Sublingual minoxidil - the new holygrail of looksmaxing (no more bloating)

[anthrocellogy]

In this guide ill be talking about what sublingual minoxidil is,
why its the best, how to avoid bloating and how to make it at home.

Section 1

What is sublingual minoxidil

Spoiler: What is sublingual minoxidil

Sublingual minoxidil is the most recent form of minoxidil and is absorped by placing a tablet or liquid drop under the tongue.
this absorption method is the best since it goes directly through the mucous membrane into the bloodstream, this method bypasses the digestive system and the liver completely making this safer and more optimal then oral and topical minoxidil.

Sublingual minoxidil mechanism

Spoiler: Sublingual minoxidil mechanism

1. drug diffuses through the mucosal membrane into the sublingual veins
2. enters the heart without going through the digestive system or liver
3. reaches the systemic arteries
4. gets converted to minoxidil sulfate by platelet and tissue enzymes
5. opens the K_ATP channels
6. vasodilation + prolonged anagen phase
7. hair growth

Why sublingual is superior

Spoiler: Why sublingual is superior

1. Sublingual vs oral
the plasma concentration of sublingual minoxidil is way lower than oral
resulting in no/minimal palpitations, peripheral oederma and hypertension
making sublingual superior for having extremely lower cardiovascular side effects
whilst still getting the same amount of hair regrowth

2. Sublingual vs topical
the absorption from topical minoxidil isnt great for everyone.
Infact ~50% of people have to little SULTA1A1 resulting in little to no hair growth
even if you do get hair growth you'll encounter shedding and annoying application processes
making sublingual superior due to everyone being able to respond and easy to apply

Citations:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12207719/
https://pubmed.ncbi.nlm.nih.gov/39688293/
https://pubmed.ncbi.nlm.nih.gov/37638619/

Why sublingual causes minimal bloating

Spoiler: Why sublingual causes minimal bloating

As we all know oral minoxidil causes bloating due to its sodium retaining properties and its vasodilatory effects.
So the reason that sublingual has a lower downtime and less of it is due to this mechanism:

1. lower plasma concentration
2. weaker vasodilation
3. causing less sodium retention
4. less fluid accumulation.

When to take sublingual minoxidil

Spoiler: When to take sublingual minoxidil

since we know that the half life of minoxidil is 4,5 hours we are able to make an approximate timeline of the plasma levels.

for reference the baseline of plasma levels is 0, with topical minoxidil you get up to 1.6ng/ml and with 5mg oral you get all the way up to 37ng/ml.
when taking a 2.5mg sublingual dose (comparable to 3.75-5mg oral) you'd have a peak plasma of 9ng/ml at 30 minutes in
and it would basicly be gone withing 8 hours in comparison 5mg oral would still have plasma levels of 6ng/ml so 6x more.
meaning that its best to take before going to sleep, so adjust it based on your needs.

Sublingual minoxidil tldr

Spoiler: Sublingual minoxidil tldr

Sublingual minoxidil has the same efficacy for hair growth as oral minoxidil whilst having less side effects.
sublingual minoxidil is also 1.5-2x stronger than oral meaning that 1mg sublinguel = 1.5-2mg oral.
For taking sublingual minoxidil i would recommend taking 2.5mg before bed.

Section 2

How to get sublingual minoxidil

Spoiler: How to get sublingual minoxidil

1. Live in autralia and get a prescribtion or know someone that has one.
2. Buy raw minoxidil powder and DIY

Those are the only ways for now since it hasnt passed FDA and is still in phase III

Compounds for DIY sublingual minoxidil

Spoiler: Compounds for DIY sublingual minoxidil

raw minoxidil powder
propylene glycol
ethanol 95% food grade
water

Optional:
sucralose (sweetener)
peppermint/mint flavor food grade
citric acid (pH regulator)

Resources for DIY sublingual minoxidil

Spoiler: Resources for DIY sublingual minoxidil

0.001g precision scale
glass beakers 50ml and 100ml
stirrer (magnetic stirrer or glass rod)
amber glass dropper bottles

optional:
pH strips
funnel + filter paper
pipettes/syringes

Formula for DIY sublingual minoxidil

Spoiler: Formula for DIY sublingual minoxidil

1. 0.3ml/ml 95% ethanol food grade
2. 2.5mg/ml minoxidil powder
3. 0.5ml/ml propylene glycol


optional:
4. 0.2-0.3mg/ml sucralose
5. 0.5-1mg citric acid adjust to pH 4.5-5.5
6. 0.001-0.002ml peppermint/mint flavor food grade

This is in order of how you should brew

100ml example:
1. 30ml ethanol
2. 250mg minoxidil powder
3. 50ml propylene glycol
4. 20-30mg sucralose
5. 50-100mg citric acid (adjust based on pH
6. 0.1-0.2ml peppermint/mint flavoring

Following these instructions you should get 2.5mg/ml meaning that 1ml is 2.5mg worth of sublingual minoxidil

Video's of DIY sublingual minoxidil

Spoiler: Video's of DIY sublingual minoxidil

these should give you an idea how it should look.
DO NOT follow these exactly since they are for topical solutions.

Tips and tricks

Spoiler: Tips and tricks

warm the ethanol slightly (30-40°C) before adding powder for faster dissolvement
make sure that the powder doesnt have any clumps, if so break them apart till fine.
DONT shake instead stir
store away from light and heat
keep in fridge (2–8°C)
shelf life of ~1 year
start low with 0.5ml daily and titrate up to 1ml daily if you respond fine
keep in mind: sublingual is 1.5-2x stronger then oral

​

Im not a doctor nor pharmacist, do your own research and be extremely carefull.

 

[combatingNorwooding]

Interesting

 

[anthrocellogy]

@Chad @imontheloose @SlayerJonas @aids

 

[anthrocellogy]

@Orka @hax @LTNUser @Clavicular @pfl

 

[away]

good thread

 

[copingcoper]

could you use topical sublingually? bc you can take topical orally in very small doses (.06) and it has the same effect as 3mg oral

 

[anthrocellogy]

could you use topical sublingually?

wouldnt recommend it since the alcohols would be a disproportionate, dosing is off and the excipients could be bad for sublingual use.

 

[anthrocellogy]

this almost took me 7 hours

 

[DrMd]

inb4 botb

 

[anthrocellogy]

inb4 botb

9 views in 16 minutes

 

[anthrocellogy]

@ReadBooksEveryday @enchanted_elixir @mcmentalonthemic @BR32 @Fleisch

 

[vzk]

Will do this, thank you!

