need high iq cels for advice on AI's

[griffonlookxmaxjfl]

i'm gonna start an aromatase inhibitor next week I was wondering like what you have to cycle and what you don't I think the two that like, stood out to me the most as like the safest were arimistane and aromasin because they won't spike your estrogen when you stop and immediately close your plates what are y'all doing? Do you cycle it or like? im 15 starting like mk cjc dac soon

 

[anzohhh]

not a high iq-cel here. Why would you cycle an AI? just cruise on it and use it every day. I don't see why you would need to cycle it like a fag who is scared of joint pain and sadness. Been on arimidex 1-2mg every day for 2.5 years no sides. Arimistane is pretty cope and thereotical from the studies i've seen. Not sure if you meant exemestane. If you're scared of estrogen rebound from something like letrozole or Arimidex just taper the dose over 4 weeks IIRC. Ideally homeostatic restoration will come back if you dont abuse like 20 mg letrozole ED for 2 years and suddenly stop.

 

[griffonlookxmaxjfl]

not a high iq-cel here. Why would you cycle an AI? just cruise on it and use it every day. I don't see why you would need to cycle it like a fag who is scared of joint pain and sadness. Been on arimidex 1-2mg every day for 2.5 years no sides. Arimistane is pretty cope and thereotical from the studies i've seen. Not sure if you meant exemestane. If you're scared of estrogen rebound from something like letrozole or Arimidex just taper the dose over 4 weeks IIRC. Ideally homeostatic restoration will come back if you dont abuse like 20 mg letrozole ED for 2 years and suddenly stop.

your body would be used to it eventually it can start producing excess aromatase to counter it

 

[anzohhh]

your body would be used to it eventually it can start producing excess aromatase to counter it

Such cap. I stopped arimidex for a solid month and my estrogen went up to only 12 pgml from 8 and test went down 200 ngdl only.

 

[griffonlookxmaxjfl]

That's interesting. I wasn't really referring to an estrogen rebound. I was more of talking about an aromatase adjustment because your body does seek homeostasis so logic dictates that when you take something like that for long enough, your body would start producing more aromatase but I guess yours didn't do you have any more information I'm kind of curious I'm gonna start soon

 

[anzohhh]

That's interesting. I wasn't really referring to an estrogen rebound. I was more of talking about an aromatase adjustment because your body does seek homeostasis so logic dictates that when you take something like that for long enough, your body would start producing more aromatase but I guess yours didn't do you have any more information I'm kind of curious I'm gonna start soon

I'm not even sure aromatase is increased in response to low estrogen. But I know that in response to low estrogen, a certain disinhibitory feedback loop is triggered in the body that increases the production of gonadotropins to try and increase estrogen, but would increase androgens instead since aromatase is inhibited.

 

[anzohhh]

That's interesting. I wasn't really referring to an estrogen rebound. I was more of talking about an aromatase adjustment because your body does seek homeostasis so logic dictates that when you take something like that for long enough, your body would start producing more aromatase but I guess yours didn't do you have any more information I'm kind of curious I'm gonna start soon

Actually long-term aromatase inhibition from AI's can cause compensatory upregulation of CYP19A1 gene expression, which may have been what you were referring to, which leads to increased efficiency of the cAMP/PKA pathway's signaling which acts as a transcriptional activator for hormonally sensitive genes, but it would still work to your favor as it would increase the response to androgens.

BUT

long-term use of it can also cause an elevation of inflammatory cytokines and prostaglandins such as IL-6, TNF-α, and PGE2 which all ultimately lead to the transcriptional activation of the CYP19A1 gene expression which encodes aromatase.

Overall it would still be not that impacting overall, you would still gain a massive reduction in estrogen and everything I mentioned wouldn't be very relevant, maybe boost your e2 by 1 pgml. But who cares about that 1pg/ml. your androgen response would be boosted a lot tho, and from the gonadotropin release gain high test.