Pazopanib for height

[Gudlifer]

I saw a TikTok (don't even start) that mentioned Pazopanib (it's a Tyrosine Kynase Inhibitor, targeting VEGFR-1, -2, and -3, PDGFR-α and -β, c-Kit and FGFR).
Well the thing is that it's been show to DRAMATICALLY widen the growth plate:

GROWTH PLATE ABNORMALITIES IN PEDIATRIC CANCER PATIENTS UNDERGOING PHASE 1 ANTI-ANGIOGENIC THERAPY: A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP PHASE I CONSORTIUM - PMC

Pre-clinical studies suggest that anti-angiogenic agents may be toxic to the developing growth plate. The purpose of this study was to evaluate the incidence of growth plate abnormalities in children with refractory cancer undergoing anti-angiogenic ...

pmc.ncbi.nlm.nih.gov

Well the reason I'm posting this is because I would assume the widening comes from an arrest of hypertrophic zone ossification rather than a resting zone expansion and from my understanding this would not result in an increase in FAH.

IS THERE SOMETHING IM MISSING?
DO YOU HAVE ANY EXPERIENCE/ANECDOTES WITH IT AND WAS IT POSITIVE OR NEGATIVE??

Even if it worked I'd probably just use erda instead bc of risk profile and evidence but still, any anecdotes/knowledge on this would be appreciated

 

[Gudlifer]

bump

 

[Gudlifer]

BUMPPPPPPPPP

 

[Gudlifer]

BUMP

 

[Gudlifer]

bump?

 

[Gea]

I saw a TikTok (don't even start) that mentioned Pazopanib (it's a Tyrosine Kynase Inhibitor, targeting VEGFR-1, -2, and -3, PDGFR-α and -β, c-Kit and FGFR).
Well the thing is that it's been show to DRAMATICALLY widen the growth plate:

View attachment 5220673

GROWTH PLATE ABNORMALITIES IN PEDIATRIC CANCER PATIENTS UNDERGOING PHASE 1 ANTI-ANGIOGENIC THERAPY: A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP PHASE I CONSORTIUM - PMC

Pre-clinical studies suggest that anti-angiogenic agents may be toxic to the developing growth plate. The purpose of this study was to evaluate the incidence of growth plate abnormalities in children with refractory cancer undergoing anti-angiogenic ...

pmc.ncbi.nlm.nih.gov

Well the reason I'm posting this is because I would assume the widening comes from an arrest of hypertrophic zone ossification rather than a resting zone expansion and from my understanding this would not result in an increase in FAH.

View attachment 5220700



IS THERE SOMETHING IM MISSING?
DO YOU HAVE ANY EXPERIENCE/ANECDOTES WITH IT AND WAS IT POSITIVE OR NEGATIVE??

Even if it worked I'd probably just use erda instead bc of risk profile and evidence but still, any anecdotes/knowledge on this would be appreciated

has potential, does it have any human studies, also impossible to source most likely

 

[Gea]

I saw a TikTok (don't even start) that mentioned Pazopanib (it's a Tyrosine Kynase Inhibitor, targeting VEGFR-1, -2, and -3, PDGFR-α and -β, c-Kit and FGFR).
Well the thing is that it's been show to DRAMATICALLY widen the growth plate:

View attachment 5220673

GROWTH PLATE ABNORMALITIES IN PEDIATRIC CANCER PATIENTS UNDERGOING PHASE 1 ANTI-ANGIOGENIC THERAPY: A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP PHASE I CONSORTIUM - PMC

Pre-clinical studies suggest that anti-angiogenic agents may be toxic to the developing growth plate. The purpose of this study was to evaluate the incidence of growth plate abnormalities in children with refractory cancer undergoing anti-angiogenic ...

pmc.ncbi.nlm.nih.gov

Well the reason I'm posting this is because I would assume the widening comes from an arrest of hypertrophic zone ossification rather than a resting zone expansion and from my understanding this would not result in an increase in FAH.

View attachment 5220700



IS THERE SOMETHING IM MISSING?
DO YOU HAVE ANY EXPERIENCE/ANECDOTES WITH IT AND WAS IT POSITIVE OR NEGATIVE??

Even if it worked I'd probably just use erda instead bc of risk profile and evidence but still, any anecdotes/knowledge on this would be appreciated

I scanned through this i didnt see the human study oops

 

[Gudlifer]

has potential, does it have any human studies, also impossible to source most likely

theres like 100 listings on indiamart, wdym it has potential

 

[Kojo]

I saw a TikTok (don't even start) that mentioned Pazopanib (it's a Tyrosine Kynase Inhibitor, targeting VEGFR-1, -2, and -3, PDGFR-α and -β, c-Kit and FGFR).
Well the thing is that it's been show to DRAMATICALLY widen the growth plate:

View attachment 5220673

GROWTH PLATE ABNORMALITIES IN PEDIATRIC CANCER PATIENTS UNDERGOING PHASE 1 ANTI-ANGIOGENIC THERAPY: A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP PHASE I CONSORTIUM - PMC

Pre-clinical studies suggest that anti-angiogenic agents may be toxic to the developing growth plate. The purpose of this study was to evaluate the incidence of growth plate abnormalities in children with refractory cancer undergoing anti-angiogenic ...

pmc.ncbi.nlm.nih.gov

Well the reason I'm posting this is because I would assume the widening comes from an arrest of hypertrophic zone ossification rather than a resting zone expansion and from my understanding this would not result in an increase in FAH.

View attachment 5220700



IS THERE SOMETHING IM MISSING?
DO YOU HAVE ANY EXPERIENCE/ANECDOTES WITH IT AND WAS IT POSITIVE OR NEGATIVE??

Even if it worked I'd probably just use erda instead bc of risk profile and evidence but still, any anecdotes/knowledge on this would be appreciated

dont use it