bruhtoobrutal
ascended
- Joined
- Jan 15, 2025
- Posts
- 3,400
- Reputation
- 7,216
TAK653:
Enhanced Glutamatergic (primary excitatory neurotransmitter in the CNS) activity via AMPA Positive Allosteric Modulation. PAM's make your receptors more sensitive and desensitized to your natural agonists. which triggers an influx of intracellular calcium. Activating pathways like AKT, ERK mTOR and p70s6 kinase. This leads to enhanced processing speed, working and recognition memory, synaptic plasticity, Long Term potentiation.
9-Me-BC:
Up-regulates tyrosine hydroxylase, the rate limiting step in the production of Dopamine. Leading to more dopamine naturally flowing in instead of it being forced like typical stimulants, Dopamine is sustained in a healthy baseline, Which will lead to sustained focus and motivation. It is also a MAO (Monoamine oxidase) inhibitor although it has a higher affinity for MAO-A. MAO breaks down dopamine along with other neurotransmitter in a process called oxidative deamination. By blocking this degradation it causes an accumulation which in par leads to higher concentrations of dopamine in the brain staying active for longer in the synapse. It is also neuroprotective as it stops aldehydes, neurotoxins and lowers oxidative stress. Useful for Dopamine Detoxes and stimulant resets.
Nefiracetam:
Acts as Positive Allosteric Modulator on Nicotinic acetylcholine receptors, strong affinity for a4B2 and weakly potentiates alpha 7. This leads to enhanced Acetylcholine currents and release of it in the Frontal Cortex and Hippocampus. It is also a NMDA Glycine Site Positive Allosteric Modulator which will lower the threshold of the magnesium block so more calcium can be influxed into neurons.
AF710B:
Positive Allosteric Modulator of M1 Muscarinic Receptors in the cerebral cortex and hippocampus, which promotes learning, memory, synaptic plasticity, and cognitive flexibility. It is a dual mechanism drug by which it's secondary main act is Agonizing Sigma-1 R, being neuroprotective while providing psychological stability.
Just quickly wanted to share some honorable examples but there's a ton of other drugs worth mentioning.
Enhanced Glutamatergic (primary excitatory neurotransmitter in the CNS) activity via AMPA Positive Allosteric Modulation. PAM's make your receptors more sensitive and desensitized to your natural agonists. which triggers an influx of intracellular calcium. Activating pathways like AKT, ERK mTOR and p70s6 kinase. This leads to enhanced processing speed, working and recognition memory, synaptic plasticity, Long Term potentiation.
9-Me-BC:
Up-regulates tyrosine hydroxylase, the rate limiting step in the production of Dopamine. Leading to more dopamine naturally flowing in instead of it being forced like typical stimulants, Dopamine is sustained in a healthy baseline, Which will lead to sustained focus and motivation. It is also a MAO (Monoamine oxidase) inhibitor although it has a higher affinity for MAO-A. MAO breaks down dopamine along with other neurotransmitter in a process called oxidative deamination. By blocking this degradation it causes an accumulation which in par leads to higher concentrations of dopamine in the brain staying active for longer in the synapse. It is also neuroprotective as it stops aldehydes, neurotoxins and lowers oxidative stress. Useful for Dopamine Detoxes and stimulant resets.
Nefiracetam:
Acts as Positive Allosteric Modulator on Nicotinic acetylcholine receptors, strong affinity for a4B2 and weakly potentiates alpha 7. This leads to enhanced Acetylcholine currents and release of it in the Frontal Cortex and Hippocampus. It is also a NMDA Glycine Site Positive Allosteric Modulator which will lower the threshold of the magnesium block so more calcium can be influxed into neurons.
AF710B:
Positive Allosteric Modulator of M1 Muscarinic Receptors in the cerebral cortex and hippocampus, which promotes learning, memory, synaptic plasticity, and cognitive flexibility. It is a dual mechanism drug by which it's secondary main act is Agonizing Sigma-1 R, being neuroprotective while providing psychological stability.
Just quickly wanted to share some honorable examples but there's a ton of other drugs worth mentioning.
Last edited:
