Mitochondrial strengthening?

[Deleted member 1849]

Mitochondria are in every cell of our body, they are vital for energy production and life. They create this thing called adenosine triphosphate (ATP) as you may have heard it. This is the energetic currency needed for life. This process happens by reacting hydrocarbons from calories or sunlight with oxygen.

As you age your mitochondria become less functional. There aren't as many mitochondria to create ATP. As you would guess your ATP lowers as you age.

Why would you want well functioning mitochondria? More androgens, better libido, better skin, better mood/energy and overall well being, better hair density/quality, slow down balding if you have AA (androgenic alopecia). And many more.


These are factors that can lower your ATP and mitochondria function/count.

High carb diet.
High stress.
Sleep deprivation and circadic mismatches.
Enviornmental toxins and pollutions.
Immflamation.

How can we increase ATP?

Creatine
Metformin
Exercise
Low carb diet
Sauna
Cold Exposure

How to strengthen and increase density in the mitochondria?

Daily sun exposure
Weight lifting
Low carb diet
Sauna
Cold exposure
Fasting and caloric restriction
Take care of your gut, fix any problems it may have
HIIT


Supplements like PQQ could very well be the a miracle pill in this topic. It increases the protein PGC1-aplha, as well as creating mitochondrial biogenisis. Stronger more dense mitochondria.

List ways to strenghten mitochondria boys.

@Seth Walsh @Alarico8 @Dyorotic2 @rax1337 @Bewusst

 

[PersianKingdom]

POWERHOUSE OF THE INCEL.

 

[Seth Walsh]

Mitochondria are in every cell of our body, they are vital for energy production and life. They create this thing called adenosine triphosphate (ATP) as you may have heard it. This is the energetic currency needed for life. This process happens by reacting hydrocarbons from calories or sunlight with oxygen.

As you age your mitochondria become less functional. There aren't as many mitochondria to create ATP. As you would guess your ATP lowers as you age.

Why would you want well functioning mitochondria? More androgens, better libido, better skin, better mood/energy and overall well being, better hair density/quality, slow down balding if you have AA (androgenic alopecia). And many more.


These are factors that can lower your ATP and mitochondria function/count.

High carb diet.
High stress.
Sleep deprivation and circadic mismatches.
Enviornmental toxins and pollutions.
Immflamation.

How can we increase ATP?

Creatine
Metformin
Exercise
Low carb diet
Sauna
Cold Exposure

How to strengthen and increase density in the mitochondria?

Daily sun exposure
Weight lifting
Low carb diet
Sauna
Cold exposure
Fasting and caloric restriction
Take care of your gut, fix any problems it may have
HIIT


Supplements like PQQ could very well be the a miracle pill in this topic. It increases the protein PGC1-aplha, as well as creating mitochondrial biogenisis. Stronger more dense mitochondria.

List ways to strenghten mitochondria boys.

@Seth Walsh @Alarico8 @Dyorotic2 @rax1337 @Bewusst

Best way is to grow more mitochondria in an already healthy cell. Vitamin B12 should help maintain function and PQQ will promote mitogenesis through PGC1-a activation

Mitochondria are in every cell of our body, they are vital for energy production and life. They create this thing called adenosine triphosphate (ATP) as you may have heard it. This is the energetic currency needed for life. This process happens by reacting hydrocarbons from calories or sunlight with oxygen.

As you age your mitochondria become less functional. There aren't as many mitochondria to create ATP. As you would guess your ATP lowers as you age.

Why would you want well functioning mitochondria? More androgens, better libido, better skin, better mood/energy and overall well being, better hair density/quality, slow down balding if you have AA (androgenic alopecia). And many more.


These are factors that can lower your ATP and mitochondria function/count.

High carb diet.
High stress.
Sleep deprivation and circadic mismatches.
Enviornmental toxins and pollutions.
Immflamation.

How can we increase ATP?

Creatine
Metformin
Exercise
Low carb diet
Sauna
Cold Exposure

How to strengthen and increase density in the mitochondria?

Daily sun exposure
Weight lifting
Low carb diet
Sauna
Cold exposure
Fasting and caloric restriction
Take care of your gut, fix any problems it may have
HIIT


Supplements like PQQ could very well be the a miracle pill in this topic. It increases the protein PGC1-aplha, as well as creating mitochondrial biogenisis. Stronger more dense mitochondria.

List ways to strenghten mitochondria boys.

@Seth Walsh @Alarico8 @Dyorotic2 @rax1337 @Bewusst

Metformin doesn't increase ATP. It activates AMPK so it actually decreases ATP and increases your AMP count. I think you might be thinking of NMN or NR for increasing ATP.

