but this also slightly closes the plate

They try to sell when we have no burgers essentially leading to lower profits for the business owner.

The ppl making burgers are the gh making the cartilage so you basically you want to keep a stockpile of cartilage so that the plate cant close because your cashiers(thyroid cant leave work until they sold all the burgers so we keep making burgers

No, you want to get it to the ideal level where they're working in perfect harmony. Hypothyroidism causes you to be shorter. I've stated that's why you only should slightly lower the level by like 10-15%.

 

[topology]

This makes more sense you want to equalize both things that make bones

Yes, that's the point, to allocate where it's most optimal.

Nice threasd

I know.

 

[lowtiersubhuman]

They try to sell when we have no burgers essentially leading to lower profits for the business owner.


No, you want to get it to the ideal level where they're working in perfect harmony. Hypothyroidism causes you to be shorter. I've stated that's why you only should slightly lower the level by like 10-15%.

Im not saying to increase the amount of cashiers im saying making making it so the cashier just barley cant keep up or can keep up absolutely perfectly with the cooks makes it so the body never has a windows to fully close the plate??

 

[ragingmanlet]

Sure, it’s been long enough. Kindly don’t do it again, otherwise I’ll have to take them away again, and for a longer period of time.

I’ll give them back after I’m done with the dishes and showering.

As much as I hate that guy, I still think the mods shouldn't be able to do shit like this

also, was that data breach thing real or js troll trying to cause mass hysteria?

 

[topology]

also, was that data breach thing real or js troll trying to cause mass hysteria?

It was stated by moderators it was not real.

Im not saying to increase the amount of cashiers im saying making making it so the cashier just barley cant keep up or can keep up absolutely perfectly with the cooks makes it so the body never has a windows to fully close the plate??

The body will close the plate regardless. The point is that it won't waste time/life on things that don't matter leading to being taller. The idea though is to make them perfectly keep up, yes.

 

[lowtiersubhuman]

They try to sell when we have no burgers essentially leading to lower profits for the business owner.

I get it i think let me restart we want the cooks to make 1 burger per second and the cashier to sell .95-1 burger per second but absolutely no more than one because we pay the customers one dollar to walk up to the counter if we dont have a burger to sell to then and make 5 dollars profit we lose that dollar flat out a perfect system like a basal metabolic rate for the human body eating the same that we burn

 

[polonaecel]

This is me spitballing, I haven't heard this discussed anywhere and I'm curious about other perspectives. The common myth is to actually TAKE more T4.

As we know, gigantism mostly occurs when a tumor forms on the pituitary gland, causing massive amounts of growth hormone to be released continuously. This skyrockets the baseline, making people dramatically taller among other things. A fair question is whether pulses would be superior to a constant baseline elevation. For normal people, yes, pulses are more efficient. But gigantism shows that if the baseline is high enough and sustained long enough, it overrides that advantage entirely. That distinction matters for what I'm about to argue.

From here on I'll refer to growth hormone as GH.

GH drives the production of new cartilage and bone material while thyroid hormone drives its conversion and maturation into actual bone. Think of GH as the person making sandwiches and thyroid hormone as the person selling them. The making is the harder and more limiting job, so allocating equal resources to both is inefficient. The bottleneck is on the production side.

Now, the chondrocyte "exhaustion timer" is commonly cited as the hard limit on height, roughly 40 replications before the cells wear out. I'd argue this is not the primary constraint. The bigger factor is simply time. Chondrocytes are mostly exhausted by how long they live and operate, not by hitting a replication ceiling. Gigantism actually demonstrates this. It forces growth to happen so rapidly that it functionally bypasses the exhaustion argument. If replication limit was the real ceiling, gigantism wouldn't work, nothing would.

