New heightmax substance

[LVZZO]

After a couple of hours of research and reverse engineering I found an important pathway which I won't bother explaining
What you want is compounds that activate the Wnt pathways and/or compounds that inhibit Wnt inhibitors

Teriparatide is a synthetic form of PTH (Parathyroid Hormone) that has been shown to stimulate Wnt signaling leading to increased bone formation
Romosozumab is monoclonal antibody and a sclerostin inhibitor, and since sclerostin inhibits Wnt you are activating the Wnt signaling pathway

Unsurprisingly these are used for the treatment of osteoporosis

 

[LVZZO]

0 reps

 

[gr34ter]

skyraper method

 

[HTN_Mentalcel]

Doesnt this just make bones stronger? How strong of a correlation will that have with making bones longer for height?

 

[Lorsss]

does cabergoline increase height in adulescents by some pathway?

 

[LVZZO]

Doesnt this just make bones stronger? How strong of a correlation will that have with making bones longer for height?

Wnt signaling continues to regulate proliferation and differentiation of the growth plate chondrocytes. Although chondrocytes in the growth plate have a high capacity to proliferate, new cells must be supplied to the growth plate from chondroprogenitor population.

Wnt signaling in chondroprogenitors during long bone development and growth - PubMed

Wnt signaling together with other signaling pathways governs cartilage development and the growth plate function during long bone formation and growth. β-catenin-dependent Wnt signaling is a specific lineage determinant of skeletal mesenchymal cells toward chondrogenic or osteogenic direction...

pubmed.ncbi.nlm.nih.gov

It's both involved in bone formation and bone mineral density

 

[HTN_Mentalcel]

Wnt signaling in chondroprogenitors during long bone development and growth - PubMed

Wnt signaling together with other signaling pathways governs cartilage development and the growth plate function during long bone formation and growth. β-catenin-dependent Wnt signaling is a specific lineage determinant of skeletal mesenchymal cells toward chondrogenic or osteogenic direction...

pubmed.ncbi.nlm.nih.gov

It's both involved in bone formation and bone mineral density

Does this run the risk of you becoming ogre like you do on hgh? big nose, downward growth etc.

 

[janitormaxxing]

lithium orotate and carnitine injections might to do it and are kinda cheap

 

[LVZZO]

Does this run the risk of you becoming ogre like you do on hgh? big nose, downward growth etc.

Most likely not
But the monoclonal antibody therapy is something new, I think sclerostin inhibition can cause heart problems (stroke) since it binds to LDL or something like that
Also PTH release is dependent on blood calcium levels, so you want low calcium on the blood (so careful if you are megadosing on D3)
Ideally you want to maximize calcium absorption and keep the levels relatively low

Romosozumab causes hypocalcemia so in itself boosts PTH

 

[yirma19]

Just use 6ft6 method bro

 

[LVZZO]

does cabergoline increase height in adulescents by some pathway?

It seems to be used to reduce prolactin levels and bone loss associated with high prolactin
So if you have high prolactin it might help, otherwise prolactin doesn't seem to be associated with height

 

[LVZZO]

lithium orotate

Doesn't seem like it although it can be involved in this pathway too and works for scaffolds for healing defected bones it seems and osteoporosis

The Skeletal-Protecting Action and Mechanisms of Action for Mood-Stabilizing Drug Lithium Chloride: Current Evidence and Future Potential Research Areas

Lithium, the lightest natural-occurring alkali metal with an atomic number of three, stabilizes the mood to prevent episodes of acute manic and depression. Multiple lines of evidence point to lithium as an anti-suicidal, anti-viral, anti-cancer, immunomodulatory, neuroprotective and...

www.frontiersin.org

Spoiler

On the contrary, several groups of researchers reported negative or negligible effects of lithium on bone in healthy animals. In female Wistar rats, the animal receiving 45 mg/kg Li2CO3 in their drinking water for 3 months showed no significant differences in the serum levels of calcium, phosphorus and alkaline phosphatase (ALP). In comparison to the control animals, bone histomorphometric analysis indicated the reductions in BV/TV, Tb.N, and lining cell surface (Lc.S) as well as increases in Tb.Sp and ES in the Li2CO3-treated animals (Lewicki et al., 2006). Comparable outcomes were identified using healthy female Holtzman rats. Daily administration of LiCl (4 meq/kg, i.p.) for 4 weeks resulted in significant decreases in periosteal mineralization rate and volume of osteoid present in the tibia relative to the control animals. Levels of calcium, phosphorus, ALP, parathyroid hormone (PTH), and creatinine in serum were similar among the two experimental groups (Baran et al., 1978). In another study using growing broiler chickens as the animal model, oral supplementation of 20 mg/kg LiCl were initiated at 1 week or 3 weeks of age. The animals were euthanized at 6 weeks of age and bones were harvested for further analysis. Three-point bending test revealed that the LiCl-treated chickens had lower stiffness in the femur and lower energy to fracture in the tibia as compared to the controls. There were no alterations in parameters measured by micro-CT (Harvey et al., 2015). In one of the earlier studies, Henneman and Zimmerberg found that LiCl-supplemented drinking water (1.43 ± 0.13 meq/day) did not cause any changes in the serum electrolytes (total calcium and inorganic phosphorus), metaphyseal bone composition (calcium, collagen and mineral salts contents), and bone metabolism (amount of neutral-salt-soluble collagen, resorption rate of collagen, formation rate of collagen and total incorporation of proline into bone matrix) in female Sprague Dawley rats (Henneman and Zimmerberg, 1974). Moreover, Bellwinkel et al. (1975) reported no significant deviations in serum calcium, magnesium, and phosphorus levels of female albino rats after daily subcutaneous (s.c.) injection of a lithium-containing solution (0.1 or 0.5 mM) for 6 weeks. The calcium and magnesium content in liver, skeletal muscle and femur were also unaltered in rats by chronic lithium administration (Bellwinkel et al., 1975).

