PHARMACEUTICAL MEGATHREAD

til<3D · 2026-04-06T08:43:05-0500

PHARMACEUTICAL MEGATHREAD

Skin, Vascularity, Fat Loss, Cognitive Enhancement & PEDs

April 2026

DISCLAIMER
Legal	These are pharmaceutical compounds requiring prescriptions in most countries. This guide is for educational purposes only. Not medical advice.
Covered	Section I: Skin & Dermatology \| Section: \|\|: Fat Loss and Metabolic Shredding \| Section III: Vascularity & Performance \| Section IV: Cognitive Enhancement (Nootropics) \| Section V: Hormonal Modulation
Section V	I honestly have very little knowledge about steroids in general, so I just included the input I happened to know. I’d definitely say there are much better threads out there on this topic.

QUICK REFERENCE

Compound	Category	Evidence	Key Use	Cost	Overall
Tretinoin	I	A+	Vitamin A derivative (retinoid).	9/10	10/10
Isotretinoin (Accutane)	I	A+	Systemic oral retinoid...	6/10	9/10
Azelaic Acid	I	A	Dicarboxylic acid with multiple mechanisms.	9/10	8/10
Adapalene (0.1% / 0.3%)	I	A	Third generation retinoid.	9/10	7/10
Finasteride	I	A	Type II 5 alpha reductase inhibitor.	9/10	7/10
Dutasteride	I	B+	Inhibits BOTH type I and type II 5 alpha reductase, reducing DHT by ~95% vs finasteride's ~70%.	8/10	7/10
Ketoconazole (Topical)	I	B	Imidazole antifungal used topically as shampoo or cream.	10/10	6/10
Clenbuterol	\|\|	A	Powerful thermogenic for final contest prep / extreme cutting.	9/10	7/10
Salbutamol (Albuterol)	\|\|	A	Manageable fat loss & bronchodilation, short acting.	10/10	6/10
Yohimbine HCL	\|\|	B+	Fasted cardio tool for alpha 2 receptor (stubborn fat) blockade.	9/10	6/10
Liothyronine (T3)	\|\|	A	Direct metabolic acceleration, high risk of muscle wasting.	8/10	5/10
Levothyroxine (T4)	\|\|	A	Long term metabolic baseline support, smoother than T3.	9/10	6/10
Metformin	\|\|	A+	Insulin sensitivity & AMPK activation, "Health-Maxxing" during cut.	10/10	9/10
DNP (2,4 Dinitrophenol)	\|\|	B	Lethal mitochondrial uncoupling, extreme weight loss.	5/10	0/10
Sibutramine	\|\|	B-	Aggressive appetite suppression, high cardiovascular risk.	6/10	3/10
Tirzepatide (Mounjaro)	\|\|	A+	The "God tier" GLP-1/GIP agonist for total appetite control.	10/10	10/10
Orlistat	\|\|	A	Blocking dietary fat absorption, for high fat "cheat" scenarios.	8/10	4/10
Tadalafil (Cialis)	III	A	PDE5 inhibitor with ~17.	8/10	8/10
Sildenafil (Viagra)	III	A	The original PDE5 inhibitor.	8/10	7/10
Telmisartan	III	A	AT1 receptor antagonist (ARB) for hypertension.	9/10	6/10
Nebivolol	III	A	Third generation selective beta 1 blocker.	8/10	6/10
Modafinil	IV	A	Wakefulness promoting agent originally developed for narcolepsy.	8/10	8/10
Armodafinil	IV	A	R-enantiomer of modafinil...	7/10	8/10
Piracetam	IV	B	The original racetam, synthesized in 1964.	9/10	6/10
Aniracetam	IV	B-	Fat soluble racetam with additional anxiolytic properties.	8/10	5/10
Phenylpiracetam	IV	C+	Piracetam with a phenyl group added produces stimulant effects in addition to cognitive enhancement.	7/10	5/10
Pramiracetam	IV	B-	One of the most potent racetams per mg.	6/10	5/10
Semax	IV	B+	Synthetic ACTH(4-7) analogue developed in Russia for cognitive enhancement and neuroprotection.	8/10	8/10
Memantine	IV	A	NMDA receptor antagonist approved for Alzheimer's treatment.	7/10	5/10
Donepezil	IV	B+	An atypical stimulant with anxiolytic properties (Actoprotector). Developed in Russia.	6/10	9/10
Methylphenidate (Ritalin)	IV	A+	Laser like focus. Immediate suppression of "distraction."	9/10	9/10
Lisdexamfetamine (Vyvanse / Elvanse)	IV	A+	10-12 hours of ultra consistent focus. Less edgy than Ritalin. High functional output.	5/10	8/10
Test Enanthate / Cypionate	V	A+	The bio identical foundation of any hormonal cycle. Essential for nitrogen retention and muscle protein synthesis.	10/10	10/10
Masteron (Drostanolone)	V	B	Providing a "hard," dry look: acts as a mild anti estrogen. Best used at low body fat.	7/10	8/10
Anavar (Oxandrolone)	V	A	Significant strength gains and muscle fullness without water retention (dry gains).	4/10	9/10
Winstrol (Stanozolol)	V	B+	Achieving the "Granite Look", flushes out subcutaneous water.	8/10	9/10
Enclomiphene	V	B+	Raising natural testosterone levels while preserving fertility and testicular size.	7/10	9/10
Anastrozole (Arimidex)	V	A	Managing high Estrogen (E2) side effects like bloating or early stage Gyno.	6/10	10/10
Exemestane (Aromasin)	V	A	Irreversibly binds to the aromatase enzyme, prevents "Estrogen Rebound."	6/10	9/10
Tamoxifen (Nolvadex)	V	A	Blocking Estrogen in breast tissue and restarting natural testosterone production (HPTA).	10/10	10/10
Raloxifene	V	A	The most effective compound for reversing existing Gynaecomastia (glandular tissue).	4/10	9/10
Cabergoline (Dostinex)	V	A	Lowering Prolactin levels: treats "puffy nipples" and significantly reduces the sexual refractory period.	2/10	8/10

COMPOUND PROFILES

── I. FACIAL AESTHETICS & SKIN ──

TRETINOIN
Category	I. Facial Aesthetics & Skin
Intro	Vitamin-A derivative (retinoid). The gold standard topical for acne treatment, skin texture improvement, and collagen stimulation. Requires prescription in most countries but widely available via online pharmacies. One of the most evidence backed topical compounds in dermatology.
Mechanism	Binds RAR alpha, beta, gamma nuclear receptors → upregulates keratinocyte differentiation genes. Accelerates cell turnover (shortens skin cycle from 28 to 14 days). Inhibits comedogenesis. Stimulates collagen I/III synthesis via TGF beta pathway.
Benefits	Acne clearance (inflammatory and non inflammatory). PIE/PIH reduction via cell turnover. Anti aging effects (reduces fine lines, improves texture). Collagen synthesis. Long term: skin rejuvenation.
Negatives	Retinization period: peeling, redness, sensitivity weeks 1-8 (not a reason to stop). Photosensitization: SPF mandatory. Pregnancy category X, absolutely contraindicated.
Dosage	0.025% start → titrate to 0.05-0.1%. Pea sized amount entire face.
Timing	Nights only. 20-30 min after cleansing on dry skin. Moisturizer after.
Cycling	Continuous, no cycling. Effects compound over 6-12 months.
Cost	€15-40 via online pharmacies.
Evidence Grade	A+ Gold standard dermatology compound. Decades of RCT data.
Synergies	Azelaic acid (PIE stack). Niacinamide (barrier support). GHK-Cu (complementary collagen).
Warnings	SPF 50+ daily mandatory. Never use with benzoylperoxide same application. Buffer method (moisturizer first) reduces irritation.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
10/10	8/10	10/10	9/10	10/10

ISOTRETINOIN (ACCUTANE)
Category	I. Facial Aesthetics & Skin
Intro	Systemic oral retinoid. The only pharmaceutical that permanently reduces sebaceous gland size and output essentially resets the skin. Used for moderate severe acne. The most effective acne treatment in existence.
Mechanism	Systemic RAR activation → sebaceous gland atrophy (permanent reduction in sebum output by ~90%). Normalizes follicular keratinization. Anti inflammatory. Modulates immune cells in skin.
Benefits	Permanent acne resolution in most patients. Skin texture transformation. Anti aging effects (deeper retinoid effects than topical). Long term remission rates >80% after one course.
Negatives	Initial flare possible. Dry lips/skin/eyes (standard). Mood effects (monitor). Liver enzyme elevation
Dosage	0.5-1mg/kg/day. Typical course 16-24 weeks to cumulative 120-150mg/kg.
Timing	With fatty meal (fat soluble).
Cycling	Single course usually sufficient. Repeat if relapse.
Cost	€50-200/month depending on dose and source.
Evidence Grade	A+ Most effective acne treatment in existence. Decades of data.
Synergies	Moisturizer + SPF (essential alongside). Lip balm.
Warnings	Pregnancy Category X catastrophic birth defects. Mental health monitoring.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
10/10	7/10	10/10	6/10	9/10

AZELAIC ACID
Category	I. Facial Aesthetics & Skin
Intro	Dicarboxylic acid with multiple mechanisms. Available OTC at 10% or prescription at 20%. Particularly effective for PIE, rosacea, and mild-moderate acne. UV stable can be used morning or evening.
Mechanism	Inhibits tyrosinase (reduces melanin/PIE). Antibacterial against P. acnes (without resistance development). Anti inflammatory (inhibits IL-1, TNF-alpha, reactive oxygen species). Mild keratolytic.
Benefits	PIE and redness reduction. Acne treatment (mild-moderate). Rosacea. Well tolerated, suitable for sensitive skin. UV stable means morning use fine.
Negatives	Mild tingling/burning initially. 15-20% may experience skin irritation. Slower acting than tretinoin.
Dosage	10% OTC or 20% prescription. Thin layer affected areas.
Timing	Morning (UV stable) or evening after tretinoin (wait 20 min).
Cycling	Continuous.
Cost	€10-25 for prescription 20% strength.
Evidence Grade	A FDA approved for acne and rosacea. Extensive RCT data.
Synergies	Tretinoin (dual PIE attack). Niacinamide. Tinted sunscreen.
Warnings	Mild initial irritation normal. If persistent burning stop use. Do not combine with high concentration glycolic acid.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
8/10	9/10	9/10	9/10	8/10

ADAPALENE (0.1% / 0.3%)
Category	I. Facial Aesthetics & Skin
Intro	Third generation retinoid. Binds RAR-beta and gamma but NOT alpha, the receptor responsible for most retinoid side effects. This selectivity makes it significantly less irritating than tretinoin while maintaining comparable efficacy for acne.
Mechanism	RAR-beta/gamma selectivity → keratinocyte differentiation without RARa-mediated irritation. Inhibits AP-1 transcription factor → anti-inflammatory. TLR-2 modulation → immune response in follicles.
Benefits	Acne efficacy comparable to tretinoin 0.025%. Significantly less irritation. Available OTC (0.1% in some countries). Better option for sensitive skin or during tretinoin retinization.
Negatives	Weaker than tretinoin 0.05-0.1% for anti aging and texture. Less collagen stimulation than tretinoin. Still causes some photosensitization.
Dosage	Pea sized 0.1% nightly. Can step up to 0.3%.
Timing	Night only. After cleansing.
Cycling	Continuous.
Cost	€15-30 OTC.
Evidence Grade	A FDA approved. RCT data comparable to tretinoin for acne.
Synergies	Azelaic acid. Niacinamide.
Warnings	SPF mandatory. Not as powerful as tretinoin for skin remodeling — use tretinoin if tolerated.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
7/10	9/10	9/10	9/10	7/10

FINASTERIDE
Category	I. Facial Aesthetics & Skin
Intro	Type II 5-alpha reductase inhibitor. Reduces DHT by ~70%. Used clinically for BPH and male pattern baldness. The most common pharmaceutical intervention for hair loss. At 17-18 years use with extreme caution given ongoing hormonal development.
Mechanism	Inhibits 5-alpha reductase type II → reduces conversion of testosterone to DHT in hair follicles and prostate. DHT binds AR on dermal papilla cells → miniaturization. Finasteride prevents this.
Benefits	Halts and partially reverses androgenetic alopecia. Reduces DHT systemically. Skin quality improvement in acne-prone users.
Negatives	Post finasteride syndrome (persistent sexual dysfunction in subset of users, mechanism debated). Reduces DHT ~70% systemically affecting all DHT-dependent processes. Libido changes. Not for use under 18.
Dosage	1mg/day for hair loss.
Timing	Any time, consistent.
Cycling	Continuous stopping causes DHT rebound and renewed hair loss.
Cost	€15-30/month generic.
Evidence Grade	A FDA approved. Decades of RCT data for AGA.
Synergies	Minoxidil topical (gold standard hair loss stack).
Warnings	Not recommended at 17-18 due to ongoing hormonal development. Post-finasteride syndrome, small but real risk. Monitor libido/sexual function.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
8/10	8/10	9/10	9/10	7/10

DUTASTERIDE
Category	I. Facial Aesthetics & Skin
Intro	Inhibits BOTH type I and type II 5-alpha reductase —> reducing DHT by ~95% vs finasteride's ~70%. More potent hair loss treatment but also more systemic DHT suppression. Used off label for hair loss.
Mechanism	Dual type I/II 5AR inhibition → ~95% DHT reduction. Type I found in skin and liver (unlike finasteride which only hits type II). More complete DHT suppression.
Benefits	Superior hair retention vs finasteride in head-to-head studies. Greater scalp DHT reduction. Skin acne improvement.
Negatives	All finasteride warnings apply, amplified. 95% DHT reduction is significant, DHT has important roles in libido, cognitive function, muscle fullness. Not for under 18.
Dosage	0.5mg every day or 2.5mg weekly.
Timing	Any time.
Cycling	Continuous.
Cost	€20-40/month.
Evidence Grade	B+ Multiple RCTs vs finasteride and placebo. Not FDA approved for hair loss (approved for BPH).
Synergies	Minoxidil topical.
Warnings	Even stronger systemic DHT suppression than finasteride. Same post-finasteride syndrome risk. Not at 17-18.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
8/10	7/10	8/10	8/10	7/10

KETOCONAZOLE (TOPICAL)
Category	I. Facial Aesthetics & Skin
Intro	Imidazole antifungal used topically as shampoo or cream. Directly inhibits DHT binding at androgen receptors in scalp follicles. Widely available OTC as shampoo (Nizoral). Often used as adjunct in hair loss protocols.
Mechanism	Inhibits sterol synthesis in fungi (antifungal mechanism). In hair follicles: directly competes with DHT at androgen receptor. Also reduces scalp inflammation. Some sebum reduction.
Benefits	Adjunct hair loss treatment. Seborrheic dermatitis treatment. Anti-inflammatory scalp effects. Minimal systemic absorption from topical use.
Negatives	Only topical, very limited systemic effects. May dry hair with frequent use. Not a standalone hair loss treatment.
Dosage	Nizoral shampoo 2%, leave 5 min on scalp 2-3x/week.
Timing	Any time during shower.
Cycling	Continuous.
Cost	€8-15/month.
Evidence Grade	B Controlled studies showing hair loss benefit as adjunct. Less RCT data than finasteride.
Synergies	Finasteride or dutasteride (complementary mechanism, receptor blockade vs DHT reduction).
Warnings	Minimal safety concerns with topical use. Some users report hair dryness.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
6/10	10/10	6/10	10/10	6/10

── II. Fat Loss and Metabolic Shredding ──

CLENBUTEROL
Category	II. Fat Loss and Metabolic Shredding
Intro	A potent Beta-2 adrenoceptor agonist. While technically a bronchodilator for asthma, it is the bodybuilding gold standard for non hormonal fat loss and final contest prep.
Mechanism	Stimulates Beta-2 receptors → increases cAMP levels → elevates core body temperature (thermogenesis) → increases Basal Metabolic Rate (BMR) by ~5-10%.
Benefits	Rapid fat oxidation. Slight anti catabolic effect (muscle sparing) during heavy deficits. Direct stimulation of the central nervous system for increased output.
Negatives	Long half life (~36h) means side effects persist 24/7. Jitters (tremor), insomnia, heavy sweating, and significant cardiac stress (tachycardia). Depletes intracellular Taurine levels.
Dosage	20mcg start → titrate up by 20mcg every few days up to 80-120mcg (advanced only).
Timing	Morning (due to long HWZ).
Cycling	Strictly 2 weeks on / 2 weeks off (to prevent receptor downregulation) or used with Ketotifen.
Cost	€15-30 per bottle / pack.
Evidence Grade	A (Extensive use in sports pharmacology).
Synergies	Taurine (3-5g daily) to prevent muscle cramps. T3 (often stacked in pro protocols, but high muscle loss risk).
Warnings	Potentially kardiotoxisch at high doses or long term use. Monitor heart rate and blood pressure constantly. Absolute contraindication with existing heart conditions.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
9/10	5/10	9/10	9/10	7/10

SALBUTAMOL (ALBUTEROL)
Category	II. Fat Loss and Metabolic Shredding
Intro	A short-acting Beta-2 adrenoceptor agonist. Primarily used as a bronchodilator for asthma, but highly effective for metabolic enhancement and fat loss in a fitness context..
Mechanism	Stimulates Beta-2 receptors → increases cAMP levels → triggers lipolysis in adipose tissue and a slight thermogenic effect. It has a much shorter half life (~4-6 hours) compared to Clenbuterol, allowing for precise control.
Benefits	Boosts metabolic rate (I would say 200 extra kcal/day). Improved breathing/cardio performance via bronchodilation. Significantly less CNS strain than long-acting stimulants.
Negatives	Can cause temporary jitters, increased heart rate (tachycardia), and mild blood pressure fluctuations. Potential for muscle cramps due to electrolyte shifts.
Dosage	4mg per dose, typically 1-3 times daily. Start with 4mg once in the morning to assess tolerance.
Timing	Morning (due to HWZ).
Cycling	Effective for short term use (e.g., the last 4 weeks of a cut). Receptor downregulation occurs with prolonged use.
Cost	€10-25 via pharmacy or online. Often very accessible.
Evidence Grade	A (Extensive clinical and athletic data).
Synergies	Taurine (3-5g daily) to prevent muscle cramps.
Warnings	Monitor heart rate and blood pressure (RR). Stop immediately if arrhythmias occur. Caution when stacking with other stimulants or if baseline RR is already low.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
8/10	8/10	10/10	10/10	8/10

YOHIMBINE HCL
Category	II. Fat Loss and Metabolic Shredding
Intro	An alpha-2 adrenoceptor antagonist derived from the bark of the African Yohimbe tree. It is specifically used for targeting "stubborn" fat areas that are resistant to normal dieting.
Mechanism	Blocks alpha-2 adrenoreceptors in adipose tissue. These receptors normally inhibit lipolysis (fat breakdown); by blocking them, Yohimbine allows catecholamines to bind to beta receptors and mobilize fat from "problem areas" like the lower back and glutes.
Benefits	Targeted lipolysis in areas with high alpha-2 density. Increased vascularity and blood flow. Works as a mild stimulant.
Negatives	Can trigger significant anxiety, cold sweats, and "inner unrest." Increases heart rate and potentially blood pressure. Insulin completely blunts the effect, making timing critical.
Dosage	0.2mg per kg of bodyweight (e.g., ~18mg for a 90kg individual). Start lower to assess tolerance.
Timing	Must be taken in a fasted state (ideally pre cardio). Even a small insulin spike from food renders it useless for fat loss.
Cycling	Effective as needed; no specific downward regulation, but ZNS fatigue can occur.
Cost	€15-30 via specialized supplement sites or pharmacies.
Evidence Grade	B+ (Solid mechanistic data and several human trials for fat loss).
Synergies	Caffeine (amplifies the effect). Fasted LISS cardio.
Warnings	Do not use if prone to anxiety or panic attacks. Avoid stacking with heavy stimulants if your baseline heart rate is already high. Monitor RR carefully.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
7/10	4/10	8/10	9/10	6/10

LIOTHYRONINE (T3)
Category	II. Fat Loss and Metabolic Shredding
Intro	Synthetic form of the thyroid hormone triiodothyronine (T3). It is the most metabolically active thyroid hormone and a powerful tool for accelerating fat loss by directly increasing the body's basal metabolic rate.
Mechanism	Directly binds to thyroid hormone receptors in cell nuclei → increases mitochondrial activity and ATP turnover → accelerates the metabolism of carbohydrates, proteins, and fats.
Benefits	Massive increase in caloric expenditure even at rest. Highly effective for breaking through fat loss plateaus
Negatives	Extremely catabolic: without adequate anabolic protection (AAS), it will rapidly burn muscle tissue alongside fat. Can cause heart palpitations, anxiety, heat intolerance, and permanent thyroid suppression if abused.
Dosage	12.5mcg - 25mcg daily for beginners. Experienced users may go up to 50mcg. Titration is mandatory.
Timing	In the morning on an empty stomach, ideally 30–60 minutes before your first meal.
Cycling	Usually limited to 4-8 weeks to minimize the risk of long term thyroid downregulation.
Cost	€15-40 via pharmacy or online sources.
Evidence Grade	A (Extensively studied in clinical and sports settings).
Synergies	Anabolic steroids (to prevent muscle wasting). Clenbuterol/Salbutamol (often stacked for synergistic thermogenesis, but adds massive cardiac strain).
Warnings	Monitor resting heart rate and body temperature. If resting HR exceeds 100 bpm, reduce dosage immediately. Risk of permanent hypothyroidism with improper use.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
10/10	4/10	10/10	5/10	5/10

LEVOTHYROXINE (T4)
Category	II. Fat Loss and Metabolic Shredding
Intro	The synthetic precursor to the active thyroid hormone T3. It is the standard treatment for hypothyroidism but is used in performance contexts to maintain a high normal metabolic baseline during extended cutting phases.
Mechanism	Acts as a pro hormone that is converted into active T3 by deiodinase enzymes in the liver and peripheral tissues. This allows the body to regulate the conversion rate based on physiological demand, leading to more stable blood levels.
Benefits	Provides a smoother, more predictable metabolic boost compared to T3. Lower risk of acute muscle wasting (catabolism). Helps prevent the metabolic slowdown associated with chronic caloric restriction (e.g. when using Tirzepatide).
Negatives	Slower onset of action due to the required conversion process. Can still lead to hyperthyroid symptoms (insomnia, palpitations) if dosed too high. Requires several weeks to reach a steady state.
Dosage	50mcg - 100mcg daily. Individual requirements vary significantly; blood work for TSH and fT4 is recommended.
Timing	In the morning on an empty stomach, ideally 30–60 minutes before your first meal.
Cycling	Often used for longer durations (8-12 weeks) during a cut. Should be tapered off gradually to allow natural thyroid function to recover.
Cost	€10-25 via pharmacy. Very cost-effective.
Evidence Grade	A+ (Gold standard for thyroid replacement therapy with immense clinical data).
Synergies	Human Growth Hormone (HGH), as HGH can accelerate the conversion of T4 to T3. GH Secretagogues.
Warnings	Less "feelable" than T3, which often leads to dangerous over dosing. Monitor heart rate and temperature.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
6/10	7/10	10/10	10/10	6/10

