My opinion on Ibutamoren/MK-677 and why it is BAD for heightmaxing

[2chevskuy]

Ibutamoren or MK-677 is known for secretion of GH, IGF-1 and IGFBPs (which you guys that are new ignore and I will explain why they are bad for you)

​

You are deluded into thinking more GH = more height gainz and it’s a half truth.

While yes, growth hormone causes height growth, continuous secretion which MK-677 increases is not that good for you.

-Why?

Because epiphyseal plates (growth plates) respond best to pulsatile GH secretion. Simply put it is infinitely (!) better to ensure GH spikes rather than constant elevated GH levels (if your goal is to maximise your height)

ALSO
​

Constantly high GH/IGF-1 levels accelerate growth plate maturation, basically speeding up their fusion or closure

Spoiler: First point

Continuously high GH levels are not as effective as some may wish for height growth and fuse epiphyseal plates early

Also two very important topics I must talk about are
Desensitisation
and
Insulin Resistance

​

First, for those who don’t know,

Spoiler

Those who know

, receptor desensitisation is when
receptor is exposed to chronically high levels of its ligand (hormone), the cell reduces its sensitivity to prevent overstimulation.

In case of MK-677, it’s not just a Growth Hormone Secretagogue but a Ghrelin mimetic ( If phrased simply Ghrelin is a hunger hormone )
MK-677 makes you want to eat more via mimicking Ghrelin. And here’s the big deal:

Increased caloric intake leads to increased blood glucose, which leads to pancreas secreting more insulin to handle it.

So, persistently high insulin levels from overeating and high GH (which is insulin-antagonistic) causes:
Insulin receptor downregulation (Cells reduce insulin receptors or dampen downstream signalling)
Insulin resistance developing…



Insulin resistance can lead to IGF-1 desensitisation because insulin and IGF-1 share similar receptor signalling pathways (PI3K-Akt-mTOR) and insulin resistance will desensitise IGF-1 receptors, reducing IGF-1’s anabolic effects on bone and muscle.

Spoiler: Second point

The fuck-up cycle summarised:
MK-677 increases ghrelin activity → you eat more.
Overeating increases blood glucose → more insulin → insulin resistance
At the same time, MK-677 keeps GH/IGF-1 constantly elevated → IGF-1 receptor desensitisation.
Both insulin resistance and IGF-1 receptor downregulation reduce anabolic signalling efficiency.
Meanwhile, constant GH/IGF-1 accelerates growth plate fusion, capping height gains early.
Desensitisation doesn’t just “work on the additional IGF-1 secreted because of MK”, it works systemically. So you even fuck up your natural growth potential that could’ve occurred if you weren’t such a disgrace and didn’t spend your parents’ money on some tiktok shop sups…


Simply said, you get little no pros and all the cons of hGH. You don’t grow and you close your plates early. With the price of insulin resistance and desensitisation.

I’m tired of writing this sorry. Critique is welcome by the way. Have a good time reading

 

[org3cel.RR]

Ibutamoren or MK-677 is known for secretion of GH, IGF-1 and IGFBPs (which you guys that are new ignore and I will explain why they are bad for you)

​

You are deluded into thinking more GH = more height gainz and it’s a half truth.

While yes, growth hormone causes height growth, continuous secretion which MK-677 increases is not that good for you.

Because epiphyseal plates (growth plates) respond best to pulsatile GH secretion. Simply put it is infinitely (!) better to ensure GH spikes rather than constant elevated GH levels (if your goal is to maximise your height)

ALSO
​

Constantly high GH/IGF-1 levels accelerate growth plate maturation, basically speeding up their fusion or closure

Spoiler: First point

Continuously high GH levels are not as effective as some may wish for height growth and fuse epiphyseal plates early

Also two very important topics I must talk about are
Desensitisation
and
Insulin Resistance

​

First, for those who don’t know,

Spoiler

Those who know

, receptor desensitisation is when
receptor is exposed to chronically high levels of its ligand (hormone), the cell reduces its sensitivity to prevent overstimulation.

In case of MK-677, it’s not just a Growth Hormone Secretagogue but a Ghrelin mimetic ( If phrased simply Ghrelin is a hunger hormone )
MK-677 makes you want to eat more via mimicking Ghrelin. And here’s the big deal:

Increased caloric intake leads to increased blood glucose, which leads to pancreas secreting more insulin to handle it.