 

[princeofpeace]

Just use 6ft6 method bro

what is that

 

[milkcuck]

After a couple of hours of research and reverse engineering I found an important pathway which I won't bother explaining
What you want is compounds that activate the Wnt pathways and/or compounds that inhibit Wnt inhibitors

Teriparatide is a synthetic form of PTH (Parathyroid Hormone) that has been shown to stimulate Wnt signaling leading to increased bone formation
Romosozumab is monoclonal antibody and a sclerostin inhibitor, and since sclerostin inhibits Wnt you are activating the Wnt signaling pathway

Unsurprisingly these are used for the treatment of osteoporosis

It’s like fucking impossible to source bro

 

[LVZZO]

It’s like fucking impossible to source bro

There is some medication that's better, i don't remember the name might post it later
You would need a prescription, paying a private doctor

 

[Deleted member 16051]

What you want is compounds that activate the Wnt pathways and/or compounds that inhibit Wnt inhibitors

Teriparatide is a synthetic form of PTH (Parathyroid Hormone) that has been shown to stimulate Wnt signaling leading to increased bone formation
Romosozumab is monoclonal antibody and a sclerostin inhibitor, and since sclerostin inhibits Wnt you are activating the Wnt signaling pathway

Wnt signaling in chondroprogenitors during long bone development and growth - PubMed

Wnt signaling together with other signaling pathways governs cartilage development and the growth plate function during long bone formation and growth. β-catenin-dependent Wnt signaling is a specific lineage determinant of skeletal mesenchymal cells toward chondrogenic or osteogenic direction...

pubmed.ncbi.nlm.nih.gov

It's both involved in bone formation and bone mineral density

@Osie

What do you guys think? Revisiting this thread, I'm starting to believe this could actually help with a couple of centimeters of growth in articular cartilage for adults.

 

[Osie]

@Osie

What do you guys think? Revisiting this thread, I'm starting to believe this could actually help with a couple of centimeters of growth in articular cartilage for adults.

I don't do much research into non-tested research chemicals that haven't been tested in humans. However, when I was researching, there were two main problems with this being viable in the sense of heightmaxxing! First, from my research, there doesn't seem to be any correlation between articular cartilage and height. If you wanted to grow your articular cartilage outside of the idea that you were growing height from it, that's a separate topic. But I'm pretty sure that articular cartilage is known for covering the ends of where bones meet to form joints. So I don't think a couple of centimeters in that department will contribute much or anything at all to bone lengthening. And while the two drugs you mentioned, Teriparatide and Romosozumab, will stimulate bone mass and increase bone mass by either inhibiting inhibitors of the pathway or stimulating the pathway directly like you said, neither of them will contribute to increased height in any meaningful way, unless you are assuming you can achieve enough bone growth in the cartilage between your joints that it will make you physically taller. The drug's ability to increase bone density and mass is completely unrelated to height growth unless once again, you are banking on growth from the articular cartilage being large enough to produce actual height changes.

This is a good theory though if you are an adult looking to grow taller, and most likely in the near future, we will stumble on a bone density drug that unintentionally can increase height in adults if you use in a specific way.

 

[Deleted member 16051]

from my research, there doesn't seem to be any correlation between articular cartilage and height. If you wanted to grow your articular cartilage outside of the idea that you were growing height from it, that's a separate topic. But I'm pretty sure that articular cartilage is known for covering the ends of where bones meet to form joints. So I don't think a couple of centimeters in that department will contribute much or anything at all to bone lengthening.

I agree. The person who initiated the discussion about LSJL and articular cartilage as a potential growth option mentioned in the LSJL forum that there hasn't been any practical success with articular cartilage—it's only theoretical, according to him.

 

[LVZZO]

@Osie

What do you guys think? Revisiting this thread, I'm starting to believe this could actually help with a couple of centimeters of growth in articular cartilage for adults.

I don't do much research into non-tested research chemicals that haven't been tested in humans. However, when I was researching, there were two main problems with this being viable in the sense of heightmaxxing! First, from my research, there doesn't seem to be any correlation between articular cartilage and height. If you wanted to grow your articular cartilage outside of the idea that you were growing height from it, that's a separate topic. But I'm pretty sure that articular cartilage is known for covering the ends of where bones meet to form joints. So I don't think a couple of centimeters in that department will contribute much or anything at all to bone lengthening. And while the two drugs you mentioned, Teriparatide and Romosozumab, will stimulate bone mass and increase bone mass by either inhibiting inhibitors of the pathway or stimulating the pathway directly like you said, neither of them will contribute to increased height in any meaningful way, unless you are assuming you can achieve enough bone growth in the cartilage between your joints that it will make you physically taller. The drug's ability to increase bone density and mass is completely unrelated to height growth unless once again, you are banking on growth from the articular cartilage being large enough to produce actual height changes.

This is a good theory though if you are an adult looking to grow taller, and most likely in the near future, we will stumble on a bone density drug that unintentionally can increase height in adults if you use in a specific way.

I forgot about this thread, later I found something that is already in use
It's main purpose is to increase height, it's called VOXZOGO
It was already mentioned in the forum, it's also crazy expensive so no bueno
The only thing here would be to analyze its working mechanism, but even that is a waste of time