So why doesn't more thyroid hormone make you taller? It should promote growth on the surface. The problem is you're deploying all your resources into selling when there isn't enough being made to keep up. Worse, research has only looked at extreme thyroid deficiency combined with GH administration in rodents. Nobody has studied the subtle range. Excess thyroid hormone accelerates growth plate ossification and closes the window faster, which is why it can actually make you shorter.

The key observation is this: a child injecting supraphysiological HGH doesn't get meaningfully taller. The growth plates are open, the GH is available, and the effect is smaller than it should be. That tells you the GH axis is not the rate-limiting step under normal physiological conditions. The only way GH overcomes this is at the extreme sustained levels seen in gigantism. Via elimination, the bottleneck sits at the chondrocyte level, and thyroid signaling is the primary driver of chondrocyte maturation and ossification rate.

Reducing thyroid signaling also reduces GH receptor sensitivity and IGF-1 production, so it can't be dropped significantly. The solution is modest suppression of thyroid activity -- whether through T4, T3, or both depending on the individual -- enough to slow ossification rate without meaningfully impairing the GH axis. The exact degree would vary by individual due to differences in thyroid sensitivity, and the window only matters while growth plates are still open. But The takeaway is that nobody actually reaches their true genetic height potential, and gigantism shows this. The ceiling isn't fixed, it's a timing problem. I don't think anyone has seriously explored this specific angle before, which is part of why I'm nervous I'm wrong or oversimplifying everything down to these three hormones. This also assumes estrogen is in check, since estrogen is its own major driver of growth plate closure and that variable needs to be controlled for any of this to hold.

Note that I simplified a lot and didn't go deep on many of the mechanisms, so there are likely gaps in how this is presented. If something seems off or underexplained, leave a comment. Any "Dnr" commentors will be promptly put on ignored.

--------------

TLDR: Chondrocytes are time-limited, not replication-limited. Thyroid signaling is the primary driver of how fast that window closes -- for everyone, including gigantism cases where GH simply overwhelms the bottleneck rather than removes it. A modest reduction in thyroid activity slows ossification rate, preserves more of the growth window, and means most people never reach their true genetic height potential.

Inb4 BOTB.

@iblamexyz @Fridx @Scandicel @polonaecel @StyIix

not a word but inb4 botb

 

[StyIix]

This is me spitballing, I haven't heard this discussed anywhere and I'm curious about other perspectives. The common myth is to actually TAKE more T4.

As we know, gigantism mostly occurs when a tumor forms on the pituitary gland, causing massive amounts of growth hormone to be released continuously. This skyrockets the baseline, making people dramatically taller among other things. A fair question is whether pulses would be superior to a constant baseline elevation. For normal people, yes, pulses are more efficient. But gigantism shows that if the baseline is high enough and sustained long enough, it overrides that advantage entirely. That distinction matters for what I'm about to argue.

From here on I'll refer to growth hormone as GH.

GH drives the production of new cartilage and bone material while thyroid hormone drives its conversion and maturation into actual bone. Think of GH as the person making sandwiches and thyroid hormone as the person selling them. The making is the harder and more limiting job, so allocating equal resources to both is inefficient. The bottleneck is on the production side.

Now, the chondrocyte "exhaustion timer" is commonly cited as the hard limit on height, roughly 40 replications before the cells wear out. I'd argue this is not the primary constraint. The bigger factor is simply time. Chondrocytes are mostly exhausted by how long they live and operate, not by hitting a replication ceiling. Gigantism actually demonstrates this. It forces growth to happen so rapidly that it functionally bypasses the exhaustion argument. If replication limit was the real ceiling, gigantism wouldn't work, nothing would.

So why doesn't more thyroid hormone make you taller? It should promote growth on the surface. The problem is you're deploying all your resources into selling when there isn't enough being made to keep up. Worse, research has only looked at extreme thyroid deficiency combined with GH administration in rodents. Nobody has studied the subtle range. Excess thyroid hormone accelerates growth plate ossification and closes the window faster, which is why it can actually make you shorter.

