MK-677 and anastrozole at 15 will I be stupid for doing this?

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Not trying to increase height just facial bone mass and bulking. Will the ai counter the effects of the mk closing growth plates? Also is the Swisschem anastrozole pills legit because I heard they were lying about their dosage rates? I will get the mk from chemyo because I heard they have good quality
 
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If I read one more MK677 post...
 
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Igf1 increases estrogen, and estrogen closes plates quicker. Taking ai can stop the closing of plates tho.
jfll what are you talking about igf-1 is a peptide hormone, not a sex steroid that makes estrogen like a factory. think about what you said for a second. if this was true robert wadlow would have stopped growing at the ripe old age of what like 3. sultan kosen too. gigantism would be a form of dwarfism then. mk677 will give supraphysiological igf-1, and igf-1 triggers chondrogenesis. Estrogen triggers osteogenesis. you dont want plates ossifying obviously. When igf-1 is supraphysiological, the rate of chondrogenesis passes the rate of osteogenesis. This physically PUSHES the ossification zone away from the resting zone. For context, at the end of puberty osteogenesis outmatches chondrogenesis and the ossification zone reaches the first zone of the growth plate making longitudinal growth impossible. igf-1 does not increase estrogen maybe by modulating like 0.000001% of aromatase activity in CERTAIN tissues but its so negligible. My hypothesis is proved by robert wadlow he had normal estradiol and INSANE igf and he wouldve grown until his mid or late 20's because his ossification zone was so far away
 
Not trying to increase height just facial bone mass and bulking. Will the ai counter the effects of the mk closing growth plates? Also is the Swisschem anastrozole pills legit because I heard they were lying about their dosage rates? I will get the mk from chemyo because I heard they have good quality
idk
 
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jfll what are you talking about igf-1 is a peptide hormone, not a sex steroid that makes estrogen like a factory. think about what you said for a second. if this was true robert wadlow would have stopped growing at the ripe old age of what like 3. sultan kosen too. gigantism would be a form of dwarfism then. mk677 will give supraphysiological igf-1, and igf-1 triggers chondrogenesis. Estrogen triggers osteogenesis. you dont want plates ossifying obviously. When igf-1 is supraphysiological, the rate of chondrogenesis passes the rate of osteogenesis. This physically PUSHES the ossification zone away from the resting zone. For context, at the end of puberty osteogenesis outmatches chondrogenesis and the ossification zone reaches the first zone of the growth plate making longitudinal growth impossible. igf-1 does not increase estrogen maybe by modulating like 0.000001% of aromatase activity in CERTAIN tissues but its so negligible. My hypothesis is proved by robert wadlow he had normal estradiol and INSANE igf and he wouldve grown until his mid or late 20's because his ossification zone was so far away
Yeah I’m ngl you’re a lot more informed than me. So your saying I just take mk individually with no anastrozole?
 
do both still i was just informing you because you were misinformed
Sorry if I sound like a dumbass but I was only planning to take anastrozole to stop growth plates closing, so since that’s not true my growth plates should be safe just taking mk individually?
 
Sorry if I sound like a dumbass but I was only planning to take anastrozole to stop growth plates closing, so since that’s not true my growth plates should be safe just taking mk individually?
anastrozole does work to stop growth plates closing. Remember, as a male the only major way to get estrogen is through aromatization since we don't have ovarian steroidogenesis. It still reduces the chondrogenesis to osteogenesis ratio because you are inhibiting osteogenesis (estrogen.) do both for optimal results. There are plenty of studies were people who lacked the aromatase enzyme grew until nearly their early 30s.
 
anastrozole does work to stop growth plates closing. Remember, as a male the only major way to get estrogen is through aromatization since we don't have ovarian steroidogenesis. It still reduces the chondrogenesis to osteogenesis ratio because you are inhibiting osteogenesis (estrogen.) do both for optimal results. There are plenty of studies were people who lacked the aromatase enzyme grew until nearly their early 30s.
I’m 6’3 at 15 and I barely grew an inch since last year (maybe even less). Doctor it’s most likely that im not gonna grow past 6’5. I think my growth plates might be closing soon.
 
S
anastrozole does work to stop growth plates closing. Remember, as a male the only major way to get estrogen is through aromatization since we don't have ovarian steroidogenesis. It still reduces the chondrogenesis to osteogenesis ratio because you are inhibiting osteogenesis (estrogen.) do both for optimal results. There are plenty of studies were people who lacked the aromatase enzyme grew until nearly their early 30s.
So basically just luck
 
I’m 6’3 at 15 and I barely grew an inch since last year (maybe even less). Doctor it’s most likely that im not gonna grow past 6’5. I think my growth plates might be closing soon.
6’3 is a good height sarr. Use anavar and squeeze out an inch or 2 maybe even 3. 6’4 is basically one of the best if not the best height. You won’t get as much knee problems and will height mog most. Unless youre trying to be an nba center then try HGH, AI
 
Bruh I’m not using it for height
What's wrong with Mk?
It's probably the most overhyped, cope-tier miracle drug you'll hear.

