PEPTIDE MEGATHREAD

Deleted member 373233 · Apr 5, 2026

brooooooooooootaler thread

til<3D · Apr 5, 2026

tqbiq said:
brooooooooooootaler thread

Thank you took some time

ropemaxxer00 · Apr 13, 2026

Phenomenal thread, bump

til<3D · Apr 14, 2026

ropemaxxer00 said:
Phenomenal thread, bump

Ty brah

rowboatski · Apr 14, 2026

til<3D said:
Complete Guide to Peptide Protocols — Dosing, Evidence & Stacking

by til<3D
Stand: April 2026

DISCLAIMER

Read First
This guide is for educational purposes only. Peptides are not approved drugs in most countries. Everything here is off label and experimental. Do your own research. You are responsible for your own choices. This is not medical advice.
Age Note
Several peptides are specifically marked as inappropriate for users under 18-20 years old due to ongoing hormonal and neural development. These warnings are clearly flagged throughout.
Sources
Evidence grades reflect actual human clinical trial data, animal studies, and in vitro research. Grade A = multiple human RCTs. Grade B = some human data. Grade C = animal/in vitro only.

PEPTIDES COVERED IN THIS THREAD

1. Semax — ACTH(4-7) Analogue — Nootropic

2. Selank — Tuftsin Analogue — Anxiolytic & Cognitive

3. GHK-Cu — Copper Peptide — Skin & Collagen

4. AHK-Cu — Copper Peptide — Hair Growth

5. Melanotan-1 (MT-1) — MC1R Agonist — Tanning

6. BPC-157 — Body Protection Compound — Healing

7. TB-500 — Thymosin Beta-4 — Recovery & Flexibility

8. DSIP — Delta Sleep-Inducing Peptide — Sleep Architecture

9. SS-31 (Elamipretide) — Mitochondria-Targeting Peptide — Energy & Cardioprotection

10. MOTS-C — Mitochondrial-Derived Peptide — Metabolic

11. 5-amino-1MQ — CD38 Inhibitor — NAD+ Preservation

12. Thymosin Alpha-1 — Immune Modulator — Immune Enhancement

13. KPV — Anti-Inflammatory Tripeptide — Gut & Skin

14. Cerebrolysin — Neuropeptide Mix — Cognitive & Neuroprotection

15. Snap-8 — Neuropeptide — Anti-Wrinkle Topical

16. Pinealon — Pineal Peptide — Neuroprotection & Circadian

17. Epithalon (Epitalon) — Tetrapeptide — Telomere (Age 40+ Only)

18. Ipamorelin — GHRP — GH Secretagogue (Age 20+ Optimal)

19. NAD+ — NAD+ Precursors — Mitochondrial (Age 35+ Only)

QUICK REFERENCE — ALL PEPTIDES

Peptide Effectiveness Evidence Age 17-18 Cost/mo Overall
Semax 8/10 B+ ✓ OK €20–35/vial (40mg) 8/10
Selank 8/10 B ✓ OK €25–40/vial (5mg) 7/10
GHK-Cu 7/10 B- ✓ OK €30/vial (50mg bulk) — much better value 7/10
AHK-Cu 6/10 C+ ✓ OK $68/100mg vial (vendor) 6/10
Melanotan-1 (MT-1) 9/10 A- ✓ OK $45/10mg vial × 10 8/10
BPC-157 7/10 C+ ✓ OK $40/5mg vial × 10 6/10
TB-500 7/10 C+ ✓ OK $75/5mg vial × 10 6/10
DSIP 6/10 C+ ✓ OK $45/5mg vial × 10 5/10
SS-31 (Elamipretide) 6/10 B- ✓ OK $86/10mg vial × 10 5/10
MOTS-C 6/10 C+ ✓ OK $65/10mg vial × 10 5/10
5-amino-1MQ 4/10 C ✓ OK $45/5mg vial or $110/50mg 3/10
Thymosin Alpha-1 7/10 B ✓ OK $80/5mg vial × 10 6/10
KPV 6/10 C+ ✓ OK $60/10mg vial × 10 6/10
Cerebrolysin 7/10 B- ✓ OK $29/60mg × 6 vials (vendor) 6/10
Snap-8 3/10 C+ ✓ OK $40/10mg vial × 10 (vendor) 4/10
Pinealon 4/10 C ✓ OK $55/5mg vial × 10 4/10
Epithalon (Epitalon) 2/10 C+ ✗ Caution $48/10mg × 10 (vendor) 2/10
Ipamorelin 6/10 C+ ✗ Caution $45/5mg vial × 10 5/10
NAD+ 2/10 B- ✗ Caution $40-130 depending on dose 2/10