 

[Fleisch]

Holy fucking shit BOTB worthy thread

@Volksstaffel @Monicaa @KanyeEast @turkcelfatcel @Zagro

 

[Deleted member 2461]

In this guide ill be talking about what sublingual minoxidil is,
why its the best, how to avoid bloating and how to make it at home.

View attachment 4767173


Section 1

What is sublingual minoxidil

Spoiler: What is sublingual minoxidil

Sublingual minoxidil is the most recent form of minoxidil and is absorped by placing a tablet or liquid drop under the tongue.
this absorption method is the best since it goes directly through the mucous membrane into the bloodstream, this method bypasses the digestive system and the liver completely making this safer and more optimal then oral and topical minoxidil.
View attachment 4766587

Sublingual minoxidil mechanism

Spoiler: Sublingual minoxidil mechanism

1. drug diffuses through the mucosal membrane into the sublingual veins
2. enters the heart without going through the digestive system or liver
3. reaches the systemic arteries
4. gets converted to minoxidil sulfate by platelet and tissue enzymes
5. opens the K_ATP channels
6. vasodilation + prolonged anagen phase
7. hair growth

View attachment 4766795

Why sublingual is superior

Spoiler: Why sublingual is superior

1. Sublingual vs oral
the plasma concentration of sublingual minoxidil is way lower than oral
resulting in no/minimal palpitations, peripheral oederma and hypertension
making sublingual superior for having extremely lower cardiovascular side effects
whilst still getting the same amount of hair regrowth

2. Sublingual vs topical
the absorption from topical minoxidil isnt great for everyone.
Infact ~50% of people have to little SULTA1A1 resulting in little to no hair growth
even if you do get hair growth you'll encounter shedding and annoying application processes
making sublingual superior due to everyone being able to respond and easy to apply

Citations:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12207719/
https://pubmed.ncbi.nlm.nih.gov/39688293/
https://pubmed.ncbi.nlm.nih.gov/37638619/

Why sublingual causes minimal bloating

Spoiler: Why sublingual causes minimal bloating

As we all know oral minoxidil causes bloating due to its sodium retaining properties and its vasodilatory effects.
So the reason that sublingual has a lower downtime and less of it is due to this mechanism:

1. lower plasma concentration
2. weaker vasodilation
3. causing less sodium retention
4. less fluid accumulation.

View attachment 4767021

When to take sublingual minoxidil

Spoiler: When to take sublingual minoxidil

since we know that the half life of minoxidil is 4,5 hours we are able to make an approximate timeline of the plasma levels.

View attachment 4767654

for reference the baseline of plasma levels is 0, with topical minoxidil you get up to 1.6ng/ml and with 5mg oral you get all the way up to 37ng/ml.
when taking a 2.5mg sublingual dose (comparable to 3.75-5mg oral) you'd have a peak plasma of 9ng/ml at 30 minutes in
and it would basicly be gone withing 8 hours in comparison 5mg oral would still have plasma levels of 6ng/ml so 6x more.
meaning that its best to take before going to sleep, so adjust it based on your needs.

Sublingual minoxidil tldr

Spoiler: Sublingual minoxidil tldr

Sublingual minoxidil has the same efficacy for hair growth as oral minoxidil whilst having less side effects.
sublingual minoxidil is also 1.5-2x stronger than oral meaning that 1mg sublinguel = 1.5-2mg oral.
For taking sublingual minoxidil i would recommend taking 2.5mg before bed.

Section 2

How to get sublingual minoxidil

Spoiler: How to get sublingual minoxidil

1. Live in autralia and get a prescribtion or know someone that has one.
2. Buy raw minoxidil powder and DIY

Those are the only ways for now since it hasnt passed FDA and is still in phase III

Compounds for DIY sublingual minoxidil

Spoiler: Compounds for DIY sublingual minoxidil

raw minoxidil powder
propylene glycol
ethanol 95% food grade
water

Optional:
sucralose (sweetener)
peppermint/mint flavor food grade
citric acid (pH regulator)

Resources for DIY sublingual minoxidil

Spoiler: Resources for DIY sublingual minoxidil

0.001g precision scale
glass beakers 50ml and 100ml
stirrer (magnetic stirrer or glass rod)
amber glass dropper bottles

optional:
pH strips
funnel + filter paper
pipettes/syringes

Formula for DIY sublingual minoxidil

Spoiler: Formula for DIY sublingual minoxidil

1. 0.3ml/ml 95% ethanol food grade
2. 2.5mg/ml minoxidil powder
3. 0.5ml/ml propylene glycol


optional:
4. 0.2-0.3mg/ml sucralose
5. 0.5-1mg citric acid adjust to pH 4.5-5.5
6. 0.001-0.002ml peppermint/mint flavor food grade

This is in order of how you should brew

100ml example:
1. 30ml ethanol
2. 250mg minoxidil powder
3. 50ml propylene glycol
4. 20-30mg sucralose
5. 50-100mg citric acid (adjust based on pH
6. 0.1-0.2ml peppermint/mint flavoring

Following these instructions you should get 2.5mg/ml meaning that 1ml is 2.5mg worth of sublingual minoxidil

Video's of DIY sublingual minoxidil

Spoiler: Video's of DIY sublingual minoxidil

View attachment 4767448

these should give you an idea how it should look.
DO NOT follow these exactly since they are for topical solutions.

Tips and tricks

Spoiler: Tips and tricks

warm the ethanol slightly (30-40°C) before adding powder for faster dissolvement
make sure that the powder doesnt have any clumps, if so break them apart till fine.
DONT shake instead stir
store away from light and heat
keep in fridge (2–8°C)
shelf life of ~1 year
start low with 0.5ml daily and titrate up to 1ml daily if you respond fine
keep in mind: sublingual is 1.5-2x stronger then oral

​

Im not a doctor nor pharmacist, do your own research and be extremely carefull.

Why not use oral minox sublingually? What's the difference?

 

[Mercurius]

In this guide ill be talking about what sublingual minoxidil is,
why its the best, how to avoid bloating and how to make it at home.

