MAXIMIZE USE OF MINOXIDIL PART 2

[Avskinov]

In the old post i talked about how to maximize use of minoxidil this is the 2nd part i will be covering so if you haven't watched the 1st part go check that out

Spoiler

MAXIMIZE USE OF MINOXIDIL (GTFIH)

Your Oral and Topical Minoxidil is not working ?:feelswah: Minoxidil is a pro drug it needs conversion to work it is mainly converted by a enzyme known as SULT1A1( SULFOTRANSFERASE ENZYME ) this enzyme exist in hair follicles Work of MINOXIDIL 1. Prolongs Anagen phase (growth phase) 2...

looksmax.org

Now ill be taking about MSM( Methyl Sulfonate methane )

Spoiler

MSM is a sulfur compound found in primitive plants ,animal and humans it also can be chemically made but the quantity is low in plants and animal and other foods

PHYSICAL PROPERTIES
Colourless, Odorless and white crystalline solid
MAIN USE
Commonly used for joint health supplement and is a anti inflammatory drug
SIDE EFFECTS
Mild gastrointestinal pain, headaches, insomnia, or skin rashes. not extreme tho
WORKING MECHANISM

Spoiler

Methylsulfonylmethane (MSM) works primarily by modulating the body's response to inflammation and oxidative stress at the cellular and genetic levels It acts as an adaptable regulator rather than a direct blocker, influencing several key biological pathways simultaneously

HOW THIS WORK FOR HAIR ?
1.SULFUR DONATION

Spoiler

MSMis a bioavailable sulfur it can provide bioavailable sulfur for SULT1A1 enzyme activity

2. ENHANCED PENETRATION

Spoiler

MSM increases cell membrane permeability when used with minoxidil it will penetrate deeper into skin works via ion and membrane modulation

Take this drug more than 3g a day to work but not fix for working with minoxidil due to
Low research for human hair but we have mechanism
FDA approved drug
NEXT NAC ( N-acetylcysteine )
WORKING MECHANISM
1.OXIDATIVE STRESS REDUCTION

Spoiler

It neutralizes free radicals and reactive oxygen species (ROS) that can damage hair follicles and trigger premature transition to the shedding phase.

2.GLUTATHOINE SYNTHESIS

Spoiler

By providing cysteine NAC helps maintain high levels of glutathione in the follicle, which is essential for protecting the rapidly dividing cells in the hair bulb

3.Inhibiting Hair-Loss Signals

Spoiler

NAC can suppress certain inflammatory mediators like PGD2 and TGF-β, which are known to inhibit hair growth in conditions like androgenetic alopecia (AGA)

Side Effects
While generally well tolerated, high intake can cause gastrointestinal issues such as nausea, vomiting, or diarrhea
Can work with minoxidil really well no fixed dosages for hair while some common dosages is 600 to 1200 mg told by some physicians
TBH these can be potent but has low roi and now will be taking about some other ways to max the usages
1. MICRO NEEDLING : We all know use it 3 times a week for 2 min at a part

2. USING TOPICAL TRETINOIN
Tretinoin upregulates the sulfotransferase enzyme. This can convert non-responders into responders
Apply a thin layer of tretinoin (0.01% to 0.025%) to thinning areas before minoxidil use it 3 to 4 times per week


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@Navity @

@Jesus_ist_König @DNR_ @mouth_cel
​

 

[DNR_]

Tagging niggas who need minoxidil in their life jfl
@norwoodingmanlet @yzarim3456 @molecule010 @v.3ex @Lamskiiii

 

[Avskinov]

bump

 

[Avskinov]

holy shit this guy is actually a beast

Thanks man did you read

 

[DNR_]

Thanks man did you read

Ofcourse, mirin.
BUMP

 

[Avskinov]

@jeoyw9192

 

[Avskinov]

@Jesus_ist_König @Navity

 

[Jesus_ist_König]

Zk will read

 

[o_Owtf]

Thanks for sharing. Didn't know about MSM and NAC for hairloss. MSM seems kind of scary honestly, I had never heard about it before and it seems like it's bad for your organs and damages your DNA.

NAC however is as far as I know safe antioxidant you can take daily. It's actually the first line treatment for acute paracetamol toxicity, but I had never heard of using it for hair growth.