The key observation is this: a child injecting supraphysiological HGH doesn't get meaningfully taller. The growth plates are open, the GH is available, and the effect is smaller than it should be. That tells you the GH axis is not the rate-limiting step under normal physiological conditions. The only way GH overcomes this is at the extreme sustained levels seen in gigantism. Via elimination, the bottleneck sits at the chondrocyte level, and thyroid signaling is the primary driver of chondrocyte maturation and ossification rate.

Reducing thyroid signaling also reduces GH receptor sensitivity and IGF-1 production, so it can't be dropped significantly. The solution is modest suppression of thyroid activity -- whether through T4, T3, or both depending on the individual -- enough to slow ossification rate without meaningfully impairing the GH axis. The exact degree would vary by individual due to differences in thyroid sensitivity, and the window only matters while growth plates are still open. But The takeaway is that nobody actually reaches their true genetic height potential, and gigantism shows this. The ceiling isn't fixed, it's a timing problem. I don't think anyone has seriously explored this specific angle before, which is part of why I'm nervous I'm wrong or oversimplifying everything down to these three hormones. This also assumes estrogen is in check, since estrogen is its own major driver of growth plate closure and that variable needs to be controlled for any of this to hold.

Note that I simplified a lot and didn't go deep on many of the mechanisms, so there are likely gaps in how this is presented. If something seems off or underexplained, leave a comment. Any "Dnr" commentors will be promptly put on ignored.

--------------

TLDR: Chondrocytes are time-limited, not replication-limited. Thyroid signaling is the primary driver of how fast that window closes -- for everyone, including gigantism cases where GH simply overwhelms the bottleneck rather than removes it. A modest reduction in thyroid activity slows ossification rate, preserves more of the growth window, and means most people never reach their true genetic height potential.

Inb4 BOTB.

@iblamexyz @Fridx @Scandicel @polonaecel @StyIix

Good thread

 

[Ahmed88]

That's just wrong

 

[topology]

I get it i think let me restart we want the cooks to make 1 burger per second and the cashier to sell .95-1 burger per second but absolutely no more than one because we pay the customers one dollar to walk up to the counter if we dont have a burger to sell to then and make 5 dollars profit we lose that dollar flat out a perfect system like a basal metabolic rate for the human body eating the same that we burn

Correct -- the cooks make one burger per second, and the cashier sells at .95 to 1 burger per second, never more than one. The reason you don't want the cashier faster than the cooks is that we pay customers a dollar just to walk up to the counter, and if there's no burger ready we lose that dollar with no sale. So overselling costs you. The perfect system is like basal metabolic rate -- eating exactly what you burn.

not a word but inb4 botb

Good thread

Thanks.

 

[topology]

That's just wrong

Yep, go ahead and tell me why. Love the emojis, really adds to the credibility.

 

[lowtiersubhuman]

Correct -- the cooks make one burger per second, and the cashier sells at .95 to 1 burger per second, never more than one. The reason you don't want the cashier faster than the cooks is that we pay customers a dollar just to walk up to the counter, and if there's no burger ready we lose that dollar with no sale. So overselling costs you. The perfect system is like basal metabolic rate -- eating exactly what you burn.



Thanks.

Yup btw are you interested in making more high effort threads ive made a few threads on the topic but with proper formatting it could literally be both material imo

 

[lowtiersubhuman]

That's just wrong

He also said he was just spitballing this is all theoretical he doesn't have a degree in anatomy im sure

 

[topology]

Yup btw are you interested in making more high effort threads ive made a few threads on the topic but with proper formatting it could literally be both material imo

Depends on my mood and the subject. Link the threads and I'll see.

 

[topology]

He also said he was just spitballing this is all theoretical he doesn't have a degree in anatomy im sure

That guy is just posting garbage. I doubt anyone here actually can debunk this even if it is wrong without using AI.

