Avskinov
Will not give up
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Your Oral and Topical Minoxidil is not working ?
Minoxidil is a pro drug it needs conversion to work it is mainly converted by a enzyme known as SULT1A1( SULFOTRANSFERASE ENZYME ) this enzyme exist in hair follicles
Work of MINOXIDIL
1. Prolongs Anagen phase (growth phase)
2. Shortens Telogen phase (shedding phase)
3.Follicle Cell proliferation (growth of cell at hair follicle)
4. Upregulates VEGF ( Vascular Endothelial Growth Factor) formation of new blood vessel
5. Active nutrients transportation
6.Blood vessel widens more blood flow
i guess every one knows this lets get to the real deal
Minoxidil is inactive it self and is a neutral molecule when we apply or use minoxidil. SULT1A1 in hair follicle binds with minoxidil to form MINOXIDIL SULFATE ( ACTIVE FORM ) in this process SO3- binds with minoxidil via SULT1A1 enzyme and in simple terms the MINOXIDIL SULFATE opens ATP channel K+ ions rush out of cell this make cell more negative (hyper polarization ) hyperpolarized cell = relaxed cell which means blood vessel relaxes and widens blood flow
Minoxidil is a pro drug it needs conversion to work it is mainly converted by a enzyme known as SULT1A1( SULFOTRANSFERASE ENZYME ) this enzyme exist in hair follicles
Work of MINOXIDIL
1. Prolongs Anagen phase (growth phase)
2. Shortens Telogen phase (shedding phase)
3.Follicle Cell proliferation (growth of cell at hair follicle)
4. Upregulates VEGF ( Vascular Endothelial Growth Factor) formation of new blood vessel
5. Active nutrients transportation
6.Blood vessel widens more blood flow
i guess every one knows this lets get to the real deal
Minoxidil is inactive it self and is a neutral molecule when we apply or use minoxidil. SULT1A1 in hair follicle binds with minoxidil to form MINOXIDIL SULFATE ( ACTIVE FORM ) in this process SO3- binds with minoxidil via SULT1A1 enzyme and in simple terms the MINOXIDIL SULFATE opens ATP channel K+ ions rush out of cell this make cell more negative (hyper polarization ) hyperpolarized cell = relaxed cell which means blood vessel relaxes and widens blood flow
Why SULT1A1 Levels Matter So Much ?
High SULT1A1 in follicles = converts lots of minoxidil = great response
Low SULT1A1 = barely any conversion = poor response
This is genetically determined but can be altered to some point
Some people genuinely cannot respond well to topical minoxidil no matter the dose
This is also why oral minoxidil mogs for some non-responders cause oral has much more SULT1A1 activity than topical
Question is how to maximize its production ?
Low SULT1A1 = barely any conversion = poor response
This is genetically determined but can be altered to some point
Some people genuinely cannot respond well to topical minoxidil no matter the dose
This is also why oral minoxidil mogs for some non-responders cause oral has much more SULT1A1 activity than topical
Question is how to maximize its production ?
What Decreases SULT1A1 / Blocks Sulfonation
PAPS Depletion (3'-Phosphoadenosine-5'-Phosphosulfate)
Remember PAPS is the sulfate donor
No PAPS = no sulfonation regardless of enzyme levels
PAPS requires sulfur and ATP to synthesize
Low sulfur intake = limiting step
Direct inhibitors
Minoxidil itself at high doses can saturate and deplete PAPS
Using too much topical minoxidil = diminishing returns
Also many healthy polyphenols compete with or block sulfonation at liver but does little effect at hair follicle but it does
Remember PAPS is the sulfate donor
No PAPS = no sulfonation regardless of enzyme levels
PAPS requires sulfur and ATP to synthesize
Low sulfur intake = limiting step
Direct inhibitors
Minoxidil itself at high doses can saturate and deplete PAPS
Using too much topical minoxidil = diminishing returns
Also many healthy polyphenols compete with or block sulfonation at liver but does little effect at hair follicle but it does
What Actually Supports SULT1A1 & Sulfonation
1. Sulfur Intake — Most Important
PAPS synthesis requires inorganic sulfate. Your body gets sulfate from:
MSM (Methylsulfonylmethane) A supplement for this has a weak effect for human ig research has only been conducted to rats but weak research has been done on humans
NAC (N-Acetyl Cysteine) raises cysteine which is imp for PAPS synthesis this mechanism works but is indirect works best by combining with minoxidil
Taurine sulfur containing
Dietary sulfur foods eggs, meat there are some vegetables but seriously who eats them
MSM is the most direct and bioavailable sulfate source for PAPS synthesis. but low rsearch
2. Support things for SULT1A1 enzyme
SULT1A1 needs cofactors to function properly:
Magnesium : involved in PAPS synthesis
B vitamins (especially B2/riboflavin) : sulfur metabolism
Selenium : supports sulfur enzyme activity generally
Zinc : general enzyme cofactor
but low potency for working with minoxidil
3. Thyroid Function
important
Thyroid hormones upregulate SULT1A1 expression
Hypothyroidism is associated with poor sulfonation
if you're a poor minoxidil responder you might have bad thyroid
Tips : have good thyroid plus dont consume soylent food supplement MSM and NAC and will talk about its potency in next thread and avoid these polyphenols 2 to 3 hrs around application although the research is mostly done around SULT1A1 in liver cell for polyphenols and has a little effect on hair but has a effect .
PAPS synthesis requires inorganic sulfate. Your body gets sulfate from:
MSM (Methylsulfonylmethane) A supplement for this has a weak effect for human ig research has only been conducted to rats but weak research has been done on humans
NAC (N-Acetyl Cysteine) raises cysteine which is imp for PAPS synthesis this mechanism works but is indirect works best by combining with minoxidil
Taurine sulfur containing
Dietary sulfur foods eggs, meat there are some vegetables but seriously who eats them
MSM is the most direct and bioavailable sulfate source for PAPS synthesis. but low rsearch
2. Support things for SULT1A1 enzyme
SULT1A1 needs cofactors to function properly:
Magnesium : involved in PAPS synthesis
B vitamins (especially B2/riboflavin) : sulfur metabolism
Selenium : supports sulfur enzyme activity generally
Zinc : general enzyme cofactor
but low potency for working with minoxidil
3. Thyroid Function
important
Thyroid hormones upregulate SULT1A1 expression
Hypothyroidism is associated with poor sulfonation
if you're a poor minoxidil responder you might have bad thyroid
Tips : have good thyroid plus dont consume soylent food supplement MSM and NAC and will talk about its potency in next thread and avoid these polyphenols 2 to 3 hrs around application although the research is mostly done around SULT1A1 in liver cell for polyphenols and has a little effect on hair but has a effect .