View attachment 4767173


Section 1

What is sublingual minoxidil

Spoiler: What is sublingual minoxidil

Sublingual minoxidil is the most recent form of minoxidil and is absorped by placing a tablet or liquid drop under the tongue.
this absorption method is the best since it goes directly through the mucous membrane into the bloodstream, this method bypasses the digestive system and the liver completely making this safer and more optimal then oral and topical minoxidil.
View attachment 4766587

Sublingual minoxidil mechanism

Spoiler: Sublingual minoxidil mechanism

1. drug diffuses through the mucosal membrane into the sublingual veins
2. enters the heart without going through the digestive system or liver
3. reaches the systemic arteries
4. gets converted to minoxidil sulfate by platelet and tissue enzymes
5. opens the K_ATP channels
6. vasodilation + prolonged anagen phase
7. hair growth

View attachment 4766795

Why sublingual is superior

Spoiler: Why sublingual is superior

1. Sublingual vs oral
the plasma concentration of sublingual minoxidil is way lower than oral
resulting in no/minimal palpitations, peripheral oederma and hypertension
making sublingual superior for having extremely lower cardiovascular side effects
whilst still getting the same amount of hair regrowth

2. Sublingual vs topical
the absorption from topical minoxidil isnt great for everyone.
Infact ~50% of people have to little SULTA1A1 resulting in little to no hair growth
even if you do get hair growth you'll encounter shedding and annoying application processes
making sublingual superior due to everyone being able to respond and easy to apply

Citations:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12207719/
https://pubmed.ncbi.nlm.nih.gov/39688293/
https://pubmed.ncbi.nlm.nih.gov/37638619/

Why sublingual causes minimal bloating

Spoiler: Why sublingual causes minimal bloating

As we all know oral minoxidil causes bloating due to its sodium retaining properties and its vasodilatory effects.
So the reason that sublingual has a lower downtime and less of it is due to this mechanism:

1. lower plasma concentration
2. weaker vasodilation
3. causing less sodium retention
4. less fluid accumulation.

View attachment 4767021

When to take sublingual minoxidil

Spoiler: When to take sublingual minoxidil

since we know that the half life of minoxidil is 4,5 hours we are able to make an approximate timeline of the plasma levels.

View attachment 4767654

for reference the baseline of plasma levels is 0, with topical minoxidil you get up to 1.6ng/ml and with 5mg oral you get all the way up to 37ng/ml.
when taking a 2.5mg sublingual dose (comparable to 3.75-5mg oral) you'd have a peak plasma of 9ng/ml at 30 minutes in
and it would basicly be gone withing 8 hours in comparison 5mg oral would still have plasma levels of 6ng/ml so 6x more.
meaning that its best to take before going to sleep, so adjust it based on your needs.

Sublingual minoxidil tldr

Spoiler: Sublingual minoxidil tldr

Sublingual minoxidil has the same efficacy for hair growth as oral minoxidil whilst having less side effects.
sublingual minoxidil is also 1.5-2x stronger than oral meaning that 1mg sublinguel = 1.5-2mg oral.
For taking sublingual minoxidil i would recommend taking 2.5mg before bed.

Section 2

How to get sublingual minoxidil

Spoiler: How to get sublingual minoxidil

1. Live in autralia and get a prescribtion or know someone that has one.
2. Buy raw minoxidil powder and DIY

Those are the only ways for now since it hasnt passed FDA and is still in phase III

Compounds for DIY sublingual minoxidil

Spoiler: Compounds for DIY sublingual minoxidil

raw minoxidil powder
propylene glycol
ethanol 95% food grade
water

Optional:
sucralose (sweetener)
peppermint/mint flavor food grade
citric acid (pH regulator)

Resources for DIY sublingual minoxidil

Spoiler: Resources for DIY sublingual minoxidil

0.001g precision scale
glass beakers 50ml and 100ml
stirrer (magnetic stirrer or glass rod)
amber glass dropper bottles

optional:
pH strips
funnel + filter paper
pipettes/syringes

Formula for DIY sublingual minoxidil

Spoiler: Formula for DIY sublingual minoxidil

1. 0.3ml/ml 95% ethanol food grade
2. 2.5mg/ml minoxidil powder
3. 0.5ml/ml propylene glycol


optional:
4. 0.2-0.3mg/ml sucralose
5. 0.5-1mg citric acid adjust to pH 4.5-5.5
6. 0.001-0.002ml peppermint/mint flavor food grade

This is in order of how you should brew

100ml example:
1. 30ml ethanol
2. 250mg minoxidil powder
3. 50ml propylene glycol
4. 20-30mg sucralose
5. 50-100mg citric acid (adjust based on pH
6. 0.1-0.2ml peppermint/mint flavoring

Following these instructions you should get 2.5mg/ml meaning that 1ml is 2.5mg worth of sublingual minoxidil

Video's of DIY sublingual minoxidil

Spoiler: Video's of DIY sublingual minoxidil

View attachment 4767448

these should give you an idea how it should look.
DO NOT follow these exactly since they are for topical solutions.

Tips and tricks

Spoiler: Tips and tricks

warm the ethanol slightly (30-40°C) before adding powder for faster dissolvement
make sure that the powder doesnt have any clumps, if so break them apart till fine.
DONT shake instead stir
store away from light and heat
keep in fridge (2–8°C)
shelf life of ~1 year
start low with 0.5ml daily and titrate up to 1ml daily if you respond fine
keep in mind: sublingual is 1.5-2x stronger then oral

​

Im not a doctor nor pharmacist, do your own research and be extremely carefull.

Good thread

 

[Oesteogenesis]

might be BOTB

 

[Fleisch]

Deserved more love ngl

 

[anthrocellogy]

Why not use oral minox sublingually? What's the difference?

you could technically dissolve the tablet into water and use it sublingually but it would result in 1.5-2x less efficacy

 

[anthrocellogy]

might be BOTB

i doubt it, maybe it'll get stickied

 

[copingcoper]

wouldnt recommend it since the alcohols would be a disproportionate, dosing is off and the excipients could be bad for sublingual use.

Not if you extract it

 

[gymcelld]

High iq mirin hard brother

 

[anthrocellogy]

View attachment 4768157
Not if you extract it

not to sure about that man, youd still have the other excipients and the minoxidil would degrade a bit but that would make it safer tbh.
just make sure you dont overdose since that could cause severe problems.

goodluck, keep us posted

 

[vertical5]

In this guide ill be talking about what sublingual minoxidil is,
why its the best, how to avoid bloating and how to make it at home.