 

[Brava]

read the whole thread. So if you are correct, I can just simply take t3/t4 and grow taller. How much taller could I get. Like an extra inch or two, how much? Great thread enjoyed reading it

 

[brotato78]

Ok how would we use this then

What decrease thyroid activity

 

[Verdam]

this is probably high iq

 

[lowtiersubhuman]

Depends on my mood and the subject. Link the threads and I'll see.

The subject is using the unhealthy dopamine loop co lined with the healthy seretonins from exercising and accomplishing things to get addicted to cardio good for leanmaxxing which is one of if not the best softmax

 

[topology]

read the whole thread. So if you are correct, I can just simply take t3/t4 and grow taller.

No, you make T3/T4 lower. I stated at the very top:

The common myth is to actually TAKE more T4.

How much taller could I get. Like an extra inch or two, how much

I don't know how much taller you could get. It really depends. It could be 5cm, 10cm, etc. There's no studies on what I'm suggesting. The closest thing is a trial in which a rat was made to have EXTREMLY low t4/t3 + hgh which is not what I'm suggesting. Hypothyroidism doesn't apply either.

Ok how would we use this then

What decrease thyroid activity

I'm not going to make any statements on how to do it as it may be entirely wrong. Why would you go ahead and do something which could be detrimental off looksmax.org with no studies to back it up? I'm going to see if this has any basis by seeing if research labs accept any inquires/suggestions.

this is probably high iq

Thanks.

The subject is using the unhealthy dopamine loop co lined with the healthy seretonins from exercising and accomplishing things to get addicted to cardio good for leanmaxxing which is one of if not the best softmax

Send me it & I'll let you know.

 

[lowtiersubhuman]

No, you make T3/T4 lower. I stated at the very top:




I don't know how much taller you could get. It really depends. It could be 5cm, 10cm, etc. There's no studies on what I'm suggesting. The closest thing is a trial in which a rat was made to have EXTREMLY low t4/t3 + hgh which is not what I'm suggesting. Hypothyroidism doesn't apply either.


I'm not going to make any statements on how to do it as it may be entirely wrong. Why would you go ahead and do something which could be detrimental off looksmax.org with no studies to back it up? I'm going to see if this has any basis by seeing if research labs accept any inquires/suggestions.


Thanks.


Send me it & I'll let you know.

I tagged you in it the thread is link in the thread I tagged you in

 

[Navity]

This is me spitballing, I haven't heard this discussed anywhere and I'm curious about other perspectives. The common myth is to actually TAKE more T4.

As we know, gigantism mostly occurs when a tumor forms on the pituitary gland, causing massive amounts of growth hormone to be released continuously. This skyrockets the baseline, making people dramatically taller among other things. A fair question is whether pulses would be superior to a constant baseline elevation. For normal people, yes, pulses are more efficient. But gigantism shows that if the baseline is high enough and sustained long enough, it overrides that advantage entirely. That distinction matters for what I'm about to argue.

From here on I'll refer to growth hormone as GH.

GH drives the production of new cartilage and bone material while thyroid hormone drives its conversion and maturation into actual bone. Think of GH as the person making sandwiches and thyroid hormone as the person selling them. The making is the harder and more limiting job, so allocating equal resources to both is inefficient. The bottleneck is on the production side.

Now, the chondrocyte "exhaustion timer" is commonly cited as the hard limit on height, roughly 40 replications before the cells wear out. I'd argue this is not the primary constraint. The bigger factor is simply time. Chondrocytes are mostly exhausted by how long they live and operate, not by hitting a replication ceiling. Gigantism actually demonstrates this. It forces growth to happen so rapidly that it functionally bypasses the exhaustion argument. If replication limit was the real ceiling, gigantism wouldn't work, nothing would.

