Gudliferr
n1 confidencemaxxer
- Joined
- Dec 22, 2025
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Well, I just crafted this stack at school (probably have like 4h screentime in Perplexity today) so lmk what u think and what ud change, especially if ur somewhat knowledgeable on nootropics/cognitive enhancement.
Context
I did the SHAPS (anhedonia test) and got 12/14 (high/severe anhedonia).
In case u dont know what anhedonia means:
I currently work maybe 10h/week but only because I'm in school rn and kinda gave up until next week once it ends but next year I'll be on online school which is effectively like having no school/time constraints.
I do e-commerce but I won't get into that in this post. I used to do about 30h/w (never consistent tbh and even if i was it would be enough).
I'm doing this mostly bc I gotta afford these giga expensive looksmax compounds and also who wouldn't like being rich.
IQ-wise, I haven't done a proper in person test but I've done Mensa Norway.
(forgot to add it here and i cant now bc of file limit, look at the attachment on the reply below, anyway got 138)
(I did it on about 5.5-6h of sleep and after 7h of school (prob didnt even use my brain at school that day JFL but still. Also, that was the week after I turned 16, the lowest range of that test is 16-17 but it does warn against potentially lower results), hopefully it did not over/underestimate it too much.
I also have some trouble sleeping and often wake up in the middle of the night.
Goals
The goal of this stack is not necessarily cognitive performance enhancement but workload duration optimization.
168h/w total-70h(sleeping)-30h bs(eating, showering, gooning, friends etc...)≈70h
I want to be able to work ~70h/w. (not necessarily doing that every single week but at least being able to).
I'd ideally be able to reach a <6 SHAPS score (moderate anhedonia) within 2 months.
Hopefully also get a slight cognitive boost, maybe 0.5SD+ IQ?
Stable sleep
Bupropion SR
Bupropion (commercialized as Wellbutrin) is a dual norepinephrine-dopamine reuptake inhibitor (NDRI).
It is the main intervention prescribed for anhedonia due to the essential role that both dopamine and norepinephrine play in in the brain's reward processing and motivation.
SR form (Sustained release): It allows for more customizable dosing and lower risk of insomnia compared to XL (extended release) due to shorter half-life.
My dosing:
It has interactions with other compounds I take (or plan on taking), mainly Erdafitinib since they're both involved with the CYP2B6 enzyme which would hypothetically double the effects of bupropion and I'm not particularly interested in having a seizure (one of the main risks of this medication) (once I switch to Dabogratinib or LOXO435 I will DNR this). I also take 20mg isotret which increases the seizure risk.
Due to this, I decided to start at 75mg rather than the standard 150mg and titrate to 150mg rather than 300mg.
For BP I will (obviously) monitor it and once I start taking GH (or if it rises too much b4 that) i will start taking perhaps a thiazide-like diuretic like indapamide or smth
This should theoretically be the equivalent of starting 150mg and titrating to 300mg (300mg being a typical adult dosing therapeutic target).
Modafinil
Modafinil is an atypical Central Nervous System stimulant often prescribed for treating sleep disorders and it is particularly interesting for my goals due to its wakefulness-promoting properties.
This could theoretically allow us to work double digit hours in a single day (I've heard anecdotal evidence on up to 20h/day but obv I don't plan on going near that) aswell as increase cognitive performance temporarily
It is also a weak DRI (Dopamine Reuptake Inhibitor)It can easily lose effectiveness and must not be chronically taken daily to preserve it's benefits.
My dosing:
100-200mg 1-2x/week (max)
Why not use an amphetamine as a stimulant instead?
basically many pathways overlap and could cause overstimulation and highly increases seizure risk (modafinil does too but not as much)
Copelements
L-Tyrosine: A dopamine, norepinephrine and epinephrine precursor
More tyrosine might help sustain dopamine/NE output under bupropion’s reuptake blockade, potentially supporting alertness, task engagement and reducing fatigue during prolonged cognitive effort.