METFORMIN
Category	II. Fat Loss and Metabolic Shredding
Intro	A biguanide primarily used for Type-2 Diabetes management, but highly popular in the longevity and bodybuilding communities for its metabolic and anti-aging properties.
Mechanism	Activates AMPK (adenosine monophosphate activated protein kinase) → mimics the physiological effects of fasting. It inhibits hepatic glucose production and increases insulin sensitivity in peripheral tissues.
Benefits	Prevents fat storage by improving nutrient partitioning. Lowers systemic inflammation and reduces IGF-1/mTOR signaling (longevity benefit). Helps maintain a lean physique.
Negatives	Gastrointestinal issues (diarrhea, bloating) are common during the titration phase. May slightly reduce maximal hypertrophy due to mTOR inhibition. Potential for Vitamin B12 deficiency over long term use.
Dosage	500mg - 1000mg daily. Start with 500mg to assess GI tolerance.
Timing	With or immediately after a meal (usually in the evening) to minimize gastrointestinal discomfort.
Cycling	Often used continuously. Some athletes cycle it "off" during heavy mass building phases to maximize mTOR signaling.
Cost	€10-20 per pack. Extremely cost effective and widely available.
Evidence Grade	A+ (One of the most researched drugs in existence with decades of safety data).
Synergies	Berberine (natural alternative/add on). Tirzepatide (excellent synergy for glucose control and weight loss).
Warnings	Risk of lactic acidosis (extremely rare in healthy individuals). Monitor B12 levels. Avoid excessive alcohol consumption while on Metformin.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
7/10	8/10	10/10	10/10	9/10

DNP (2,4-DINITROPHENOL)
Category	II. Fat Loss and Metabolic Shredding
Intro	An industrial chemical used in the manufacturing of explosives and dyes. It was briefly used as a weight loss drug in the 1930s before being banned due to extreme toxicity and fatalities.
Mechanism	Acts as a mitochondrial uncoupler. It dissipates the proton gradient across the inner mitochondrial membrane, forcing the body to burn energy (fat and carbs) as pure heat instead of producing ATP.
Benefits	Unmatched fat loss (up to 0.5kg of pure fat per day). No "ceiling" to its effectiveness.
Negatives	Fatal Hyperthermia: The body literally cooks from the inside out; there is no physiological cooling mechanism that can counteract DN induced heat. No Antidote: If you overdose, medical science cannot save you.Severe peripheral neuropathy, rapid onset cataracts (blindness), and multi organ failure.
Dosage	Any dosage carries a risk of death. There is no "safe" therapeutic index.
Timing	Irrelevant: the compound accumulates in the system due to a long half life, leading to accidental overdoses.
Cycling	Should not be used.
Cost	Low (Industrial chemical), but the "cost" is potentially your life.
Evidence Grade	B (Documented as a potent fat burner, but primarily evidenced through toxicology reports and mortality cases).
Synergies	None. Stacking with other stimulants or thyroid hormones significantly increases the risk of immediate death.
Warnings	EXTREME LEFAL DANGER. Unlike Clenbuterol or T3, DNP does not have a biological "off switch." Inclusion in this guide is for historical and harm reduction purposes only. DO NOT USE.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
10/10	1/10	5/10	10/10	0/10

SIBUTRAMINE
Category	II. Fat Loss and Metabolic Shredding
Intro	A serotonin norepinephrine reuptake inhibitor (SNRI) originally developed as an antidepressant but primarily used as a potent appetite suppressant. It was withdrawn from many markets due to cardiovascular safety concerns.
Mechanism	Inhibits the reuptake of dopamine, norepinephrine, and serotonin in the brain → increases satiety and elevates resting metabolic rate via thermogenesis.
Benefits	Aggressive suppression of "food noise" and appetite. Increased energy expenditure. Effective for rapid weight loss in the short term.
Negatives	Significant cardiovascular strain: increases blood pressure and heart rate. High risk of dry mouth, insomnia, constipation, and in severe cases, stroke or myocardial infarction.
Dosage	10mg - 15mg daily.
Timing	In the morning.
Cycling	Not recommended for long term use (max. 4-12 weeks) due to cardiac stress.
Cost	€20-40 via gray market sources: legally unavailable in most Western countries.
Evidence Grade	B- (Documented efficacy for weight loss, but heavily overshadowed by safety data leading to its withdrawal).
Synergies	None recommended. Stacking with other stimulants (like Salbutamol) exponentially increases the risk of a cardiac event.
Warnings	High Cardiovascular Risk. Do not use if you have any history of hypertension or heart disease. Largely replaced by superior and safer GLP-1 agonists like Tirzepatide.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
8/10	7/10	6/10	6/10	3/10

TIRZEPATIDE (MOUNJARO)	Mogs Reta in my opinion
Category	II. Fat Loss and Metabolic Shredding
Intro	A dual glucose dependent insulinotropic polypeptide (GIP) and glucagon like peptide 1 (GLP-1) receptor agonist. Currently the most potent pharmaceutical tool for weight loss, surpassing Semaglutide (Ozempic) in both speed and total fat reduction.
Mechanism	Acts on two key metabolic pathways: GLP-1 (delays gastric emptying, signals satiety to the brain) and GIP (improves insulin sensitivity and lipid metabolism). It effectively "mutes" the brain's hunger signals (Food Noise) while optimizing how the body handles glucose.
Benefits	Extreme appetite suppression. Rapid fat loss while maintaining stable blood sugar. Improved insulin sensitivity. Minimal CNS stimulation compared to traditional burners (Clen/T3).
Negatives	Gastrointestinal side effects (nausea, constipation, sulfur burps) especially during titration. High cost and availability issues. Potential for "muscle wasting" if protein intake isn't strictly monitored (due to massive caloric deficit).
Dosage	2.5mg start (4 weeks) → titrate to 5mg → 7.5mg → max 15mg weekly.
Timing	Subcutaneous injection, once weekly (any time of day).
Cycling	Can be used for the duration of a cut (8-16 weeks) or as a long term weight management tool.
Cost	$170 for 600mg (depending on source/pharmacy).
Evidence Grade	A+ (SURMOUNT clinical trials show up to 20%+ body weight loss).
Synergies	High protein diet (mandatory). Metformin (for peak insulin sensitivity). Testosterone/AAS (to protect muscle mass during the deficit).
Warnings	Risk of pancreatitis (rare). Must monitor gallbladder health. Do not use if you have a family history of medullary thyroid carcinoma (MTC).

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
10/10	9/10	10/10	10/10	10/10

Why it's NOT in the main Guide (yet):

Cardiac Strain: Glucagon receptor activation increases resting heart rate significantly.
Muscle Wasting: The metabolic drive is so high that maintaining a good looking body becomes nearly impossible without high dose anabolics.
Experimental Status: No long term human safety data outside of clinical trials.
Conclusion: Stick to Tirzepatide for controlled, elite level fat loss. Retatrutide is for those who are willing to be "human lab rats."

ORLISTAT
Category	II. Fat Loss and Metabolic Shredding
Intro	A gastrointestinal lipase inhibitor. Unlike most other fat burners, it does not act on the central nervous system or metabolism directly; it works solely in the digestive tract to prevent the absorption of dietary fats.
Mechanism	Inhibits the enzyme gastric and pancreatic lipase. These enzymes are necessary to break down triglycerides into free fatty acids. Without them, about 25-30% of ingested fat passes through the intestines undigested.
Benefits	Non systemic (does not affect heart rate or blood pressure). Proven to reduce visceral fat over time. Can be used as a "cheat meal insurance" to limit caloric impact from high fat social events.
Negatives	Gastrointestinal Side Effects: Frequent, oily spotting, flatulence with discharge ("sharting"), and urgent bowel movements. Malabsorption of fat soluble vitamins (A, D, E, K) and Beta Carotene.
Dosage	60mg (OTC/Alli) to 120mg (Prescription/Xenical) taken with each fat containing meal.
Timing	Immediately before, during, or up to one hour after a high fat meal.
Cycling	Can be used long term, but requires a hig quality multivitamin (taken 2 hours apart) to prevent deficiencies.
Cost	€30-60 per month via pharmacy.
Evidence Grade	A (Decades of clinical use and FDA approval).
Synergies	Fiber supplements (Psyllium Husk) to mitigate GI side effects.
Warnings	If a meal contains no fat, the dose should be skipped. Excessive fat intake while on Orlistat leads to severe "emergency" bathroom situations.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
4/10	2/10	10/10	7/10	3/10

── III. VASCULARITY & PERFORMANCE ──

TADALAFIL (CIALIS)
Category	III. Vascularity & Performance
Intro	PDE5 inhibitor with ~17.5 hour half life the longest of the PDE5 inhibitors. Daily low dose creates true steady state NO enhancement. The most practical PDE5 inhibitor for ongoing vascularity and cardiovascular benefits.
Mechanism	Inhibits phosphodiesterase type 5 → prevents cGMP breakdown → elevated cGMP → smooth muscle relaxation → vasodilation via NO pathway. Steady-state at 5mg EOD or 2.5-5mg daily.
Benefits	Enhanced muscle pump and vascularity in training. Cardiovascular health (NO mediated endothelial protection). Blood pressure reduction. Erectile function. Potential cognitive benefits via cerebral blood flow.
Negatives	Hypotension at low blood pressure baseline. Absolute contraindication with nitrates. Facial flushing, nasal congestion at high doses. Back pain (unique to tadalafil, PDE11 inhibition).
Dosage	2.5-5mg daily OR 5mg EOD for steady-state. 10-20mg as needed.
Timing	Morning with or without food.
Cycling	No cycling needed. Can be used continuously.
Cost	€15-30/month generic.
Evidence Grade	A FDA approved. Extensive RCT data for multiple indications.
Synergies	L-Citrulline (complementary NO pathway, do not stack at high citrulline doses). Training.
Warnings	Absolute contraindication with nitrates (life threatening hypotension). Avoid with alpha blockers. Monitor blood pressure, particularly at baseline <110/70.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
8/10	9/10	9/10	8/10	8/10

SILDENAFIL (VIAGRA)
Category	III. Vascularity & Performance
Intro	The original PDE5 inhibitor. Shorter half-life (~4 hours) vs tadalafil, creates strong acute peak rather than steady state. More intense pump effect but not suitable for daily dosing. First choice for acute pre-workout vascularity.
Mechanism	Same PDE5 inhibition as tadalafil but with faster onset (30-60 min) and shorter duration. Stronger acute NO amplification. More PDE5-selective than tadalafil (less PDE11 side effects).
Benefits	Intense acute muscle pump pre-workout. Rapid onset. Strong vasodilation. No back pain (unlike tadalafil).
Negatives	Short duration means less practical for daily use. Facial flushing, visual disturbances (blue tint) at high doses. Same contraindications as tadalafil.
Dosage	25-50mg 30-60 min pre workout.
Timing	30-60 min pre workout on empty stomach for fastest effect.
Cycling	As needed only, not suitable for daily steady-state.
Cost	€10-25 for several doses generic.
Evidence Grade	A FDA approved. Extensive RCT data.
Synergies	Training. Citrulline (reduce citrulline dose when stacking).
Warnings	Same contraindications as tadalafil. Food significantly reduces absorption. Vision disturbances (blue tint) possible.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
8/10	8/10	9/10	8/10	7/10

TELMISARTAN
Category	III. Vascularity & Performance
Intro	AT1 receptor antagonist (ARB) for hypertension. Unique additional mechanism, PPAR-gamma partial agonist → metabolic benefits beyond blood pressure. Used in performance context for cardiovascular protection and endurance enhancement.
Mechanism	Blocks angiotensin II AT1 receptor → vasodilation, reduced aldosterone, lower blood pressure. PPAR-gamma activation → improved insulin sensitivity, fatty acid oxidation, mitochondrial biogenesis. Crosses BBB — potential nootropic effects.
Benefits	Blood pressure control in steroid users. Endurance enhancement via PPAR-gamma (AICAR like metabolic effects). Cardiovascular protection. Potential insulin sensitivity improvement.
Negatives	Hypotension at low blood pressure baseline, ot indicated in normal or low BP individuals without specific reason. Hyperkalemia risk.
Dosage	20-40mg/day for cardioprotection. 80mg/day for hypertension.
Timing	Morning.
Cycling	Continuous for hypertension management.
Cost	€10-20/month generic.
Evidence Grade	A FDA approved. PPAR-gamma mechanism adds unique performance angle.
Synergies	Cardiovascular protection stack. PPAR gamma effects synergy with cardio training.
Warnings	Not appropriate if blood pressure already low (baseline <120/75). Monitor potassium. Not a performance supplement for healthy normotensive individuals.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
7/10	7/10	8/10	9/10	6/10

NEBIVOLOL
Category	III. Vascularity & Performance
Intro	Third generation selective beta 1 blocker. Unique among beta-blockers, stimulates eNOS → increases NO production. Provides cardiovascular protection without the exercise performance reduction seen with older beta-blockers.
Mechanism	Beta-1 selective blockade → reduced heart rate and cardiac workload. Unique: stimulates endothelial NO synthase (eNOS) → vasodilation. Unlike older beta-blockers, does not significantly impair exercise capacity due to NO effects.
Benefits	Cardiovascular protection when using stimulants (Modafinil, Salbutamol). Blood pressure reduction without exercise impairment. Vasodilation via NO. Anxiety reduction in performance situations.
Negatives	Still some reduction in maximum heart rate. Not for asthma/COPD (beta blockade). Bradycardia at excessive doses.
Dosage	2.5-5mg/day.
Timing	Morning.
Cycling	Continuous when indicated.
Cost	€15-25/month.
Evidence Grade	A FDA approved for hypertension. eNOS mechanism well characterized.
Synergies	Stimulant stack cardiac protection. Talmisartan.
Warnings	Not for asthma. Monitor resting heart rate. Only use when cardiovascular protection specifically needed.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
6/10	7/10	8/10	8/10	6/10

@tqbiq @Jesus_ist_König @Datto29 @OCD @Niebvll

OCD · 2026-04-06T08:43:25-0500

danke fürs taggen aber NZK

til<3D · 2026-04-06T08:43:25-0500

── IV. COGNITIVE ENHANCEMENT ──

MODAFINIL
Category	IV. Cognitive Enhancement
Intro	Wakefulness-promoting agent originally developed for narcolepsy. Dopamine reuptake inhibitor + histaminergic activation in hypothalamus. Creates sustained wakefulness and focus without the crash of amphetamines. The most evidence backed cognitive enhancer among smart drugs.
Mechanism	Primary: dopamine transporter inhibitor (increases synaptic dopamine). Secondary: histamine H1 activation in tuberomammillary nucleus (wakefulness). Orexin system activation. NE and glutamate modulation. Does NOT cause major dopamine release (vs amphetamines) hence less addiction potential.
Benefits	Sustained wakefulness and focus 8-12 hours. Reduced fatigue. Improved working memory and executive function. No significant peripheral stimulation. Widely used in military, medicine, academia.
Negatives	Tolerance with daily use, cycling essential. Headache initially (histamine). Insomnia if taken after 10am. Mild appetite suppression. Rare skin reactions (serious SJS). Not a substitute for sleep.
Dosage	100-200mg/day. Start at 100mg.
Timing	Morning with food. NEVER after 10am.
Cycling	Maximum 3x/week. 4 month washout after extended use for full reset.
Cost	€1-3/dose generic. €20-40/month at 2x/week.
Evidence Grade	A Extensive data. FDA approved. Used in military and medical settings.
Synergies	Citicoline (dopamine receptor density support). L Theanine (reduces edge). I like it with alcohol.
Warnings	Steven Johnson Syndrome risk (rare but serious, discontinue immediately with any rash). Cycle, daily use causes tolerance and potential dopaminergic adaptation.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
9/10	8/10	8/10	8/10	8/10

ARMODAFINIL
Category	IV. Cognitive Enhancement
Intro	R-enantiomer of modafinil. Longer half-life (~15 hours vs 12 hours) and considered more potent per mg. Approved for shift work sleep disorder, OSA, and narcolepsy. "Cleaner" cognitive effect profile than racemic modafinil according to user reports.
Mechanism	Same mechanism as modafinil R-enantiomer is the pharmacologically active component. Longer plasma half life due to slower metabolism. Higher peak concentration per mg.
Benefits	Longer duration of effect. Lower dose needed vs modafinil. Potentially "cleaner'"focus without racemic effects. Useful for night shift / unusual sleep schedule.
Negatives	Longer half life cuts both ways insomnia if taken too late even more problematic than modafinil.
Dosage	75-150mg/day.
Timing	Morning only. Even stricter, take before 9am due to longer half life.
Cycling	Same as modafinil 3x/week maximum.
Cost	Slightly more expensive than modafinil. €2-4/dose.
Evidence Grade	A FDA approved. Same evidence base as modafinil.
Synergies	Same as modafinil.
Warnings	Same SJS warning as modafinil. Even stricter timing requirements due to long half life.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
6/10	7/10	6/10	9/10	6/10

PIRACETAM
Category	IV. Cognitive Enhancement
Intro	The original racetam, synthesized in 1964. Mechanism still not fully characterized, which is unusual. Modulates AMPA receptors and membrane fluidity. Effects are subtle and require regular use. Used clinically in Eastern Europe for cognitive decline.
Mechanism	Positive AMPA receptor modulator → enhanced glutamatergic neurotransmission. Increases membrane fluidity (cholesterol-independent). Improves corpus callosum function (interhemispheric communication). Enhances acetylcholine release. Increases cerebral blood flow.
Benefits	Memory consolidation improvement. Interhemispheric communication. Neuroprotection. Cognitive enhancement in elderly with decline. Enhanced music appreciation and perception (anecdotal but consistent).
Negatives	Requires choline supplementation depletes acetylcholine without it. Effects subtle in healthy young subjects. Very high doses required (4-8g/day).
Dosage	1.6-4.8g/day. Split into 2-3 doses.
Timing	With meals. Take with Citicoline or Alpha-GPC.
Cycling	Daily continuous or cycling: both used.
Cost	Very cheap. €10-20/month.
Evidence Grade	B Clinical use in Europe for decades. RCT data in elderly/clinical populations. Less data in healthy young subjects.
Synergies	Citicoline or Alpha-GPC (ESSENTIAL racetams deplete choline). Aniracetam.
Warnings	ALWAYS take with a choline source. Without choline: headaches and brain fog. Start with lower doses.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
6/10	7/10	6/10	9/10	6/10

ANIRACETAM
Category	IV. Cognitive Enhancement
Intro	Fat soluble racetam with additional anxiolytic properties. More potent than piracetam per mg and adds AMPA modulation plus serotonin/dopamine effects. One of the more interesting racetams for combining cognitive enhancement with anxiety reduction.
Mechanism	AMPA receptor positive modulation (faster receptor recovery from desensitization). Cholinergic enhancement. D2/D3 dopamine modulation. 5-HT2A modulation (anxiolytic component). Fat-soluble, crosses BBB more readily.
Benefits	Cognitive enhancement. Anxiolytic effect without sedation. Mood improvement. Creative thinking enhancement. Social anxiety reduction.
Negatives	Fat soluble: must be taken with fat. Short half-life (1-3 hours) requires frequent dosing. Choline depletion like all racetams.
Dosage	750-1500mg/day, split into 2 doses.
Timing	With fatty meals.
Cycling	Daily or cycling.
Cost	€20-30/month.
Evidence Grade	B- Limited independent human RCTs. Strong mechanistic data.
Synergies	Citicoline (essential choline source). Piracetam (stack for broader coverage).
Warnings	Must take with fat. Must supplement choline. Short half life requires split dosing.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
6/10	6/10	5/10	8/10	5/10

PHENYLPIRACETAM
Category	IV. Cognitive Enhancement
Intro	Piracetam with a phenyl group added, produces stimulant effects in addition to cognitive enhancement. Significantly more potent than piracetam. Banned by WADA for athletic competition. Very high tolerance development with frequent use.
Mechanism	All piracetam mechanisms + phenyl group adds: dopamine/norepinephrine reuptake inhibition → stimulant effects. Cold-resistance effect (reduces temperature sensitivity). Enhanced motor function.
Benefits	Cognitive enhancement plus stimulation. Cold resistance. Athletic performance improvement. Motivation and drive.
Negatives	Very rapid tolerance, maximum 2-3 doses per week. Banned in sport (WADA). Stimulant cardiovascular effects.
Dosage	100-200mg per dose. Maximum 2-3x/week.
Timing	Morning only.
Cycling	STRICT maximum 2-3x/week. Tolerance develops after 3+ consecutive days.
Cost	€20-30/month.
Evidence Grade	C+ Limited human RCTs. Russian military and sport data.
Synergies	Choline source. Not stacked with other stimulants.
Warnings	Rapid tolerance do not use daily. WADA banned. Cardiovascular stimulant effects.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
7/10	7/10	4/10	8/10	5/10

PRAMIRACETAM
Category	IV. Cognitive Enhancement
Intro	One of the most potent racetams per mg. High affinity choline uptake enhancement makes it particularly effective for memory. Less anxiolytic than aniracetam, more focused on pure cognitive and memory enhancement.
Mechanism	Enhances high affinity choline uptake (HACU) in hippocampus more potently than other racetams → sustained acetylcholine elevation. AMPA modulation. Increases nitric oxide synthesis in brain.
Benefits	Memory formation and recall enhancement. Learning capacity. More potent per mg than piracetam. Focused effect on memory circuits.
Negatives	Expensive per mg. Requires choline supplementation. Effects mostly on memory rather than broad cognitive enhancement.
Dosage	400-1200mg/day, split doses.
Timing	With meals.
Cycling	Daily or cycling.
Cost	€30-50/month, more expensive than piracetam.
Evidence Grade	B- Some human trials mostly European. Mechanism well characterized.
Synergies	Citicoline (ESSENTIAL). Piracetam for synergistic effects.
Warnings	Must take with choline source. Expensive.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
6/10	6/10	5/10	6/10	5/10

SEMAX
Category	IV. Cognitive Enhancement
Intro	Synthetic ACTH(4-7) analogue developed in Russia for cognitive enhancement and neuroprotection. One of the most studied nootropic peptides with clinical-grade evidence. Covered in the Peptide Megathread, included here for completeness.
Mechanism	Upregulates BDNF. Modulates dopaminergic and serotonergic transmission. Increases enkephalinase activity. NO signalling enhancement in brain. Crosses BBB intranasally efficiently.
Benefits	Focus, memory consolidation, learning. BDNF upregulation. Neuroprotection. Rapid onset 15-30 min. No physical dependence.
Negatives	Desensitization, cycling required. See Peptide Megathread for full profile.
Dosage	0.5-1mg/day intranasal. See Peptide Megathread.
Timing	Morning.
Cycling	5 days ON / 2 OFF.
Cost	€15-25/month.
Evidence Grade	B+ Russian Phase II/III clinical trials.
Synergies	Citicoline (BDNF + ACh complementary). See Peptide Megathread.
Warnings	See Peptide Megathread for complete profile. https://looksmax.org/threads/peptide-megathread.1975946/

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
8/10	9/10	7/10	8/10	8/10

MEMANTINE
Category	IV. Cognitive Enhancement
Intro	NMDA receptor antagonist approved for Alzheimer's treatment. Used in biohacking for tolerance resetting, neuroprotection, and cognitive enhancement. Unique pharmacology, protects against glutamate excitotoxicity while allowing normal synaptic signaling.
Mechanism	Uncompetitive, low-affinity NMDA receptor antagonist. Blocks pathologically high NMDA activation without blocking normal synaptic transmission. Resets opioid and stimulant tolerance via NMDA pathway. Potential antidepressant effects.
Benefits	Tolerance reset for opioids, stimulants, or other NMDA-pathway substances. Neuroprotection. Dissociative cognitive enhancement at low doses. Memory improvement in some users.
Negatives	Dissociative effects at higher doses. Dizziness. Potential tolerance to memantine itself. Interaction with other NMDA active compounds.
Dosage	5-20mg/day. Start at 5mg.
Timing	Evening, dissociative effects make morning dosing impractical for most.
Cycling	Tolerance reset: short courses (1-2 weeks). Ongoing: low dose continuous.
Cost	€20-35/month generic.
Evidence Grade	A (Alzheimer's). B (healthy cognitive enhancement).
Synergies	Tolerance reset for Modafinil or other nootropics. Not stacked with other dissociatives.
Warnings	Dissociative at high doses. Do not combine with ketamine or other NMDA antagonists. Low dose only for cognitive use.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
6/10	6/10	6/10	7/10	5/10

