My science based longevity stack to extend your prime

[Deleted member 4310]

Why haven't anybody mentioned MSM supplements? They're good for collagen

 

[6ft8InTheNetherlands]

Bump

Will come with a good update soon. I have quit metformin.

Right now I'm corona prevention maxxing.

 

[Seth Walsh]

Will come with a good update soon. I have quit metformin.

Right now I'm corona prevention maxxing.

Good choice!

 

[Deusmaximus]

I just saw a tv documentary about anti aging, and they spoke about the huge anti aging potential of Glucosamin.
Is this on the stack of anyone here?

 

[PURE ARYAN GENETICS]

hey how about something a little more lightweight/less esoteric? more essential? food/lifestyle tier advice?

 

[anti caking agents]

IMPLYING A POSTIVE DEATH ESCAPE VELOCITY MATTERS WHEN OUR FUTURE AND TECHNOLOGICAL GROWTH WILL BE HAMPERED BY CLIMATE CHANGE.

IF YOU BELIEVE YOU WILL BECOME IMMORTAL = DELUSIONAL.

 

[Seth Walsh]

I just saw a tv documentary about anti aging, and they spoke about the huge anti aging potential of Glucosamin.
Is this on the stack of anyone here?

Glycogen Synthase inhibition without AMPK signalling with mTORCs active. Can be used very intricately and specifically to stop this synthesis and allowing for other syntheses such as protein synthesis. Credit to @Mayorga for finding the info on glucosamine.

There was more to it as well. But essentially it can be used for inhibiting specific anabolic routines without touching the mTOR/AMPK switch.

Used correctly it can accelerate the rate protein synthesis if used with Creatine, intraworkout Carbs and BCAAS and pre-workout NMN so to not inhibit mTOR signalling during weight training but inhibiting the storage of glycogen from the IW Carbs.

(I think it inhibits fatty acid synthesis too, but I'm not 100% sure).

Acetyl-L-Carnitine and methylcobalamin help shuttle the excess amount of glucose in the myocyte nuclei to the mitochondria where it can be burned as energy before it can be used in the Citric Acid Cycle to form ATP. Mitochondria are supposed to use ATP as fuel and it's really uncertain whether the ALCAR helps the mitochondria use glucose for energy or maybe it works as a glucose disposal agent through other MoAs, but those MoAs aren't known. So as for the mitochondria directly using glucose as fuel; that's speculation.

Acetyl-L-Carnitine helps form Fatty Acyl CoAs. FA CoAs are essentially fatty acids degraded by oxidation, which can enter the Citric Acid Cycle through the "Fat route" (Fatty Acyl CoA) rather than the traditional glucose doorway to the CaC which converts pyruvates to citrate through Acetyl-CoA.

It's believed that Acetyl-L-Carnitine acts as a shuttle system that allows Fatty Acids to enter the mitochondria, whilst working as a GDA. The Fatty Acyl CoA is a modified form of ATP combined with regular CoA and the oxidized fatty acid.

The combination of ALCAR and Glucosamine can completely adjust your body into using fatty acids as an input in the CaC rather than taking pyruvates. As the body is in a state of intense exercise, and cannot use the glucose from the carbohydrates as an input in metabolizing energy, the glucose gets disposed somehow (possibly before it even breaks down).

With no possibility of being used for energy, the glucose looks to store itself in tissue as glycogen, but glucosamine prevents that. Being sent to adipose tissue is also out of the question since the body can't preform de Novo lipogenesis when it's in need of energy.

Fatty acids become the exclusive input for energy production, and the amino acids and glucose cannot act as secondary inputs in the energy production process, instead they're used for other syntheses, such as skeletal muscle protein synthesis; and if you can have mTOR active intra-workout, by supplementing with BCAAs and/or glucose, the supplemental BCAAs/glucose will rapidly increase the rate of muscle protein synthesis so long as you put your body in a state where your muscles need to be repaired. And this is possible through a very delicate protocol so long as you don't use enough ATP to kick your body into AMPK. But that can be controlled through maintaining your energy balance during the weight training itself.