So, persistently high insulin levels from overeating and high GH (which is insulin-antagonistic) causes:
Insulin receptor downregulation (Cells reduce insulin receptors or dampen downstream signalling)
Insulin resistance developing…



Insulin resistance can lead to IGF-1 desensitisation because insulin and IGF-1 share similar receptor signalling pathways (PI3K-Akt-mTOR) and insulin resistance will desensitise IGF-1 receptors, reducing IGF-1’s anabolic effects on bone and muscle.

Spoiler: Second point

The fuck-up cycle summarised:
MK-677 increases ghrelin activity → you eat more.
Overeating increases blood glucose → more insulin → insulin resistance
At the same time, MK-677 keeps GH/IGF-1 constantly elevated → IGF-1 receptor desensitisation.
Both insulin resistance and IGF-1 receptor downregulation reduce anabolic signalling efficiency.
Meanwhile, constant GH/IGF-1 accelerates growth plate fusion, capping height gains early.
Desensitisation doesn’t just “work on the additional IGF-1 secreted because of MK”, it works systemically. So you even fuck up your natural growth potential that could’ve occurred if you weren’t such a disgrace and didn’t spend your parents’ money on some tiktok shop sups…


Simply said, you get little no pros and all the cons of hGH. You don’t grow and you close your plates early. With the price of insulin resistance and desensitisation.

I’m tired of writing this sorry. Critique is welcome by the way. Have a good time reading

Thats why HGH always mogs
@MyDreamIsToBe183CM

 

[2chevskuy]

Thats why HGH always mogs
@MyDreamIsToBe183CM

Trve

 

[BlendedBlade]

Wait till you find out mk-677 doesn’t interfere with your natural GH pulses but increases their peaks

 

[org3cel.RR]

Wait till you find out mk-677 doesn’t interfere with your natural GH pulses but increases their peaks

How did u got the title "master"??

 

[BlendedBlade]

How did u got the title "master"??

Idk

 

[2chevskuy]

Wait till you find out mk-677 doesn’t interfere with your natural GH pulses but increases their peaks

I’ll wait till you read the thread

 

[BlendedBlade]

I’ll wait till you read the thread

That’s not how mk-677 works and you can keep blood sugar levels in check

I dirty bulked on it and my sugar was really good

 

[2chevskuy]

I dirty bulked on it and my sugar was really good

then you’re from mars or something

 

[BlendedBlade]

then you’re from mars or something

Idk, blood work showed increased GH and IGF and sugar was completely fine

 

[tit]

Ibutamoren or MK-677 is known for secretion of GH, IGF-1 and IGFBPs (which you guys that are new ignore and I will explain why they are bad for you)

​

You are deluded into thinking more GH = more height gainz and it’s a half truth.

While yes, growth hormone causes height growth, continuous secretion which MK-677 increases is not that good for you.

Because epiphyseal plates (growth plates) respond best to pulsatile GH secretion. Simply put it is infinitely (!) better to ensure GH spikes rather than constant elevated GH levels (if your goal is to maximise your height)

ALSO
​

Constantly high GH/IGF-1 levels accelerate growth plate maturation, basically speeding up their fusion or closure

Spoiler: First point

Continuously high GH levels are not as effective as some may wish for height growth and fuse epiphyseal plates early

Also two very important topics I must talk about are
Desensitisation
and
Insulin Resistance

​

First, for those who don’t know,

Spoiler

Those who know

, receptor desensitisation is when
receptor is exposed to chronically high levels of its ligand (hormone), the cell reduces its sensitivity to prevent overstimulation.

In case of MK-677, it’s not just a Growth Hormone Secretagogue but a Ghrelin mimetic ( If phrased simply Ghrelin is a hunger hormone )
MK-677 makes you want to eat more via mimicking Ghrelin. And here’s the big deal:

Increased caloric intake leads to increased blood glucose, which leads to pancreas secreting more insulin to handle it.

So, persistently high insulin levels from overeating and high GH (which is insulin-antagonistic) causes:
Insulin receptor downregulation (Cells reduce insulin receptors or dampen downstream signalling)
Insulin resistance developing…



Insulin resistance can lead to IGF-1 desensitisation because insulin and IGF-1 share similar receptor signalling pathways (PI3K-Akt-mTOR) and insulin resistance will desensitise IGF-1 receptors, reducing IGF-1’s anabolic effects on bone and muscle.