Low carb diet doesn't increase ATP either

Best way is to grow more mitochondria in an already healthy cell. Vitamin B12 should help maintain function and PQQ will promote mitogenesis through PGC1-a activation

Metformin doesn't increase ATP. It activates AMPK so it actually decreases ATP and increases your AMP count. I think you might be thinking of NMN or NR for increasing ATP.

Low carb diet doesn't increase ATP either

Everything looks good though. Very nice outlook.

 

[sandcelmuttcel]

MITOCHONDRIA IS THE POWERHOUSE OF THE CELL

 

[Deleted member 1849]

Best way is to grow more mitochondria in an already healthy cell. Vitamin B12 should help maintain function and PQQ will promote mitogenesis through PGC1-a activation

Metformin doesn't increase ATP. It activates AMPK so it actually decreases ATP and increases your AMP count. I think you might be thinking of NMN or NR for increasing ATP

Of course, but I think It would be foolish to supp PQQ with an unhealthy lifestyle. People report sides when taken on a full stomach and or not being active afterword.

David Sinclair said metformin increases ATP. He said something like it decreases but it allows it to increase over time. I'll have to find the video.

 

[Seth Walsh]

Best way is to grow more mitochondria in an already healthy cell. Vitamin B12 should help maintain function and PQQ will promote mitogenesis through PGC1-a activation

Metformin doesn't increase ATP. It activates AMPK so it actually decreases ATP and increases your AMP count. I think you might be thinking of NMN or NR for increasing ATP.

Low carb diet doesn't increase ATP either

Everything looks good though. Very nice outlook.

Red light therapy is one of the things that improves mitochondrial function. It's uncommon that a person who isn't very unhealthy would have malfunctioning mitochondria so a better strategy is to sporadically use senolytics like routine autophagy and quercetin to clear out senescent cells and then focus on increasing mitochondrial density in already healthy cells. That'll make everything exponentially stronger.

 

[Deleted member 1849]

The effects of a ketogenic diet on ATP concentrations and the number of hippocampal mitochondria in Aldh5a1−/− mice

Succinic semialdehyde dehydrogenase (SSADH) deficiency is an inborn error of GABA metabolism characterized clinically by ataxia, psychomotor retardation and seizures. A mouse model of SSADH deficiency, the Aldh5a1[−/−] mouse, has been ...

www.ncbi.nlm.nih.gov

Ok, it looks like a low carb diet can actually restore your ill functioning mitochondria and thus increase ATP. If you already have dysfunctional mitochondria.

 

[Seth Walsh]

Of course, but I think It would be foolish to supp PQQ with an unhealthy lifestyle. People report sides when taken on a full stomach and or not being active afterword.

David Sinclair said metformin increases ATP. He said something like it decreases but it allows it to increase over time. I'll have to find the video.

Yeah I think it's not a good idea to take PQQ on a day where you're not exercising hard and going to the sauna and eating well etc. 20mg PQQ is enough too.

Sinclair goes overboard sometimes. He might've said something out of context but Metformin definitely doesn't increase ATP. Increasing ATP directly goes against signalling AMPK. I wrote a thread on here about AMPK and how it's signaled via the AMP:ATP balance. https://looksmax.org/threads/what-exactly-is-ep1-ampk-signalling-pathway-basic-overview.109627/

 

[Deleted member 1849]

Red light therapy is one of the things that improves mitochondrial function. It's uncommon that a person who isn't very unhealthy would have malfunctioning mitochondria so a better strategy is to sporadically use senolytics like routine autophagy and quercetin to clear out senescent cells and then focus on increasing mitochondrial density in already healthy cells. That'll make everything exponentially stronger.

Red light therapy + Sunlight exposure is the goat to improve and strengthen the mitochondria tbh.

 

[Deleted member 4563]

Mitochondria is the powerhouse of the cell

 

[Deleted member 1849]

Yeah I think it's not a good idea to take PQQ on a day where you're not exercising hard and going to the sauna and eating well etc. 20mg PQQ is enough too.

Sinclair goes overboard sometimes. He might've said something out of context but Metformin definitely doesn't increase ATP. Increasing ATP directly goes against signalling AMPK. I wrote a thread on here about AMPK and how it's signaled via the AMP:ATP balance. https://looksmax.org/threads/what-exactly-is-ep1-ampk-signalling-pathway-basic-overview.109627/

interesting. I'll take a look.

 

[Seth Walsh]

The effects of a ketogenic diet on ATP concentrations and the number of hippocampal mitochondria in Aldh5a1−/− mice

Succinic semialdehyde dehydrogenase (SSADH) deficiency is an inborn error of GABA metabolism characterized clinically by ataxia, psychomotor retardation and seizures. A mouse model of SSADH deficiency, the Aldh5a1[−/−] mouse, has been ...

www.ncbi.nlm.nih.gov

Ok, it looks like a low carb diet can actually restore your ill functioning mitochondria and thus increase ATP. If you already have dysfunctional mitochondria.

Mitochondria will always be able to source ATP unless you're taking a mitochondrial pronophore like DNP. The mechanism involving fat burning on DNP is that ATP "leaks past" mitochondria and so the mitochondria can't source energy, and that energy gets expelled as heat.

Increasing ATP is not something to be concerned about. It's very intricate and you'd only benefit from an increase in ATP in very nuanced times such as during weight training when you need energy to push out 1 more rep etc.

Mitochondria will always be able to source ATP unless you're taking a mitochondrial pronophore like DNP. The mechanism involving fat burning on DNP is that ATP "leaks past" mitochondria and so the mitochondria can't source energy, and that energy gets expelled as heat.

Increasing ATP is not something to be concerned about. It's very intricate and you'd only benefit from an increase in ATP in very nuanced times such as during weight training when you need energy to push out 1 more rep etc.

About maintaining cellular function and increasing mitochondria count, that's really really important. Even when it comes to things like skin-care. You'll benefit from optimizing the make-up and function of the skin cells.

 

[Deleted member 1849]

Mitochondria will always be able to source ATP unless you're taking a mitochondrial pronophore like DNP. The mechanism involving fat burning on DNP is that ATP "leaks past" mitochondria and so the mitochondria can't source energy, and that energy gets expelled as heat.

Increasing ATP is not something to be concerned about. It's very intricate and you'd only benefit from an increase in ATP in very nuanced times such as during weight training when you need energy to push out 1 more rep etc.

About maintaining cellular function and increasing mitochondria count, that's really really important. Even when it comes to things like skin-care. You'll benefit from optimizing the make-up and function of the skin cells.

gotcha

 

[Dios]

Sleep deprivation and circadic mismatches.

For me this is the most important one, If I were to post all the things that my ruined sleep cycle derived onto I wouldn't end in a day, but altering my circadian rhythms in a regular way made me waste atleast 3 years of body development, that is the biggest life lesson I've learned.

 

[Deleted member 1849]

Mitochondria will always be able to source ATP unless you're taking a mitochondrial pronophore like DNP. The mechanism involving fat burning on DNP is that ATP "leaks past" mitochondria and so the mitochondria can't source energy, and that energy gets expelled as heat.

Increasing ATP is not something to be concerned about. It's very intricate and you'd only benefit from an increase in ATP in very nuanced times such as during weight training when you need energy to push out 1 more rep etc.

About maintaining cellular function and increasing mitochondria count, that's really really important. Even when it comes to things like skin-care. You'll benefit from optimizing the make-up and function of the skin cells.

Everything has to fit into 1. It all has to work routinely together to work. Great sleep but a shitty diet don't work together. It's all about creating a routine you can stick too.

 

[Seth Walsh]

Everything has to fit into 1. It all has to work routinely together to work. Great sleep but a shitty diet don't work together. It's all about creating a routine you can stick too.

Absolutely! Nothing will work if your sleep is shit and circadian rhythm is out of sync.

 

[Deleted member 1849]

Absolutely! Nothing will work if your sleep is shit and circadian rhythm is out of sync.

At what age do you think it would be optimal to start running fasting protocols and taking NMN and metformin?

Once done growing fasting and working in a energy defecient state?

NMN and Metformin age 30?

 

[Seth Walsh]

At what age do you think it would be optimal to start running fasting protocols and taking NMN and metformin?

Once done growing fasting and working in a energy defecient state?

NMN and Metformin age 30?

I don't advise ever taking Metformin, it's really not a good drug and is a lazy man's thing to do; reward isn't worth the risk. You can get the same benefits from IF that you can from metformin. Not to mention that metformin instantly inhibits your mTOR which includes some important anabolic procedures, inhibits Vitamin B1 absorption which leads to problems with anxiety etc.