View attachment 4767173


Section 1

What is sublingual minoxidil

Spoiler: What is sublingual minoxidil

Sublingual minoxidil is the most recent form of minoxidil and is absorped by placing a tablet or liquid drop under the tongue.
this absorption method is the best since it goes directly through the mucous membrane into the bloodstream, this method bypasses the digestive system and the liver completely making this safer and more optimal then oral and topical minoxidil.
View attachment 4766587

Sublingual minoxidil mechanism

Spoiler: Sublingual minoxidil mechanism

1. drug diffuses through the mucosal membrane into the sublingual veins
2. enters the heart without going through the digestive system or liver
3. reaches the systemic arteries
4. gets converted to minoxidil sulfate by platelet and tissue enzymes
5. opens the K_ATP channels
6. vasodilation + prolonged anagen phase
7. hair growth

View attachment 4766795

Why sublingual is superior

Spoiler: Why sublingual is superior

1. Sublingual vs oral
the plasma concentration of sublingual minoxidil is way lower than oral
resulting in no/minimal palpitations, peripheral oederma and hypertension
making sublingual superior for having extremely lower cardiovascular side effects
whilst still getting the same amount of hair regrowth

2. Sublingual vs topical
the absorption from topical minoxidil isnt great for everyone.
Infact ~50% of people have to little SULTA1A1 resulting in little to no hair growth
even if you do get hair growth you'll encounter shedding and annoying application processes
making sublingual superior due to everyone being able to respond and easy to apply

Citations:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12207719/
https://pubmed.ncbi.nlm.nih.gov/39688293/
https://pubmed.ncbi.nlm.nih.gov/37638619/

Why sublingual causes minimal bloating

Spoiler: Why sublingual causes minimal bloating

As we all know oral minoxidil causes bloating due to its sodium retaining properties and its vasodilatory effects.
So the reason that sublingual has a lower downtime and less of it is due to this mechanism:

1. lower plasma concentration
2. weaker vasodilation
3. causing less sodium retention
4. less fluid accumulation.

View attachment 4767021

When to take sublingual minoxidil

Spoiler: When to take sublingual minoxidil

since we know that the half life of minoxidil is 4,5 hours we are able to make an approximate timeline of the plasma levels.

View attachment 4767654

for reference the baseline of plasma levels is 0, with topical minoxidil you get up to 1.6ng/ml and with 5mg oral you get all the way up to 37ng/ml.
when taking a 2.5mg sublingual dose (comparable to 3.75-5mg oral) you'd have a peak plasma of 9ng/ml at 30 minutes in
and it would basicly be gone withing 8 hours in comparison 5mg oral would still have plasma levels of 6ng/ml so 6x more.
meaning that its best to take before going to sleep, so adjust it based on your needs.

Sublingual minoxidil tldr

Spoiler: Sublingual minoxidil tldr

Sublingual minoxidil has the same efficacy for hair growth as oral minoxidil whilst having less side effects.
sublingual minoxidil is also 1.5-2x stronger than oral meaning that 1mg sublinguel = 1.5-2mg oral.
For taking sublingual minoxidil i would recommend taking 2.5mg before bed.

Section 2

How to get sublingual minoxidil

Spoiler: How to get sublingual minoxidil

1. Live in autralia and get a prescribtion or know someone that has one.
2. Buy raw minoxidil powder and DIY

Those are the only ways for now since it hasnt passed FDA and is still in phase III

Compounds for DIY sublingual minoxidil

Spoiler: Compounds for DIY sublingual minoxidil

raw minoxidil powder
propylene glycol
ethanol 95% food grade
water

Optional:
sucralose (sweetener)
peppermint/mint flavor food grade
citric acid (pH regulator)

Resources for DIY sublingual minoxidil

Spoiler: Resources for DIY sublingual minoxidil

0.001g precision scale
glass beakers 50ml and 100ml
stirrer (magnetic stirrer or glass rod)
amber glass dropper bottles

optional:
pH strips
funnel + filter paper
pipettes/syringes

Formula for DIY sublingual minoxidil

Spoiler: Formula for DIY sublingual minoxidil

1. 0.3ml/ml 95% ethanol food grade
2. 2.5mg/ml minoxidil powder
3. 0.5ml/ml propylene glycol


optional:
4. 0.2-0.3mg/ml sucralose
5. 0.5-1mg citric acid adjust to pH 4.5-5.5
6. 0.001-0.002ml peppermint/mint flavor food grade

This is in order of how you should brew

100ml example:
1. 30ml ethanol
2. 250mg minoxidil powder
3. 50ml propylene glycol
4. 20-30mg sucralose
5. 50-100mg citric acid (adjust based on pH
6. 0.1-0.2ml peppermint/mint flavoring

Following these instructions you should get 2.5mg/ml meaning that 1ml is 2.5mg worth of sublingual minoxidil

Video's of DIY sublingual minoxidil

Spoiler: Video's of DIY sublingual minoxidil

View attachment 4767448

these should give you an idea how it should look.
DO NOT follow these exactly since they are for topical solutions.

Tips and tricks

Spoiler: Tips and tricks

warm the ethanol slightly (30-40°C) before adding powder for faster dissolvement
make sure that the powder doesnt have any clumps, if so break them apart till fine.
DONT shake instead stir
store away from light and heat
keep in fridge (2–8°C)
shelf life of ~1 year
start low with 0.5ml daily and titrate up to 1ml daily if you respond fine
keep in mind: sublingual is 1.5-2x stronger then oral

​

Im not a doctor nor pharmacist, do your own research and be extremely carefull.

could you get this off of indiamart

 

[anthrocellogy]

could you get this off of indiamart

nah, atleast not that im aware of

 

[whodoievenbelieve]

Great post bro

 

[whodoievenbelieve]

nah, atleast not that im aware of

Imma ask my seller cause rn I'm using topical on eyebrows only and this sounds great

 

[louis bloom]

could i not just place the pill under my tongue and be the same

 

[exvh]

great thread

 

[anthrocellogy]

could i not just place the pill under my tongue and be the same

it'd be better to dissolve the pill first and use it after, so you'd need to go through the same process eiterway.

placing the pill under your tongue just wouldnt dissolve and would probably get slightly higher and longer plasma levels.

 

[[G]]

Still a little skeptical about bloat and safety efficacy of sublingual; the peak plasma levels of it are still about half of oral when dose adjusted, yet about ~5x greater than topical. ~8 ng/mL still might be enough plasma to cause a little bloat—although less then OM.

Pericardial effusion being not just dose-dependant, but idiosyncratic as well might make sublingual dangerous, although safer than OM.

Inshallah, phase III trials comeback this year with a squeaky-clean safety profile.

 

[FLvZyy]

In this guide ill be talking about what sublingual minoxidil is,
why its the best, how to avoid bloating and how to make it at home.

View attachment 4767173


Section 1

What is sublingual minoxidil

Spoiler: What is sublingual minoxidil

Sublingual minoxidil is the most recent form of minoxidil and is absorped by placing a tablet or liquid drop under the tongue.
this absorption method is the best since it goes directly through the mucous membrane into the bloodstream, this method bypasses the digestive system and the liver completely making this safer and more optimal then oral and topical minoxidil.
View attachment 4766587

Sublingual minoxidil mechanism

Spoiler: Sublingual minoxidil mechanism

1. drug diffuses through the mucosal membrane into the sublingual veins
2. enters the heart without going through the digestive system or liver
3. reaches the systemic arteries
4. gets converted to minoxidil sulfate by platelet and tissue enzymes
5. opens the K_ATP channels
6. vasodilation + prolonged anagen phase
7. hair growth

View attachment 4766795

Why sublingual is superior

Spoiler: Why sublingual is superior

1. Sublingual vs oral
the plasma concentration of sublingual minoxidil is way lower than oral
resulting in no/minimal palpitations, peripheral oederma and hypertension
making sublingual superior for having extremely lower cardiovascular side effects
whilst still getting the same amount of hair regrowth

2. Sublingual vs topical
the absorption from topical minoxidil isnt great for everyone.
Infact ~50% of people have to little SULTA1A1 resulting in little to no hair growth
even if you do get hair growth you'll encounter shedding and annoying application processes
making sublingual superior due to everyone being able to respond and easy to apply

Citations:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12207719/
https://pubmed.ncbi.nlm.nih.gov/39688293/
https://pubmed.ncbi.nlm.nih.gov/37638619/

Why sublingual causes minimal bloating

Spoiler: Why sublingual causes minimal bloating

As we all know oral minoxidil causes bloating due to its sodium retaining properties and its vasodilatory effects.
So the reason that sublingual has a lower downtime and less of it is due to this mechanism:

1. lower plasma concentration
2. weaker vasodilation
3. causing less sodium retention
4. less fluid accumulation.

View attachment 4767021

When to take sublingual minoxidil

Spoiler: When to take sublingual minoxidil

since we know that the half life of minoxidil is 4,5 hours we are able to make an approximate timeline of the plasma levels.

View attachment 4767654

for reference the baseline of plasma levels is 0, with topical minoxidil you get up to 1.6ng/ml and with 5mg oral you get all the way up to 37ng/ml.
when taking a 2.5mg sublingual dose (comparable to 3.75-5mg oral) you'd have a peak plasma of 9ng/ml at 30 minutes in
and it would basicly be gone withing 8 hours in comparison 5mg oral would still have plasma levels of 6ng/ml so 6x more.
meaning that its best to take before going to sleep, so adjust it based on your needs.

Sublingual minoxidil tldr

Spoiler: Sublingual minoxidil tldr

Sublingual minoxidil has the same efficacy for hair growth as oral minoxidil whilst having less side effects.
sublingual minoxidil is also 1.5-2x stronger than oral meaning that 1mg sublinguel = 1.5-2mg oral.
For taking sublingual minoxidil i would recommend taking 2.5mg before bed.

Section 2

How to get sublingual minoxidil

Spoiler: How to get sublingual minoxidil

1. Live in autralia and get a prescribtion or know someone that has one.
2. Buy raw minoxidil powder and DIY

Those are the only ways for now since it hasnt passed FDA and is still in phase III

Compounds for DIY sublingual minoxidil

Spoiler: Compounds for DIY sublingual minoxidil

raw minoxidil powder
propylene glycol
ethanol 95% food grade
water

Optional:
sucralose (sweetener)
peppermint/mint flavor food grade
citric acid (pH regulator)

Resources for DIY sublingual minoxidil

Spoiler: Resources for DIY sublingual minoxidil

0.001g precision scale
glass beakers 50ml and 100ml
stirrer (magnetic stirrer or glass rod)
amber glass dropper bottles

optional:
pH strips
funnel + filter paper
pipettes/syringes

Formula for DIY sublingual minoxidil

Spoiler: Formula for DIY sublingual minoxidil

1. 0.3ml/ml 95% ethanol food grade
2. 2.5mg/ml minoxidil powder
3. 0.5ml/ml propylene glycol


optional:
4. 0.2-0.3mg/ml sucralose
5. 0.5-1mg citric acid adjust to pH 4.5-5.5
6. 0.001-0.002ml peppermint/mint flavor food grade

This is in order of how you should brew

100ml example:
1. 30ml ethanol
2. 250mg minoxidil powder
3. 50ml propylene glycol
4. 20-30mg sucralose
5. 50-100mg citric acid (adjust based on pH
6. 0.1-0.2ml peppermint/mint flavoring

Following these instructions you should get 2.5mg/ml meaning that 1ml is 2.5mg worth of sublingual minoxidil

Video's of DIY sublingual minoxidil

Spoiler: Video's of DIY sublingual minoxidil

View attachment 4767448

these should give you an idea how it should look.
DO NOT follow these exactly since they are for topical solutions.

Tips and tricks

Spoiler: Tips and tricks

warm the ethanol slightly (30-40°C) before adding powder for faster dissolvement
make sure that the powder doesnt have any clumps, if so break them apart till fine.
DONT shake instead stir
store away from light and heat
keep in fridge (2–8°C)
shelf life of ~1 year
start low with 0.5ml daily and titrate up to 1ml daily if you respond fine
keep in mind: sublingual is 1.5-2x stronger then oral

​

Im not a doctor nor pharmacist, do your own research and be extremely carefull.

Ethanol? So that will make me have alcohol in my system 24/7?

 

[MindOfBeni]

cant i just put the pill under my tounge?

 

[anthrocellogy]

cant i just put the pill under my tounge?

it'd be better to dissolve the pill first and use it after, so you'd need to go through the same process eiterway.

placing the pill under your tongue just wouldnt dissolve and would probably get slightly higher and longer plasma levels.

 

[SoNotFunny]

Bump

 

[greycel]

@Chad What were your thoughts? You're pretty knowledgable in this

 

[srh4an]

In this guide ill be talking about what sublingual minoxidil is,
why its the best, how to avoid bloating and how to make it at home.

View attachment 4767173


Section 1

What is sublingual minoxidil

Spoiler: What is sublingual minoxidil

Sublingual minoxidil is the most recent form of minoxidil and is absorped by placing a tablet or liquid drop under the tongue.
this absorption method is the best since it goes directly through the mucous membrane into the bloodstream, this method bypasses the digestive system and the liver completely making this safer and more optimal then oral and topical minoxidil.
View attachment 4766587

Sublingual minoxidil mechanism

Spoiler: Sublingual minoxidil mechanism

1. drug diffuses through the mucosal membrane into the sublingual veins
2. enters the heart without going through the digestive system or liver
3. reaches the systemic arteries
4. gets converted to minoxidil sulfate by platelet and tissue enzymes
5. opens the K_ATP channels
6. vasodilation + prolonged anagen phase
7. hair growth

View attachment 4766795

Why sublingual is superior

Spoiler: Why sublingual is superior

1. Sublingual vs oral
the plasma concentration of sublingual minoxidil is way lower than oral
resulting in no/minimal palpitations, peripheral oederma and hypertension
making sublingual superior for having extremely lower cardiovascular side effects
whilst still getting the same amount of hair regrowth

2. Sublingual vs topical
the absorption from topical minoxidil isnt great for everyone.
Infact ~50% of people have to little SULTA1A1 resulting in little to no hair growth
even if you do get hair growth you'll encounter shedding and annoying application processes
making sublingual superior due to everyone being able to respond and easy to apply

Citations:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12207719/
https://pubmed.ncbi.nlm.nih.gov/39688293/
https://pubmed.ncbi.nlm.nih.gov/37638619/

Why sublingual causes minimal bloating

Spoiler: Why sublingual causes minimal bloating

As we all know oral minoxidil causes bloating due to its sodium retaining properties and its vasodilatory effects.
So the reason that sublingual has a lower downtime and less of it is due to this mechanism:

1. lower plasma concentration
2. weaker vasodilation
3. causing less sodium retention
4. less fluid accumulation.

View attachment 4767021

When to take sublingual minoxidil

Spoiler: When to take sublingual minoxidil

since we know that the half life of minoxidil is 4,5 hours we are able to make an approximate timeline of the plasma levels.

View attachment 4767654

for reference the baseline of plasma levels is 0, with topical minoxidil you get up to 1.6ng/ml and with 5mg oral you get all the way up to 37ng/ml.
when taking a 2.5mg sublingual dose (comparable to 3.75-5mg oral) you'd have a peak plasma of 9ng/ml at 30 minutes in
and it would basicly be gone withing 8 hours in comparison 5mg oral would still have plasma levels of 6ng/ml so 6x more.
meaning that its best to take before going to sleep, so adjust it based on your needs.

Sublingual minoxidil tldr

Spoiler: Sublingual minoxidil tldr

Sublingual minoxidil has the same efficacy for hair growth as oral minoxidil whilst having less side effects.
sublingual minoxidil is also 1.5-2x stronger than oral meaning that 1mg sublinguel = 1.5-2mg oral.
For taking sublingual minoxidil i would recommend taking 2.5mg before bed.

Section 2

How to get sublingual minoxidil

Spoiler: How to get sublingual minoxidil

1. Live in autralia and get a prescribtion or know someone that has one.
2. Buy raw minoxidil powder and DIY

Those are the only ways for now since it hasnt passed FDA and is still in phase III

Compounds for DIY sublingual minoxidil

Spoiler: Compounds for DIY sublingual minoxidil

raw minoxidil powder
propylene glycol
ethanol 95% food grade
water

Optional:
sucralose (sweetener)
peppermint/mint flavor food grade
citric acid (pH regulator)

Resources for DIY sublingual minoxidil

Spoiler: Resources for DIY sublingual minoxidil

0.001g precision scale
glass beakers 50ml and 100ml
stirrer (magnetic stirrer or glass rod)
amber glass dropper bottles

optional:
pH strips
funnel + filter paper
pipettes/syringes

Formula for DIY sublingual minoxidil

Spoiler: Formula for DIY sublingual minoxidil

1. 0.3ml/ml 95% ethanol food grade
2. 2.5mg/ml minoxidil powder
3. 0.5ml/ml propylene glycol


optional:
4. 0.2-0.3mg/ml sucralose
5. 0.5-1mg citric acid adjust to pH 4.5-5.5
6. 0.001-0.002ml peppermint/mint flavor food grade

This is in order of how you should brew

100ml example:
1. 30ml ethanol
2. 250mg minoxidil powder
3. 50ml propylene glycol
4. 20-30mg sucralose
5. 50-100mg citric acid (adjust based on pH
6. 0.1-0.2ml peppermint/mint flavoring

Following these instructions you should get 2.5mg/ml meaning that 1ml is 2.5mg worth of sublingual minoxidil

Video's of DIY sublingual minoxidil

Spoiler: Video's of DIY sublingual minoxidil

View attachment 4767448

these should give you an idea how it should look.
DO NOT follow these exactly since they are for topical solutions.

Tips and tricks

Spoiler: Tips and tricks

warm the ethanol slightly (30-40°C) before adding powder for faster dissolvement
make sure that the powder doesnt have any clumps, if so break them apart till fine.
DONT shake instead stir
store away from light and heat
keep in fridge (2–8°C)
shelf life of ~1 year
start low with 0.5ml daily and titrate up to 1ml daily if you respond fine
keep in mind: sublingual is 1.5-2x stronger then oral

​

Im not a doctor nor pharmacist, do your own research and be extremely carefull.

would it still work as efficiently because it isnt converted by the liver?

 

[1stRanked]

In this guide ill be talking about what sublingual minoxidil is,
why its the best, how to avoid bloating and how to make it at home.

View attachment 4767173


Section 1

What is sublingual minoxidil

Spoiler: What is sublingual minoxidil

Sublingual minoxidil is the most recent form of minoxidil and is absorped by placing a tablet or liquid drop under the tongue.
this absorption method is the best since it goes directly through the mucous membrane into the bloodstream, this method bypasses the digestive system and the liver completely making this safer and more optimal then oral and topical minoxidil.
View attachment 4766587

Sublingual minoxidil mechanism

Spoiler: Sublingual minoxidil mechanism

1. drug diffuses through the mucosal membrane into the sublingual veins
2. enters the heart without going through the digestive system or liver
3. reaches the systemic arteries
4. gets converted to minoxidil sulfate by platelet and tissue enzymes
5. opens the K_ATP channels
6. vasodilation + prolonged anagen phase
7. hair growth

View attachment 4766795

Why sublingual is superior

Spoiler: Why sublingual is superior

1. Sublingual vs oral
the plasma concentration of sublingual minoxidil is way lower than oral
resulting in no/minimal palpitations, peripheral oederma and hypertension
making sublingual superior for having extremely lower cardiovascular side effects
whilst still getting the same amount of hair regrowth

2. Sublingual vs topical
the absorption from topical minoxidil isnt great for everyone.
Infact ~50% of people have to little SULTA1A1 resulting in little to no hair growth
even if you do get hair growth you'll encounter shedding and annoying application processes
making sublingual superior due to everyone being able to respond and easy to apply

Citations:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12207719/
https://pubmed.ncbi.nlm.nih.gov/39688293/
https://pubmed.ncbi.nlm.nih.gov/37638619/

Why sublingual causes minimal bloating

Spoiler: Why sublingual causes minimal bloating

As we all know oral minoxidil causes bloating due to its sodium retaining properties and its vasodilatory effects.
So the reason that sublingual has a lower downtime and less of it is due to this mechanism:

1. lower plasma concentration
2. weaker vasodilation
3. causing less sodium retention
4. less fluid accumulation.