Dosage: 1-2g/day
Rhodiola: A weak monoamine oxidase (MAO) inhibitor and AMPK activator
By mildly slowing the enzymatic breakdown of neurotransmitters, rhodiola may prevent the rapid depletion of dopamine and norepinephrine left floating in the synapses by bupropion's reuptake blockade, potentially extending focus and easing the load of a heavy workday. Can also lower cortisol.
Dosage: 600mg/day, 6-12w cycles with 2-4w breaks
Daridorexant
Daridorexant is a Dual Orexin Receptor Antagonist (DORA).
Orexin is a chemical messenger essential for regulating wakefulness, arousal, appetite, and the sleep-wake cycle.
As you may assume from this graph, it is prescribed to treat chronic insomnia including trouble falling or staying asleep.
And as you probably know, sleep is just about the most important factor in neural recovery and overall cognition.
Not much more to say here
My dosing:
will skip on days i take modafinil due to interaction through the CYP3A4 enzyme
start at 25mg, potentially titrate to 50mg
Cerebrolysin
Cerebrolysin is an injectable neuropeptide made from pig brains jfl
Its mostly used in eurasia to treat dementia, brain injury, stroke recovery and overall cognitive recovery
It offers a fuck ton of benefits including neuroprotection and brain repair by mimicking neurotrophic factors (BDNF, GDNF, NGF, CNTF), enhancing neurogenesis in the hippocampus and improving axonal regeneration and synaptic density.
I can't bother myself explaining all of them (and i also dont fully understand all of them bc i havent looked into it in detail yet)
Essentially takes u back to a giga optimized baseline
My dosing:
I will do a cyce of this but tbh I haven't investigated on doses or anything yet, will probably do whatever's standard or similar
Conclusion
This stack includes anhedonia counteracting interventions, occasional stimulants, sleep optimization and baseline restoration + optimization. So pretty much I'm going to become Isaac Newton w this shit.
Now seriously what do you guys think of my stack? What would you change considering my conditions/goals?
Ts took me like two hours to write so yall better rep the fuck out of it niggers
Context
I did the SHAPS (anhedonia test) and got 12/14 (high/severe anhedonia).
In case u dont know what anhedonia means:
I currently work maybe 10h/week but only because I'm in school rn and kinda gave up until next week once it ends but next year I'll be on online school which is effectively like having no school/time constraints.
I do e-commerce but I won't get into that in this post. I used to do about 30h/w (never consistent tbh and even if i was it would be enough).
I'm doing this mostly bc I gotta afford these giga expensive looksmax compounds and also who wouldn't like being rich.
IQ-wise, I haven't done a proper in person test but I've done Mensa Norway.
(forgot to add it here and i cant now bc of file limit, look at the attachment on the reply below, anyway got 138)
(I did it on about 5.5-6h of sleep and after 7h of school (prob didnt even use my brain at school that day JFL but still. Also, that was the week after I turned 16, the lowest range of that test is 16-17 but it does warn against potentially lower results), hopefully it did not over/underestimate it too much.
I also have some trouble sleeping and often wake up in the middle of the night.
Goals
The goal of this stack is not necessarily cognitive performance enhancement but workload duration optimization.
168h/w total-70h(sleeping)-30h bs(eating, showering, gooning, friends etc...)≈70h
I want to be able to work ~70h/w. (not necessarily doing that every single week but at least being able to).
I'd ideally be able to reach a <6 SHAPS score (moderate anhedonia) within 2 months.
Hopefully also get a slight cognitive boost, maybe 0.5SD+ IQ?
Stable sleep
Bupropion SR
Bupropion (commercialized as Wellbutrin) is a dual norepinephrine-dopamine reuptake inhibitor (NDRI).
It is the main intervention prescribed for anhedonia due to the essential role that both dopamine and norepinephrine play in in the brain's reward processing and motivation.
SR form (Sustained release): It allows for more customizable dosing and lower risk of insomnia compared to XL (extended release) due to shorter half-life.
My dosing:
It has interactions with other compounds I take (or plan on taking), mainly Erdafitinib since they're both involved with the CYP2B6 enzyme which would hypothetically double the effects of bupropion and I'm not particularly interested in having a seizure (one of the main risks of this medication) (once I switch to Dabogratinib or LOXO435 I will DNR this). I also take 20mg isotret which increases the seizure risk.
Due to this, I decided to start at 75mg rather than the standard 150mg and titrate to 150mg rather than 300mg.
For BP I will (obviously) monitor it and once I start taking GH (or if it rises too much b4 that) i will start taking perhaps a thiazide-like diuretic like indapamide or smth
This should theoretically be the equivalent of starting 150mg and titrating to 300mg (300mg being a typical adult dosing therapeutic target).
Modafinil
Modafinil is an atypical Central Nervous System stimulant often prescribed for treating sleep disorders and it is particularly interesting for my goals due to its wakefulness-promoting properties.
This could theoretically allow us to work double digit hours in a single day (I've heard anecdotal evidence on up to 20h/day but obv I don't plan on going near that) aswell as increase cognitive performance temporarily
It is also a weak DRI (Dopamine Reuptake Inhibitor)It can easily lose effectiveness and must not be chronically taken daily to preserve it's benefits.
My dosing:
100-200mg 1-2x/week (max)
Why not use an amphetamine as a stimulant instead?
basically many pathways overlap and could cause overstimulation and highly increases seizure risk (modafinil does too but not as much)
Copelements
L-Tyrosine: A dopamine, norepinephrine and epinephrine precursor
More tyrosine might help sustain dopamine/NE output under bupropion’s reuptake blockade, potentially supporting alertness, task engagement and reducing fatigue during prolonged cognitive effort.
Dosage: 1-2g/day
Rhodiola: A weak monoamine oxidase (MAO) inhibitor and AMPK activator
By mildly slowing the enzymatic breakdown of neurotransmitters, rhodiola may prevent the rapid depletion of dopamine and norepinephrine left floating in the synapses by bupropion's reuptake blockade, potentially extending focus and easing the load of a heavy workday. Can also lower cortisol.
Dosage: 600mg/day, 6-12w cycles with 2-4w breaks
Daridorexant
Daridorexant is a Dual Orexin Receptor Antagonist (DORA).
Orexin is a chemical messenger essential for regulating wakefulness, arousal, appetite, and the sleep-wake cycle.
As you may assume from this graph, it is prescribed to treat chronic insomnia including trouble falling or staying asleep.
And as you probably know, sleep is just about the most important factor in neural recovery and overall cognition.
Not much more to say here
My dosing:
will skip on days i take modafinil due to interaction through the CYP3A4 enzyme
start at 25mg, potentially titrate to 50mg
Cerebrolysin
Cerebrolysin is an injectable neuropeptide made from pig brains jfl
Its mostly used in eurasia to treat dementia, brain injury, stroke recovery and overall cognitive recovery
It offers a fuck ton of benefits including neuroprotection and brain repair by mimicking neurotrophic factors (BDNF, GDNF, NGF, CNTF), enhancing neurogenesis in the hippocampus and improving axonal regeneration and synaptic density.
I can't bother myself explaining all of them (and i also dont fully understand all of them bc i havent looked into it in detail yet)
Essentially takes u back to a giga optimized baseline
My dosing:
I will do a cyce of this but tbh I haven't investigated on doses or anything yet, will probably do whatever's standard or similar
Conclusion
This stack includes anhedonia counteracting interventions, occasional stimulants, sleep optimization and baseline restoration + optimization. So pretty much I'm going to become Isaac Newton w this shit.
Now seriously what do you guys think of my stack? What would you change considering my conditions/goals?
Ts took me like two hours to write so yall better rep the fuck out of it niggers
Last edited:
