Out of range T levels & SHBG

[DrTony]

My dad tested out of range high T (consistently) at around 980ng/dL at the age of 65. A bit concerning. the upper limit for his age is 700s. His SHBG was also out of range high. Any insight?

 

[MentalistKebab]

Does he use anything that can cause this ?

 

[DrTony]

No...

 

[TheEndHasNoEnd]

ur jelly tht ur dad t mogs u

 

[Deleted member 5694]

Mirin

 

[ChadsAreCool]

will die early

 

[Deleted member 2756]

My dad tested out of range high T (consistently) at around 980ng/dL at the age of 65. A bit concerning. the upper limit for his age is 700s. His SHBG was also out of range high. Any insight?

what's the issue? tell him he's a genetically superior high test beast, jokes aside.
give him some boron and magnesium, that'll fix the shbg issue, but you're better off keeping his shbg out of range as it's needed for the transportation of sex steroids into the cells, retards think low shbg is good, smh.

 

[DrTony]

@Dyorotic2. Thanks. There is no issue other than potentially elevated risk for prostate cancer. It is also my understanding that bioavailable testosterone is both the free (non-SHBG bound) testosterone + albumin-bound testosterone. Albumin-bound testosterone IS bioavailable and some of it is definitely captured in total testosterone levels but not free levels (the measurements of the latter are largely inaccurate anyway)

 

[Deleted member 2756]

Thanks. There is no issue other than potentially elevated risk for prostate cancer. It is also my understanding that bioavailable testosterone is both the free (non-SHBG bound) testosterone + albumin-bound testosterone. Albumin-bound testosterone IS bioavailable and some of it is definitely captured in total testosterone levels but not free levels (the measurements of the latter are largely inaccurate anyway)

If I recall correctly, high testosterone along with high shbg is indicative of an underexpression of aromatase. Have you ever had a genetic test done? it'd be interesting to see whether or not you would come back positive for a CYP19A1 polymorphism, maybe your dad could possibly be a candidate.

 

[Vitruvian]

ur jelly tht ur dad t mogs u

 

[DrTony]

If I recall correctly, high testosterone along with high shbg is indicative of an underexpression of aromatase. Have you ever had a genetic test done? it'd be interesting to see whether or not you would come back positive for a CYP19A1 polymorphism, maybe your dad could possibly be a candidate.

Don't forget there are over 250 single nucleotide polymorphisms (SNPs) that (genetically) determine higher total testosterone levels in men. https://www.nature.com/articles/s41591-020-0751-5#MOESM3
(Go to supp table 6) I have never measured my T levels and in general I dont even remember the last time I have even had a blood test. But that's some interesting info, thanks. Might have to test mine as well