So why doesn't more thyroid hormone make you taller? It should promote growth on the surface. The problem is you're deploying all your resources into selling when there isn't enough being made to keep up. Worse, research has only looked at extreme thyroid deficiency combined with GH administration in rodents. Nobody has studied the subtle range. Excess thyroid hormone accelerates growth plate ossification and closes the window faster, which is why it can actually make you shorter.

The key observation is this: a child injecting supraphysiological HGH doesn't get meaningfully taller. The growth plates are open, the GH is available, and the effect is smaller than it should be. That tells you the GH axis is not the rate-limiting step under normal physiological conditions. The only way GH overcomes this is at the extreme sustained levels seen in gigantism. Via elimination, the bottleneck sits at the chondrocyte level, and thyroid signaling is the primary driver of chondrocyte maturation and ossification rate.

Reducing thyroid signaling also reduces GH receptor sensitivity and IGF-1 production, so it can't be dropped significantly. The solution is modest suppression of thyroid activity -- whether through T4, T3, or both depending on the individual -- enough to slow ossification rate without meaningfully impairing the GH axis. The exact degree would vary by individual due to differences in thyroid sensitivity, and the window only matters while growth plates are still open. But The takeaway is that nobody actually reaches their true genetic height potential, and gigantism shows this. The ceiling isn't fixed, it's a timing problem. I don't think anyone has seriously explored this specific angle before, which is part of why I'm nervous I'm wrong or oversimplifying everything down to these three hormones. This also assumes estrogen is in check, since estrogen is its own major driver of growth plate closure and that variable needs to be controlled for any of this to hold.

Note that I simplified a lot and didn't go deep on many of the mechanisms, so there are likely gaps in how this is presented. If something seems off or underexplained, leave a comment. Any "Dnr" commentors will be promptly put on ignored.

--------------

TLDR: Chondrocytes are time-limited, not replication-limited. Thyroid signaling is the primary driver of how fast that window closes -- for everyone, including gigantism cases where GH simply overwhelms the bottleneck rather than removes it. A modest reduction in thyroid activity slows ossification rate, preserves more of the growth window, and means most people never reach their true genetic height potential.

Inb4 BOTB.

@iblamexyz @Fridx @Scandicel @polonaecel @StyIix

Mirin thread

 

[Scandicel]

This is me spitballing, I haven't heard this discussed anywhere and I'm curious about other perspectives. The common myth is to actually TAKE more T4.

As we know, gigantism mostly occurs when a tumor forms on the pituitary gland, causing massive amounts of growth hormone to be released continuously. This skyrockets the baseline, making people dramatically taller among other things. A fair question is whether pulses would be superior to a constant baseline elevation. For normal people, yes, pulses are more efficient. But gigantism shows that if the baseline is high enough and sustained long enough, it overrides that advantage entirely. That distinction matters for what I'm about to argue.

From here on I'll refer to growth hormone as GH.

GH drives the production of new cartilage and bone material while thyroid hormone drives its conversion and maturation into actual bone. Think of GH as the person making sandwiches and thyroid hormone as the person selling them. The making is the harder and more limiting job, so allocating equal resources to both is inefficient. The bottleneck is on the production side.

Now, the chondrocyte "exhaustion timer" is commonly cited as the hard limit on height, roughly 40 replications before the cells wear out. I'd argue this is not the primary constraint. The bigger factor is simply time. Chondrocytes are mostly exhausted by how long they live and operate, not by hitting a replication ceiling. Gigantism actually demonstrates this. It forces growth to happen so rapidly that it functionally bypasses the exhaustion argument. If replication limit was the real ceiling, gigantism wouldn't work, nothing would.

So why doesn't more thyroid hormone make you taller? It should promote growth on the surface. The problem is you're deploying all your resources into selling when there isn't enough being made to keep up. Worse, research has only looked at extreme thyroid deficiency combined with GH administration in rodents. Nobody has studied the subtle range. Excess thyroid hormone accelerates growth plate ossification and closes the window faster, which is why it can actually make you shorter.