DONEPEZIL
Category	IV. Cognitive Enhancement
Intro	A potent, reversible inhibitor of the enzyme acetylcholinesterase. By preventing the breakdown of acetylcholine in the synaptic cleft, it increases the concentration of this "learning neurotransmitter" in the brain.
Mechanism	Inhibits Acetylcholinesterase (AChE) → higher levels of Acetylcholine (ACh) → enhanced signal transmission between neurons, particularly in the hippocampus and cerebral cortex.
Benefits	Significant improvement in short term memory, focus, and verbal fluency. Heavily used for Lucid Dreaming and dream recall (vivid, high definition dreams). May counteract "brain fog" from other compounds.
Negatives	Cholinergic Overload: Can cause severe nausea, cramps, diarrhea, and muscle twitching. Risk of bradycardia (low heart rate). Known for causing "nightmares" or disturbingly intense dreams if taken before bed.
Dosage	2.5mg - 5mg daily. (Standard medical dose is 5mg-10mg, but for cognitive enhancement, "less is more" to avoid side effects).
Timing	In the morning to boost cognitive function \| immediately before bed for lucid dreaming (Caution: may cause insomnia).
Cycling	Should be cycled (e.g., 5 days on / 2 days off) to prevent receptor downregulation and maintain sensitivity.
Cost	€20-50 per pack (Generic versions are affordable).
Evidence Grade	A (Clinical gold standard for AD B for "Off Label" cognitive enhancement in healthy adults).
Synergies	Choline sources (Alpha GPC, CDP Choline) to provide the raw material for ACh synthesis. Semax/Selank for neuroprotective synergy.
Warnings	Do not combine with other potent AChE inhibitors (like Huperzine A). Monitor heart rate. May exacerbate asthma or GI ulcers.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
8/10	5/10	9/10	8/10	7/10

METHYLPHENIDAT (RITALIN)
Category	IV. Cognitive Enhancement
Intro	A central nervous system (CNS) stimulant of the phenethylamine and piperidine classes. Primarily used for ADHD, but widely utilized off label for cognitive enhancement and fatigue suppression.
Mechanism	Acts as a Norepinephrine Dopamine Reuptake Inhibitor (NDRI). It blocks the dopamine transporter (DAT) and norepinephrine transporter (NET), leading to increased concentrations of these neurotransmitters in the synaptic cleft, especially in the prefrontal cortex.
Benefits	Significant increase in executive function, sustained attention, and task-switching ability. Unlike Amphetamines (Adderall), it is less "euphoric" and more "robotic/functional." Suppresses appetite
Negatives	Crash: Possible "comedown" with irritability and anxiety. Cardiovascular: Increases heart rate and blood pressure. Vasoconstriction: Cold hands/feet. Long term use can lead to downregulation of dopamine receptors.
Dosage	5mg - 20mg (Instant Release/IR) for acute tasks. 10mg - 40mg (Extended Release/XR) for a full workday.
Timing	IR: 30 mins before the "Deep Work" session. XR: Morning, to avoid insomnia.
Cycling	Mandatory. Use only on high demand days. 2-3 days off per week to maintain sensitivity.
Cost	€10-30 per pack (Generic/Medikinet is very cheap).
Evidence Grade	A+ (Extensively studied for decades).
Synergies	L-Theanine: To smooth out the "jittery" edge. Magnesium: To reduce jaw clenching and muscle tension.
Warnings	High addiction potential if abused. Risk of hypertensive crisis if combined with MAOIs. Can exacerbate tics or anxiety disorders.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
9/10	7/10	10/10	9/10	9/10

LISDEXAMFETAMIN (LDX)
Category	IV. Cognitive Enhancement
Intro	A prodrug of dextroamphetamine. It is pharmacologically inactive until it is converted by enzymes in red blood cells. This results in a much smoother, longer lasting effect compared to traditional amphetamines or Ritalin.
Mechanism	Acts as a releasing agent of Dopamine and Norepinephrine. It enters the presynaptic neuron via transporters (DAT/NET) and triggers the release of neurotransmitters from storage vesicles into the synaptic cleft. It also inhibits reuptake.
Benefits	Consistency: No "rollercoaster" effect, very linear onset and offset. Duration: Lasts 10–14 hours, covering a full productive day. Focus: Extremely potent for cognitive endurance and complex problem solving. Lower abuse potential due to the slow rate of conversion in the blood.
Negatives	Long Half Life: If taken too late, sleep is impossible. Physical Strain: Increased heart rate, vasoconstriction, and potential "clenched jaw" (Bruxismus). Appetit Suppression: Even stronger than Ritalin.
Dosage	30mg (Starter) - 70mg (Max). For off label cognitive enhancement, 30mg is often the "sweet spot."
Timing	Must be taken early morning (6:00 AM - 8:00 AM) to ensure sleep at night.
Cycling	Highly recommended. Use for intense deep work phases, then take 2-3 days off to reset the dopamine receptors.
Cost	€70-130 per pack (Expensive, as it is still under patent/brand-protection in many regions).
Evidence Grade	A+ (Gold standard for adult ADHD).
Synergies	Magnesium-Glycinat: Essential against muscle tension. Vitamin C: Taking high doses in the evening helps "flush" the remaining amphetamine out of the system.
Warnings	High risk of cardiovascular strain when combined with other stimulants. Potential for "Amphetamine Psychosis" if abused or combined with extreme sleep deprivation.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
10/10	8/10	10/10	3/10	9/10

── V: HORMONAL MODULATION ──

TESTOSTERON (Test E / Test C)
Category	V: HORMONAL MODULATION
Intro	The primary male sex hormone and the absolute pillar of every steroid cycle. It provides the essential androgenic and estrogenic base required for mental health, libido, and tissue repair. Without a testosterone base, most stacks will lead to a mental and physical crash.
Mechanism	Binds to the Androgen Receptor (AR) to promote protein synthesis and erythropoiesis. It undergoes 5α-reduction into Dihydrotestosterone (DHT) and aromatises into Oestradiol (E2). E2 is highly anabolic and neuroprotective but acts as the primary signal for epiphyseal plate closure.
Benefits	Anabolism: Drastic increase in recovery, strength, and muscle mass. Well being: Improved mood, confidence, and cognitive "drive." Bone Health: Essential for bone remodeling and density (crucial for structural integrity during growth phases).
Negatives	Aromatization: High doses lead to water retention and gynecomastia without an AI. Shutdown: Suppresses the natural HPG axis (requires HCG/HMG to maintain fertility). Cosmetic: Potential for acne and accelerated hair loss in prone individuals.
Dosage	TRT/Cruise: 100mg - 150mg/week. Blasting: 300mg - 600mg+ per week. For height maxxing purposes, a moderate dose (200-250mg) is often superior to avoid premature plate maturation.
Timing	Intramuscular (IM) injection is preferred for stable kinetics. Split the weekly dose into at least two injections (e.g., Monday/Thursday) to minimize E2 spikes.
Cycling	Can be run in "Blasts" (16-24 weeks) followed by a "Cruise" (TRT dose). Never fully "off" if you want to maintain supraphysiological gains.
Cost	€25-50 per 10ml vial (UGL) / €0.20-0.50 per day. Extremely cost effective.
Evidence Grade	A++ (The most studied anabolic compound in human history).
Synergies	Growth Hormone: Synergistic elevation of systemic IGF-1. Letrozole: Mandatory synergy for height maxxing to block E2 induced plate closure. Telmisartan: To manage blood pressure elevations from increased red blood cell count.
Warnings	Monitor Hematocrit and Blood Pressure regularly. If used during puberty for height maxxing, E2 levels must be nuked to near zero to prevent permanent height loss.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
10/10	8/10	10/10	9/10	10/10

MASTERON (MAST E / MAST P)
Category	V: HORMONAL MODULATION
Intro	A dihydrotestosterone (DHT) derived anabolic steroid. Originally developed as an anti breast cancer medication, it is now the gold standard for achieving a "hard," grainy, and dry physique. It is a non aromatizing compound with mild anti estrogenic properties.
Mechanism	Binds with high affinity to the Androgen Receptor (AR). As a DHT derivative, it cannot convert to Estrogen. It acts as a weak Aromatase Inhibitor (AI) by competing for the aromatase enzyme, effectively lowering the amount of Testosterone that converts to E2.
Benefits	Cosmetic: Forces intracellular water into the muscle and eliminates subcutaneous bloat ("The Dry Look"). Neurogenic: Increases CNS drive and aggression/focus without the "Tren brain" toxicity. SHBG Lowering: Binds to SHBG, leaving more Free Testosterone available for muscle growth.
Negatives	Androgenic Side Effects: High risk for accelerated male pattern baldness (MPB) and acne. Prostate: Can cause Benign Prostatic Hyperplasia (BPH) in high doses. Lipids: Can be harsh on HDL/LDL ratios, requiring Statin support.
Dosage	Mild/Support: 200mg - 300mg/week. Hardcore/Contest: 400mg - 600mg+/week.
Timing	Propionate (Mast P) requires EOD injections; Enanthate (Mast E) can be injected twice weekly (e.g., Monday/Thursday).
Cycling	Often used in the last 8-12 weeks of a "Shredding" phase or as a permanent "Feel Good" addition to a TRT+ cruise.
Cost	€35-60 per 10ml vial (UGL). Moderately priced.
Evidence Grade	A (Decades of use in clinical and athletic settings).
Synergies	Testosterone: Mast allows you to run higher Test doses with less Letrozole. Tirzepatide: Enhances the "shredded" look by maintaining muscle fullness during extreme fat loss. Winstrol: Synergistic "dryness" for the ultimate peak week.
Warnings	If you value your hair, use RU-58841 topically. Masteron will "rape" your hair follicles if they are genetically sensitive. Monitor prostate health via PSA markers if used long-term.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
7/10	8/10	9/10	7/10	8/10

ANAVAR (OXANDROLONE)
Category	V: HORMONAL MODULATION
Intro	Often called the "Girl Steroid," which is a massive 140 IQ underestimation. It is a highly anabolic, low androgenic oral steroid. Originally designed for tissue wasting diseases and bone density improvement, it is now the premier choice for strength to weight ratio optimization and "dry" gains.
Mechanism	A 17α-alkylated DHT derivative. It is unique because it is primarily metabolized by the kidneys rather than the liver, making it significantly less hepatotoxic than other orals like D-Bol or Adrol. It increases Creatine Phosphate synthesis in the muscle cells, leading to rapid strength gains without water retention.
Benefits	Strength: Drastic increase in ATP regeneration; you will lift more without getting "bulky." Lipolysis: Proven to reduce visceral and subcutaneous fat directly (synergy with Tirzepatide). Bone Health: Increases hydroxyproline and bone mineral content (synergy for height-maxxing support). Vaskularity: Promotes a "veiny," roadmap like look within days.
Negatives	Lipids: Known to nuke HDL (good cholesterol) rapidly. Kidneys: High doses over long periods can strain renal function. Pump Pain: Can cause "back pumps" (painful lower back cramps) due to extreme intracellular water shifting.
Dosage	Low/Support: 20mg - 30mg/day. Performance: 50mg - 80mg/day.
Timing	Split dose twice daily (e.g., morning/pre workout) due to a short half life of ~9-10 hours.
Cycling	6-8 weeks as a "kickstart" to a blast or a "finisher" before a photoshoot/event.
Cost	€40-80 per 100 tabs (10mg). One of the most faked/expensive orals (often replaced with cheap Winny).
Evidence Grade	A++ (Extensive medical history in pediatrics and burn victims).
Synergies	Creatine Monohydrate: Mandatory to maximize the ATP pathway. Telmisartan: To protect the kidneys from the increased filtration load. Taurine: 3-5g daily to stop painful "back pumps."
Warnings	Must monitor LDL/HDL. Since it’s a DHT derivative, it won't aromatize, but it can suppress SHBG, making your Testosterone base aromatize more. Adjust Letrozole accordingly.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
8/10	9/10	10/10	4/10	9/10

WINSTROL (STANOZOLOL)
Category	V: HORMONAL MODULATION
Intro	The legendary "cutting" steroid. Winstrol is a DHT derivative altered to be highly anabolic with minimal androgenic activity. It is the gold standard for competitive bodybuilders and athletes requiring explosive power without added water weight. It is famous for creating a 3D, "photoshopped" muscle look.
Mechanism	A 17α-alkylated steroid (oral) or aqueous suspension (injectable). It has a unique ability to antagonize Progesterone receptors and significantly lower SHBG (Sex Hormone Binding Globulin). By nuking SHBG, it drastically increases the amount of "Free Testosterone" in the bloodstream, amplifying the effects of every other compound in the stack.
Benefits	Hardness: Forces every drop of extracellular water out of the body, creating a dry, "hard as rock" muscle texture. Power: Increases explosive strength and speed without mass gain (used by sprinters). Synergy: Makes all other steroids work "harder" by freeing up bound hormones. Non-Aromatizing: Zero conversion to Estrogen.
Negatives	Joint Health: Known for "drying out" joints, leading to severe pain and increased injury risk. Lipids: One of the harshest compounds on HDL/LDL cholesterol levels. Liver: High hepatotoxicity (oral version). Androgenic: Can be brutal on the hairline (DHT-derivative).
Dosage	Oral: 20mg - 50mg/day (Split dose). Injectable: 50mg every other day (EOD).
Timing	Oral has a half life of ~9 hours; split morning and evening. Injectable (Water based) is painful but bypasses the first pass liver metabolism.
Cycling	Strictly limited to 4-6 weeks, usually at the very end of a "Shredding" phase
Cost	€25-45 per 100 tabs (10mg). Very affordable, rarely faked.
Evidence Grade	A (Decades of clinical use in treating hereditary angioedema and anemia).
Synergies	Testosterone: Required base to combat "lethargy" and joint dryness. Glucosamine/Chondroitin: Essential to protect joint integrity. Taurine: To manage the extreme muscle pumps. NAC: Mandatory for liver protection.
Warnings	If you are already using Letrozole for height maxxing, be EXTREMELY careful with Winstrol. The combination of low E2 (from Letro) and Winstrol will make your tendons as brittle as glass. Avoid heavy 1-rep-max lifting on this combo.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
9/10	6/10	10/10	10/10	9/10

ENCLOMIPHENE (ENCLO / ANDROXAL)
Category	V: HORMONAL MODULATION
Intro	The purified trans-isomer of Clomiphene Citrate. Unlike standard Clomid (which contains Zuclomiphene, a long acting estrogen agonist), Enclomiphene acts as a pure estrogen antagonist in the pituitary gland. It is the gold standard for "non suppressive" testosterone enhancement and PCT.
Mechanism	Acts as a Selective Estrogen Receptor Modulator (SERM). It blocks the negative feedback of Estrogen at the hypothalamus and pituitary gland. This tricks the brain into thinking E2 is too low, triggering a massive release of LH (Luteinizing Hormone) and FSH (Follicle Stimulating Hormone), which forces the testes to produce more endogenous Testosterone and sperm.
Benefits	HPTA Restart: The most effective compound for restoring natural production after a cycle. Test Boost: Can double or triple natural testosterone levels while maintaining fertility. Mental Clarity: Lacks the "emotional/depressive" side effects of Zuclomiphene (found in Clomid). Oral Bioavailability: No needles required for a significant hormonal boost.
Negatives	IGF-1 Suppression: Like most SERMs, it can slightly lower systemic IGF-1 levels (counterproductive for height-maxxing). Vision: Rare reports of "floaters" or light sensitivity (though less than Clomid). E2 Management: High LH leads to high Test, which can lead to high E2; an AI might still be needed.
Dosage	Monotherapy/PCT: 6.25mg - 12.5mg daily. High Dose Recovery: 25mg daily.
Timing	Once daily, ideally in the morning to mimic natural circadian rhythms.
Cycling	Can be used for 4-6 weeks as a PCT or as a long term "Test Base" for mild SARM cycles.
Cost	€40-70 per 30ml (Liquid/UGL) or 50 tabs (12.5mg). Harder to source than Clomid but worth the premium.
Evidence Grade	A (Extensively studied in Phase II and III clinical trials for hypogonadism).
Synergies	HCG: To keep the testes primed during a cycle before switching to Enclo for PCT. Boron: 6-10mg daily to lower SHBG and further increase Free Testosterone. NAC: To support general health during recovery.
Warnings	Do not use if you have pre existing vision issues. While it keeps the HPTA "on," it cannot compete with the suppression of heavy compounds like Trenbolone or highdose Deca.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
8/10	10/10	9/10	7/10	9/10

ANASTROZOLE (ADEX)
Category	V: HORMONAL MODULATION
Intro	A potent, reversible non-steroidal aromatase inhibitor (AI). It is the most commonly used ancillary in the bodybuilding community to combat the side effects of aromatizing steroids. It allows for precise control over oestradiol levels without the extreme potency of Letrozole.
Mechanism	Competitively binds to the aromatase enzyme, preventing the conversion of androgens (Testosterone) into oestrogens (Oestradiol). It is a "Type II" AI, meaning it binds reversibly; once the drug leaves the system, the enzyme can function again.
Benefits	E2 Control: Effectively prevents gynecomastia, water retention (bloat), and high blood pressure. Aesthetics: Keeps the physique "dry" and defined during high-dose Testosterone cycles. Hormonal Balance: Helps maintain the ideal T:E2 ratio for libido and mental health.
Negatives	Lipid Strain: Can negatively impact HDL/LDL cholesterol (synergy with Statins required). Bone Health: Long-term crushed E2 leads to decreased bone mineral density (high risk if not monitored). Joint Pain: Low E2 causes "dry" and clicking joints.
Dosage	Prevention: 0.25mg - 0.5mg Every Other Day (EOD). Acute Issues: 1mg daily until symptoms (nipple sensitivity) subside.
Timing	Can be taken any time of day, with or without food. Has a half-life of ~40-50 hours.
Cycling	Used throughout the entire duration of a cycle involving aromatizing compounds (Test, D-Bol).
Cost	€20-40 per 28-30 tabs (1mg). Extremely affordable and widely available.
Evidence Grade	A++ (Clinical gold standard for breast cancer and hormonal therapy).
Synergies	Testosterone: Essential to manage the inevitable aromatization. Telmisartan: To offset the BP elevating effects of potential E2 spikes. Pitavastatin: To protect lipids from AI induced strain.
Warnings	Do not "nuke" your E2. Oestrogen is needed for brain health, libido, and muscle growth. Only use enough to stay within the high normal range (20-40 pg/mL) unless height maxxing.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
9/10	10/10	10/10	10/10	10/10

EXEMESTANE (AROMASIN)
Category	V: HORMONAL MODULATION
Intro	A potent, permanent (suicidal) aromatase inactivator. Unlike non steroidal AIs (Adex/Letro), Exemestane is a steroidal compound structurally related to androstenedione. It is preferred by many high level users for its lack of "estrogen rebound" and its slight androgenic feel.
Mechanism	Acts as a Type I Aromatase Inhibitor. It binds irreversibly to the aromatase enzyme, forming a permanent bond that deactivates it ("suicide inhibition"). The body must synthesize new enzymes to resume aromatization. It also possesses a metabolite, 17ß-Hydroxyexemestane, which has high affinity for the androgen receptor.
Benefits	No Rebound: Since the enzymes are destroyed, there is no sudden spike in E2 after cessation. IGF-1 Support: Unlike other AIs, it may slightly increase IGF-1 levels, which is synergistic with HGH. Libido: Often reported to be "better" for sexual drive compared to non-steroidal AIs due to its androgenic nature.
Negatives	Hair Loss: The metabolite 17ß-Hydroxyexemestane is highly androgenic and is known to "rape" the hairline in prone individuals. Lipids: Harsh on HDL/LDL (though slightly less so than Letrozole). Dosing Difficulty: Because it is permanent, "crushing" your E2 by accident is much harder to fix quickly.
Dosage	Standard: 12.5mg - 25mg Every Other Day (EOD) or every 3 days.
Timing	Must be taken with a high fat meal to ensure proper absorption (bioavailability increases by ~40% with fats).
Cycling	Used throughout the cycle; especially useful for those prone to E2 rebounds or those utilizing high dose HGH.
Cost	€40-80 per 30 tabs (25mg). More expensive than Anastrozole.
Evidence Grade	A+ (Clinical gold standard for post menopausal breast cancer).
Synergies	Growth Hormone: Best AI to pair with HGH due to the lack of IGF-1 suppression. Dutasteride/RU-58841: MANDATORY if you want to keep your hair while using this compound.
Warnings	Exemestane is a "one-way street" for the enzyme. If you crash your E2, you have to wait days/weeks for new enzymes to grow or use Dianabol/Exogenous E2 for an acute fix.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
10/10	7/10	10/10	6/10	8/10

TAMOXIFEN (NOLVADEX)
Category	V: HORMONAL MODULATION
Intro	A first generation Selective Estrogen Receptor Modulator (SERM). While originally a breast cancer medication, it is the most essential emergency drug in a steroid user's arsenal to combat developing gynaecomastia (bitch tits) and a core component of traditional PCT protocols.
Mechanism	Acts as an Estrogen Receptor Antagonist in the mammary (breast) tissue by competing for the receptor site. However, it acts as an Estrogen Agonist in other tissues like the liver and bone. By blocking E2 in the pituitary, it stimulates the release of LH and FSH to restart natural testosterone production.
Benefits	Gyno Protection: The #1 drug to stop itchy or sore nipples mid cycle without crushing systemic E2. Lipids: Improves the lipid profile (HDL/LDL) because it acts like estrogen in the liver. Bone Density: Helps maintain bone mineral density (estrogen agonist in bone). PCT: Proven to effectively restart the HPTA axis after suppression.
Negatives	IGF-1 Suppression: Significantly lowers systemic IGF-1 levels (counterproductive for height maxxing and muscle growth). Brain Fog: Some users report "chemo brain" or reduced cognitive clarity. Vision: Long term use or high doses carry a risk of cataracts or retinal changes.
Dosage	Gyno Flare up: 20mg - 40mg daily until symptoms disappear. PCT: 20mg daily for 4-6 weeks.
Timing	Once daily. Half life is long (~5-7 days), so timing is flexible, but consistency is key.
Cycling	Only used during PCT or as an emergency intervention during a "Blast." Not intended for long-term use during a cycle.
Cost	€20-40 per 30-60 tabs (20mg). Very cheap and widely available.
Evidence Grade	A++ (Decades of clinical use and FDA approval).
Synergies	Testosterone: To prevent gyno while keeping E2 high enough for its anabolic benefits. HCG: Used at the end of a cycle to prime the testes before starting Tamoxifen for PCT.
Warnings	Do not use Tamoxifen if you are using 19-nor compounds like Trenbolone or Deca to treat gyno: it can potentially upregulate Progesterone receptors, making "Tren Gyno" worse. Use P-5-P or Cabergoline instead for 19-nors.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
9/10	10/10	10/10	10/10	10/10

