weex300
Iron
- Joined
- May 15, 2026
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a lot of people are looking forward to inhibit FGFR3 to heightmax, and for that there's a direct inhibitor for it (that being Erdafitinib alongside others) however not everyone can afford to buy Erda for obvious reasons, it's a cancer medication and sometimes your country is too harsh on packages so all your purchases in Indiamart may get seized, but there is a possible way to attenuate FGFR3 without Erda and that is the Antihistamine Meclizine, it's an OTC medication in most countries I know and it has a pathway that leads to the attenuation of FGFR3.
the key paper behind my theory is "Matsushita et al., PLOS ONE (2013)", basically the pathway Meclizine affects is the following: FGF → FGFR3 → RAS/RAF → MEK → ERK, researches found that Meclizine reduced ERK phosphorylation, and did not reduce MEK phosphorylation, which means the effect might happen at or downstream of MEK but upstream of ERK, which means it is not a direct FGFR3 inhibitor unfortunately, but it is very close to attenuating it, it acts on the MEK - ERK pathway, it has been shown that Meclizine promoted bone growth in mice trough that pathway, which is very interesting and promising, the real problem is getting the concentrations of 20 µM used for the studies in your plasma, for that you can use a CYP2D6 inhibitor like fluoxetine to increase the concentrations of Meclizine in your blood, but that's another discussion.
the key paper behind my theory is "Matsushita et al., PLOS ONE (2013)", basically the pathway Meclizine affects is the following: FGF → FGFR3 → RAS/RAF → MEK → ERK, researches found that Meclizine reduced ERK phosphorylation, and did not reduce MEK phosphorylation, which means the effect might happen at or downstream of MEK but upstream of ERK, which means it is not a direct FGFR3 inhibitor unfortunately, but it is very close to attenuating it, it acts on the MEK - ERK pathway, it has been shown that Meclizine promoted bone growth in mice trough that pathway, which is very interesting and promising, the real problem is getting the concentrations of 20 µM used for the studies in your plasma, for that you can use a CYP2D6 inhibitor like fluoxetine to increase the concentrations of Meclizine in your blood, but that's another discussion.
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