opinion on irisin

[Deleted member 48352]

Irisin – a myth rather than an exercise-inducible myokine - Scientific Reports

The myokine irisin is supposed to be cleaved from a transmembrane precursor, FNDC5 (fibronectin type III domain containing 5) and to mediate beneficial effects of exercise on human metabolism. However, evidence for irisin circulating in blood is largely based on commercial ELISA kits which are...

www.nature.com

 

[Deleted member 48352]

Evidence against a Beneficial Effect of Irisin in Humans - PMC

Brown adipose tissue has gained interest as a potential target to treat obesity and metabolic diseases. Irisin is a newly identified hormone secreted from skeletal muscle enhancing browning of white fat cells, which improves systemic metabolism by ...

pmc.ncbi.nlm.nih.gov

 

[LLcel]

never heard but sounds interesting.