Spoiler: Second point

The fuck-up cycle summarised:
MK-677 increases ghrelin activity → you eat more.
Overeating increases blood glucose → more insulin → insulin resistance
At the same time, MK-677 keeps GH/IGF-1 constantly elevated → IGF-1 receptor desensitisation.
Both insulin resistance and IGF-1 receptor downregulation reduce anabolic signalling efficiency.
Meanwhile, constant GH/IGF-1 accelerates growth plate fusion, capping height gains early.
Desensitisation doesn’t just “work on the additional IGF-1 secreted because of MK”, it works systemically. So you even fuck up your natural growth potential that could’ve occurred if you weren’t such a disgrace and didn’t spend your parents’ money on some tiktok shop sups…


Simply said, you get little no pros and all the cons of hGH. You don’t grow and you close your plates early. With the price of insulin resistance and desensitisation.

I’m tired of writing this sorry. Critique is welcome by the way. Have a good time reading

Shit thread, you are completely wrong about almost everything. Really no one listen to this.

 

[2chevskuy]

Idk, blood work showed increased GH and IGF and sugar was completely fine

bro you said yourself you were dirty bulking it is common to have a higher level of IGF-1 during a bulk because again more caloric intake equals more glucose equals more insulin
and why would you even grt analysis for gh

 

[BlendedBlade]

Shit thread, you are completely wrong about almost everything. Really no one listen to this.

Yes, he is even wrong about how mk-677 is “constantly spiking your GH IGF”, while it’s exogenous GH that does it, mk-677 just makes your natural pulses higher

 

[2chevskuy]

Shit thread, you are completely wrong about almost everything. Really no one listen to this.

Mind elaborating?

 

[BlendedBlade]

bro you said yourself you were dirty bulking it is common to have a higher level of IGF-1 during a bulk because again more caloric intake equals more glucose equals more insulin
and why would you even grt analysis for gh

Not 10x higher GH (25 and something ng/ml) and 560 ng/ml IGF-1

 

[2chevskuy]

Yes, he is even wrong about how mk-677 is “constantly spiking your GH IGF”,

Hold up let me look this up

 

[BlendedBlade]

Hold up let me look this up

I do agree that mk-677 isn’t a magic pill, but some people hating on it too much

It can definitely help maximize your genetic potential if you do it correctly

 

[2chevskuy]

Yes, he is even wrong about how mk-677 is “constantly spiking your GH IGF”, while it’s exogenous GH that does it, mk-677 just makes your natural pulses higher

Bro that’s a half truth again, while mk makes natural pulses higher it still makes your throughs higher which was my point

 

[tit]

Mind elaborating?

There is no evidence for the claim 'Constantly high GH/IGF-1 levels accelerate growth plate maturation'. The only known causal factor for epiphyseal growth plate closure is estrogen. Hgh indirectly converts to estrogen, however it is wrong to saw hgh itself speeds up growth plate maturation. Secondly you seem to say hgh makes you grow this is not true, igf-1 is what makes you grow. Theres also different isoforms of igf-1 you can get from mk-677 which may be beneficial and could even be advantageous when used alongside hgh due to the variance in isoforms. I wont waste my time addressing every point you made but you make some other also really stupid points, these were just the main 2 I guess.

 

[tokaeyyer]

I do agree that mk-677 isn’t a magic pill, but some people hating on it too much

It can definitely help maximize your genetic potential if you do it correctly

how to do it correctly?

 

[2chevskuy]

igf-1 is what makes you grow.

I don’t argue with that, but what’s the point of that correction if igf-1 is produced because of growth hormone dude

 

[Sujumh]

dnr fully but i saw " those who know " and that was pretty fun so i repped

 

[2chevskuy]

dnr fully but i saw " those who know " and that was pretty fun so i repped

Hahaha ly

 

[BlendedBlade]

how to do it correctly?

I cba to explain, I think there is should be a guide

Also you can watch Connor Murphy on YouTube Natty Plus protocol

He explained how to mitigate mk677 side effects

 

[tit]

I don’t argue with that, but what’s the point of that correction if igf-1 is produced because of growth hormone dude

Hgh is precursor to igf-1, but it also stimulates the production of other hormones it's just not correct to say, it's kind of like confounding aromatase with estrogen.