 

[Avskinov]

Thanks for sharing. Didn't know about MSM and NAC for hairloss. MSM seems kind of scary honestly, I had never heard about it before and it seems like it's bad for your organs and damages your DNA.

NAC however is as far as I know safe antioxidant you can take daily. It's actually the first line treatment for acute paracetamol toxicity, but I had never heard of using it for hair growth.

YEah msm works to alter the cell from producing less pro inflammatory cytokines its fda approved so no worries and also increases sult1a1 enzyme activity i made the guide especially for sult1a1 activity but tested in rats but it worked

 

[avgsub5human]

mirin, finally someone speaking about tret for minox I felt like a retard everytime I mention it for 0 reason

 

[Avskinov]

mirin, finally someone speaking about tret for minox I felt like a retard everytime I mention it for 0 reason

Yeah but i didnt discussed it fully it might work miracle and i should have explained how it should have worked via other mechanism

 

[o_Owtf]

Yeah but i didnt discussed it fully it might work miracle and i should have explained how it should have worked via other mechanism

Tret is kind of water, I think most people on MX already know about it. It directly addresses the mechanistic problem most non-responders have without causing much fuss. It's good that you bring up these less known treatments that work by different mechanisms.

 

[Avskinov]

@kdev​

 

[kdev]

@kdev​

just got done reason nice thread buddy

 

[Avskinov]

Y

just got done reason nice thread buddy

YEah but we anit getting nac and msm in Nepal I hardly got my hands on corticosteroids

 

[Rabbi]

You really shouldn’t use tretinoin close to microneedling all undoubtedly fuck you up.

I made that mistake once

 

[Rabbi]

Also interesting thread I’ve never heard of this mechanism before, it’s not well studied but there’s potential.

EVALUATION OF THE EFFECT OF TOPICALLY APPLIED METHYLSULFONYLMETHANE AND THEIR COMBINATION WITH MINOXIDIL SOLUTION FOR IMPROVEMENT OF HAIR GROWTH IN MALE MICE - PubMed

Conclusions: We concluded that MSM, through its antioxidant and anti-inflammatory properties, dramatically reduces hair loss in male mice.

pubmed.ncbi.nlm.nih.gov

Is there a specific concentration?

 

[Avskinov]

You really shouldn’t use tretinoin close to microneedling all undoubtedly fuck you up.

I made that mistake once

Yeah cause tret penetrates stratum corneum and using derma with its like its hell

 

[Avskinov]

used 10 % conc on mice

Also interesting thread I’ve never heard of this mechanism before, it’s not well studied but there’s potential.

EVALUATION OF THE EFFECT OF TOPICALLY APPLIED METHYLSULFONYLMETHANE AND THEIR COMBINATION WITH MINOXIDIL SOLUTION FOR IMPROVEMENT OF HAIR GROWTH IN MALE MICE - PubMed

Conclusions: We concluded that MSM, through its antioxidant and anti-inflammatory properties, dramatically reduces hair loss in male mice.

pubmed.ncbi.nlm.nih.gov

Is there a specific concentration?

 

[Avskinov]

Also interesting thread I’ve never heard of this mechanism before, it’s not well studied but there’s potential.

EVALUATION OF THE EFFECT OF TOPICALLY APPLIED METHYLSULFONYLMETHANE AND THEIR COMBINATION WITH MINOXIDIL SOLUTION FOR IMPROVEMENT OF HAIR GROWTH IN MALE MICE - PubMed

Conclusions: We concluded that MSM, through its antioxidant and anti-inflammatory properties, dramatically reduces hair loss in male mice.

pubmed.ncbi.nlm.nih.gov

Is there a specific concentration?

You might be intrested in Thread 'MAXIMIZE SOFMAXXING DRUGS OR SUPPLEMENT {1}' https://looksmax.org/threads/maximize-sofmaxxing-drugs-or-supplement-1.2066214/

 

[Avskinov]

@teddy101 ok watch this

 

[Nodal]

@teddy101 ok watch this

your givin me hw buddy i dont like chemistry ion learn it buddy

 

[Avskinov]

sry its cool tho

your givin me hw buddy i dont like chemistry ion learn it buddy