I'll start taking NMN pre-workout when I'm like 23-24. NMN is quite a useful compound when used as a part of an overall strategy like you previously pointed out. Pterostilbene is something I'll take alongside NMN. Metformin really is trash, and although Sinclair is amazing with the studies he does and discoveries he makes; he still is quite lazy lifestyle-wise and spends most of his time at a desk and isn't trying to optimize everything. He's more-so just focused on his work and following up on his trials. I'm happy to see someone on here as interested and motivated as you are now, it's been a while.

I don't advise ever taking Metformin, it's really not a good drug and is a lazy man's thing to do; reward isn't worth the risk. You can get the same benefits from IF that you can from metformin. Not to mention that metformin instantly inhibits your mTOR which includes some important anabolic procedures, inhibits Vitamin B1 absorption which leads to problems with anxiety etc.

I'll start taking NMN pre-workout when I'm like 23-24. NMN is quite a useful compound when used as a part of an overall strategy like you previously pointed out. Pterostilbene is something I'll take alongside NMN. Metformin really is trash, and although Sinclair is amazing with the studies he does and discoveries he makes; he still is quite lazy lifestyle-wise and spends most of his time at a desk and isn't trying to optimize everything. He's more-so just focused on his work and following up on his trials. I'm happy to see someone on here as interested and motivated as you are now, it's been a while.

https://looksmax.org/threads/hallmarks-of-aging.56432/ take a look at this too

 

[BasedSpinelet257]

Metformin doesn't increase ATP. It activates AMPK so it actually decreases ATP and increases your AMP count. I think you might be thinking of NMN or NR for increasing ATP.

[/QUOTE]

Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK

Calorie restriction (CR) or methionine (Met) restriction extends the lifespan of diverse model organisms. Here we carefully examined how Met metabolites influenced aging in yeast. We showed that stimulating S-adenosyl--methionine (AdoMet) synthesis, which ...

www.ncbi.nlm.nih.gov

What do you make of this? What are the benefits of increased AMPK over ATP?

 

[Deleted member 1849]

I don't advise ever taking Metformin, it's really not a good drug and is a lazy man's thing to do; reward isn't worth the risk. You can get the same benefits from IF that you can from metformin. Not to mention that metformin instantly inhibits your mTOR which includes some important anabolic procedures, inhibits Vitamin B1 absorption which leads to problems with anxiety etc.

I'll start taking NMN pre-workout when I'm like 23-24. NMN is quite a useful compound when used as a part of an overall strategy like you previously pointed out. Pterostilbene is something I'll take alongside NMN. Metformin really is trash, and although Sinclair is amazing with the studies he does and discoveries he makes; he still is quite lazy lifestyle-wise and spends most of his time at a desk and isn't trying to optimize everything. He's more-so just focused on his work and following up on his trials. I'm happy to see someone on here as interested and motivated as you are now, it's been a while.

https://looksmax.org/threads/hallmarks-of-aging.56432/ take a look at this too

Interesting.

I love the field of longevity and biohacking. Still have much to learn but It's very cool right now.
I'll make a thread of what a daily routine for "anti aging" or longevity should look like.

 

[robtical]

enjoy creatine hairloss

 

[Deleted member 1849]

I remember a couple months back a wrote a giant routine for longevity, fun shit.

enjoy creatine hairloss

gtfo, hairloss is contributed to many things not only dht lmao

 

[Seth Walsh]

Interesting.

I love the field of longevity and biohacking. Still have much to learn but It's very cool right now.
I'll make a thread of what a daily routine for "anti aging" or longevity should look like.

Looking forward to reading it

 

[6ft8InTheNetherlands]

I don't advise ever taking Metformin, it's really not a good drug and is a lazy man's thing to do; reward isn't worth the risk. You can get the same benefits from IF that you can from metformin. Not to mention that metformin instantly inhibits your mTOR which includes some important anabolic procedures, inhibits Vitamin B1 absorption which leads to problems with anxiety etc.

I'll start taking NMN pre-workout when I'm like 23-24. NMN is quite a useful compound when used as a part of an overall strategy like you previously pointed out. Pterostilbene is something I'll take alongside NMN. Metformin really is trash, and although Sinclair is amazing with the studies he does and discoveries he makes; he still is quite lazy lifestyle-wise and spends most of his time at a desk and isn't trying to optimize everything. He's more-so just focused on his work and following up on his trials. I'm happy to see someone on here as interested and motivated as you are now, it's been a while.

https://looksmax.org/threads/hallmarks-of-aging.56432/ take a look at this too

 

[paranakee]

lol isnt this stuff recommended in every looksmaxxing guide ever

i could replace "mitochondria" and "atp" with "red blood cell" and "oxygen" or any other bioword and it wouldnt be any different lol