Meclizine – Possibly the most gatekept growth plate modulator?

[tomd1234566]

Let me step here, meclizine is same effective as CNP for inhabiting fgfr3 lol

source?

 

[rotation]

I am genuinely surprised that almost nobody here has ever brought up Meclizine in the context of skeletal growth. The entire community seems focused on GH, IGF-1, CNP analogues, and other well-known interventions, yet Meclizine appears to have slipped completely under the radar.



Mechanistically, it is fascinating. Meclizine is an old antihistamine prescribed for motion sickness, but beyond its H1 receptor blockade, it has a very specific off-target effect: it downregulates FGFR3 signaling in growth plate chondrocytes. For context, FGFR3 is the single most important negative regulator of longitudinal bone growth. High FGFR3 activity suppresses chondrocyte proliferation and hypertrophy, thereby reducing the efficiency of endochondral ossification.



By attenuating FGFR3, Meclizine essentially removes part of the “brake” on the growth plate. The implications:

• Wider proliferative zones in the physis.
• Greater hypertrophic chondrocyte size.
• Increased longitudinal growth velocity while the plates remain open.



Crucially, this has nothing to do with accelerating epiphyseal closure. That process is primarily driven by estrogen exposure and senescence within the growth plate, not FGFR3 signaling. In other words, Meclizine cannot extend the lifespan of the growth plate, but it can plausibly increase the amount of growth achieved during its remaining lifespan.



Animal models support this: in achondroplasia mouse studies, Meclizine treatment partially rescued longitudinal bone growth by counteracting overactive FGFR3. Yet, for some reason, this compound remains almost entirely unmentioned in discussions on height optimization.



I cannot help but feel that Meclizine is one of the most gatekept drugs in this space. Readily available, mechanistically sound, supported by preclinical data — yet absent from virtually every conversation. Perhaps I am among the very few drawing attention to it here, but it seems to me like an overlooked key in the growth optimization puzzle.



Has anyone else seriously considered or experimented with this? I would be very interested to hear perspectives and reasons why it’s not as good as i’m saying it is.

Chatgpt wrote it for me cuz ion wanna write but trust me y’all meclizine is fucking op please bump.

I don’t know too much about this, but from the research i’ve done it seems like the FGFR3 inhibition is pretty minimal

 

[idnap]

I am genuinely surprised that almost nobody here has ever brought up Meclizine in the context of skeletal growth. The entire community seems focused on GH, IGF-1, CNP analogues, and other well-known interventions, yet Meclizine appears to have slipped completely under the radar.



Mechanistically, it is fascinating. Meclizine is an old antihistamine prescribed for motion sickness, but beyond its H1 receptor blockade, it has a very specific off-target effect: it downregulates FGFR3 signaling in growth plate chondrocytes. For context, FGFR3 is the single most important negative regulator of longitudinal bone growth. High FGFR3 activity suppresses chondrocyte proliferation and hypertrophy, thereby reducing the efficiency of endochondral ossification.



By attenuating FGFR3, Meclizine essentially removes part of the “brake” on the growth plate. The implications:

• Wider proliferative zones in the physis.
• Greater hypertrophic chondrocyte size.
• Increased longitudinal growth velocity while the plates remain open.



Crucially, this has nothing to do with accelerating epiphyseal closure. That process is primarily driven by estrogen exposure and senescence within the growth plate, not FGFR3 signaling. In other words, Meclizine cannot extend the lifespan of the growth plate, but it can plausibly increase the amount of growth achieved during its remaining lifespan.



Animal models support this: in achondroplasia mouse studies, Meclizine treatment partially rescued longitudinal bone growth by counteracting overactive FGFR3. Yet, for some reason, this compound remains almost entirely unmentioned in discussions on height optimization.



I cannot help but feel that Meclizine is one of the most gatekept drugs in this space. Readily available, mechanistically sound, supported by preclinical data — yet absent from virtually every conversation. Perhaps I am among the very few drawing attention to it here, but it seems to me like an overlooked key in the growth optimization puzzle.



Has anyone else seriously considered or experimented with this? I would be very interested to hear perspectives and reasons why it’s not as good as i’m saying it is.

Chatgpt wrote it for me cuz ion wanna write but trust me y’all meclizine is fucking op please bump.

DNR wheres the TLDR word salad nigger

 

[oska_blnn]

Let me step here, meclizine is same effective as CNP for inhabiting fgfr3 lol

wait really ? how’d youd find out ?

 

[oska_blnn]

I don’t know too much about this, but from the research i’ve done it seems like the FGFR3 inhibition is pretty minimal

didn’t find anything abt it sadly, you mind linking where’d / how’d you find out ?
bcs someone else said that it is effective as cnp.

 

[ihatemySOST]

wait really ? how’d youd find out ?

I just found out it’s more effective

 

[oska_blnn]

I just found out it’s more effective

link source

 

[ihatemySOST]

link source

<@938821351991554129>
Which is more effective in increasing length in wild type mice, meclizine or Vosoritide? Well, I will answer this question now. In this study, "https://www.researchgate.net/public...ast_Growth_Factor_Receptor_3-Related_Dwarfism", mice were treated with a medium and high dose of BMN-111 (the chemical name for Vosoritide). The mice were three weeks old and the treatment period was five weeks. The tibia length increased by approximately 3.5% and 4.5% for the medium and high doses compared to the control group, while the femur length increased by 7% and 9.5% for the medium dose. And the high compared to the control group approximately, so we will take the largest effect, which is a 4.5% increase in tibia length and 9.5% in femur length for high doses for mice aged 3 weeks that were treated for five weeks, with respect to the effect of meclizine in wild mice, in this study "https://sci-hub.vg/10.1210/en.2014-1914" Wild mice aged 2 weeks were treated for three weeks, the dose was 0.2g-0.4g meclizine per kilogram of food, the concentration of meclizine in the blood reached about 30-36/ng/ml (a concentration that humans can reach with a dose of 25-50mg meclizine), the results on the increase in femur length, the length of the femur was 13.5mm in the treated group compared to 12mm in the control approximately, so an increase of approximately 12.5%, with respect to the length of the tibia The treated group had a tibia length of approximately 17.3 mm, while the control group had 16 mm, meaning that the tibia increased by approximately 8.15% mm. Even with a three-week treatment period for meclizine , it was overwhelmingly superior to Vosoritide, which had a five-week treatment period

 

[GokuSSJ3]

use your brain if u wanna post sped fag

 

[oska_blnn]

please give me your attention daddy my parents don’t care for me

 

[GokuSSJ3]

oooo my dick is so fucking tiny and i cant get it up i tried to rape someone but i couldnt even do it because it was too small

damn that must be hard bro