The key observation is this: a child injecting supraphysiological HGH doesn't get meaningfully taller. The growth plates are open, the GH is available, and the effect is smaller than it should be. That tells you the GH axis is not the rate-limiting step under normal physiological conditions. The only way GH overcomes this is at the extreme sustained levels seen in gigantism. Via elimination, the bottleneck sits at the chondrocyte level, and thyroid signaling is the primary driver of chondrocyte maturation and ossification rate.

Reducing thyroid signaling also reduces GH receptor sensitivity and IGF-1 production, so it can't be dropped significantly. The solution is modest suppression of thyroid activity -- whether through T4, T3, or both depending on the individual -- enough to slow ossification rate without meaningfully impairing the GH axis. The exact degree would vary by individual due to differences in thyroid sensitivity, and the window only matters while growth plates are still open. But The takeaway is that nobody actually reaches their true genetic height potential, and gigantism shows this. The ceiling isn't fixed, it's a timing problem. I don't think anyone has seriously explored this specific angle before, which is part of why I'm nervous I'm wrong or oversimplifying everything down to these three hormones. This also assumes estrogen is in check, since estrogen is its own major driver of growth plate closure and that variable needs to be controlled for any of this to hold.

Note that I simplified a lot and didn't go deep on many of the mechanisms, so there are likely gaps in how this is presented. If something seems off or underexplained, leave a comment. Any "Dnr" commentors will be promptly put on ignored.

--------------

TLDR: Chondrocytes are time-limited, not replication-limited. Thyroid signaling is the primary driver of how fast that window closes -- for everyone, including gigantism cases where GH simply overwhelms the bottleneck rather than removes it. A modest reduction in thyroid activity slows ossification rate, preserves more of the growth window, and means most people never reach their true genetic height potential.

Inb4 BOTB.

@iblamexyz @Fridx @Scandicel @polonaecel @StyIix

my adhd won't let me understand everything hereby only reading it once, and i don't want to read it again, but it was good

 

[topology]

my adhd won't let me understand everything hereby only reading it once, and i don't want to read it again, but it was good

Are you not on medication?

 

[Ghost Philosophy]

Thanks.

No need to thank me. They have been restored. The issue was the spamming, you can still ugh me all you want. But give it some space in between.

 

[topology]

No need to thank me. They have been restored. The issue was the spamming, you can still ugh me all you want. But give it some space in between.

Ok, so what are the limitations? No spamming any reactions? Can I have a general guideline on what my limit is?

 

[Ghost Philosophy]

Ok, so what are the limitations? No spamming any reactions? Can I have a general guideline on what my limit is?

It’s mainly the ugh reaction spamming. Emphasis on spamming, so if you’re doing it every post in any given thread or minute, then it becomes excessive and it would be considered spamming. If you ugh a single post every hour or so, or every two hours, I’d say that’s fine. Or someone says you really dislike while you’re engaging them in an argument, that’s fine as well.

 

[topology]

It’s mainly the ugh reaction spamming. Emphasis on spamming, so if you’re doing it every post in any given thread or minute, then it becomes excessive and it would be considered spamming. If you ugh a single post every hour or so, or every two hours, I’d say that’s fine. Or someone says you really dislike while you’re engaging them in an argument, that’s fine as well.

Can I alternate between negative emojis to counteract this?

 

[Ghost Philosophy]

Can I alternate between negative emojis to counteract this?

Yes, that’s fine, you can use and . Along with , they make up the unholy trinity of reacts.

 

[Scandicel]

Are you not on medication?

No not now, i go on and off it.

sometimes i like it and sometimes i don't.

And i also want to up my dose.

 

[kisslessvirgin]

enrolling in the t4 program can make you taller

 

[iblamexyz]

you seem to of tagged which I appericate

shame I DNR u unless I alr replied?

 

[topology]

you seem to of tagged which I appericate

shame I DNR u unless I alr replied?

Shame on you indeed.