opinions on theoretical usage of PTH analogs

[ajshabs]

been reading up on parathyroid hormone analogs and was wondering if any dons ever looked into their potential for craniofacial enhancement (zygos, orbital rims, mandible density etc)

quick rundown:

– what are pth analogs?
synthetic versions of parathyroid hormone normally pth regulates calcium + bone turnover
BUT if dosed intermittently (e.g. daily injection), it becomes anabolic = builds bone

– main analogs:
teriparatide = PTH 1-34 fragment (highly anabolic)
abaloparatide = similar to teri, possibly less sides
PTH 1-84 = full-length hormone, used less

– how it works:
binds to PTH1 receptors on osteoblasts (bone builders)
activates cAMP/PKA pathway → leads to:
more osteoblasts
longer survival
more bone matrix laid down

only works anabolically if used intermittently
chronic high PTH = bone loss
controlled spikes = bone gain

most research is on spine/hip, but theoretically could improve density/thickness of facial bones over long-term usage

maybe potential for minor orbital/zygo/maxilla gains via remodeling?

anyone ever looked into this angle seriously or know if anyone’s tried? not suggesting it’s a miracle fix but wondering about potential for density-based mog enhancement over time

 

[ajshabs]

bump

 

[Bryce]

but wondering about potential for density-based mog enhancement over time

Jfl you people are nuts

 

[ajshabs]

Jfl you people are nuts

rope

 

[slaters]

been reading up on parathyroid hormone analogs and was wondering if any dons ever looked into their potential for craniofacial enhancement (zygos, orbital rims, mandible density etc)

quick rundown:

– what are pth analogs?
synthetic versions of parathyroid hormone normally pth regulates calcium + bone turnover
BUT if dosed intermittently (e.g. daily injection), it becomes anabolic = builds bone

– main analogs:
teriparatide = PTH 1-34 fragment (highly anabolic)
abaloparatide = similar to teri, possibly less sides
PTH 1-84 = full-length hormone, used less

– how it works:
binds to PTH1 receptors on osteoblasts (bone builders)
activates cAMP/PKA pathway → leads to:
more osteoblasts
longer survival
more bone matrix laid down

only works anabolically if used intermittently
chronic high PTH = bone loss
controlled spikes = bone gain

most research is on spine/hip, but theoretically could improve density/thickness of facial bones over long-term usage

maybe potential for minor orbital/zygo/maxilla gains via remodeling?

anyone ever looked into this angle seriously or know if anyone’s tried? not suggesting it’s a miracle fix but wondering about potential for density-based mog enhancement over time

Someone here claimed he’s been using them for 4 months but he got banned
I think there’s theories that Loox used pth analogs but idk
Also where tf would you even source this

 

[Deleted member 161065]

bump