mathis
Equinox
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Half chat gpt-made thread to anderstand the mecanism of action of my last thread on anti aging
@teefight
Rapamycin :
functions by inhibiting mTOR, key regulator of cellular growth and metabolism. It integrates signals from nutrients, growth factors and cellular stress to control processes like protein synthesis, cell growth, and autophagy.
(Autophagy): process by which cells degrade and recycle damaged components. helps maintain cellular health.
Cellular Metabolism: rapamycin can shift metabolism towards more efficient energy use, reducing metabolic diseases and age-related decline.
( note ) mice studies have shown that rapamycin can extend lifespan in mice
Metformin
metformin affects pathways related to aging.
AMPK Activation: Metformin activates AMP-activated protein kinase (AMPK), which improves insulin sensitivity and helps regulate energy metabolism.
metformin can reduce chronic inflammation and oxidative stress, which are associated with aging.
like rapamycin, metformin influences mTOR signaling, albeit contributing to enhanced autophagy and metabolic health.
Nicotinamide Adenine Dinucleotide (NAD+) Boosters
NAD+ is a coenzyme involved in redox reactions and cellular metabolism. NAD+ levels decline with age, impacting various cellular processes.
Sirtuin Activation: NAD+ is crucial for the activity of sirtuins, a family of proteins involved in regulating metabolism, stress resistance, and aging. By boosting NAD+ levels, sirtuins can be activated, promoting cellular repair and longevity.
Cellular Energy: NAD+ is essential for mitochondrial function and energy production. Enhancing NAD+ levels can improve mitochondrial health, compromised with age.
-DNA Repair : NAD+ is involved in DNA repair processes. Increased NAD+ may help maintain genome stability and prevent age-related cellular damage.
Spermidine
Spermidine is a polyamine that has been linked to autophagy and cellular health.
Autophagy Induction: Spermidine promotes autophagy = helps clear damaged cellular components and reduce inflammation and cellular aging.
Oxidative Stress Reduction : By enhancing autophagy, spermidine reduce oxidative stress and damage, which are implicated in aging and various diseases
Some studies have also been done with mices, results are positives.
Resveratrol
has been studied for its potential anti-aging effects.
Sirtuin Activation : Resveratrol activates sirtuins, particularly SIRT1, which is involved in metabolic regulation and stress responses.
Antioxidant Properties Resveratrol has antioxidant properties, which help reduce oxidative stress and inflammation, both of which are associated with aging.
Metabolic Health: It can improve insulin sensitivity and lipid profiles, contributing to better overall metabolic health and potentially extending lifespan.
Most of it should be here
@teefight
Rapamycin :
functions by inhibiting mTOR, key regulator of cellular growth and metabolism. It integrates signals from nutrients, growth factors and cellular stress to control processes like protein synthesis, cell growth, and autophagy.
(Autophagy): process by which cells degrade and recycle damaged components. helps maintain cellular health.
Cellular Metabolism: rapamycin can shift metabolism towards more efficient energy use, reducing metabolic diseases and age-related decline.
( note ) mice studies have shown that rapamycin can extend lifespan in mice
Metformin
metformin affects pathways related to aging.
AMPK Activation: Metformin activates AMP-activated protein kinase (AMPK), which improves insulin sensitivity and helps regulate energy metabolism.
metformin can reduce chronic inflammation and oxidative stress, which are associated with aging.
like rapamycin, metformin influences mTOR signaling, albeit contributing to enhanced autophagy and metabolic health.
Nicotinamide Adenine Dinucleotide (NAD+) Boosters
NAD+ is a coenzyme involved in redox reactions and cellular metabolism. NAD+ levels decline with age, impacting various cellular processes.
Sirtuin Activation: NAD+ is crucial for the activity of sirtuins, a family of proteins involved in regulating metabolism, stress resistance, and aging. By boosting NAD+ levels, sirtuins can be activated, promoting cellular repair and longevity.
Cellular Energy: NAD+ is essential for mitochondrial function and energy production. Enhancing NAD+ levels can improve mitochondrial health, compromised with age.
-DNA Repair : NAD+ is involved in DNA repair processes. Increased NAD+ may help maintain genome stability and prevent age-related cellular damage.
Spermidine
Spermidine is a polyamine that has been linked to autophagy and cellular health.
Autophagy Induction: Spermidine promotes autophagy = helps clear damaged cellular components and reduce inflammation and cellular aging.
Oxidative Stress Reduction : By enhancing autophagy, spermidine reduce oxidative stress and damage, which are implicated in aging and various diseases
Some studies have also been done with mices, results are positives.
Resveratrol
has been studied for its potential anti-aging effects.
Sirtuin Activation : Resveratrol activates sirtuins, particularly SIRT1, which is involved in metabolic regulation and stress responses.
Antioxidant Properties Resveratrol has antioxidant properties, which help reduce oxidative stress and inflammation, both of which are associated with aging.
Metabolic Health: It can improve insulin sensitivity and lipid profiles, contributing to better overall metabolic health and potentially extending lifespan.
Most of it should be here
