Modern medicine cannot solve my disease...

[IAMNOTANINCEL]

Interestingly, vegetables feel better, but my doctor said it has nothing to do with eating or drinking.

fuck your doctor, just try it

 

[gargomel]

Downstream affects of those genes is what causes UC, we dont fully understand the pathways so its too risky, knowing what the problem is isnt enough, also editing one gene wont fix the entire network

Edit: crisprs designed to edit signle genes

Possible trigger of Crohn’s disease discovered

Researchers at TUM have shown that dysfunctional mitochondria trigger symptoms of chronic inflammatory bowel disease and influence the microbiome.

www.tum.de

Could you comment on this study? Disease not related to ulcerative colitis, but similar to ulcerative colitis

 

[Rigged]

Possible trigger of Crohn’s disease discovered

Researchers at TUM have shown that dysfunctional mitochondria trigger symptoms of chronic inflammatory bowel disease and influence the microbiome.

www.tum.de

Could you comment on this study? Disease not related to ulcerative colitis, but similar to ulcerative colitis

Dirk haller is so random, his field has nothing to do with this, tbh all that study says is that IBD has a deeper shared mechanism, doesnt do anything for getting a solution

Edit: even if they ended up being similar, UC and Crohns have different immune profile UC is Th2-driven Crohn Th1/Th17 driven, so again pointless article

 

[gargomel]

Dirk haller is so random, his field has nothing to do with this, tbh all that study says is that IBD has a deeper shared mechanism, doesnt do anything for getting a solution

Edit: even if they ended up being similar, UC and Crohns have different immune profile UC is Th2-driven Crohn Th1/Th17 driven, so again pointless article

Could you comment on this? An extraordinary discovery, according to researchers.

A disease-associated gene desert directs macrophage inflammation through ETS2 - Nature

ETS2—which is associated with inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis—is a central regulator of human inflammatory macrophages.

www.nature.com

 

[oily703]

Dirk haller is so random, his field has nothing to do with this, tbh all that study says is that IBD has a deeper shared mechanism, doesnt do anything for getting a solution

Edit: even if they ended up being similar, UC and Crohns have different immune profile UC is Th2-driven Crohn Th1/Th17 driven, so again pointless article

dude you know everything
where do you work if you dont mind me asking

 

[Rigged]

Could you comment on this? An extraordinary discovery, according to researchers.

A disease-associated gene desert directs macrophage inflammation through ETS2 - Nature

ETS2—which is associated with inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis—is a central regulator of human inflammatory macrophages.

www.nature.com

Thats like 30 pages long bro

 

[Rigged]

dude you know everything
where do you work if you dont mind me asking

Until i get my NP license, i do phlebotomy and some other stuff for a few hospices

 

[gargomel]

Until i get my NP license, i do phlebotomy and some other stuff for a few hospices

The ETS2 gene and IBD

Founder and President of the Microscopic Colitis Foundation

www.microscopiccolitisfoundation.org

This is short bro.

 

[oily703]

Until i get my NP license, i do phlebotomy and some other stuff for a few hospices

do you study all this shit for fun or is it appart of what ur learning

 

[gargomel]

do you study all this shit for fun or is it appart of what ur learning

What is nonsense, learning science?

 

[oily703]

What is nonsense, learning science?

he knows everything about experimental drugs used on rats
just go on his profile
all in the name of looksmaxx.org
or not thats what im asking

 

[gargomel]

he knows everything about experimental drugs used on rats
just go on his profile
all in the name of looksmaxx.org
or not thats what im asking

lol he clearly has a high iq

 

[Rigged]

Could you comment on this? An extraordinary discovery, according to researchers.

A disease-associated gene desert directs macrophage inflammation through ETS2 - Nature

ETS2—which is associated with inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis—is a central regulator of human inflammatory macrophages.

www.nature.com

oh i skimmed through it ive read this b4, the only correlation it has is to IBD but if ETS2 influences macrophages in UC, then it could be a partial solution, the study was more about finding drugs supressing ETS2 without broad immune supression, tbh never reached anything further than that, its just a theory that they didnt prove nor disprove

 

[gargomel]

oh i skimmed through it ive read this b4, the only correlation it has is to IBD but if ETS2 influences macrophages in UC, then it could be a partial solution, the study was more about finding drugs supressing ETS2 without broad immune supression, tbh never reached anything further than that, its just a theory that they didnt prove nor disprove

What's on your mind for a possible cause? So if you were to throw out a theory, what would it be?

 

[Rigged]

The ETS2 gene and IBD

Founder and President of the Microscopic Colitis Foundation

www.microscopiccolitisfoundation.org

This is short bro.

Just tests MEK inhibitors its not the same as the other study, MEK inhibitors arent safe long term, maybe if they found a delivery method to target macrophages it could work, ETS2 is more a path they can use to find treatments not one thatll be a solution

 

[Sixxstar]

They don't know what causes my disease and they have no idea. I only receive symptom suppression treatments. Opinions?

 

[Rigged]

What's on your mind for a possible cause? So if you were to throw out a theory, what would it be?

For a solution thats not using crisprs

First restore the microbiome with precission probiotics or any bacteriophage that specifically eliminate only harmful bacteria and boosts useful species like Faecalibacterium and Akkermansia since they promote metabolites like butyrate to repair the gut lining, next step is probably strengrhening the epithelial barrier using small molecules like MitoQ or any compound that increases ATP production and stabilizes tight junction proteins, immune mods can be done using biologics like IL-23 or TNF inhibitors, combining that with JAK inhibitors to suppress local inflam without immunen supression widespread, epigentic reprogram could be done using HDAC inhibitors, which already are in trial phases for autoimmune, and then lastly ud need an advanced drug delivery systems, like pH sensitive nanoparticles (i have a guide on my post that had a DIY nanoparticle guide i wrote in it) or an oral forumla that somehow would release meds only into the colon

 

[Rigged]

For a solution thats not using crisprs

First restore the microbiome with precission probiotics or any bacteriophage that specifically eliminate only harmful bacteria and boosts useful species like Faecalibacterium and Akkermansia since they promote metabolites like butyrate to repair the gut lining, next step is probably strengrhening the epithelial barrier using small molecules like MitoQ or any compound that increases ATP production and stabilizes tight junction proteins, immune mods can be done using biologics like IL-23 or TNF inhibitors, combining that with JAK inhibitors to suppress local inflam without immunen supression widespread, epigentic reprogram could be done using HDAC inhibitors, which already are in trial phases for autoimmune, and then lastly ud need an advanced drug delivery systems, like pH sensitive nanoparticles (i have a guide on my post that had a DIY nanoparticle guide i wrote in it) or an oral forumla that somehow would release meds only into the colon

Idk why i wrote this lets keep it 100% ur not gonna do shit about UC and probably end up eating eggs and cope

 

[Rigged]

do you study all this shit for fun or is it appart of what ur learning

Has absolutely nothing to do with what im learning lmao NPs only have to know about shit like GERD COPD alzeihmers, shit that 90% of old niggas have

 

[gargomel]

Idk why i wrote this lets keep it 100% ur not gonna do shit about UC and probably end up eating eggs and cope

Will Crispr be the definitive solution?

 

[Rigged]

Will Crispr be the definitive solution?

Yea

 

[Rigged]

@wollet2 i remember writing a shit ton to try and help u with PFS did u end up doing anything i said?

 

[Rigged]

@wollet2 i remember writing a shit ton to try and help u with PFS did u end up doing anything i said?

Gotta A/B test if ppl actually do anything to help themselves after i give them a 12 page step by step guide

 

[gargomel]

@User28823

 

[User28823]

Why would anyone want surgery as a first option? It’s incredibly invasive and presents risks. If you could treat the condition and improve quality of life of medication beforehand, then that is logically the better choice.