I'll tell you the truth here:
ClaimReality Check
"It's like taking GH orally"No, it just spikes GH/IGF uncontrollably, not intelligently or pulsatily
"You'll grow muscle + burn fat"Maybe if you're a GH-deficient 60-year-old, else enjoy bloat town
"It increases REM sleep"True. but it also makes you a lethargic zombie during the day
"You'll recover like a god"Right after you eat 9000 calories because your hunger is fucked
"Better than GH"KYS

It is non-pulsatile, spikes prolactin/cortisol, worsens insulin. Bloat is so bad you'll look like a Pixar character. Crippling carb cravings like an Auschwitz kid. Zero control over when GH rises. Insulin resistance making you fatter on a fat-burning drug. You gain weight, but it's 90% water, sodium, and suffering.

It's literally just taking a powerful signal molecule and just smashing the gas pedal down for a day straight. No nuance. Just down syndrome level cope.
 
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ClaimReality Check
"It's like taking GH orally"No, it just spikes GH/IGF uncontrollably, not intelligently or pulsatily
"You'll grow muscle + burn fat"Maybe if you're a GH-deficient 60-year-old, else enjoy bloat town
"It increases REM sleep"True. but it also makes you a lethargic zombie during the day
"You'll recover like a god"Right after you eat 9000 calories because your hunger is fucked
"Better than GH"KYS
[/TD]
"No, it just spikes GH/IGF uncontrollably, not intelligently or pulsatily"
Fake.

And no one in their right mind says MK is better than GH. But it's useful; it effectively increases GH. Depending on the individual, it could be equivalent to 2 or 3 IU of GH, which isn't bad at all and is a good step before taking GH directly for a teen who can't inject himself. And it's a pretty useful compound if you're going to do a PCT and JFL to using HGH, IGF-1 or Mk for muscle build.
 
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1747931836346
 
"No, it just spikes GH/IGF uncontrollably, not intelligently or pulsatily"
Fake.
MK677 literally causes non-pulsatile GH/IGF-1 elevation biochemically. It's a ghrelin receptor agonist (binds to GHSR-1a), it continuously stimulates the hypothalamus to release GHRH, GHRH = upstream driver of GH release. Because MK677 has a half-life of about 24hrs, it causes persistent stimulation thus elevated GH throughout the day. As long as the compound is active, it will eliminate the ultradian (pulsatile) rhythm your body naturally relies on.

"A single dose of MK677 induced a significant and sustained increase in GH levels over 24 hours." Murphy et al., J Clin Endocrinol Metab in 1998.

"Ibutamoren overcomes endogenous GH regulation by overriding somatostatin inhibition." Smith RG et al., Endocrinology from 2000
And no one in their right mind says MK is better than GH. But it's useful; it effectively increases GH. Depending on the individual, it could be equivalent to 2 or 3 IU of GH, which isn't bad at all and is a good step before taking GH directly for a teen who can't inject himself. And it's a pretty useful compound if you're going to do a PCT and JFL to using HGH, IGF-1 or Mk for muscle build.
GH is highly anabolic indirectly. People only use it with androgens which makes total sense. No one uses it alone for muscle hypertrophy. Also, MK677 is not even close to a good PCT. Doesn't help restart the HPTA, doesn't improve test production, only improves recovery cosmetically via fullness. You're just putting icing on a fucked up cake.

You need to remember lab value equivalency isn't functional equivalency. Actual GH treatment is far more precise and safer to titrate than MK677.

3IU/day GH, although similar on bloodwork, mogs the shit out of MK677. I can explain further if you wish. But let's not pretend MK677 is any smarter than it is.
 
MK677 literally causes non-pulsatile GH/IGF-1 elevation biochemically. It's a ghrelin receptor agonist (binds to GHSR-1a), it continuously stimulates the hypothalamus to release GHRH, GHRH = upstream driver of GH release. Because MK677 has a half-life of about 24hrs, it causes persistent stimulation thus elevated GH throughout the day. As long as the compound is active, it will eliminate the ultradian (pulsatile) rhythm your body naturally relies on.

"A single dose of MK677 induced a significant and sustained increase in GH levels over 24 hours." Murphy et al., J Clin Endocrinol Metab in 1998.
Serum 24 h mean GH and IGF I results in pivotal year 1 GH and IGF I data were not

GH is highly anabolic indirectly. People only use it with androgens which makes total sense. No one uses it alone for muscle hypertrophy. Also, MK677 is not even close to a good PCT. Doesn't help restart the HPTA, doesn't improve test production, only improves recovery cosmetically via fullness. You're just putting icing on a fucked up cake.
The only interesting anabolic process that GH triggers is hyperplasia, it is not useful/interesting for hypertrophy. And with its use in PCT I was referring to its anti-catabolic properties, easy consumption and increased hunger.
You need to remember lab value equivalency isn't functional equivalency. Actual GH treatment is far more precise and safer to titrate than MK677.

3IU/day GH, although similar on bloodwork, mogs the shit out of MK677. I can explain further if you wish. But let's not pretend MK677 is any smarter than it is.
Elab.
 
"No, it just spikes GH/IGF uncontrollably, not intelligently or pulsatily"
Fake.

And no one in their right mind says MK is better than GH. But it's useful; it effectively increases GH. Depending on the individual, it could be equivalent to 2 or 3 IU of GH, which isn't bad at all and is a good step before taking GH directly for a teen who can't inject himself. And it's a pretty useful compound if you're going to do a PCT and JFL to using HGH, IGF-1 or Mk for muscle build.
Nicolas cage crazy
 
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