View attachment 4767021

When to take sublingual minoxidil

Spoiler: When to take sublingual minoxidil

since we know that the half life of minoxidil is 4,5 hours we are able to make an approximate timeline of the plasma levels.

View attachment 4767654

for reference the baseline of plasma levels is 0, with topical minoxidil you get up to 1.6ng/ml and with 5mg oral you get all the way up to 37ng/ml.
when taking a 2.5mg sublingual dose (comparable to 3.75-5mg oral) you'd have a peak plasma of 9ng/ml at 30 minutes in
and it would basicly be gone withing 8 hours in comparison 5mg oral would still have plasma levels of 6ng/ml so 6x more.
meaning that its best to take before going to sleep, so adjust it based on your needs.

Sublingual minoxidil tldr

Spoiler: Sublingual minoxidil tldr

Sublingual minoxidil has the same efficacy for hair growth as oral minoxidil whilst having less side effects.
sublingual minoxidil is also 1.5-2x stronger than oral meaning that 1mg sublinguel = 1.5-2mg oral.
For taking sublingual minoxidil i would recommend taking 2.5mg before bed.

Section 2

How to get sublingual minoxidil

Spoiler: How to get sublingual minoxidil

1. Live in autralia and get a prescribtion or know someone that has one.
2. Buy raw minoxidil powder and DIY

Those are the only ways for now since it hasnt passed FDA and is still in phase III

Compounds for DIY sublingual minoxidil

Spoiler: Compounds for DIY sublingual minoxidil

raw minoxidil powder
propylene glycol
ethanol 95% food grade
water

Optional:
sucralose (sweetener)
peppermint/mint flavor food grade
citric acid (pH regulator)

Resources for DIY sublingual minoxidil

Spoiler: Resources for DIY sublingual minoxidil

0.001g precision scale
glass beakers 50ml and 100ml
stirrer (magnetic stirrer or glass rod)
amber glass dropper bottles

optional:
pH strips
funnel + filter paper
pipettes/syringes

Formula for DIY sublingual minoxidil

Spoiler: Formula for DIY sublingual minoxidil

1. 0.3ml/ml 95% ethanol food grade
2. 2.5mg/ml minoxidil powder
3. 0.5ml/ml propylene glycol


optional:
4. 0.2-0.3mg/ml sucralose
5. 0.5-1mg citric acid adjust to pH 4.5-5.5
6. 0.001-0.002ml peppermint/mint flavor food grade

This is in order of how you should brew

100ml example:
1. 30ml ethanol
2. 250mg minoxidil powder
3. 50ml propylene glycol
4. 20-30mg sucralose
5. 50-100mg citric acid (adjust based on pH
6. 0.1-0.2ml peppermint/mint flavoring

Following these instructions you should get 2.5mg/ml meaning that 1ml is 2.5mg worth of sublingual minoxidil

Video's of DIY sublingual minoxidil

Spoiler: Video's of DIY sublingual minoxidil

View attachment 4767448

these should give you an idea how it should look.
DO NOT follow these exactly since they are for topical solutions.

Tips and tricks

Spoiler: Tips and tricks

warm the ethanol slightly (30-40°C) before adding powder for faster dissolvement
make sure that the powder doesnt have any clumps, if so break them apart till fine.
DONT shake instead stir
store away from light and heat
keep in fridge (2–8°C)
shelf life of ~1 year
start low with 0.5ml daily and titrate up to 1ml daily if you respond fine
keep in mind: sublingual is 1.5-2x stronger then oral

​

Im not a doctor nor pharmacist, do your own research and be extremely carefull.

Hey, solid write-up overall — the pharmacokinetic reasoning is largely correct and the SULT1A1 point is genuinely underappreciated. But there are a few things worth addressing honestly, because some of what you wrote overstates what the science actually supports right now.


1. "Bypasses the liver completely" — this is incorrect


Sublingual administration avoids hepatic first-pass metabolism, meaning the drug isn't partially broken down before it reaches systemic circulation. But it absolutely still reaches the liver afterward. Minoxidil is metabolized by the liver NCBI, and minoxidil is a prodrug that is converted to an active metabolite by hepatic and follicular sulfotransferases. ScienceDirect The liver is still involved — you're just changing when in the journey it gets there, not whether. The distinction matters because it affects how you frame the safety argument.


2. "Same efficacy as oral" is a premature conclusion


Your core claim — that sublingual has the same hair regrowth efficacy as oral — isn't supported by the volume of evidence you're implying. Sublingual administration is an emerging route, and current data are limited to early observational studies and case series. FrontiersPubMed Central To put that in perspective: oral minoxidil alone has been evaluated across 17 single-arm clinical studies and 10 randomized controlled trials encompassing a total of 2,933 patients. PubMed Central Sublingual? To date, only 4 studies have evaluated the efficacy of sublingual minoxidil in the treatment of AGA. Frontiers The Bokhari 2022 trial — the one most people cite — was a Phase 1B trial. That's a safety/dosing study, not an efficacy trial. Calling it "proven superior" goes well beyond what those 4 studies can support.


3. The cardiovascular safety advantage is real, but narrower than you present


You're right that sublingual appears to produce fewer palpitations. In the RCT comparing sublingual minoxidil 5 mg with oral minoxidil 5 mg, palpitations occurred in 0% of the sublingual group versus 9.3% in the oral group (p = 0.048). Frontiers That's a legitimate finding. But here's what you're leaving out: at the low doses typically used for hair loss (0.25–2.5 mg oral), cardiovascular side effects are already uncommon. Low-dose oral minoxidil has shown little to no influence on blood pressure in normotensive patients, supported by a recent meta-analysis that included 2,387 patients from 16 studies. MDPI So the cardiovascular advantage of sublingual over low-dose oral is likely much smaller than your guide implies. You're comparing sublingual to oral as if oral means the hypertension doses (10–40 mg), when most hair loss patients use 1–2.5 mg.


