Necrotic
Maybe I Should Hardmaxx, Stacy Doesn't Want Me
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- Apr 8, 2026
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I know a big part of the community is against bonesmashing but I will use what i've gathered from science to determine if It's copium
Mechanisms that i will focus on
1.Mechanotransduction along with mechanosensation
2.Piezoelectric Effect
3.Passive Biophysical Effects on Membranes and Organelles
Mechanotransduction and Mechanosensation
Introduction (you can skip over this)
Mechanosensation is necessary for mammals to perceive signals from the external world through touch and hearing, to monitor our internal states through sensing flow, osmotic pressure and blood pressure, and to perceive the relationship of our bodies to the external world through balance and proprioception. Though these senses seem quite disparate, they each encode a physical measurement of force
"– every cell responds to osmotic pressure and even single cell organisms react to touch."
How does this apply to bonesmashing?
Encyclopedia
-mechanosensitive channels like (Piezo1, etc.)- specialized transmembrane proteins that act as cellular force sensors, converting mechanical forces (touch, pressure, stretch, shear stress) into electrochemical signals
Ca²⁺ influx- The activation of mechanosensitive channels like Piezo1 and Piezo2 triggers a rapid influx of calcium ions, which serves as a primary "second messenger" to convert physical pressure into biological action
Signaling molecules- Signaling molecules are chemical "messages" that cells use to talk to each other and coordinate the body's functions
Mechanosensation and mechanotransduction together allow cells and organisms to detect and respond to mechanical forces (such as stretch, compression, shear stress, or fluid flow)
-Mechanosensation (or mechanosensing) is the initial detection step: specialized structures or proteins sense the physical force and undergo a conformational (shape) change
-Mechanotransduction is the conversion step: the sensed mechanical signal is turned into a biochemical or electrical signal that the cell can use to trigger responses like changes in gene expression, cell differentiation, proliferation, or remodeling
In the nervous system, sensory transduction culminates in change of the electrical potential of a neuron This is accomplished by proteins in the membrane called ion channels, which are gated pores that allow the exchange of ions across the cell membrane
-Mechanical loading deforms bone - causes interstitial fluid flow - shear stress on osteocyte processes.
-Osteocytes sense this via mechanosensitive channels (Piezo1, etc.) - rapid intracellular Ca²⁺ increase.
-Ca²⁺ triggers release of signaling molecules (ATP, PGE₂, NO) and modulates gene expression (inhibition of sclerostin, Upregulation of Wnt signaling).
-These chemical signals are transmitted to surface cells (via gap junctions or paracrine diffusion) - stimulate osteoblast recruitment and activity - more bone matrix is deposited.
Mechanical forces are transmitted through a structural pathway linking the extracellular matrix (ECM) → integrins → cytoskeleton
-allowing physical forces to directly influence intracellular signaling and cell behaviorIn addition to mechanosensitive ion channels, cells use other mechanosensors such as integrins (focal adhesions) and primary cilia, which contribute to detecting and amplifying mechanical stimuli
Mechanotransduction operates on different timescales:
Rapid responses involve ion flux (Ca²⁺ influx)
Slower responses involve changes in gene expression and protein synthesis
This process is essential for maintaining tissue homeostasis, ensuring that bone adapts to mechanical loading by increasing strength in response to stress
Conversely, reduced mechanical loading (immobilization or microgravity) results in increased sclerostin expression, decreased osteoblast activity, and subsequent bone loss
Piezoelectric Effect
Bones contain a protein called collagen that has piezoelectric properties. That just means when the bone is slightly bent or compressed (like when you walk, run, or lift something), it produces tiny electrical signals.
When stress is applied to a bone, different parts of it experience compression and tension. The compressed areas develop a small negative charge, and the stretched areas develop a small positive charge. These electrical differences act like signals to bone cells.
Bone-building cells (osteoblasts) are drawn to the negatively charged, compressed areas, and they start depositing more bone there. Bone-resorbing cells (osteoclasts) are more active in areas with less stress or different charge patterns.
Over time, this process causes the bone to grow stronger and denser exactly where it’s being used the most. So the piezoelectric effect is basically how mechanical forces get turned into biological instructions that tell the body where to build more bone.
Passive Biophysical Effects on Membranes and Organelles
When you put load on a bone-like during walking or lifting-it creates physical forces such as compression, fluid flow, and pressure inside the bone tissue. These forces don’t require energy from the cell; they directly affect the structure of bone cells.
The cell membrane gets slightly stretched or deformed, which can open mechanosensitive ion channels. This allows ions (like calcium) to move into the cell, starting signaling processes. At the same time, fluid moving through the tiny (canaliculi) creates shear stress on the membranes of bone cells, especially osteocytes, which are the main sensors of mechanical load.
These physical forces are also transmitted through the cytoskeleton to internal organelles. For example, the nucleus can change shape slightly, which can influence gene expression, and mitochondria can adjust their activity to support increased energy needs for building bone.
All of these passive effects help convert mechanical stress into biological signals. As a result, osteoblasts are activated to produce more bone material in areas under load, while less-used areas may lose bone.
So in bone increase, passive biophysical effects are part of how physical forces directly influence bone cells and trigger the processes that lead to stronger, denser bone.
Thank you for reading, the grammar i used was written by chatgpt, all of my studies are from pubmed
I love that u are so brave to come out with ur sexuality