RALOXIFENE (RALO)
Category	V: HORMONAL MODULATION
Intro	A second-generation SERM. While Tamoxifen is the classic choice for PCT, Raloxifene is the superior compound for targeted gynaecomastia reversal and bone mineral density maintenance. It is highly tissue-specific, making it a favorite for "aesthetic first" athletes.
Mechanism	Acts as a potent Estrogen Receptor Antagonist in breast tissue and an Estrogen Agonist in bone. It has a higher binding affinity for the estrogen receptor in the mammary glands than Tamoxifen, making it more effective at shrinking established pubertal or steroid induced gyno.
Benefits	Gyno Reversal: The gold standard for reducing existing lumps (glandular tissue). Bone Health: Strongly promotes bone mineralization (used to treat osteoporosis). IGF-1 Integrity: Significantly less suppressive to systemic IGF-1 levels compared to Tamoxifen. Lipids: Positive effect on LDL cholesterol without the "bloat" of exogenous estrogen.
Negatives	Thrombosis Risk: Like all SERMs, it slightly increases the risk of blood clots (DVT). Leg Cramps: Some users report muscle cramps or hot flashes. PCT Efficiency: Not as effective as Enclomiphene or Tamoxifen for restarting the HPTA axis (LH/FSH stimulation is weaker).
Dosage	Acute Gyno Reversal: 60mg daily until the lump shrinks (can take 3-6 months), then taper to 30mg. Maintenance: 30mg daily.
Timing	Once daily, with or without food. Long half life (~28 hours).
Cycling	Can be used mid cycle to combat flare-ups or as a targeted treatment for several months to reverse old gyno.
Cost	€50-90 per pack. More expensive and harder to source than Tamoxifen.
Evidence Grade	A (Solid clinical data for both osteoporosis and gynaecomastia treatment).
Synergies	HGH: The best SERM to pair with Growth Hormone, as it preserves IGF-1 levels better than Nolvadex. Letrozole: Combined with a strong AI, Raloxifene is the ultimate "Gyno Nuke." Vitamin D3/K2: Synergistic for bone density during height maxxing.
Warnings	Monitor for any signs of calf pain or shortness of breath (clot risk). If gyno is "Grade 3" or very old (calcified), surgery is the only 100% fix, but Ralo is the best pharmaceutical attempt.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
10/10	9/10	9/10	4/10	9/10

CABERGOLINE (CABER / DOSTINEX)
Category	V: HORMONAL MODULATION
Intro	A potent, long acting dopamine receptor agonist with a high affinity for the D2 receptor. In the bodybuilding world, it is the primary defense against hyperprolactinemia caused by 1-9-nor compounds (Trenbolone, Nandrolone). It is also legendary for its "lifestyle" benefits regarding sexual performance.
Mechanism	Directly stimulates Dopamine D2 receptors in the lactotroph cells of the pituitary gland. This inhibits the secretion of Prolactin. By keeping Prolactin low, it prevents the negative feedback loop that suppresses LH/FSH and causes sexual dysfunction ("Deca Dick").
Benefits	Prolactin Control: Eliminates nipple discharge (lactation) and gyno caused by Prolactin. Refractory Period: Dramatically reduces or eliminates the refractory period between orgasms (the "Multi Shot" effect). Mood: Increases drive and motivation due to higher dopaminergic signaling. Sleep: Often improves sleep quality and vividness of dreams (synergy with Donepezil).
Negatives	Heart Valves: High doses (medical/Parkinson's levels) are linked to cardiac valvulopathy. Dopamine Dysregulation: Risk of compulsive behaviors (gambling, hypersexuality) if abused. Blood Pressure: Can cause orthostatic hypotension (dizziness when standing up). GH Suppression: High doses can slightly lower GH/IGF-1 levels.
Dosage	On Cycle (Tren/Deca): 0.25mg - 0.5mg twice weekly (e.g., Monday/Thursday). Acute High Prolactin: 0.5mg every 3 days until levels normalize.
Timing	Ideally taken before bed to mitigate potential nausea or dizziness.
Cycling	Only used when running 19-nor compounds or when bloodwork shows elevated Prolactin.
Cost	€60-120 per 8 tabs (0.5mg). One of the most expensive ancillaries per pill.
Evidence Grade	A++ (Medical gold standard for prolactinomas).
Synergies	Trenbolone: Essential to maintain sexual function and mental stability. P-5-P: Can be used alongside to keep the Caber dose lower. Lisdexamfetamine: CAUTION: both affect dopamine; potential for overstimulation/anxiety.
Warnings	Do not "crash" Prolactin to zero some is needed for immune function and mental health. Monitor heart health if used long term. Avoid combining with heavy stimulants without checking blood pressure first.

Ratings:

Effectiveness	Ease	Evidence	Cost	Overall
10/10	10/10	10/10	2/10	9/10

CRITICAL INTERACTIONS

Key Interactions to Know
Tadalafil + Nitrates	ABSOLUTE CONTRAINDICATION life-threatening hypotension.
Tadalafil + Citrulline	Additive vasodilation reduce citrulline dose.
Modafinil + Stimulants	Additive cardiovascular load. Avoid stacking with Salbutamol same day if concerned.
Racetams + Choline	ALWAYS supplement choline with racetams headache and brain fog without it.
Finasteride + Aromatase	Reducing DHT shifts T→E2 balance monitor estrogen if using long-term.
Isotretinoin + Vitamin A	Never combine with high dose Vitamin A supplements additive toxicity.

For Peptides: see Peptide Megathread. For Supplements: see Supplement Megathread.

MixedBoyo12 · 2026-04-06T08:44:32-0500

Well thought out, will read later

jd922 · 2026-04-06T08:46:07-0500

i luv u nigger

til<3D · 2026-04-06T08:48:01-0500

jd922 said:
i luv u nigger

I love you too

Niebvll · 2026-04-06T08:58:50-0500

Knew this was coming but great thread

til<3D · 2026-04-06T09:01:56-0500

Niebvll said:
Knew this was coming but great thread

High IQ as always

bosnian · 2026-04-06T09:03:03-0500

mirin great thread

very accurate ratings etc

til<3D · 2026-04-06T09:31:33-0500

bosnian said:
mirin great thread

very accurate ratings etc

thank you took like 2 days

til<3D · 2026-04-06T12:12:14-0500

Bump </3

aaronbp · 2026-04-06T13:06:37-0500

good effort

tqbiq · 2026-04-06T13:24:33-0500

til<3D said:
── IV. COGNITIVE ENHANCEMENT ──

MODAFINIL

Category
IV. Cognitive Enhancement
Intro
Wakefulness-promoting agent originally developed for narcolepsy. Dopamine reuptake inhibitor + histaminergic activation in hypothalamus. Creates sustained wakefulness and focus without the crash of amphetamines. The most evidence backed cognitive enhancer among smart drugs.
Mechanism
Primary: dopamine transporter inhibitor (increases synaptic dopamine). Secondary: histamine H1 activation in tuberomammillary nucleus (wakefulness). Orexin system activation. NE and glutamate modulation. Does NOT cause major dopamine release (vs amphetamines) hence less addiction potential.
Benefits
Sustained wakefulness and focus 8-12 hours. Reduced fatigue. Improved working memory and executive function. No significant peripheral stimulation. Widely used in military, medicine, academia.
Negatives
Tolerance with daily use, cycling essential. Headache initially (histamine). Insomnia if taken after 10am. Mild appetite suppression. Rare skin reactions (serious SJS). Not a substitute for sleep.
Dosage
100-200mg/day. Start at 100mg.
Timing
Morning with food. NEVER after 10am.
Cycling
Maximum 3x/week. 4 month washout after extended use for full reset.
Cost
€1-3/dose generic. €20-40/month at 2x/week.
Evidence Grade
A Extensive data. FDA approved. Used in military and medical settings.
Synergies
Citicoline (dopamine receptor density support). L Theanine (reduces edge). I like it with alcohol.
Warnings
Steven Johnson Syndrome risk (rare but serious, discontinue immediately with any rash). Cycle, daily use causes tolerance and potential dopaminergic adaptation.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
8/10
8/10
8/10
8/10

ARMODAFINIL

Category
IV. Cognitive Enhancement
Intro
R-enantiomer of modafinil. Longer half-life (~15 hours vs 12 hours) and considered more potent per mg. Approved for shift work sleep disorder, OSA, and narcolepsy. "Cleaner" cognitive effect profile than racemic modafinil according to user reports.
Mechanism
Same mechanism as modafinil R-enantiomer is the pharmacologically active component. Longer plasma half life due to slower metabolism. Higher peak concentration per mg.
Benefits
Longer duration of effect. Lower dose needed vs modafinil. Potentially "cleaner'"focus without racemic effects. Useful for night shift / unusual sleep schedule.
Negatives
Longer half life cuts both ways insomnia if taken too late even more problematic than modafinil.
Dosage
75-150mg/day.
Timing
Morning only. Even stricter, take before 9am due to longer half life.
Cycling
Same as modafinil 3x/week maximum.
Cost
Slightly more expensive than modafinil. €2-4/dose.
Evidence Grade
A FDA approved. Same evidence base as modafinil.
Synergies
Same as modafinil.
Warnings
Same SJS warning as modafinil. Even stricter timing requirements due to long half life.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
6/10
9/10
6/10

PIRACETAM

Category
IV. Cognitive Enhancement
Intro
The original racetam, synthesized in 1964. Mechanism still not fully characterized, which is unusual. Modulates AMPA receptors and membrane fluidity. Effects are subtle and require regular use. Used clinically in Eastern Europe for cognitive decline.
Mechanism
Positive AMPA receptor modulator → enhanced glutamatergic neurotransmission. Increases membrane fluidity (cholesterol-independent). Improves corpus callosum function (interhemispheric communication). Enhances acetylcholine release. Increases cerebral blood flow.
Benefits
Memory consolidation improvement. Interhemispheric communication. Neuroprotection. Cognitive enhancement in elderly with decline. Enhanced music appreciation and perception (anecdotal but consistent).
Negatives
Requires choline supplementation depletes acetylcholine without it. Effects subtle in healthy young subjects. Very high doses required (4-8g/day).
Dosage
1.6-4.8g/day. Split into 2-3 doses.
Timing
With meals. Take with Citicoline or Alpha-GPC.
Cycling
Daily continuous or cycling: both used.
Cost
Very cheap. €10-20/month.
Evidence Grade
B Clinical use in Europe for decades. RCT data in elderly/clinical populations. Less data in healthy young subjects.
Synergies
Citicoline or Alpha-GPC (ESSENTIAL racetams deplete choline). Aniracetam.
Warnings
ALWAYS take with a choline source. Without choline: headaches and brain fog. Start with lower doses.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
6/10
9/10
6/10

ANIRACETAM

Category
IV. Cognitive Enhancement
Intro
Fat soluble racetam with additional anxiolytic properties. More potent than piracetam per mg and adds AMPA modulation plus serotonin/dopamine effects. One of the more interesting racetams for combining cognitive enhancement with anxiety reduction.
Mechanism
AMPA receptor positive modulation (faster receptor recovery from desensitization). Cholinergic enhancement. D2/D3 dopamine modulation. 5-HT2A modulation (anxiolytic component). Fat-soluble, crosses BBB more readily.
Benefits
Cognitive enhancement. Anxiolytic effect without sedation. Mood improvement. Creative thinking enhancement. Social anxiety reduction.
Negatives
Fat soluble: must be taken with fat. Short half-life (1-3 hours) requires frequent dosing. Choline depletion like all racetams.
Dosage
750-1500mg/day, split into 2 doses.
Timing
With fatty meals.
Cycling
Daily or cycling.
Cost
€20-30/month.
Evidence Grade
B- Limited independent human RCTs. Strong mechanistic data.
Synergies
Citicoline (essential choline source). Piracetam (stack for broader coverage).
Warnings
Must take with fat. Must supplement choline. Short half life requires split dosing.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
6/10
5/10
8/10
5/10

PHENYLPIRACETAM

Category
IV. Cognitive Enhancement
Intro
Piracetam with a phenyl group added, produces stimulant effects in addition to cognitive enhancement. Significantly more potent than piracetam. Banned by WADA for athletic competition. Very high tolerance development with frequent use.
Mechanism
All piracetam mechanisms + phenyl group adds: dopamine/norepinephrine reuptake inhibition → stimulant effects. Cold-resistance effect (reduces temperature sensitivity). Enhanced motor function.
Benefits
Cognitive enhancement plus stimulation. Cold resistance. Athletic performance improvement. Motivation and drive.
Negatives
Very rapid tolerance, maximum 2-3 doses per week. Banned in sport (WADA). Stimulant cardiovascular effects.
Dosage
100-200mg per dose. Maximum 2-3x/week.
Timing
Morning only.
Cycling
STRICT maximum 2-3x/week. Tolerance develops after 3+ consecutive days.
Cost
€20-30/month.
Evidence Grade
C+ Limited human RCTs. Russian military and sport data.
Synergies
Choline source. Not stacked with other stimulants.
Warnings
Rapid tolerance do not use daily. WADA banned. Cardiovascular stimulant effects.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
4/10
8/10
5/10

PRAMIRACETAM

Category
IV. Cognitive Enhancement
Intro
One of the most potent racetams per mg. High affinity choline uptake enhancement makes it particularly effective for memory. Less anxiolytic than aniracetam, more focused on pure cognitive and memory enhancement.
Mechanism
Enhances high affinity choline uptake (HACU) in hippocampus more potently than other racetams → sustained acetylcholine elevation. AMPA modulation. Increases nitric oxide synthesis in brain.
Benefits
Memory formation and recall enhancement. Learning capacity. More potent per mg than piracetam. Focused effect on memory circuits.
Negatives
Expensive per mg. Requires choline supplementation. Effects mostly on memory rather than broad cognitive enhancement.
Dosage
400-1200mg/day, split doses.
Timing
With meals.
Cycling
Daily or cycling.
Cost
€30-50/month, more expensive than piracetam.
Evidence Grade
B- Some human trials mostly European. Mechanism well characterized.
Synergies
Citicoline (ESSENTIAL). Piracetam for synergistic effects.
Warnings
Must take with choline source. Expensive.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
6/10
5/10
6/10
5/10

SEMAX

Category
IV. Cognitive Enhancement
Intro
Synthetic ACTH(4-7) analogue developed in Russia for cognitive enhancement and neuroprotection. One of the most studied nootropic peptides with clinical-grade evidence. Covered in the Peptide Megathread, included here for completeness.
Mechanism
Upregulates BDNF. Modulates dopaminergic and serotonergic transmission. Increases enkephalinase activity. NO signalling enhancement in brain. Crosses BBB intranasally efficiently.
Benefits
Focus, memory consolidation, learning. BDNF upregulation. Neuroprotection. Rapid onset 15-30 min. No physical dependence.
Negatives
Desensitization, cycling required. See Peptide Megathread for full profile.
Dosage
0.5-1mg/day intranasal. See Peptide Megathread.
Timing
Morning.
Cycling
5 days ON / 2 OFF.
Cost
€15-25/month.
Evidence Grade
B+ Russian Phase II/III clinical trials.
Synergies
Citicoline (BDNF + ACh complementary). See Peptide Megathread.
Warnings
See Peptide Megathread for complete profile. https://looksmax.org/threads/peptide-megathread.1975946/

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
7/10
8/10
8/10

MEMANTINE

Category
IV. Cognitive Enhancement
Intro
NMDA receptor antagonist approved for Alzheimer's treatment. Used in biohacking for tolerance resetting, neuroprotection, and cognitive enhancement. Unique pharmacology, protects against glutamate excitotoxicity while allowing normal synaptic signaling.
Mechanism
Uncompetitive, low-affinity NMDA receptor antagonist. Blocks pathologically high NMDA activation without blocking normal synaptic transmission. Resets opioid and stimulant tolerance via NMDA pathway. Potential antidepressant effects.
Benefits
Tolerance reset for opioids, stimulants, or other NMDA-pathway substances. Neuroprotection. Dissociative cognitive enhancement at low doses. Memory improvement in some users.
Negatives
Dissociative effects at higher doses. Dizziness. Potential tolerance to memantine itself. Interaction with other NMDA active compounds.
Dosage
5-20mg/day. Start at 5mg.
Timing
Evening, dissociative effects make morning dosing impractical for most.
Cycling
Tolerance reset: short courses (1-2 weeks). Ongoing: low dose continuous.
Cost
€20-35/month generic.
Evidence Grade
A (Alzheimer's). B (healthy cognitive enhancement).
Synergies
Tolerance reset for Modafinil or other nootropics. Not stacked with other dissociatives.
Warnings
Dissociative at high doses. Do not combine with ketamine or other NMDA antagonists. Low dose only for cognitive use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
6/10
6/10
7/10
5/10

DONEPEZIL

Category
IV. Cognitive Enhancement
Intro
A potent, reversible inhibitor of the enzyme acetylcholinesterase. By preventing the breakdown of acetylcholine in the synaptic cleft, it increases the concentration of this "learning neurotransmitter" in the brain.
Mechanism
Inhibits Acetylcholinesterase (AChE) → higher levels of Acetylcholine (ACh) → enhanced signal transmission between neurons, particularly in the hippocampus and cerebral cortex.
Benefits
Significant improvement in short term memory, focus, and verbal fluency. Heavily used for Lucid Dreaming and dream recall (vivid, high definition dreams). May counteract "brain fog" from other compounds.
Negatives
Cholinergic Overload: Can cause severe nausea, cramps, diarrhea, and muscle twitching. Risk of bradycardia (low heart rate). Known for causing "nightmares" or disturbingly intense dreams if taken before bed.
Dosage
2.5mg - 5mg daily. (Standard medical dose is 5mg-10mg, but for cognitive enhancement, "less is more" to avoid side effects).
Timing
In the morning to boost cognitive function | immediately before bed for lucid dreaming (Caution: may cause insomnia).
Cycling
Should be cycled (e.g., 5 days on / 2 days off) to prevent receptor downregulation and maintain sensitivity.
Cost
€20-50 per pack (Generic versions are affordable).
Evidence Grade
A (Clinical gold standard for AD B for "Off Label" cognitive enhancement in healthy adults).
Synergies
Choline sources (Alpha GPC, CDP Choline) to provide the raw material for ACh synthesis. Semax/Selank for neuroprotective synergy.
Warnings
Do not combine with other potent AChE inhibitors (like Huperzine A). Monitor heart rate. May exacerbate asthma or GI ulcers.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
5/10
9/10
8/10
7/10

METHYLPHENIDAT (RITALIN)

Category
IV. Cognitive Enhancement
Intro
A central nervous system (CNS) stimulant of the phenethylamine and piperidine classes. Primarily used for ADHD, but widely utilized off label for cognitive enhancement and fatigue suppression.
Mechanism
Acts as a Norepinephrine Dopamine Reuptake Inhibitor (NDRI). It blocks the dopamine transporter (DAT) and norepinephrine transporter (NET), leading to increased concentrations of these neurotransmitters in the synaptic cleft, especially in the prefrontal cortex.
Benefits
Significant increase in executive function, sustained attention, and task-switching ability. Unlike Amphetamines (Adderall), it is less "euphoric" and more "robotic/functional." Suppresses appetite
Negatives
Crash: Possible "comedown" with irritability and anxiety. Cardiovascular: Increases heart rate and blood pressure. Vasoconstriction: Cold hands/feet. Long term use can lead to downregulation of dopamine receptors.
Dosage
5mg - 20mg (Instant Release/IR) for acute tasks. 10mg - 40mg (Extended Release/XR) for a full workday.
Timing
IR: 30 mins before the "Deep Work" session. XR: Morning, to avoid insomnia.
Cycling
Mandatory. Use only on high demand days. 2-3 days off per week to maintain sensitivity.
Cost
€10-30 per pack (Generic/Medikinet is very cheap).
Evidence Grade
A+ (Extensively studied for decades).
Synergies
L-Theanine: To smooth out the "jittery" edge. Magnesium: To reduce jaw clenching and muscle tension.
Warnings
High addiction potential if abused. Risk of hypertensive crisis if combined with MAOIs. Can exacerbate tics or anxiety disorders.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
7/10
10/10
9/10
9/10

LISDEXAMFETAMIN (LDX)

Category
IV. Cognitive Enhancement
Intro
A prodrug of dextroamphetamine. It is pharmacologically inactive until it is converted by enzymes in red blood cells. This results in a much smoother, longer lasting effect compared to traditional amphetamines or Ritalin.
Mechanism
Acts as a releasing agent of Dopamine and Norepinephrine. It enters the presynaptic neuron via transporters (DAT/NET) and triggers the release of neurotransmitters from storage vesicles into the synaptic cleft. It also inhibits reuptake.
Benefits
Consistency: No "rollercoaster" effect, very linear onset and offset. Duration: Lasts 10–14 hours, covering a full productive day. Focus: Extremely potent for cognitive endurance and complex problem solving. Lower abuse potential due to the slow rate of conversion in the blood.
Negatives
Long Half Life: If taken too late, sleep is impossible. Physical Strain: Increased heart rate, vasoconstriction, and potential "clenched jaw" (Bruxismus). Appetit Suppression: Even stronger than Ritalin.
Dosage
30mg (Starter) - 70mg (Max). For off label cognitive enhancement, 30mg is often the "sweet spot."
Timing
Must be taken early morning (6:00 AM - 8:00 AM) to ensure sleep at night.
Cycling
Highly recommended. Use for intense deep work phases, then take 2-3 days off to reset the dopamine receptors.
Cost
€70-130 per pack (Expensive, as it is still under patent/brand-protection in many regions).
Evidence Grade
A+ (Gold standard for adult ADHD).
Synergies
Magnesium-Glycinat: Essential against muscle tension. Vitamin C: Taking high doses in the evening helps "flush" the remaining amphetamine out of the system.
Warnings
High risk of cardiovascular strain when combined with other stimulants. Potential for "Amphetamine Psychosis" if abused or combined with extreme sleep deprivation.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
8/10
10/10
3/10
9/10

── V: HORMONAL MODULATION ──

TESTOSTERON (Test E / Test C)

Category
V: HORMONAL MODULATION
Intro
The primary male sex hormone and the absolute pillar of every steroid cycle. It provides the essential androgenic and estrogenic base required for mental health, libido, and tissue repair. Without a testosterone base, most stacks will lead to a mental and physical crash.
Mechanism
Binds to the Androgen Receptor (AR) to promote protein synthesis and erythropoiesis. It undergoes 5α-reduction into Dihydrotestosterone (DHT) and aromatises into Oestradiol (E2). E2 is highly anabolic and neuroprotective but acts as the primary signal for epiphyseal plate closure.
Benefits
Anabolism: Drastic increase in recovery, strength, and muscle mass. Well being: Improved mood, confidence, and cognitive "drive." Bone Health: Essential for bone remodeling and density (crucial for structural integrity during growth phases).
Negatives
Aromatization: High doses lead to water retention and gynecomastia without an AI. Shutdown: Suppresses the natural HPG axis (requires HCG/HMG to maintain fertility). Cosmetic: Potential for acne and accelerated hair loss in prone individuals.
Dosage
TRT/Cruise: 100mg - 150mg/week. Blasting: 300mg - 600mg+ per week. For height maxxing purposes, a moderate dose (200-250mg) is often superior to avoid premature plate maturation.
Timing
Intramuscular (IM) injection is preferred for stable kinetics. Split the weekly dose into at least two injections (e.g., Monday/Thursday) to minimize E2 spikes.
Cycling
Can be run in "Blasts" (16-24 weeks) followed by a "Cruise" (TRT dose). Never fully "off" if you want to maintain supraphysiological gains.
Cost
€25-50 per 10ml vial (UGL) / €0.20-0.50 per day. Extremely cost effective.
Evidence Grade
A++ (The most studied anabolic compound in human history).
Synergies
Growth Hormone: Synergistic elevation of systemic IGF-1. Letrozole: Mandatory synergy for height maxxing to block E2 induced plate closure. Telmisartan: To manage blood pressure elevations from increased red blood cell count.
Warnings
Monitor Hematocrit and Blood Pressure regularly. If used during puberty for height maxxing, E2 levels must be nuked to near zero to prevent permanent height loss.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
8/10
10/10
9/10
10/10

MASTERON (MAST E / MAST P)