But anyways, have fun suffering eating food and not knowing whether or not you’ll be on the toilet in pain for the days after, all because you’re too pussy to get the surgery you need

surgery is a last ditch effort when all immunosuppressants have failed or you have developed cancer or other complication due to the disease like toxic megacolon, both of which are rare

also, surgically removing your colon is generally stage 1 of a 3 stage surgery ultimately resulting in the small intestine being attached to the rectum mimicking a normal digestive tract bypassing your once was colon, aka a j-pouch surgery

the problem is that those with ulcerative colitis usually have inflammation in the rectum, too, so the "cure" you were expecting is now still present in the form of proctitis

and if that is enough of a pain in the ass (literally), they likely elect to get a 4th surgery to undo the j-pouch and revert to a ileostomy aka small intestine sticking out of your abdomen where you now have to shit in a bag autonomously for the rest of your life, which you already had to do temporarily for months leading up to your final j-pouch attachment

now tell me, why would anyone on earth choose to go through 3 surgeries with the risk of having to get a 4th in the event of proctitis when they can take immunosuppressants instead and live a normal life?

why would one choose to shit in a bag when they can treat their symptoms with meds?

why would anyone in their early adulthood opt for a shit bag and exposed intestine than an injection every couple of weeks?

I don't have to worry about what I eat in remission

 

[mfk]

surgery is a last ditch effort when all immunosuppressants have failed or you have developed cancer or other complication due to the disease like toxic megacolon, both of which are rare

also, surgically removing your colon is generally stage 1 of a 3 stage surgery ultimately resulting in the small intestine being attached to the rectum mimicking a normal digestive tract bypassing your once was colon, aka a j-pouch surgery

the problem is that those with ulcerative colitis usually have inflammation in the rectum, too, so the "cure" you were expecting is now still present in the form of proctitis

and if that is enough of a pain in the ass (literally), they likely elect to get a 4th surgery to undo the j-pouch and revert to a ileostomy aka small intestine sticking out of your abdomen where you now have to shit in a bag autonomously for the rest of your life, which you already had to do temporarily for months leading up to your final j-pouch attachment

now tell me, why would anyone on earth choose to go through 3 surgeries with the risk of having to get a 4th in the event of proctitis when they can take immunosuppressants instead and live a normal life?

why would one choose to shit in a bag when they can treat their symptoms with meds?

why would anyone in their early adulthood opt for a shit bag and exposed intestine than an injection every couple of weeks?

I don't have to worry about what I eat in remission

literally said surgery was a last option tf we have the same point

 

[User28823]

Did the genetic mutation happen later because I was healthy for decades?

he doesnt have any idea what hes talking about btw

 

[User28823]

literally said surgery was a last option tf we have the same point

just get the surgery you high inhib skank

just get a surgery u dont need bro !!!

 

[playxiing]

wow bro this is pain hope u will get better

 

[mfk]

just get a surgery u dont need bro !!!

he was complaining about his symptom suppressing drugs so yeah then get the surgery??

you talk as if immunosuppressants are in any way a good option, jfl have fun contracting the common flu and rotting in bed for 3 weeks to recover

as someone who has actually taken immunosuppressants before, they’re shit

 

[gargomel]

semptomlarını baskılayan ilaçlardan şikayetçiydi, o zaman ameliyat mı olmalı?

sanki bağışıklık baskılayıcılar iyi bir seçenekmiş gibi konuşuyorsun, jfl sıradan bir gribe yakalanmanın ve iyileşmek için 3 hafta yatakta çürümenin tadını çıkar

daha önce bağışıklık baskılayıcı ilaçlar almış biri olarak, bunlar boktan

Does the flu really last 3 weeks?

 

[mfk]

Does the flu really last 3 weeks?

depends on the immunosuppressants, but many common ones tend to suppress your immune response to an extent where recovering from illnesses caused by infection take far longer than they normally would

it varies from person to person

 

[gargomel]

depends on the immunosuppressants, but many common ones tend to suppress your immune response to an extent where recovering from illnesses caused by infection take far longer than they normally would

it varies from person to person

What immunosuppressant did you use? Biologics target more specific pathways rather than general suppression

 

[mfk]

What immunosuppressant did you use? Biologics target more specific pathways rather than general suppression

Ciclosporine

 

[gargomel]

Ciclosporine

I think you used it as eye drops and I think it's a local suppressant

 

[mfk]

I think you used it as eye drops and I think it's a local suppressant

There’s the eye drop version but it’s not available in my country so I took the oral instead

 

[gargomel]

There’s the eye drop version but it’s not available in my country so I took the oral instead

Are you going to use this for life?