4. The most common side effect isn't cardiovascular — it's hypertrichosis


Your guide focuses almost entirely on bloating and cardiovascular effects. But the most frequent adverse event of low-dose oral minoxidil is hypertrichosis, occurring in approximately 15% of patients, with a higher incidence in women and patients at higher doses. MDPI There's no reason to believe sublingual is meaningfully different on this front, since it's a systemic route too. This is the side effect most people actually experience and you don't mention it once.

 

[UrFavouriteSub3]

In this guide ill be talking about what sublingual minoxidil is,
why its the best, how to avoid bloating and how to make it at home.

View attachment 4767173


Section 1

What is sublingual minoxidil

Spoiler: What is sublingual minoxidil

Sublingual minoxidil is the most recent form of minoxidil and is absorped by placing a tablet or liquid drop under the tongue.
this absorption method is the best since it goes directly through the mucous membrane into the bloodstream, this method bypasses the digestive system and the liver completely making this safer and more optimal then oral and topical minoxidil.
View attachment 4766587

Sublingual minoxidil mechanism

Spoiler: Sublingual minoxidil mechanism

1. drug diffuses through the mucosal membrane into the sublingual veins
2. enters the heart without going through the digestive system or liver
3. reaches the systemic arteries
4. gets converted to minoxidil sulfate by platelet and tissue enzymes
5. opens the K_ATP channels
6. vasodilation + prolonged anagen phase
7. hair growth

View attachment 4766795

Why sublingual is superior

Spoiler: Why sublingual is superior

1. Sublingual vs oral
the plasma concentration of sublingual minoxidil is way lower than oral
resulting in no/minimal palpitations, peripheral oederma and hypertension
making sublingual superior for having extremely lower cardiovascular side effects
whilst still getting the same amount of hair regrowth

2. Sublingual vs topical
the absorption from topical minoxidil isnt great for everyone.
Infact ~50% of people have to little SULTA1A1 resulting in little to no hair growth
even if you do get hair growth you'll encounter shedding and annoying application processes
making sublingual superior due to everyone being able to respond and easy to apply

Citations:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12207719/
https://pubmed.ncbi.nlm.nih.gov/39688293/
https://pubmed.ncbi.nlm.nih.gov/37638619/

Why sublingual causes minimal bloating

Spoiler: Why sublingual causes minimal bloating

As we all know oral minoxidil causes bloating due to its sodium retaining properties and its vasodilatory effects.
So the reason that sublingual has a lower downtime and less of it is due to this mechanism:

1. lower plasma concentration
2. weaker vasodilation
3. causing less sodium retention
4. less fluid accumulation.

View attachment 4767021

When to take sublingual minoxidil

Spoiler: When to take sublingual minoxidil

since we know that the half life of minoxidil is 4,5 hours we are able to make an approximate timeline of the plasma levels.

View attachment 4767654

for reference the baseline of plasma levels is 0, with topical minoxidil you get up to 1.6ng/ml and with 5mg oral you get all the way up to 37ng/ml.
when taking a 2.5mg sublingual dose (comparable to 3.75-5mg oral) you'd have a peak plasma of 9ng/ml at 30 minutes in
and it would basicly be gone withing 8 hours in comparison 5mg oral would still have plasma levels of 6ng/ml so 6x more.
meaning that its best to take before going to sleep, so adjust it based on your needs.

Sublingual minoxidil tldr

Spoiler: Sublingual minoxidil tldr

Sublingual minoxidil has the same efficacy for hair growth as oral minoxidil whilst having less side effects.
sublingual minoxidil is also 1.5-2x stronger than oral meaning that 1mg sublinguel = 1.5-2mg oral.
For taking sublingual minoxidil i would recommend taking 2.5mg before bed.

Section 2

How to get sublingual minoxidil

Spoiler: How to get sublingual minoxidil

1. Live in autralia and get a prescribtion or know someone that has one.
2. Buy raw minoxidil powder and DIY

Those are the only ways for now since it hasnt passed FDA and is still in phase III

Compounds for DIY sublingual minoxidil

Spoiler: Compounds for DIY sublingual minoxidil

raw minoxidil powder
propylene glycol
ethanol 95% food grade
water

Optional:
sucralose (sweetener)
peppermint/mint flavor food grade
citric acid (pH regulator)

Resources for DIY sublingual minoxidil

Spoiler: Resources for DIY sublingual minoxidil

0.001g precision scale
glass beakers 50ml and 100ml
stirrer (magnetic stirrer or glass rod)
amber glass dropper bottles

optional:
pH strips
funnel + filter paper
pipettes/syringes

Formula for DIY sublingual minoxidil

Spoiler: Formula for DIY sublingual minoxidil

1. 0.3ml/ml 95% ethanol food grade
2. 2.5mg/ml minoxidil powder
3. 0.5ml/ml propylene glycol


optional:
4. 0.2-0.3mg/ml sucralose
5. 0.5-1mg citric acid adjust to pH 4.5-5.5
6. 0.001-0.002ml peppermint/mint flavor food grade

This is in order of how you should brew

100ml example:
1. 30ml ethanol
2. 250mg minoxidil powder
3. 50ml propylene glycol
4. 20-30mg sucralose
5. 50-100mg citric acid (adjust based on pH
6. 0.1-0.2ml peppermint/mint flavoring

Following these instructions you should get 2.5mg/ml meaning that 1ml is 2.5mg worth of sublingual minoxidil

Video's of DIY sublingual minoxidil

Spoiler: Video's of DIY sublingual minoxidil

View attachment 4767448

these should give you an idea how it should look.
DO NOT follow these exactly since they are for topical solutions.

Tips and tricks

Spoiler: Tips and tricks

warm the ethanol slightly (30-40°C) before adding powder for faster dissolvement
make sure that the powder doesnt have any clumps, if so break them apart till fine.
DONT shake instead stir
store away from light and heat
keep in fridge (2–8°C)
shelf life of ~1 year
start low with 0.5ml daily and titrate up to 1ml daily if you respond fine
keep in mind: sublingual is 1.5-2x stronger then oral

​

Im not a doctor nor pharmacist, do your own research and be extremely carefull.

Yo, how bad is it to just take an oral minoxidil pill and put it under ur tongue

 

[vzk]

@anthrocellogy Why does the 100ml example only add up to 80ml? How long have you yourself been using this formula for?

 

[Shirobon]

Sources for minoxidil USP?

 

[stigmaboy]

lol sublingual minox. is that like drinking it? jfl. just get the topical fam.