Category
V: HORMONAL MODULATION
Intro
A dihydrotestosterone (DHT) derived anabolic steroid. Originally developed as an anti breast cancer medication, it is now the gold standard for achieving a "hard," grainy, and dry physique. It is a non aromatizing compound with mild anti estrogenic properties.
Mechanism
Binds with high affinity to the Androgen Receptor (AR). As a DHT derivative, it cannot convert to Estrogen. It acts as a weak Aromatase Inhibitor (AI) by competing for the aromatase enzyme, effectively lowering the amount of Testosterone that converts to E2.
Benefits
Cosmetic: Forces intracellular water into the muscle and eliminates subcutaneous bloat ("The Dry Look"). Neurogenic: Increases CNS drive and aggression/focus without the "Tren brain" toxicity. SHBG Lowering: Binds to SHBG, leaving more Free Testosterone available for muscle growth.
Negatives
Androgenic Side Effects: High risk for accelerated male pattern baldness (MPB) and acne. Prostate: Can cause Benign Prostatic Hyperplasia (BPH) in high doses. Lipids: Can be harsh on HDL/LDL ratios, requiring Statin support.
Dosage
Mild/Support: 200mg - 300mg/week. Hardcore/Contest: 400mg - 600mg+/week.
Timing
Propionate (Mast P) requires EOD injections; Enanthate (Mast E) can be injected twice weekly (e.g., Monday/Thursday).
Cycling
Often used in the last 8-12 weeks of a "Shredding" phase or as a permanent "Feel Good" addition to a TRT+ cruise.
Cost
€35-60 per 10ml vial (UGL). Moderately priced.
Evidence Grade
A (Decades of use in clinical and athletic settings).
Synergies
Testosterone: Mast allows you to run higher Test doses with less Letrozole. Tirzepatide: Enhances the "shredded" look by maintaining muscle fullness during extreme fat loss. Winstrol: Synergistic "dryness" for the ultimate peak week.
Warnings
If you value your hair, use RU-58841 topically. Masteron will "rape" your hair follicles if they are genetically sensitive. Monitor prostate health via PSA markers if used long-term.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
8/10
9/10
7/10
8/10

ANAVAR (OXANDROLONE)

Category
V: HORMONAL MODULATION
Intro
Often called the "Girl Steroid," which is a massive 140 IQ underestimation. It is a highly anabolic, low androgenic oral steroid. Originally designed for tissue wasting diseases and bone density improvement, it is now the premier choice for strength to weight ratio optimization and "dry" gains.
Mechanism
A 17α-alkylated DHT derivative. It is unique because it is primarily metabolized by the kidneys rather than the liver, making it significantly less hepatotoxic than other orals like D-Bol or Adrol. It increases Creatine Phosphate synthesis in the muscle cells, leading to rapid strength gains without water retention.
Benefits
Strength: Drastic increase in ATP regeneration; you will lift more without getting "bulky." Lipolysis: Proven to reduce visceral and subcutaneous fat directly (synergy with Tirzepatide). Bone Health: Increases hydroxyproline and bone mineral content (synergy for height-maxxing support). Vaskularity: Promotes a "veiny," roadmap like look within days.
Negatives
Lipids: Known to nuke HDL (good cholesterol) rapidly. Kidneys: High doses over long periods can strain renal function. Pump Pain: Can cause "back pumps" (painful lower back cramps) due to extreme intracellular water shifting.
Dosage
Low/Support: 20mg - 30mg/day. Performance: 50mg - 80mg/day.
Timing
Split dose twice daily (e.g., morning/pre workout) due to a short half life of ~9-10 hours.
Cycling
6-8 weeks as a "kickstart" to a blast or a "finisher" before a photoshoot/event.
Cost
€40-80 per 100 tabs (10mg). One of the most faked/expensive orals (often replaced with cheap Winny).
Evidence Grade
A++ (Extensive medical history in pediatrics and burn victims).
Synergies
Creatine Monohydrate: Mandatory to maximize the ATP pathway. Telmisartan: To protect the kidneys from the increased filtration load. Taurine: 3-5g daily to stop painful "back pumps."
Warnings
Must monitor LDL/HDL. Since it’s a DHT derivative, it won't aromatize, but it can suppress SHBG, making your Testosterone base aromatize more. Adjust Letrozole accordingly.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
10/10
4/10
9/10

WINSTROL (STANOZOLOL)

Category
V: HORMONAL MODULATION
Intro
The legendary "cutting" steroid. Winstrol is a DHT derivative altered to be highly anabolic with minimal androgenic activity. It is the gold standard for competitive bodybuilders and athletes requiring explosive power without added water weight. It is famous for creating a 3D, "photoshopped" muscle look.
Mechanism
A 17α-alkylated steroid (oral) or aqueous suspension (injectable). It has a unique ability to antagonize Progesterone receptors and significantly lower SHBG (Sex Hormone Binding Globulin). By nuking SHBG, it drastically increases the amount of "Free Testosterone" in the bloodstream, amplifying the effects of every other compound in the stack.
Benefits
Hardness: Forces every drop of extracellular water out of the body, creating a dry, "hard as rock" muscle texture. Power: Increases explosive strength and speed without mass gain (used by sprinters). Synergy: Makes all other steroids work "harder" by freeing up bound hormones. Non-Aromatizing: Zero conversion to Estrogen.
Negatives
Joint Health: Known for "drying out" joints, leading to severe pain and increased injury risk. Lipids: One of the harshest compounds on HDL/LDL cholesterol levels. Liver: High hepatotoxicity (oral version). Androgenic: Can be brutal on the hairline (DHT-derivative).
Dosage
Oral: 20mg - 50mg/day (Split dose). Injectable: 50mg every other day (EOD).
Timing
Oral has a half life of ~9 hours; split morning and evening. Injectable (Water based) is painful but bypasses the first pass liver metabolism.
Cycling
Strictly limited to 4-6 weeks, usually at the very end of a "Shredding" phase
Cost
€25-45 per 100 tabs (10mg). Very affordable, rarely faked.
Evidence Grade
A (Decades of clinical use in treating hereditary angioedema and anemia).
Synergies
Testosterone: Required base to combat "lethargy" and joint dryness. Glucosamine/Chondroitin: Essential to protect joint integrity. Taurine: To manage the extreme muscle pumps. NAC: Mandatory for liver protection.
Warnings
If you are already using Letrozole for height maxxing, be EXTREMELY careful with Winstrol. The combination of low E2 (from Letro) and Winstrol will make your tendons as brittle as glass. Avoid heavy 1-rep-max lifting on this combo.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
6/10
10/10
10/10
9/10

ENCLOMIPHENE (ENCLO / ANDROXAL)

Category
V: HORMONAL MODULATION
Intro
The purified trans-isomer of Clomiphene Citrate. Unlike standard Clomid (which contains Zuclomiphene, a long acting estrogen agonist), Enclomiphene acts as a pure estrogen antagonist in the pituitary gland. It is the gold standard for "non suppressive" testosterone enhancement and PCT.
Mechanism
Acts as a Selective Estrogen Receptor Modulator (SERM). It blocks the negative feedback of Estrogen at the hypothalamus and pituitary gland. This tricks the brain into thinking E2 is too low, triggering a massive release of LH (Luteinizing Hormone) and FSH (Follicle Stimulating Hormone), which forces the testes to produce more endogenous Testosterone and sperm.
Benefits
HPTA Restart: The most effective compound for restoring natural production after a cycle. Test Boost: Can double or triple natural testosterone levels while maintaining fertility. Mental Clarity: Lacks the "emotional/depressive" side effects of Zuclomiphene (found in Clomid). Oral Bioavailability: No needles required for a significant hormonal boost.
Negatives
IGF-1 Suppression: Like most SERMs, it can slightly lower systemic IGF-1 levels (counterproductive for height-maxxing). Vision: Rare reports of "floaters" or light sensitivity (though less than Clomid). E2 Management: High LH leads to high Test, which can lead to high E2; an AI might still be needed.
Dosage
Monotherapy/PCT: 6.25mg - 12.5mg daily. High Dose Recovery: 25mg daily.
Timing
Once daily, ideally in the morning to mimic natural circadian rhythms.
Cycling
Can be used for 4-6 weeks as a PCT or as a long term "Test Base" for mild SARM cycles.
Cost
€40-70 per 30ml (Liquid/UGL) or 50 tabs (12.5mg). Harder to source than Clomid but worth the premium.
Evidence Grade
A (Extensively studied in Phase II and III clinical trials for hypogonadism).
Synergies
HCG: To keep the testes primed during a cycle before switching to Enclo for PCT. Boron: 6-10mg daily to lower SHBG and further increase Free Testosterone. NAC: To support general health during recovery.
Warnings
Do not use if you have pre existing vision issues. While it keeps the HPTA "on," it cannot compete with the suppression of heavy compounds like Trenbolone or highdose Deca.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
10/10
9/10
7/10
9/10

ANASTROZOLE (ADEX)

Category
V: HORMONAL MODULATION
Intro
A potent, reversible non-steroidal aromatase inhibitor (AI). It is the most commonly used ancillary in the bodybuilding community to combat the side effects of aromatizing steroids. It allows for precise control over oestradiol levels without the extreme potency of Letrozole.
Mechanism
Competitively binds to the aromatase enzyme, preventing the conversion of androgens (Testosterone) into oestrogens (Oestradiol). It is a "Type II" AI, meaning it binds reversibly; once the drug leaves the system, the enzyme can function again.
Benefits
E2 Control: Effectively prevents gynecomastia, water retention (bloat), and high blood pressure. Aesthetics: Keeps the physique "dry" and defined during high-dose Testosterone cycles. Hormonal Balance: Helps maintain the ideal T:E2 ratio for libido and mental health.
Negatives
Lipid Strain: Can negatively impact HDL/LDL cholesterol (synergy with Statins required). Bone Health: Long-term crushed E2 leads to decreased bone mineral density (high risk if not monitored). Joint Pain: Low E2 causes "dry" and clicking joints.
Dosage
Prevention: 0.25mg - 0.5mg Every Other Day (EOD). Acute Issues: 1mg daily until symptoms (nipple sensitivity) subside.
Timing
Can be taken any time of day, with or without food. Has a half-life of ~40-50 hours.
Cycling
Used throughout the entire duration of a cycle involving aromatizing compounds (Test, D-Bol).
Cost
€20-40 per 28-30 tabs (1mg). Extremely affordable and widely available.
Evidence Grade
A++ (Clinical gold standard for breast cancer and hormonal therapy).
Synergies
Testosterone: Essential to manage the inevitable aromatization. Telmisartan: To offset the BP elevating effects of potential E2 spikes. Pitavastatin: To protect lipids from AI induced strain.
Warnings
Do not "nuke" your E2. Oestrogen is needed for brain health, libido, and muscle growth. Only use enough to stay within the high normal range (20-40 pg/mL) unless height maxxing.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
10/10
10/10
10/10
10/10

EXEMESTANE (AROMASIN)

Category
V: HORMONAL MODULATION
Intro
A potent, permanent (suicidal) aromatase inactivator. Unlike non steroidal AIs (Adex/Letro), Exemestane is a steroidal compound structurally related to androstenedione. It is preferred by many high level users for its lack of "estrogen rebound" and its slight androgenic feel.
Mechanism
Acts as a Type I Aromatase Inhibitor. It binds irreversibly to the aromatase enzyme, forming a permanent bond that deactivates it ("suicide inhibition"). The body must synthesize new enzymes to resume aromatization. It also possesses a metabolite, 17ß-Hydroxyexemestane, which has high affinity for the androgen receptor.
Benefits
No Rebound: Since the enzymes are destroyed, there is no sudden spike in E2 after cessation. IGF-1 Support: Unlike other AIs, it may slightly increase IGF-1 levels, which is synergistic with HGH. Libido: Often reported to be "better" for sexual drive compared to non-steroidal AIs due to its androgenic nature.
Negatives
Hair Loss: The metabolite 17ß-Hydroxyexemestane is highly androgenic and is known to "rape" the hairline in prone individuals. Lipids: Harsh on HDL/LDL (though slightly less so than Letrozole). Dosing Difficulty: Because it is permanent, "crushing" your E2 by accident is much harder to fix quickly.
Dosage
Standard: 12.5mg - 25mg Every Other Day (EOD) or every 3 days.
Timing
Must be taken with a high fat meal to ensure proper absorption (bioavailability increases by ~40% with fats).
Cycling
Used throughout the cycle; especially useful for those prone to E2 rebounds or those utilizing high dose HGH.
Cost
€40-80 per 30 tabs (25mg). More expensive than Anastrozole.
Evidence Grade
A+ (Clinical gold standard for post menopausal breast cancer).
Synergies
Growth Hormone: Best AI to pair with HGH due to the lack of IGF-1 suppression. Dutasteride/RU-58841: MANDATORY if you want to keep your hair while using this compound.
Warnings
Exemestane is a "one-way street" for the enzyme. If you crash your E2, you have to wait days/weeks for new enzymes to grow or use Dianabol/Exogenous E2 for an acute fix.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
7/10
10/10
6/10
8/10

TAMOXIFEN (NOLVADEX)

Category
V: HORMONAL MODULATION
Intro
A first generation Selective Estrogen Receptor Modulator (SERM). While originally a breast cancer medication, it is the most essential emergency drug in a steroid user's arsenal to combat developing gynaecomastia (bitch tits) and a core component of traditional PCT protocols.
Mechanism
Acts as an Estrogen Receptor Antagonist in the mammary (breast) tissue by competing for the receptor site. However, it acts as an Estrogen Agonist in other tissues like the liver and bone. By blocking E2 in the pituitary, it stimulates the release of LH and FSH to restart natural testosterone production.
Benefits
Gyno Protection: The #1 drug to stop itchy or sore nipples mid cycle without crushing systemic E2. Lipids: Improves the lipid profile (HDL/LDL) because it acts like estrogen in the liver. Bone Density: Helps maintain bone mineral density (estrogen agonist in bone). PCT: Proven to effectively restart the HPTA axis after suppression.
Negatives
IGF-1 Suppression: Significantly lowers systemic IGF-1 levels (counterproductive for height maxxing and muscle growth). Brain Fog: Some users report "chemo brain" or reduced cognitive clarity. Vision: Long term use or high doses carry a risk of cataracts or retinal changes.
Dosage
Gyno Flare up: 20mg - 40mg daily until symptoms disappear. PCT: 20mg daily for 4-6 weeks.
Timing
Once daily. Half life is long (~5-7 days), so timing is flexible, but consistency is key.
Cycling
Only used during PCT or as an emergency intervention during a "Blast." Not intended for long-term use during a cycle.
Cost
€20-40 per 30-60 tabs (20mg). Very cheap and widely available.
Evidence Grade
A++ (Decades of clinical use and FDA approval).
Synergies
Testosterone: To prevent gyno while keeping E2 high enough for its anabolic benefits. HCG: Used at the end of a cycle to prime the testes before starting Tamoxifen for PCT.
Warnings
Do not use Tamoxifen if you are using 19-nor compounds like Trenbolone or Deca to treat gyno: it can potentially upregulate Progesterone receptors, making "Tren Gyno" worse. Use P-5-P or Cabergoline instead for 19-nors.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
10/10
10/10
10/10
10/10

RALOXIFENE (RALO)

Category
V: HORMONAL MODULATION
Intro
A second-generation SERM. While Tamoxifen is the classic choice for PCT, Raloxifene is the superior compound for targeted gynaecomastia reversal and bone mineral density maintenance. It is highly tissue-specific, making it a favorite for "aesthetic first" athletes.
Mechanism
Acts as a potent Estrogen Receptor Antagonist in breast tissue and an Estrogen Agonist in bone. It has a higher binding affinity for the estrogen receptor in the mammary glands than Tamoxifen, making it more effective at shrinking established pubertal or steroid induced gyno.
Benefits
Gyno Reversal: The gold standard for reducing existing lumps (glandular tissue). Bone Health: Strongly promotes bone mineralization (used to treat osteoporosis). IGF-1 Integrity: Significantly less suppressive to systemic IGF-1 levels compared to Tamoxifen. Lipids: Positive effect on LDL cholesterol without the "bloat" of exogenous estrogen.
Negatives
Thrombosis Risk: Like all SERMs, it slightly increases the risk of blood clots (DVT). Leg Cramps: Some users report muscle cramps or hot flashes. PCT Efficiency: Not as effective as Enclomiphene or Tamoxifen for restarting the HPTA axis (LH/FSH stimulation is weaker).
Dosage
Acute Gyno Reversal: 60mg daily until the lump shrinks (can take 3-6 months), then taper to 30mg. Maintenance: 30mg daily.
Timing
Once daily, with or without food. Long half life (~28 hours).
Cycling
Can be used mid cycle to combat flare-ups or as a targeted treatment for several months to reverse old gyno.
Cost
€50-90 per pack. More expensive and harder to source than Tamoxifen.
Evidence Grade
A (Solid clinical data for both osteoporosis and gynaecomastia treatment).
Synergies
HGH: The best SERM to pair with Growth Hormone, as it preserves IGF-1 levels better than Nolvadex. Letrozole: Combined with a strong AI, Raloxifene is the ultimate "Gyno Nuke." Vitamin D3/K2: Synergistic for bone density during height maxxing.
Warnings
Monitor for any signs of calf pain or shortness of breath (clot risk). If gyno is "Grade 3" or very old (calcified), surgery is the only 100% fix, but Ralo is the best pharmaceutical attempt.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
9/10
9/10
4/10
9/10

CABERGOLINE (CABER / DOSTINEX)

Category
V: HORMONAL MODULATION
Intro
A potent, long acting dopamine receptor agonist with a high affinity for the D2 receptor. In the bodybuilding world, it is the primary defense against hyperprolactinemia caused by 1-9-nor compounds (Trenbolone, Nandrolone). It is also legendary for its "lifestyle" benefits regarding sexual performance.
Mechanism
Directly stimulates Dopamine D2 receptors in the lactotroph cells of the pituitary gland. This inhibits the secretion of Prolactin. By keeping Prolactin low, it prevents the negative feedback loop that suppresses LH/FSH and causes sexual dysfunction ("Deca Dick").
Benefits
Prolactin Control: Eliminates nipple discharge (lactation) and gyno caused by Prolactin. Refractory Period: Dramatically reduces or eliminates the refractory period between orgasms (the "Multi Shot" effect). Mood: Increases drive and motivation due to higher dopaminergic signaling. Sleep: Often improves sleep quality and vividness of dreams (synergy with Donepezil).
Negatives
Heart Valves: High doses (medical/Parkinson's levels) are linked to cardiac valvulopathy. Dopamine Dysregulation: Risk of compulsive behaviors (gambling, hypersexuality) if abused. Blood Pressure: Can cause orthostatic hypotension (dizziness when standing up). GH Suppression: High doses can slightly lower GH/IGF-1 levels.
Dosage
On Cycle (Tren/Deca): 0.25mg - 0.5mg twice weekly (e.g., Monday/Thursday). Acute High Prolactin: 0.5mg every 3 days until levels normalize.
Timing
Ideally taken before bed to mitigate potential nausea or dizziness.
Cycling
Only used when running 19-nor compounds or when bloodwork shows elevated Prolactin.
Cost
€60-120 per 8 tabs (0.5mg). One of the most expensive ancillaries per pill.
Evidence Grade
A++ (Medical gold standard for prolactinomas).
Synergies
Trenbolone: Essential to maintain sexual function and mental stability. P-5-P: Can be used alongside to keep the Caber dose lower. Lisdexamfetamine: CAUTION: both affect dopamine; potential for overstimulation/anxiety.
Warnings
Do not "crash" Prolactin to zero some is needed for immune function and mental health. Monitor heart health if used long term. Avoid combining with heavy stimulants without checking blood pressure first.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
10/10
10/10
2/10
9/10

CRITICAL INTERACTIONS

Key Interactions to Know

Tadalafil + Nitrates
ABSOLUTE CONTRAINDICATION life-threatening hypotension.
Tadalafil + Citrulline
Additive vasodilation reduce citrulline dose.
Modafinil + Stimulants
Additive cardiovascular load. Avoid stacking with Salbutamol same day if concerned.
Racetams + Choline
ALWAYS supplement choline with racetams headache and brain fog without it.
Finasteride + Aromatase
Reducing DHT shifts T→E2 balance monitor estrogen if using long-term.
Isotretinoin + Vitamin A
Never combine with high dose Vitamin A supplements additive toxicity.

For Peptides: see Peptide Megathread. For Supplements: see Supplement Megathread.

mirin good effort

exvh · 2026-04-06T13:32:50-0500

nice, mirin the effort

sherry12 · 2026-04-06T18:37:04-0500

til<3D said:
PHARMACEUTICAL MEGATHREAD

Skin, Vascularity, Fat Loss, Cognitive Enhancement & PEDs

April 2026

DISCLAIMER

Legal
These are pharmaceutical compounds requiring prescriptions in most countries. This guide is for educational purposes only. Not medical advice.
Covered
Section I: Skin & Dermatology | Section: ||: Fat Loss and Metabolic Shredding | Section III: Vascularity & Performance | Section IV: Cognitive Enhancement (Nootropics) | Section V: Hormonal Modulation
Section V
I honestly have very little knowledge about steroids in general, so I just included the input I happened to know. I’d definitely say there are much better threads out there on this topic.