 

[mfk]

Are you going to use this for life?

No I don’t take it anymore. My condition improved and went away as we tapered down the dosage until I was fine without it. I don’t use any treatments anymore.

I occasionally get flare ups but they go away without intervention most of the time. If I get a flare up that is really bad, which hasn’t happened in a long time, I will use a Dexamethasone eye drop that will stop the inflammatory pathway locally and return my eyes to normal.

This was about 4 years ago

 

[User28823]

he was complaining about his symptom suppressing drugs so yeah then get the surgery??

you talk as if immunosuppressants are in any way a good option, jfl have fun contracting the common flu and rotting in bed for 3 weeks to recover

as someone who has actually taken immunosuppressants before, they’re shit

flu has me down for a week, been on 4 immunosuppressants

rather take suppressants than surgery any day of the week

 

[gargomel]

flu has me down for a week, been on 4 immunosuppressants

rather take suppressants than surgery any day of the week

What do you use? I only use remicade and imuran

 

[oily703]

Has absolutely nothing to do with what im learning lmao NPs only have to know about shit like GERD COPD alzeihmers, shit that 90% of old niggas have

I just remembered this bro
Thoughts on raw meat

 

[Rigged]

I just remembered this bro
Thoughts on raw meat

bro ive said i didnt make that post why am i getting org bullied

 

[oily703]

bro ive said i didnt make that post why am i getting org bullied

What
I didnt read anything on this thread
I just remenbered that the raw meat fanatics exist
And i want to get an actual professionals opinion

 

[Rigged]

What
I didnt read anything on this thread
I just remenbered that the raw meat fanatics exist
And i want to get an actual professionals opinion

Oh alr mb lol, raw meads good if u can get high quality meat, @MA_ascender u seem to know everything about every user on this site iirc there was a known user on here who said he got it straight from farm could u @ him maybe he could could help tell oily how to get some himself

 

[Rigged]

Oh alr mb lol, raw meads good if u can get high quality meat, @MA_ascender u seem to know everything about every user on this site iirc there was a known user on here who said he got it straight from farm could u @ him maybe he could could help tell oily how to get some himself

Oh right MA_Banned

 

[oily703]

Oh alr mb lol, raw meads good if u can get high quality meat, @MA_ascender u seem to know everything about every user on this site iirc there was a known user on here who said he got it straight from farm could u @ him maybe he could could help tell oily how to get some himself

I know how to get some quality meat dont worry lmao
But do you think stricly raw carnivore is benefitial
I cant just believe all the broscience
And the average medical professional would tell me to go fuck myself if i even brought up this topic

 

[Rigged]

I know how to get some quality meat dont worry lmao
But do you think stricly raw carnivore is benefitial
I cant just believe all the broscience
And the average medical professional would tell me to go fuck myself if i even brought up this topic

No strictly carnivore makes no sense, the lack of a positive nutrient wont end up making u healthier

 

[oily703]

No strictly carnivore makes no sense, the lack of a positive nutrient wont end up making u healthier

What is ideal then?
Raw carnivore and no carbs?
Fuck i would love a debate between you and @Never Get Up

 

[Rigged]

What is ideal then?
Raw carnivore and no carbs?
Fuck i would love a debate between you and @Never Get Up

We were supposed to and he dodged a live debate infront of 30 ppl, pls never take him seriously

 

[Rigged]

What is ideal then?
Raw carnivore and no carbs?
Fuck i would love a debate between you and @Never Get Up

Pls read my replies here

Why counting calories is a fucking scam

You probably heard @Never Get Up say this a million times but calories is a unit for measuring heat. We don't burn heat for energy, we are not a fucking train, we use ATP for energy. This heat energy in also in a closed system. You don’t eat heat energy, you’re not a closed system. Calories...

looksmax.org

Ur decision on how much of a retard he is decide after