QUICK REFERENCE

Compound
Category
Evidence
Key Use
Cost
Overall
Tretinoin
I
A+
Vitamin A derivative (retinoid).
9/10
10/10
Isotretinoin (Accutane)
I
A+
Systemic oral retinoid...
6/10
9/10
Azelaic Acid
I
A
Dicarboxylic acid with multiple mechanisms.
9/10
8/10
Adapalene (0.1% / 0.3%)
I
A
Third generation retinoid.
9/10
7/10
Finasteride
I
A
Type II 5 alpha reductase inhibitor.
9/10
7/10
Dutasteride
I
B+
Inhibits BOTH type I and type II 5 alpha reductase, reducing DHT by ~95% vs finasteride's ~70%.
8/10
7/10
Ketoconazole (Topical)
I
B
Imidazole antifungal used topically as shampoo or cream.
10/10
6/10
Clenbuterol
||
A
Powerful thermogenic for final contest prep / extreme cutting.
9/10
7/10
Salbutamol (Albuterol)
||
A
Manageable fat loss & bronchodilation, short acting.
10/10
6/10
Yohimbine HCL
||
B+
Fasted cardio tool for alpha 2 receptor (stubborn fat) blockade.
9/10
6/10
Liothyronine (T3)
||
A
Direct metabolic acceleration, high risk of muscle wasting.
8/10
5/10
Levothyroxine (T4)
||
A
Long term metabolic baseline support, smoother than T3.
9/10
6/10
Metformin
||
A+
Insulin sensitivity & AMPK activation, "Health-Maxxing" during cut.
10/10
9/10
DNP (2,4 Dinitrophenol)
||
B
Lethal mitochondrial uncoupling, extreme weight loss.
5/10
0/10
Sibutramine
||
B-
Aggressive appetite suppression, high cardiovascular risk.
6/10
3/10
Tirzepatide (Mounjaro)
||
A+
The "God tier" GLP-1/GIP agonist for total appetite control.
10/10
10/10
Orlistat
||
A
Blocking dietary fat absorption, for high fat "cheat" scenarios.
8/10
4/10
Tadalafil (Cialis)
III
A
PDE5 inhibitor with ~17.
8/10
8/10
Sildenafil (Viagra)
III
A
The original PDE5 inhibitor.
8/10
7/10
Telmisartan
III
A
AT1 receptor antagonist (ARB) for hypertension.
9/10
6/10
Nebivolol
III
A
Third generation selective beta 1 blocker.
8/10
6/10
Modafinil
IV
A
Wakefulness promoting agent originally developed for narcolepsy.
8/10
8/10
Armodafinil
IV
A
R-enantiomer of modafinil...
7/10
8/10
Piracetam
IV
B
The original racetam, synthesized in 1964.
9/10
6/10
Aniracetam
IV
B-
Fat soluble racetam with additional anxiolytic properties.
8/10
5/10
Phenylpiracetam
IV
C+
Piracetam with a phenyl group added produces stimulant effects
in addition to cognitive enhancement.
7/10
5/10
Pramiracetam
IV
B-
One of the most potent racetams per mg.
6/10
5/10
Semax
IV
B+
Synthetic ACTH(4-7) analogue developed in Russia for cognitive
enhancement and neuroprotection.
8/10
8/10
Memantine
IV
A
NMDA receptor antagonist approved for Alzheimer's treatment.
7/10
5/10
Donepezil
IV
B+
An atypical stimulant with anxiolytic properties (Actoprotector). Developed in Russia.
6/10
9/10
Methylphenidate (Ritalin)
IV
A+
Laser like focus. Immediate suppression of "distraction."
9/10
9/10
Lisdexamfetamine (Vyvanse / Elvanse)
IV
A+
10-12 hours of ultra consistent focus. Less edgy than Ritalin. High functional output.
5/10
8/10
Test Enanthate / Cypionate
V
A+
The bio identical foundation of any hormonal cycle. Essential for nitrogen retention and muscle protein synthesis.
10/10
10/10
Masteron (Drostanolone)
V
B
Providing a "hard," dry look: acts as a mild anti estrogen. Best used at low body fat.
7/10
8/10
Anavar (Oxandrolone)
V
A
Significant strength gains and muscle fullness without water retention (dry gains).
4/10
9/10
Winstrol (Stanozolol)
V
B+
Achieving the "Granite Look", flushes out subcutaneous water.
8/10
9/10
Enclomiphene
V
B+
Raising natural testosterone levels while preserving fertility and testicular size.
7/10
9/10
Anastrozole (Arimidex)
V
A
Managing high Estrogen (E2) side effects like bloating or early stage Gyno.
6/10
10/10
Exemestane (Aromasin)
V
A
Irreversibly binds to the aromatase enzyme, prevents "Estrogen Rebound."
6/10
9/10
Tamoxifen (Nolvadex)
V
A
Blocking Estrogen in breast tissue and restarting natural testosterone production (HPTA).
10/10
10/10
Raloxifene
V
A
The most effective compound for reversing existing Gynaecomastia (glandular tissue).
4/10
9/10
Cabergoline (Dostinex)
V
A
Lowering Prolactin levels: treats "puffy nipples" and significantly reduces the sexual refractory period.
2/10
8/10

COMPOUND PROFILES

── I. FACIAL AESTHETICS & SKIN ──

TRETINOIN

Category
I. Facial Aesthetics & Skin
Intro
Vitamin-A derivative (retinoid). The gold standard topical for acne treatment, skin texture improvement, and collagen stimulation. Requires prescription in most countries but widely available via online pharmacies. One of the most evidence backed topical compounds in dermatology.
Mechanism
Binds RAR alpha, beta, gamma nuclear receptors → upregulates keratinocyte differentiation genes. Accelerates cell turnover (shortens skin cycle from 28 to 14 days). Inhibits comedogenesis. Stimulates collagen I/III synthesis via TGF beta pathway.
Benefits
Acne clearance (inflammatory and non inflammatory). PIE/PIH reduction via cell turnover. Anti aging effects (reduces fine lines, improves texture). Collagen synthesis. Long term: skin rejuvenation.
Negatives
Retinization period: peeling, redness, sensitivity weeks 1-8 (not a reason to stop).
Photosensitization: SPF mandatory. Pregnancy category X, absolutely contraindicated.
Dosage
0.025% start → titrate to 0.05-0.1%. Pea sized amount entire face.
Timing
Nights only. 20-30 min after cleansing on dry skin. Moisturizer after.
Cycling
Continuous, no cycling. Effects compound over 6-12 months.
Cost
€15-40 via online pharmacies.
Evidence Grade
A+ Gold standard dermatology compound. Decades of RCT data.
Synergies
Azelaic acid (PIE stack). Niacinamide (barrier support). GHK-Cu (complementary collagen).
Warnings
SPF 50+ daily mandatory. Never use with benzoylperoxide same application. Buffer method (moisturizer first) reduces irritation.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
8/10
10/10
9/10
10/10

ISOTRETINOIN (ACCUTANE)

Category
I. Facial Aesthetics & Skin
Intro
Systemic oral retinoid. The only pharmaceutical that permanently reduces sebaceous gland size and output essentially resets the skin. Used for moderate severe acne. The most effective acne treatment in existence.
Mechanism
Systemic RAR activation → sebaceous gland atrophy (permanent reduction in sebum output by ~90%). Normalizes follicular keratinization. Anti inflammatory. Modulates immune cells in skin.
Benefits
Permanent acne resolution in most patients. Skin texture transformation. Anti aging effects (deeper retinoid effects than topical). Long term remission rates >80% after one course.
Negatives
Initial flare possible. Dry lips/skin/eyes (standard). Mood effects (monitor).
Liver enzyme elevation
Dosage
0.5-1mg/kg/day. Typical course 16-24 weeks to cumulative 120-150mg/kg.
Timing
With fatty meal (fat soluble).
Cycling
Single course usually sufficient. Repeat if relapse.
Cost
€50-200/month depending on dose and source.
Evidence Grade
A+ Most effective acne treatment in existence. Decades of data.
Synergies
Moisturizer + SPF (essential alongside). Lip balm.
Warnings
Pregnancy Category X catastrophic birth defects. Mental health monitoring.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
7/10
10/10
6/10
9/10

AZELAIC ACID

Category
I. Facial Aesthetics & Skin
Intro
Dicarboxylic acid with multiple mechanisms. Available OTC at 10% or prescription at 20%. Particularly effective for PIE, rosacea, and mild-moderate acne. UV stable can be used morning or evening.
Mechanism
Inhibits tyrosinase (reduces melanin/PIE). Antibacterial against P. acnes (without resistance development). Anti inflammatory (inhibits IL-1, TNF-alpha, reactive oxygen species). Mild keratolytic.
Benefits
PIE and redness reduction. Acne treatment (mild-moderate). Rosacea. Well tolerated, suitable for sensitive skin. UV stable means morning use fine.
Negatives
Mild tingling/burning initially. 15-20% may experience skin irritation. Slower acting than tretinoin.
Dosage
10% OTC or 20% prescription. Thin layer affected areas.
Timing
Morning (UV stable) or evening after tretinoin (wait 20 min).
Cycling
Continuous.
Cost
€10-25 for prescription 20% strength.
Evidence Grade
A FDA approved for acne and rosacea. Extensive RCT data.
Synergies
Tretinoin (dual PIE attack). Niacinamide. Tinted sunscreen.
Warnings
Mild initial irritation normal. If persistent burning stop use. Do not combine with high concentration glycolic acid.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
9/10
9/10
8/10

ADAPALENE (0.1% / 0.3%)

Category
I. Facial Aesthetics & Skin
Intro
Third generation retinoid. Binds RAR-beta and gamma but NOT alpha, the receptor responsible for most retinoid side effects. This selectivity makes it significantly less irritating than tretinoin while maintaining comparable efficacy for acne.
Mechanism
RAR-beta/gamma selectivity → keratinocyte differentiation without RARa-mediated irritation. Inhibits AP-1 transcription factor → anti-inflammatory. TLR-2 modulation → immune response in follicles.
Benefits
Acne efficacy comparable to tretinoin 0.025%. Significantly less irritation. Available OTC (0.1% in some countries). Better option for sensitive skin or during tretinoin retinization.
Negatives
Weaker than tretinoin 0.05-0.1% for anti aging and texture. Less collagen stimulation than tretinoin. Still causes some photosensitization.
Dosage
Pea sized 0.1% nightly. Can step up to 0.3%.
Timing
Night only. After cleansing.
Cycling
Continuous.
Cost
€15-30 OTC.
Evidence Grade
A FDA approved. RCT data comparable to tretinoin for acne.
Synergies
Azelaic acid. Niacinamide.
Warnings
SPF mandatory. Not as powerful as tretinoin for skin remodeling — use tretinoin if tolerated.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
9/10
9/10
9/10
7/10

FINASTERIDE

Category
I. Facial Aesthetics & Skin
Intro
Type II 5-alpha reductase inhibitor. Reduces DHT by ~70%. Used clinically for BPH and male pattern baldness. The most common pharmaceutical intervention for hair loss. At 17-18 years use with extreme caution given ongoing hormonal development.
Mechanism
Inhibits 5-alpha reductase type II → reduces conversion of testosterone to DHT in hair follicles and prostate. DHT binds AR on dermal papilla cells → miniaturization. Finasteride prevents this.
Benefits
Halts and partially reverses androgenetic alopecia. Reduces DHT systemically. Skin quality improvement in acne-prone users.
Negatives
Post finasteride syndrome (persistent sexual dysfunction in subset of users, mechanism debated). Reduces DHT ~70% systemically affecting all DHT-dependent processes. Libido changes. Not for use under 18.
Dosage
1mg/day for hair loss.
Timing
Any time, consistent.
Cycling
Continuous stopping causes DHT rebound and renewed hair loss.
Cost
€15-30/month generic.
Evidence Grade
A FDA approved. Decades of RCT data for AGA.
Synergies
Minoxidil topical (gold standard hair loss stack).
Warnings
Not recommended at 17-18 due to ongoing hormonal development. Post-finasteride syndrome, small but real risk. Monitor libido/sexual function.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
9/10
9/10
7/10

DUTASTERIDE

Category
I. Facial Aesthetics & Skin
Intro
Inhibits BOTH type I and type II 5-alpha reductase —> reducing DHT by ~95% vs finasteride's ~70%. More potent hair loss treatment but also more systemic DHT suppression. Used off label for hair loss.
Mechanism
Dual type I/II 5AR inhibition → ~95% DHT reduction. Type I found in skin and liver (unlike finasteride which only hits type II). More complete DHT suppression.
Benefits
Superior hair retention vs finasteride in head-to-head studies. Greater scalp DHT reduction. Skin acne improvement.
Negatives
All finasteride warnings apply, amplified. 95% DHT reduction is significant, DHT has important roles in libido, cognitive function, muscle fullness. Not for under 18.
Dosage
0.5mg every day or 2.5mg weekly.
Timing
Any time.
Cycling
Continuous.
Cost
€20-40/month.
Evidence Grade
B+ Multiple RCTs vs finasteride and placebo. Not FDA approved for hair loss (approved for BPH).
Synergies
Minoxidil topical.
Warnings
Even stronger systemic DHT suppression than finasteride. Same post-finasteride syndrome risk. Not at 17-18.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
7/10
8/10
8/10
7/10

KETOCONAZOLE (TOPICAL)

Category
I. Facial Aesthetics & Skin
Intro
Imidazole antifungal used topically as shampoo or cream. Directly inhibits DHT binding at androgen receptors in scalp follicles. Widely available OTC as shampoo (Nizoral). Often used as adjunct in hair loss protocols.
Mechanism
Inhibits sterol synthesis in fungi (antifungal mechanism). In hair follicles: directly competes with DHT at androgen receptor. Also reduces scalp inflammation. Some sebum reduction.
Benefits
Adjunct hair loss treatment. Seborrheic dermatitis treatment. Anti-inflammatory scalp effects. Minimal systemic absorption from topical use.
Negatives
Only topical, very limited systemic effects. May dry hair with frequent use. Not a standalone hair loss treatment.
Dosage
Nizoral shampoo 2%, leave 5 min on scalp 2-3x/week.
Timing
Any time during shower.
Cycling
Continuous.
Cost
€8-15/month.
Evidence Grade
B Controlled studies showing hair loss benefit as adjunct. Less RCT data than finasteride.
Synergies
Finasteride or dutasteride (complementary mechanism, receptor blockade vs DHT reduction).
Warnings
Minimal safety concerns with topical use. Some users report hair dryness.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
10/10
6/10
10/10
6/10

── II. Fat Loss and Metabolic Shredding ──

CLENBUTEROL

Category
II. Fat Loss and Metabolic Shredding
Intro
A potent Beta-2 adrenoceptor agonist. While technically a bronchodilator for asthma, it is the bodybuilding gold standard for non hormonal fat loss and final contest prep.
Mechanism
Stimulates Beta-2 receptors → increases cAMP levels → elevates core body temperature (thermogenesis) → increases Basal Metabolic Rate (BMR) by ~5-10%.
Benefits
Rapid fat oxidation. Slight anti catabolic effect (muscle sparing) during heavy deficits. Direct stimulation of the central nervous system for increased output.
Negatives
Long half life (~36h) means side effects persist 24/7. Jitters (tremor), insomnia, heavy sweating, and significant cardiac stress (tachycardia). Depletes intracellular Taurine levels.
Dosage
20mcg start → titrate up by 20mcg every few days up to 80-120mcg (advanced only).
Timing
Morning (due to long HWZ).
Cycling
Strictly 2 weeks on / 2 weeks off (to prevent receptor downregulation) or used with Ketotifen.
Cost
€15-30 per bottle / pack.
Evidence Grade
A (Extensive use in sports pharmacology).
Synergies
Taurine (3-5g daily) to prevent muscle cramps. T3 (often stacked in pro protocols, but high muscle loss risk).
Warnings
Potentially kardiotoxisch at high doses or long term use. Monitor heart rate and blood pressure constantly. Absolute contraindication with existing heart conditions.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
5/10
9/10
9/10
7/10

SALBUTAMOL (ALBUTEROL)

Category
II. Fat Loss and Metabolic Shredding
Intro
A short-acting Beta-2 adrenoceptor agonist. Primarily used as a bronchodilator for asthma, but highly effective for metabolic enhancement and fat loss in a fitness context..
Mechanism
Stimulates Beta-2 receptors → increases cAMP levels → triggers lipolysis in adipose tissue and a slight thermogenic effect. It has a much shorter half life (~4-6 hours) compared to Clenbuterol, allowing for precise control.
Benefits
Boosts metabolic rate (I would say 200 extra kcal/day). Improved breathing/cardio performance via bronchodilation. Significantly less CNS strain than long-acting stimulants.
Negatives
Can cause temporary jitters, increased heart rate (tachycardia), and mild blood pressure fluctuations. Potential for muscle cramps due to electrolyte shifts.
Dosage
4mg per dose, typically 1-3 times daily. Start with 4mg once in the morning to assess tolerance.
Timing
Morning (due to HWZ).
Cycling
Effective for short term use (e.g., the last 4 weeks of a cut). Receptor downregulation occurs with prolonged use.
Cost
€10-25 via pharmacy or online. Often very accessible.
Evidence Grade
A (Extensive clinical and athletic data).
Synergies
Taurine (3-5g daily) to prevent muscle cramps.
Warnings
Monitor heart rate and blood pressure (RR). Stop immediately if arrhythmias occur. Caution when stacking with other stimulants or if baseline RR is already low.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
10/10
10/10
8/10

YOHIMBINE HCL

Category
II. Fat Loss and Metabolic Shredding
Intro
An alpha-2 adrenoceptor antagonist derived from the bark of the African Yohimbe tree. It is specifically used for targeting "stubborn" fat areas that are resistant to normal dieting.
Mechanism
Blocks alpha-2 adrenoreceptors in adipose tissue. These receptors normally inhibit lipolysis (fat breakdown); by blocking them, Yohimbine allows catecholamines to bind to beta receptors and mobilize fat from "problem areas" like the lower back and glutes.
Benefits
Targeted lipolysis in areas with high alpha-2 density. Increased vascularity and blood flow. Works as a mild stimulant.
Negatives
Can trigger significant anxiety, cold sweats, and "inner unrest." Increases heart rate and potentially blood pressure. Insulin completely blunts the effect, making timing critical.
Dosage
0.2mg per kg of bodyweight (e.g., ~18mg for a 90kg individual). Start lower to assess tolerance.
Timing
Must be taken in a fasted state (ideally pre cardio). Even a small insulin spike from food renders it useless for fat loss.
Cycling
Effective as needed; no specific downward regulation, but ZNS fatigue can occur.
Cost
€15-30 via specialized supplement sites or pharmacies.
Evidence Grade
B+ (Solid mechanistic data and several human trials for fat loss).
Synergies
Caffeine (amplifies the effect). Fasted LISS cardio.
Warnings
Do not use if prone to anxiety or panic attacks. Avoid stacking with heavy stimulants if your baseline heart rate is already high. Monitor RR carefully.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
4/10
8/10
9/10
6/10

LIOTHYRONINE (T3)

Category
II. Fat Loss and Metabolic Shredding
Intro
Synthetic form of the thyroid hormone triiodothyronine (T3). It is the most metabolically active thyroid hormone and a powerful tool for accelerating fat loss by directly increasing the body's basal metabolic rate.
Mechanism
Directly binds to thyroid hormone receptors in cell nuclei → increases mitochondrial activity and ATP turnover → accelerates the metabolism of carbohydrates, proteins, and fats.
Benefits
Massive increase in caloric expenditure even at rest. Highly effective for breaking through fat loss plateaus
Negatives
Extremely catabolic: without adequate anabolic protection (AAS), it will rapidly burn muscle tissue alongside fat. Can cause heart palpitations, anxiety, heat intolerance, and permanent thyroid suppression if abused.
Dosage
12.5mcg - 25mcg daily for beginners. Experienced users may go up to 50mcg. Titration is mandatory.
Timing
In the morning on an empty stomach, ideally 30–60 minutes before your first meal.
Cycling
Usually limited to 4-8 weeks to minimize the risk of long term thyroid downregulation.
Cost
€15-40 via pharmacy or online sources.
Evidence Grade
A (Extensively studied in clinical and sports settings).
Synergies
Anabolic steroids (to prevent muscle wasting). Clenbuterol/Salbutamol (often stacked for synergistic thermogenesis, but adds massive cardiac strain).
Warnings
Monitor resting heart rate and body temperature. If resting HR exceeds 100 bpm, reduce dosage immediately. Risk of permanent hypothyroidism with improper use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
4/10
10/10
5/10
5/10

LEVOTHYROXINE (T4)

Category
II. Fat Loss and Metabolic Shredding
Intro
The synthetic precursor to the active thyroid hormone T3. It is the standard treatment for hypothyroidism but is used in performance contexts to maintain a high normal metabolic baseline during extended cutting phases.
Mechanism
Acts as a pro hormone that is converted into active T3 by deiodinase enzymes in the liver and peripheral tissues. This allows the body to regulate the conversion rate based on physiological demand, leading to more stable blood levels.
Benefits
Provides a smoother, more predictable metabolic boost compared to T3. Lower risk of acute muscle wasting (catabolism). Helps prevent the metabolic slowdown associated with chronic caloric restriction (e.g. when using Tirzepatide).
Negatives
Slower onset of action due to the required conversion process. Can still lead to hyperthyroid symptoms (insomnia, palpitations) if dosed too high. Requires several weeks to reach a steady state.
Dosage
50mcg - 100mcg daily. Individual requirements vary significantly; blood work for TSH and fT4 is recommended.
Timing
In the morning on an empty stomach, ideally 30–60 minutes before your first meal.
Cycling
Often used for longer durations (8-12 weeks) during a cut. Should be tapered off gradually to allow natural thyroid function to recover.
Cost
€10-25 via pharmacy. Very cost-effective.
Evidence Grade
A+ (Gold standard for thyroid replacement therapy with immense clinical data).
Synergies
Human Growth Hormone (HGH), as HGH can accelerate the conversion of T4 to T3. GH Secretagogues.
Warnings
Less "feelable" than T3, which often leads to dangerous over dosing. Monitor heart rate and temperature.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
10/10
10/10
6/10

METFORMIN

Category
II. Fat Loss and Metabolic Shredding
Intro
A biguanide primarily used for Type-2 Diabetes management, but highly popular in the longevity and bodybuilding communities for its metabolic and anti-aging properties.
Mechanism
Activates AMPK (adenosine monophosphate activated protein kinase) → mimics the physiological effects of fasting. It inhibits hepatic glucose production and increases insulin sensitivity in peripheral tissues.
Benefits
Prevents fat storage by improving nutrient partitioning. Lowers systemic inflammation and reduces IGF-1/mTOR signaling (longevity benefit). Helps maintain a lean physique.
Negatives
Gastrointestinal issues (diarrhea, bloating) are common during the titration phase. May slightly reduce maximal hypertrophy due to mTOR inhibition. Potential for Vitamin B12 deficiency over long term use.
Dosage
500mg - 1000mg daily. Start with 500mg to assess GI tolerance.
Timing
With or immediately after a meal (usually in the evening) to minimize gastrointestinal discomfort.
Cycling
Often used continuously. Some athletes cycle it "off" during heavy mass building phases to maximize mTOR signaling.
Cost
€10-20 per pack. Extremely cost effective and widely available.
Evidence Grade
A+ (One of the most researched drugs in existence with decades of safety data).
Synergies
Berberine (natural alternative/add on). Tirzepatide (excellent synergy for glucose control and weight loss).
Warnings
Risk of lactic acidosis (extremely rare in healthy individuals). Monitor B12 levels. Avoid excessive alcohol consumption while on Metformin.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
8/10
10/10
10/10
9/10

DNP (2,4-DINITROPHENOL)

Category
II. Fat Loss and Metabolic Shredding
Intro
An industrial chemical used in the manufacturing of explosives and dyes. It was briefly used as a weight loss drug in the 1930s before being banned due to extreme toxicity and fatalities.
Mechanism
Acts as a mitochondrial uncoupler. It dissipates the proton gradient across the inner mitochondrial membrane, forcing the body to burn energy (fat and carbs) as pure heat instead of producing ATP.
Benefits
Unmatched fat loss (up to 0.5kg of pure fat per day). No "ceiling" to its effectiveness.
Negatives
Fatal Hyperthermia: The body literally cooks from the inside out; there is no physiological cooling mechanism that can counteract DN induced heat.
No Antidote: If you overdose, medical science cannot save you.Severe peripheral neuropathy, rapid onset cataracts (blindness), and multi organ failure.
Dosage
Any dosage carries a risk of death. There is no "safe" therapeutic index.
Timing
Irrelevant: the compound accumulates in the system due to a long half life, leading to accidental overdoses.
Cycling
Should not be used.
Cost
Low (Industrial chemical), but the "cost" is potentially your life.
Evidence Grade
B (Documented as a potent fat burner, but primarily evidenced through toxicology reports and mortality cases).
Synergies
None. Stacking with other stimulants or thyroid hormones significantly increases the risk of immediate death.
Warnings
EXTREME LEFAL DANGER. Unlike Clenbuterol or T3, DNP does not have a biological "off switch." Inclusion in this guide is for historical and harm reduction purposes only. DO NOT USE.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
1/10
5/10
10/10
0/10

SIBUTRAMINE

Category
II. Fat Loss and Metabolic Shredding
Intro
A serotonin norepinephrine reuptake inhibitor (SNRI) originally developed as an antidepressant but primarily used as a potent appetite suppressant. It was withdrawn from many markets due to cardiovascular safety concerns.
Mechanism
Inhibits the reuptake of dopamine, norepinephrine, and serotonin in the brain → increases satiety and elevates resting metabolic rate via thermogenesis.
Benefits
Aggressive suppression of "food noise" and appetite. Increased energy expenditure. Effective for rapid weight loss in the short term.
Negatives
Significant cardiovascular strain: increases blood pressure and heart rate. High risk of dry mouth, insomnia, constipation, and in severe cases, stroke or myocardial infarction.
Dosage
10mg - 15mg daily.
Timing
In the morning.
Cycling
Not recommended for long term use (max. 4-12 weeks) due to cardiac stress.
Cost
€20-40 via gray market sources: legally unavailable in most Western countries.
Evidence Grade
B- (Documented efficacy for weight loss, but heavily overshadowed by safety data leading to its withdrawal).
Synergies
None recommended. Stacking with other stimulants (like Salbutamol) exponentially increases the risk of a cardiac event.
Warnings
High Cardiovascular Risk. Do not use if you have any history of hypertension or heart disease. Largely replaced by superior and safer GLP-1 agonists like Tirzepatide.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
7/10
6/10
6/10
3/10

TIRZEPATIDE (MOUNJARO)
Mogs Reta in my opinion
Category
II. Fat Loss and Metabolic Shredding
Intro
A dual glucose dependent insulinotropic polypeptide (GIP) and glucagon like peptide 1 (GLP-1) receptor agonist. Currently the most potent pharmaceutical tool for weight loss, surpassing Semaglutide (Ozempic) in both speed and total fat reduction.
Mechanism
Acts on two key metabolic pathways: GLP-1 (delays gastric emptying, signals satiety to the brain) and GIP (improves insulin sensitivity and lipid metabolism). It effectively "mutes" the brain's hunger signals (Food Noise) while optimizing how the body handles glucose.
Benefits
Extreme appetite suppression. Rapid fat loss while maintaining stable blood sugar. Improved insulin sensitivity. Minimal CNS stimulation compared to traditional burners (Clen/T3).
Negatives
Gastrointestinal side effects (nausea, constipation, sulfur burps) especially during titration. High cost and availability issues. Potential for "muscle wasting" if protein intake isn't strictly monitored (due to massive caloric deficit).
Dosage
2.5mg start (4 weeks) → titrate to 5mg → 7.5mg → max 15mg weekly.
Timing
Subcutaneous injection, once weekly (any time of day).
Cycling
Can be used for the duration of a cut (8-16 weeks) or as a long term weight management tool.
Cost
$170 for 600mg (depending on source/pharmacy).
Evidence Grade
A+ (SURMOUNT clinical trials show up to 20%+ body weight loss).
Synergies
High protein diet (mandatory). Metformin (for peak insulin sensitivity). Testosterone/AAS (to protect muscle mass during the deficit).
Warnings
Risk of pancreatitis (rare). Must monitor gallbladder health. Do not use if you have a family history of medullary thyroid carcinoma (MTC).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
9/10
10/10
10/10
10/10

Why it's NOT in the main Guide (yet):

Cardiac Strain: Glucagon receptor activation increases resting heart rate significantly.

Muscle Wasting: The metabolic drive is so high that maintaining a good looking body becomes nearly impossible without high dose anabolics.

Experimental Status: No long term human safety data outside of clinical trials.

Conclusion: Stick to Tirzepatide for controlled, elite level fat loss. Retatrutide is for those who are willing to be "human lab rats."

ORLISTAT

Category
II. Fat Loss and Metabolic Shredding
Intro
A gastrointestinal lipase inhibitor. Unlike most other fat burners, it does not act on the central nervous system or metabolism directly; it works solely in the digestive tract to prevent the absorption of dietary fats.
Mechanism
Inhibits the enzyme gastric and pancreatic lipase. These enzymes are necessary to break down triglycerides into free fatty acids. Without them, about 25-30% of ingested fat passes through the intestines undigested.
Benefits
Non systemic (does not affect heart rate or blood pressure). Proven to reduce visceral fat over time. Can be used as a "cheat meal insurance" to limit caloric impact from high fat social events.
Negatives
Gastrointestinal Side Effects: Frequent, oily spotting, flatulence with discharge ("sharting"), and urgent bowel movements. Malabsorption of fat soluble vitamins (A, D, E, K) and Beta Carotene.
Dosage
60mg (OTC/Alli) to 120mg (Prescription/Xenical) taken with each fat containing meal.
Timing
Immediately before, during, or up to one hour after a high fat meal.
Cycling
Can be used long term, but requires a hig quality multivitamin (taken 2 hours apart) to prevent deficiencies.
Cost
€30-60 per month via pharmacy.
Evidence Grade
A (Decades of clinical use and FDA approval).
Synergies
Fiber supplements (Psyllium Husk) to mitigate GI side effects.
Warnings
If a meal contains no fat, the dose should be skipped. Excessive fat intake while on Orlistat leads to severe "emergency" bathroom situations.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
2/10
10/10
7/10
3/10

── III. VASCULARITY & PERFORMANCE ──

TADALAFIL (CIALIS)

Category
III. Vascularity & Performance
Intro
PDE5 inhibitor with ~17.5 hour half life the longest of the PDE5 inhibitors. Daily low dose creates true steady state NO enhancement. The most practical PDE5 inhibitor for ongoing vascularity and cardiovascular benefits.
Mechanism
Inhibits phosphodiesterase type 5 → prevents cGMP breakdown → elevated cGMP → smooth muscle relaxation → vasodilation via NO pathway. Steady-state at 5mg EOD or 2.5-5mg daily.
Benefits
Enhanced muscle pump and vascularity in training. Cardiovascular health (NO mediated endothelial protection). Blood pressure reduction. Erectile function. Potential cognitive benefits via cerebral blood flow.
Negatives
Hypotension at low blood pressure baseline. Absolute contraindication with nitrates. Facial flushing, nasal congestion at high doses. Back pain (unique to tadalafil, PDE11 inhibition).
Dosage
2.5-5mg daily OR 5mg EOD for steady-state. 10-20mg as needed.
Timing
Morning with or without food.
Cycling
No cycling needed. Can be used continuously.
Cost
€15-30/month generic.
Evidence Grade
A FDA approved. Extensive RCT data for multiple indications.
Synergies
L-Citrulline (complementary NO pathway, do not stack at high citrulline doses). Training.
Warnings
Absolute contraindication with nitrates (life threatening hypotension). Avoid with alpha blockers. Monitor blood pressure, particularly at baseline <110/70.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
9/10
8/10
8/10

SILDENAFIL (VIAGRA)

Category
III. Vascularity & Performance
Intro
The original PDE5 inhibitor. Shorter half-life (~4 hours) vs tadalafil, creates strong acute peak rather than steady state. More intense pump effect but not suitable for daily dosing. First choice for acute pre-workout vascularity.
Mechanism
Same PDE5 inhibition as tadalafil but with faster onset (30-60 min) and shorter duration. Stronger acute NO amplification. More PDE5-selective than tadalafil (less PDE11 side effects).
Benefits
Intense acute muscle pump pre-workout. Rapid onset. Strong vasodilation. No back pain (unlike tadalafil).
Negatives
Short duration means less practical for daily use. Facial flushing, visual disturbances (blue tint) at high doses. Same contraindications as tadalafil.
Dosage
25-50mg 30-60 min pre workout.
Timing
30-60 min pre workout on empty stomach for fastest effect.
Cycling
As needed only, not suitable for daily steady-state.
Cost
€10-25 for several doses generic.
Evidence Grade
A FDA approved. Extensive RCT data.
Synergies
Training. Citrulline (reduce citrulline dose when stacking).
Warnings
Same contraindications as tadalafil. Food significantly reduces absorption. Vision disturbances (blue tint) possible.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
9/10
8/10
7/10

TELMISARTAN

Category
III. Vascularity & Performance
Intro
AT1 receptor antagonist (ARB) for hypertension. Unique additional mechanism, PPAR-gamma partial agonist → metabolic benefits beyond blood pressure. Used in performance context for cardiovascular protection and endurance enhancement.
Mechanism
Blocks angiotensin II AT1 receptor → vasodilation, reduced aldosterone, lower blood pressure. PPAR-gamma activation → improved insulin sensitivity, fatty acid oxidation, mitochondrial biogenesis. Crosses BBB — potential nootropic effects.
Benefits
Blood pressure control in steroid users. Endurance enhancement via PPAR-gamma (AICAR like metabolic effects). Cardiovascular protection. Potential insulin sensitivity improvement.
Negatives
Hypotension at low blood pressure baseline, ot indicated in normal or low BP individuals without specific reason. Hyperkalemia risk.
Dosage
20-40mg/day for cardioprotection. 80mg/day for hypertension.
Timing
Morning.
Cycling
Continuous for hypertension management.
Cost
€10-20/month generic.
Evidence Grade
A FDA approved. PPAR-gamma mechanism adds unique performance angle.
Synergies
Cardiovascular protection stack. PPAR gamma effects synergy with cardio training.
Warnings
Not appropriate if blood pressure already low (baseline <120/75). Monitor potassium. Not a performance supplement for healthy normotensive individuals.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
8/10
9/10
6/10

NEBIVOLOL

Category
III. Vascularity & Performance
Intro
Third generation selective beta 1 blocker. Unique among beta-blockers, stimulates eNOS → increases NO production. Provides cardiovascular protection without the exercise performance reduction seen with older beta-blockers.
Mechanism
Beta-1 selective blockade → reduced heart rate and cardiac workload. Unique: stimulates endothelial NO synthase (eNOS) → vasodilation. Unlike older beta-blockers, does not significantly impair exercise capacity due to NO effects.
Benefits
Cardiovascular protection when using stimulants (Modafinil, Salbutamol). Blood pressure reduction without exercise impairment. Vasodilation via NO. Anxiety reduction in performance situations.
Negatives
Still some reduction in maximum heart rate. Not for asthma/COPD (beta blockade). Bradycardia at excessive doses.
Dosage
2.5-5mg/day.
Timing
Morning.
Cycling
Continuous when indicated.
Cost
€15-25/month.
Evidence Grade
A FDA approved for hypertension. eNOS mechanism well characterized.
Synergies
Stimulant stack cardiac protection. Talmisartan.
Warnings
Not for asthma. Monitor resting heart rate. Only use when cardiovascular protection specifically needed.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
8/10
8/10
6/10

@tqbiq @Jesus_ist_König @Datto29 @OCD @Niebvll

DNR semax at 8/10? WTF

anthony267 · 2026-04-06T18:38:52-0500

til<3D said:
PHARMACEUTICAL MEGATHREAD

Skin, Vascularity, Fat Loss, Cognitive Enhancement & PEDs

April 2026

DISCLAIMER

Legal
These are pharmaceutical compounds requiring prescriptions in most countries. This guide is for educational purposes only. Not medical advice.
Covered
Section I: Skin & Dermatology | Section: ||: Fat Loss and Metabolic Shredding | Section III: Vascularity & Performance | Section IV: Cognitive Enhancement (Nootropics) | Section V: Hormonal Modulation
Section V
I honestly have very little knowledge about steroids in general, so I just included the input I happened to know. I’d definitely say there are much better threads out there on this topic.

QUICK REFERENCE

Compound
Category
Evidence
Key Use
Cost
Overall
Tretinoin
I
A+
Vitamin A derivative (retinoid).
9/10
10/10
Isotretinoin (Accutane)
I
A+
Systemic oral retinoid...
6/10
9/10
Azelaic Acid
I
A
Dicarboxylic acid with multiple mechanisms.
9/10
8/10
Adapalene (0.1% / 0.3%)
I
A
Third generation retinoid.
9/10
7/10
Finasteride
I
A
Type II 5 alpha reductase inhibitor.
9/10
7/10
Dutasteride
I
B+
Inhibits BOTH type I and type II 5 alpha reductase, reducing DHT by ~95% vs finasteride's ~70%.
8/10
7/10
Ketoconazole (Topical)
I
B
Imidazole antifungal used topically as shampoo or cream.
10/10
6/10
Clenbuterol
||
A
Powerful thermogenic for final contest prep / extreme cutting.
9/10
7/10
Salbutamol (Albuterol)
||
A
Manageable fat loss & bronchodilation, short acting.
10/10
6/10
Yohimbine HCL
||
B+
Fasted cardio tool for alpha 2 receptor (stubborn fat) blockade.
9/10
6/10
Liothyronine (T3)
||
A
Direct metabolic acceleration, high risk of muscle wasting.
8/10
5/10
Levothyroxine (T4)
||
A
Long term metabolic baseline support, smoother than T3.
9/10
6/10
Metformin
||
A+
Insulin sensitivity & AMPK activation, "Health-Maxxing" during cut.
10/10
9/10
DNP (2,4 Dinitrophenol)
||
B
Lethal mitochondrial uncoupling, extreme weight loss.
5/10
0/10
Sibutramine
||
B-
Aggressive appetite suppression, high cardiovascular risk.
6/10
3/10
Tirzepatide (Mounjaro)
||
A+
The "God tier" GLP-1/GIP agonist for total appetite control.
10/10
10/10
Orlistat
||
A
Blocking dietary fat absorption, for high fat "cheat" scenarios.
8/10
4/10
Tadalafil (Cialis)
III
A
PDE5 inhibitor with ~17.
8/10
8/10
Sildenafil (Viagra)
III
A
The original PDE5 inhibitor.
8/10
7/10
Telmisartan
III
A
AT1 receptor antagonist (ARB) for hypertension.
9/10
6/10
Nebivolol
III
A
Third generation selective beta 1 blocker.
8/10
6/10
Modafinil
IV
A
Wakefulness promoting agent originally developed for narcolepsy.
8/10
8/10
Armodafinil
IV
A
R-enantiomer of modafinil...
7/10
8/10
Piracetam
IV
B
The original racetam, synthesized in 1964.
9/10
6/10
Aniracetam
IV
B-
Fat soluble racetam with additional anxiolytic properties.
8/10
5/10
Phenylpiracetam
IV
C+
Piracetam with a phenyl group added produces stimulant effects
in addition to cognitive enhancement.
7/10
5/10
Pramiracetam
IV
B-
One of the most potent racetams per mg.
6/10
5/10
Semax
IV
B+
Synthetic ACTH(4-7) analogue developed in Russia for cognitive
enhancement and neuroprotection.
8/10
8/10
Memantine
IV
A
NMDA receptor antagonist approved for Alzheimer's treatment.
7/10
5/10
Donepezil
IV
B+
An atypical stimulant with anxiolytic properties (Actoprotector). Developed in Russia.
6/10
9/10
Methylphenidate (Ritalin)
IV
A+
Laser like focus. Immediate suppression of "distraction."
9/10
9/10
Lisdexamfetamine (Vyvanse / Elvanse)
IV
A+
10-12 hours of ultra consistent focus. Less edgy than Ritalin. High functional output.
5/10
8/10
Test Enanthate / Cypionate
V
A+
The bio identical foundation of any hormonal cycle. Essential for nitrogen retention and muscle protein synthesis.
10/10
10/10
Masteron (Drostanolone)
V
B
Providing a "hard," dry look: acts as a mild anti estrogen. Best used at low body fat.
7/10
8/10
Anavar (Oxandrolone)
V
A
Significant strength gains and muscle fullness without water retention (dry gains).
4/10
9/10
Winstrol (Stanozolol)
V
B+
Achieving the "Granite Look", flushes out subcutaneous water.
8/10
9/10
Enclomiphene
V
B+
Raising natural testosterone levels while preserving fertility and testicular size.
7/10
9/10
Anastrozole (Arimidex)
V
A
Managing high Estrogen (E2) side effects like bloating or early stage Gyno.
6/10
10/10
Exemestane (Aromasin)
V
A
Irreversibly binds to the aromatase enzyme, prevents "Estrogen Rebound."
6/10
9/10
Tamoxifen (Nolvadex)
V
A
Blocking Estrogen in breast tissue and restarting natural testosterone production (HPTA).
10/10
10/10
Raloxifene
V
A
The most effective compound for reversing existing Gynaecomastia (glandular tissue).
4/10
9/10
Cabergoline (Dostinex)
V
A
Lowering Prolactin levels: treats "puffy nipples" and significantly reduces the sexual refractory period.
2/10
8/10

COMPOUND PROFILES

── I. FACIAL AESTHETICS & SKIN ──

TRETINOIN

Category
I. Facial Aesthetics & Skin
Intro
Vitamin-A derivative (retinoid). The gold standard topical for acne treatment, skin texture improvement, and collagen stimulation. Requires prescription in most countries but widely available via online pharmacies. One of the most evidence backed topical compounds in dermatology.
Mechanism
Binds RAR alpha, beta, gamma nuclear receptors → upregulates keratinocyte differentiation genes. Accelerates cell turnover (shortens skin cycle from 28 to 14 days). Inhibits comedogenesis. Stimulates collagen I/III synthesis via TGF beta pathway.
Benefits
Acne clearance (inflammatory and non inflammatory). PIE/PIH reduction via cell turnover. Anti aging effects (reduces fine lines, improves texture). Collagen synthesis. Long term: skin rejuvenation.
Negatives
Retinization period: peeling, redness, sensitivity weeks 1-8 (not a reason to stop).
Photosensitization: SPF mandatory. Pregnancy category X, absolutely contraindicated.
Dosage
0.025% start → titrate to 0.05-0.1%. Pea sized amount entire face.
Timing
Nights only. 20-30 min after cleansing on dry skin. Moisturizer after.
Cycling
Continuous, no cycling. Effects compound over 6-12 months.
Cost
€15-40 via online pharmacies.
Evidence Grade
A+ Gold standard dermatology compound. Decades of RCT data.
Synergies
Azelaic acid (PIE stack). Niacinamide (barrier support). GHK-Cu (complementary collagen).
Warnings
SPF 50+ daily mandatory. Never use with benzoylperoxide same application. Buffer method (moisturizer first) reduces irritation.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
8/10
10/10
9/10
10/10

ISOTRETINOIN (ACCUTANE)

Category
I. Facial Aesthetics & Skin
Intro
Systemic oral retinoid. The only pharmaceutical that permanently reduces sebaceous gland size and output essentially resets the skin. Used for moderate severe acne. The most effective acne treatment in existence.
Mechanism
Systemic RAR activation → sebaceous gland atrophy (permanent reduction in sebum output by ~90%). Normalizes follicular keratinization. Anti inflammatory. Modulates immune cells in skin.
Benefits
Permanent acne resolution in most patients. Skin texture transformation. Anti aging effects (deeper retinoid effects than topical). Long term remission rates >80% after one course.
Negatives
Initial flare possible. Dry lips/skin/eyes (standard). Mood effects (monitor).
Liver enzyme elevation
Dosage
0.5-1mg/kg/day. Typical course 16-24 weeks to cumulative 120-150mg/kg.
Timing
With fatty meal (fat soluble).
Cycling
Single course usually sufficient. Repeat if relapse.
Cost
€50-200/month depending on dose and source.
Evidence Grade
A+ Most effective acne treatment in existence. Decades of data.
Synergies
Moisturizer + SPF (essential alongside). Lip balm.
Warnings
Pregnancy Category X catastrophic birth defects. Mental health monitoring.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
7/10
10/10
6/10
9/10

AZELAIC ACID

Category
I. Facial Aesthetics & Skin
Intro
Dicarboxylic acid with multiple mechanisms. Available OTC at 10% or prescription at 20%. Particularly effective for PIE, rosacea, and mild-moderate acne. UV stable can be used morning or evening.
Mechanism
Inhibits tyrosinase (reduces melanin/PIE). Antibacterial against P. acnes (without resistance development). Anti inflammatory (inhibits IL-1, TNF-alpha, reactive oxygen species). Mild keratolytic.
Benefits
PIE and redness reduction. Acne treatment (mild-moderate). Rosacea. Well tolerated, suitable for sensitive skin. UV stable means morning use fine.
Negatives
Mild tingling/burning initially. 15-20% may experience skin irritation. Slower acting than tretinoin.
Dosage
10% OTC or 20% prescription. Thin layer affected areas.
Timing
Morning (UV stable) or evening after tretinoin (wait 20 min).
Cycling
Continuous.
Cost
€10-25 for prescription 20% strength.
Evidence Grade
A FDA approved for acne and rosacea. Extensive RCT data.
Synergies
Tretinoin (dual PIE attack). Niacinamide. Tinted sunscreen.
Warnings
Mild initial irritation normal. If persistent burning stop use. Do not combine with high concentration glycolic acid.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
9/10
9/10
8/10

ADAPALENE (0.1% / 0.3%)

Category
I. Facial Aesthetics & Skin
Intro
Third generation retinoid. Binds RAR-beta and gamma but NOT alpha, the receptor responsible for most retinoid side effects. This selectivity makes it significantly less irritating than tretinoin while maintaining comparable efficacy for acne.
Mechanism
RAR-beta/gamma selectivity → keratinocyte differentiation without RARa-mediated irritation. Inhibits AP-1 transcription factor → anti-inflammatory. TLR-2 modulation → immune response in follicles.
Benefits
Acne efficacy comparable to tretinoin 0.025%. Significantly less irritation. Available OTC (0.1% in some countries). Better option for sensitive skin or during tretinoin retinization.
Negatives
Weaker than tretinoin 0.05-0.1% for anti aging and texture. Less collagen stimulation than tretinoin. Still causes some photosensitization.
Dosage
Pea sized 0.1% nightly. Can step up to 0.3%.
Timing
Night only. After cleansing.
Cycling
Continuous.
Cost
€15-30 OTC.
Evidence Grade
A FDA approved. RCT data comparable to tretinoin for acne.
Synergies
Azelaic acid. Niacinamide.
Warnings
SPF mandatory. Not as powerful as tretinoin for skin remodeling — use tretinoin if tolerated.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
9/10
9/10
9/10
7/10

FINASTERIDE

Category
I. Facial Aesthetics & Skin
Intro
Type II 5-alpha reductase inhibitor. Reduces DHT by ~70%. Used clinically for BPH and male pattern baldness. The most common pharmaceutical intervention for hair loss. At 17-18 years use with extreme caution given ongoing hormonal development.
Mechanism
Inhibits 5-alpha reductase type II → reduces conversion of testosterone to DHT in hair follicles and prostate. DHT binds AR on dermal papilla cells → miniaturization. Finasteride prevents this.
Benefits
Halts and partially reverses androgenetic alopecia. Reduces DHT systemically. Skin quality improvement in acne-prone users.
Negatives
Post finasteride syndrome (persistent sexual dysfunction in subset of users, mechanism debated). Reduces DHT ~70% systemically affecting all DHT-dependent processes. Libido changes. Not for use under 18.
Dosage
1mg/day for hair loss.
Timing
Any time, consistent.
Cycling
Continuous stopping causes DHT rebound and renewed hair loss.
Cost
€15-30/month generic.
Evidence Grade
A FDA approved. Decades of RCT data for AGA.
Synergies
Minoxidil topical (gold standard hair loss stack).
Warnings
Not recommended at 17-18 due to ongoing hormonal development. Post-finasteride syndrome, small but real risk. Monitor libido/sexual function.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
9/10
9/10
7/10

DUTASTERIDE

Category
I. Facial Aesthetics & Skin
Intro
Inhibits BOTH type I and type II 5-alpha reductase —> reducing DHT by ~95% vs finasteride's ~70%. More potent hair loss treatment but also more systemic DHT suppression. Used off label for hair loss.
Mechanism
Dual type I/II 5AR inhibition → ~95% DHT reduction. Type I found in skin and liver (unlike finasteride which only hits type II). More complete DHT suppression.
Benefits
Superior hair retention vs finasteride in head-to-head studies. Greater scalp DHT reduction. Skin acne improvement.
Negatives
All finasteride warnings apply, amplified. 95% DHT reduction is significant, DHT has important roles in libido, cognitive function, muscle fullness. Not for under 18.
Dosage
0.5mg every day or 2.5mg weekly.
Timing
Any time.
Cycling
Continuous.
Cost
€20-40/month.
Evidence Grade
B+ Multiple RCTs vs finasteride and placebo. Not FDA approved for hair loss (approved for BPH).
Synergies
Minoxidil topical.
Warnings
Even stronger systemic DHT suppression than finasteride. Same post-finasteride syndrome risk. Not at 17-18.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
7/10
8/10
8/10
7/10

KETOCONAZOLE (TOPICAL)

Category
I. Facial Aesthetics & Skin
Intro
Imidazole antifungal used topically as shampoo or cream. Directly inhibits DHT binding at androgen receptors in scalp follicles. Widely available OTC as shampoo (Nizoral). Often used as adjunct in hair loss protocols.
Mechanism
Inhibits sterol synthesis in fungi (antifungal mechanism). In hair follicles: directly competes with DHT at androgen receptor. Also reduces scalp inflammation. Some sebum reduction.
Benefits
Adjunct hair loss treatment. Seborrheic dermatitis treatment. Anti-inflammatory scalp effects. Minimal systemic absorption from topical use.
Negatives
Only topical, very limited systemic effects. May dry hair with frequent use. Not a standalone hair loss treatment.
Dosage
Nizoral shampoo 2%, leave 5 min on scalp 2-3x/week.
Timing
Any time during shower.
Cycling
Continuous.
Cost
€8-15/month.
Evidence Grade
B Controlled studies showing hair loss benefit as adjunct. Less RCT data than finasteride.
Synergies
Finasteride or dutasteride (complementary mechanism, receptor blockade vs DHT reduction).
Warnings
Minimal safety concerns with topical use. Some users report hair dryness.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
10/10
6/10
10/10
6/10

── II. Fat Loss and Metabolic Shredding ──

CLENBUTEROL

Category
II. Fat Loss and Metabolic Shredding
Intro
A potent Beta-2 adrenoceptor agonist. While technically a bronchodilator for asthma, it is the bodybuilding gold standard for non hormonal fat loss and final contest prep.
Mechanism
Stimulates Beta-2 receptors → increases cAMP levels → elevates core body temperature (thermogenesis) → increases Basal Metabolic Rate (BMR) by ~5-10%.
Benefits
Rapid fat oxidation. Slight anti catabolic effect (muscle sparing) during heavy deficits. Direct stimulation of the central nervous system for increased output.
Negatives
Long half life (~36h) means side effects persist 24/7. Jitters (tremor), insomnia, heavy sweating, and significant cardiac stress (tachycardia). Depletes intracellular Taurine levels.
Dosage
20mcg start → titrate up by 20mcg every few days up to 80-120mcg (advanced only).
Timing
Morning (due to long HWZ).
Cycling
Strictly 2 weeks on / 2 weeks off (to prevent receptor downregulation) or used with Ketotifen.
Cost
€15-30 per bottle / pack.
Evidence Grade
A (Extensive use in sports pharmacology).
Synergies
Taurine (3-5g daily) to prevent muscle cramps. T3 (often stacked in pro protocols, but high muscle loss risk).
Warnings
Potentially kardiotoxisch at high doses or long term use. Monitor heart rate and blood pressure constantly. Absolute contraindication with existing heart conditions.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
5/10
9/10
9/10
7/10

SALBUTAMOL (ALBUTEROL)

Category
II. Fat Loss and Metabolic Shredding
Intro
A short-acting Beta-2 adrenoceptor agonist. Primarily used as a bronchodilator for asthma, but highly effective for metabolic enhancement and fat loss in a fitness context..
Mechanism
Stimulates Beta-2 receptors → increases cAMP levels → triggers lipolysis in adipose tissue and a slight thermogenic effect. It has a much shorter half life (~4-6 hours) compared to Clenbuterol, allowing for precise control.
Benefits
Boosts metabolic rate (I would say 200 extra kcal/day). Improved breathing/cardio performance via bronchodilation. Significantly less CNS strain than long-acting stimulants.
Negatives
Can cause temporary jitters, increased heart rate (tachycardia), and mild blood pressure fluctuations. Potential for muscle cramps due to electrolyte shifts.
Dosage
4mg per dose, typically 1-3 times daily. Start with 4mg once in the morning to assess tolerance.
Timing
Morning (due to HWZ).
Cycling
Effective for short term use (e.g., the last 4 weeks of a cut). Receptor downregulation occurs with prolonged use.
Cost
€10-25 via pharmacy or online. Often very accessible.
Evidence Grade
A (Extensive clinical and athletic data).
Synergies
Taurine (3-5g daily) to prevent muscle cramps.
Warnings
Monitor heart rate and blood pressure (RR). Stop immediately if arrhythmias occur. Caution when stacking with other stimulants or if baseline RR is already low.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
10/10
10/10
8/10

YOHIMBINE HCL

Category
II. Fat Loss and Metabolic Shredding
Intro
An alpha-2 adrenoceptor antagonist derived from the bark of the African Yohimbe tree. It is specifically used for targeting "stubborn" fat areas that are resistant to normal dieting.
Mechanism
Blocks alpha-2 adrenoreceptors in adipose tissue. These receptors normally inhibit lipolysis (fat breakdown); by blocking them, Yohimbine allows catecholamines to bind to beta receptors and mobilize fat from "problem areas" like the lower back and glutes.
Benefits
Targeted lipolysis in areas with high alpha-2 density. Increased vascularity and blood flow. Works as a mild stimulant.
Negatives
Can trigger significant anxiety, cold sweats, and "inner unrest." Increases heart rate and potentially blood pressure. Insulin completely blunts the effect, making timing critical.
Dosage
0.2mg per kg of bodyweight (e.g., ~18mg for a 90kg individual). Start lower to assess tolerance.
Timing
Must be taken in a fasted state (ideally pre cardio). Even a small insulin spike from food renders it useless for fat loss.
Cycling
Effective as needed; no specific downward regulation, but ZNS fatigue can occur.
Cost
€15-30 via specialized supplement sites or pharmacies.
Evidence Grade
B+ (Solid mechanistic data and several human trials for fat loss).
Synergies
Caffeine (amplifies the effect). Fasted LISS cardio.
Warnings
Do not use if prone to anxiety or panic attacks. Avoid stacking with heavy stimulants if your baseline heart rate is already high. Monitor RR carefully.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
4/10
8/10
9/10
6/10

LIOTHYRONINE (T3)

Category
II. Fat Loss and Metabolic Shredding
Intro
Synthetic form of the thyroid hormone triiodothyronine (T3). It is the most metabolically active thyroid hormone and a powerful tool for accelerating fat loss by directly increasing the body's basal metabolic rate.
Mechanism
Directly binds to thyroid hormone receptors in cell nuclei → increases mitochondrial activity and ATP turnover → accelerates the metabolism of carbohydrates, proteins, and fats.
Benefits
Massive increase in caloric expenditure even at rest. Highly effective for breaking through fat loss plateaus
Negatives
Extremely catabolic: without adequate anabolic protection (AAS), it will rapidly burn muscle tissue alongside fat. Can cause heart palpitations, anxiety, heat intolerance, and permanent thyroid suppression if abused.
Dosage
12.5mcg - 25mcg daily for beginners. Experienced users may go up to 50mcg. Titration is mandatory.
Timing
In the morning on an empty stomach, ideally 30–60 minutes before your first meal.
Cycling
Usually limited to 4-8 weeks to minimize the risk of long term thyroid downregulation.
Cost
€15-40 via pharmacy or online sources.
Evidence Grade
A (Extensively studied in clinical and sports settings).
Synergies
Anabolic steroids (to prevent muscle wasting). Clenbuterol/Salbutamol (often stacked for synergistic thermogenesis, but adds massive cardiac strain).
Warnings
Monitor resting heart rate and body temperature. If resting HR exceeds 100 bpm, reduce dosage immediately. Risk of permanent hypothyroidism with improper use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
4/10
10/10
5/10
5/10

LEVOTHYROXINE (T4)

Category
II. Fat Loss and Metabolic Shredding
Intro
The synthetic precursor to the active thyroid hormone T3. It is the standard treatment for hypothyroidism but is used in performance contexts to maintain a high normal metabolic baseline during extended cutting phases.
Mechanism
Acts as a pro hormone that is converted into active T3 by deiodinase enzymes in the liver and peripheral tissues. This allows the body to regulate the conversion rate based on physiological demand, leading to more stable blood levels.
Benefits
Provides a smoother, more predictable metabolic boost compared to T3. Lower risk of acute muscle wasting (catabolism). Helps prevent the metabolic slowdown associated with chronic caloric restriction (e.g. when using Tirzepatide).
Negatives
Slower onset of action due to the required conversion process. Can still lead to hyperthyroid symptoms (insomnia, palpitations) if dosed too high. Requires several weeks to reach a steady state.
Dosage
50mcg - 100mcg daily. Individual requirements vary significantly; blood work for TSH and fT4 is recommended.
Timing
In the morning on an empty stomach, ideally 30–60 minutes before your first meal.
Cycling
Often used for longer durations (8-12 weeks) during a cut. Should be tapered off gradually to allow natural thyroid function to recover.
Cost
€10-25 via pharmacy. Very cost-effective.
Evidence Grade
A+ (Gold standard for thyroid replacement therapy with immense clinical data).
Synergies
Human Growth Hormone (HGH), as HGH can accelerate the conversion of T4 to T3. GH Secretagogues.
Warnings
Less "feelable" than T3, which often leads to dangerous over dosing. Monitor heart rate and temperature.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
10/10
10/10
6/10

METFORMIN

Category
II. Fat Loss and Metabolic Shredding
Intro
A biguanide primarily used for Type-2 Diabetes management, but highly popular in the longevity and bodybuilding communities for its metabolic and anti-aging properties.
Mechanism
Activates AMPK (adenosine monophosphate activated protein kinase) → mimics the physiological effects of fasting. It inhibits hepatic glucose production and increases insulin sensitivity in peripheral tissues.
Benefits
Prevents fat storage by improving nutrient partitioning. Lowers systemic inflammation and reduces IGF-1/mTOR signaling (longevity benefit). Helps maintain a lean physique.
Negatives
Gastrointestinal issues (diarrhea, bloating) are common during the titration phase. May slightly reduce maximal hypertrophy due to mTOR inhibition. Potential for Vitamin B12 deficiency over long term use.
Dosage
500mg - 1000mg daily. Start with 500mg to assess GI tolerance.
Timing
With or immediately after a meal (usually in the evening) to minimize gastrointestinal discomfort.
Cycling
Often used continuously. Some athletes cycle it "off" during heavy mass building phases to maximize mTOR signaling.
Cost
€10-20 per pack. Extremely cost effective and widely available.
Evidence Grade
A+ (One of the most researched drugs in existence with decades of safety data).
Synergies
Berberine (natural alternative/add on). Tirzepatide (excellent synergy for glucose control and weight loss).
Warnings
Risk of lactic acidosis (extremely rare in healthy individuals). Monitor B12 levels. Avoid excessive alcohol consumption while on Metformin.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
8/10
10/10
10/10
9/10

DNP (2,4-DINITROPHENOL)

Category
II. Fat Loss and Metabolic Shredding
Intro
An industrial chemical used in the manufacturing of explosives and dyes. It was briefly used as a weight loss drug in the 1930s before being banned due to extreme toxicity and fatalities.
Mechanism
Acts as a mitochondrial uncoupler. It dissipates the proton gradient across the inner mitochondrial membrane, forcing the body to burn energy (fat and carbs) as pure heat instead of producing ATP.
Benefits
Unmatched fat loss (up to 0.5kg of pure fat per day). No "ceiling" to its effectiveness.
Negatives
Fatal Hyperthermia: The body literally cooks from the inside out; there is no physiological cooling mechanism that can counteract DN induced heat.
No Antidote: If you overdose, medical science cannot save you.Severe peripheral neuropathy, rapid onset cataracts (blindness), and multi organ failure.
Dosage
Any dosage carries a risk of death. There is no "safe" therapeutic index.
Timing
Irrelevant: the compound accumulates in the system due to a long half life, leading to accidental overdoses.
Cycling
Should not be used.
Cost
Low (Industrial chemical), but the "cost" is potentially your life.
Evidence Grade
B (Documented as a potent fat burner, but primarily evidenced through toxicology reports and mortality cases).
Synergies
None. Stacking with other stimulants or thyroid hormones significantly increases the risk of immediate death.
Warnings
EXTREME LEFAL DANGER. Unlike Clenbuterol or T3, DNP does not have a biological "off switch." Inclusion in this guide is for historical and harm reduction purposes only. DO NOT USE.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
1/10
5/10
10/10
0/10

SIBUTRAMINE

Category
II. Fat Loss and Metabolic Shredding
Intro
A serotonin norepinephrine reuptake inhibitor (SNRI) originally developed as an antidepressant but primarily used as a potent appetite suppressant. It was withdrawn from many markets due to cardiovascular safety concerns.
Mechanism
Inhibits the reuptake of dopamine, norepinephrine, and serotonin in the brain → increases satiety and elevates resting metabolic rate via thermogenesis.
Benefits
Aggressive suppression of "food noise" and appetite. Increased energy expenditure. Effective for rapid weight loss in the short term.
Negatives
Significant cardiovascular strain: increases blood pressure and heart rate. High risk of dry mouth, insomnia, constipation, and in severe cases, stroke or myocardial infarction.
Dosage
10mg - 15mg daily.
Timing
In the morning.
Cycling
Not recommended for long term use (max. 4-12 weeks) due to cardiac stress.
Cost
€20-40 via gray market sources: legally unavailable in most Western countries.
Evidence Grade
B- (Documented efficacy for weight loss, but heavily overshadowed by safety data leading to its withdrawal).
Synergies
None recommended. Stacking with other stimulants (like Salbutamol) exponentially increases the risk of a cardiac event.
Warnings
High Cardiovascular Risk. Do not use if you have any history of hypertension or heart disease. Largely replaced by superior and safer GLP-1 agonists like Tirzepatide.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
7/10
6/10
6/10
3/10

TIRZEPATIDE (MOUNJARO)
Mogs Reta in my opinion
Category
II. Fat Loss and Metabolic Shredding
Intro
A dual glucose dependent insulinotropic polypeptide (GIP) and glucagon like peptide 1 (GLP-1) receptor agonist. Currently the most potent pharmaceutical tool for weight loss, surpassing Semaglutide (Ozempic) in both speed and total fat reduction.
Mechanism
Acts on two key metabolic pathways: GLP-1 (delays gastric emptying, signals satiety to the brain) and GIP (improves insulin sensitivity and lipid metabolism). It effectively "mutes" the brain's hunger signals (Food Noise) while optimizing how the body handles glucose.
Benefits
Extreme appetite suppression. Rapid fat loss while maintaining stable blood sugar. Improved insulin sensitivity. Minimal CNS stimulation compared to traditional burners (Clen/T3).
Negatives
Gastrointestinal side effects (nausea, constipation, sulfur burps) especially during titration. High cost and availability issues. Potential for "muscle wasting" if protein intake isn't strictly monitored (due to massive caloric deficit).
Dosage
2.5mg start (4 weeks) → titrate to 5mg → 7.5mg → max 15mg weekly.
Timing
Subcutaneous injection, once weekly (any time of day).
Cycling
Can be used for the duration of a cut (8-16 weeks) or as a long term weight management tool.
Cost
$170 for 600mg (depending on source/pharmacy).
Evidence Grade
A+ (SURMOUNT clinical trials show up to 20%+ body weight loss).
Synergies
High protein diet (mandatory). Metformin (for peak insulin sensitivity). Testosterone/AAS (to protect muscle mass during the deficit).
Warnings
Risk of pancreatitis (rare). Must monitor gallbladder health. Do not use if you have a family history of medullary thyroid carcinoma (MTC).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
10/10
9/10
10/10
10/10
10/10

Why it's NOT in the main Guide (yet):

Cardiac Strain: Glucagon receptor activation increases resting heart rate significantly.

Muscle Wasting: The metabolic drive is so high that maintaining a good looking body becomes nearly impossible without high dose anabolics.

Experimental Status: No long term human safety data outside of clinical trials.

Conclusion: Stick to Tirzepatide for controlled, elite level fat loss. Retatrutide is for those who are willing to be "human lab rats."

ORLISTAT

Category
II. Fat Loss and Metabolic Shredding
Intro
A gastrointestinal lipase inhibitor. Unlike most other fat burners, it does not act on the central nervous system or metabolism directly; it works solely in the digestive tract to prevent the absorption of dietary fats.
Mechanism
Inhibits the enzyme gastric and pancreatic lipase. These enzymes are necessary to break down triglycerides into free fatty acids. Without them, about 25-30% of ingested fat passes through the intestines undigested.
Benefits
Non systemic (does not affect heart rate or blood pressure). Proven to reduce visceral fat over time. Can be used as a "cheat meal insurance" to limit caloric impact from high fat social events.
Negatives
Gastrointestinal Side Effects: Frequent, oily spotting, flatulence with discharge ("sharting"), and urgent bowel movements. Malabsorption of fat soluble vitamins (A, D, E, K) and Beta Carotene.
Dosage
60mg (OTC/Alli) to 120mg (Prescription/Xenical) taken with each fat containing meal.
Timing
Immediately before, during, or up to one hour after a high fat meal.
Cycling
Can be used long term, but requires a hig quality multivitamin (taken 2 hours apart) to prevent deficiencies.
Cost
€30-60 per month via pharmacy.
Evidence Grade
A (Decades of clinical use and FDA approval).
Synergies
Fiber supplements (Psyllium Husk) to mitigate GI side effects.
Warnings
If a meal contains no fat, the dose should be skipped. Excessive fat intake while on Orlistat leads to severe "emergency" bathroom situations.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
2/10
10/10
7/10
3/10

── III. VASCULARITY & PERFORMANCE ──

TADALAFIL (CIALIS)

Category
III. Vascularity & Performance
Intro
PDE5 inhibitor with ~17.5 hour half life the longest of the PDE5 inhibitors. Daily low dose creates true steady state NO enhancement. The most practical PDE5 inhibitor for ongoing vascularity and cardiovascular benefits.
Mechanism
Inhibits phosphodiesterase type 5 → prevents cGMP breakdown → elevated cGMP → smooth muscle relaxation → vasodilation via NO pathway. Steady-state at 5mg EOD or 2.5-5mg daily.
Benefits
Enhanced muscle pump and vascularity in training. Cardiovascular health (NO mediated endothelial protection). Blood pressure reduction. Erectile function. Potential cognitive benefits via cerebral blood flow.
Negatives
Hypotension at low blood pressure baseline. Absolute contraindication with nitrates. Facial flushing, nasal congestion at high doses. Back pain (unique to tadalafil, PDE11 inhibition).
Dosage
2.5-5mg daily OR 5mg EOD for steady-state. 10-20mg as needed.
Timing
Morning with or without food.
Cycling
No cycling needed. Can be used continuously.
Cost
€15-30/month generic.
Evidence Grade
A FDA approved. Extensive RCT data for multiple indications.
Synergies
L-Citrulline (complementary NO pathway, do not stack at high citrulline doses). Training.
Warnings
Absolute contraindication with nitrates (life threatening hypotension). Avoid with alpha blockers. Monitor blood pressure, particularly at baseline <110/70.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
9/10
8/10
8/10

SILDENAFIL (VIAGRA)

Category
III. Vascularity & Performance
Intro
The original PDE5 inhibitor. Shorter half-life (~4 hours) vs tadalafil, creates strong acute peak rather than steady state. More intense pump effect but not suitable for daily dosing. First choice for acute pre-workout vascularity.
Mechanism
Same PDE5 inhibition as tadalafil but with faster onset (30-60 min) and shorter duration. Stronger acute NO amplification. More PDE5-selective than tadalafil (less PDE11 side effects).
Benefits
Intense acute muscle pump pre-workout. Rapid onset. Strong vasodilation. No back pain (unlike tadalafil).
Negatives
Short duration means less practical for daily use. Facial flushing, visual disturbances (blue tint) at high doses. Same contraindications as tadalafil.
Dosage
25-50mg 30-60 min pre workout.
Timing
30-60 min pre workout on empty stomach for fastest effect.
Cycling
As needed only, not suitable for daily steady-state.
Cost
€10-25 for several doses generic.
Evidence Grade
A FDA approved. Extensive RCT data.
Synergies
Training. Citrulline (reduce citrulline dose when stacking).
Warnings
Same contraindications as tadalafil. Food significantly reduces absorption. Vision disturbances (blue tint) possible.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
9/10
8/10
7/10

TELMISARTAN

Category
III. Vascularity & Performance
Intro
AT1 receptor antagonist (ARB) for hypertension. Unique additional mechanism, PPAR-gamma partial agonist → metabolic benefits beyond blood pressure. Used in performance context for cardiovascular protection and endurance enhancement.
Mechanism
Blocks angiotensin II AT1 receptor → vasodilation, reduced aldosterone, lower blood pressure. PPAR-gamma activation → improved insulin sensitivity, fatty acid oxidation, mitochondrial biogenesis. Crosses BBB — potential nootropic effects.
Benefits
Blood pressure control in steroid users. Endurance enhancement via PPAR-gamma (AICAR like metabolic effects). Cardiovascular protection. Potential insulin sensitivity improvement.
Negatives
Hypotension at low blood pressure baseline, ot indicated in normal or low BP individuals without specific reason. Hyperkalemia risk.
Dosage
20-40mg/day for cardioprotection. 80mg/day for hypertension.
Timing
Morning.
Cycling
Continuous for hypertension management.
Cost
€10-20/month generic.
Evidence Grade
A FDA approved. PPAR-gamma mechanism adds unique performance angle.
Synergies
Cardiovascular protection stack. PPAR gamma effects synergy with cardio training.
Warnings
Not appropriate if blood pressure already low (baseline <120/75). Monitor potassium. Not a performance supplement for healthy normotensive individuals.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
8/10
9/10
6/10

NEBIVOLOL

Category
III. Vascularity & Performance
Intro
Third generation selective beta 1 blocker. Unique among beta-blockers, stimulates eNOS → increases NO production. Provides cardiovascular protection without the exercise performance reduction seen with older beta-blockers.
Mechanism
Beta-1 selective blockade → reduced heart rate and cardiac workload. Unique: stimulates endothelial NO synthase (eNOS) → vasodilation. Unlike older beta-blockers, does not significantly impair exercise capacity due to NO effects.
Benefits
Cardiovascular protection when using stimulants (Modafinil, Salbutamol). Blood pressure reduction without exercise impairment. Vasodilation via NO. Anxiety reduction in performance situations.
Negatives
Still some reduction in maximum heart rate. Not for asthma/COPD (beta blockade). Bradycardia at excessive doses.
Dosage
2.5-5mg/day.
Timing
Morning.
Cycling
Continuous when indicated.
Cost
€15-25/month.
Evidence Grade
A FDA approved for hypertension. eNOS mechanism well characterized.
Synergies
Stimulant stack cardiac protection. Talmisartan.
Warnings
Not for asthma. Monitor resting heart rate. Only use when cardiovascular protection specifically needed.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
8/10
8/10
6/10

@tqbiq @Jesus_ist_König @Datto29 @OCD @Niebvll

Shi bookmarked

til<3D · 2026-04-06T18:40:00-0500

sherry12 said:
DNR semax at 8/10? WTF

what rating should it have?

sherry12 · 2026-04-06T19:45:22-0500

til<3D said:
what rating should it have?

negative 500 billion

polarpop · 2026-04-06T20:08:37-0500

good thread

PHARMACEUTICAL MEGATHREAD

til<3D

NZK du Hurensohn

Cabergoline (Dostinex)​

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bro/bra/brotato/bhai

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Gold

jd922

True German

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NZK du Hurensohn

Niebvll

Twink slaying BVLL

til<3D

NZK du Hurensohn

bosnian

🇧🇦

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NZK du Hurensohn

aaronbp

Equinox

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Der Mensch ist nur eine grenzenlose Chance

exvh

Cars

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Tren induced rage on greys

Cabergoline (Dostinex)​

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Italian

Cabergoline (Dostinex)​

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NZK du Hurensohn

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Tren induced rage on greys

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