INDIVIDUAL PEPTIDE PROFILES

SEMAX

Intro
Synthetic heptapeptide analogue of ACTH(4-7), developed in Russia for stroke and cognitive enhancement. Decades of clinical data. Crosses BBB efficiently intranasally. You could also do subq but in my opinion it's unnecessary.
Mechanism
Upregulates BDNF. Modulates dopaminergic/serotonergic transmission. Increases enkephalinase activity. NO signalling enhancement.
Benefits
Enhanced focus, memory, learning. Neuroprotection. Anti anxiety via serotonin. Rapid onset 15-30 min. No physical dependence.
Negatives
Receptor desensitization — cycling required. Mild anxiety at high doses. Most studies Russian literature.
Reconstitution
4ml BAC water on 40mg vial = 10mg/ml. 1mg = 0.1ml = 1 pump.
Dosage
0.5–1mg/day intranasal.
Timing
Morning, fasted or first meal.
Cycling
5 days ON / 2 OFF. Or 3 weeks ON / 1 week OFF.

Storage
Lyophilized 12+ months. Reconstituted 4°C, 4 weeks.
Cost (vendor)
$50/100mg vial (vendor).
Evidence Grade
B+ — Russian Phase II/III trials. Growing Western replication.
Synergies
Citicoline, Selank. Never combine with high dose Modafinil same day.
Warnings
Monitor with Modafinil stack. Avoid MAOIs.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
7/10
8/10
8/10

SELANK

Intro
Synthetic analogue of tuftsin. Official anxiolytic drug status in Russia/Ukraine. Anxiolysis without sedation, tolerance, or withdrawal.
Mechanism
Allosteric GABA-A modulation. Inhibits enkephalinase. Modulates BDNF/NGF. Complements Semax via distinct brain connectivity patterns.
Benefits
Anxiolysis without sedation or dependence. Cognitive enhancement. Anti inflammatory. No BtMG. Low desensitization risk at standard doses.
Negatives
Most evidence Russian studies. Additive CNS depression with other GABAergics — critical interaction. Short half-life ~2h intranasal.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
250–800mcg/day intranasal.
Timing
Morning or 30-60 min before stressful situations.
Cycling
14 days ON / 14 days OFF, or situational.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/100mg vial (vendor). Very cost effective per mg.
Evidence Grade
B — Russian Phase II clinical trials in GAD.
Synergies
Semax (complementary). NEVER with Etifoxine, Pregabalin, or alcohol same day.
Warnings
NEVER combine with Etifoxine, Pregabalin, or benzodiazepines same day. Additive CNS depression.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
6/10
8/10
7/10

GHK-CU

Intro
Naturally occurring copper-binding peptide. Plasma levels decline with age. Gold standard for skin regeneration and wound healing.
Mechanism
Activates fibroblasts → collagen I/III/elastin synthesis. VEGF-driven angiogenesis. Inhibits TGF-β1 (anti-fibrotic). Antioxidant enzyme upregulation.
Benefits
PIE/acne scar remodeling. Skin density improvement. Wound/post-surgery healing. Tendon collagen support. Anti-inflammatory.
Negatives
Systemic human RCT data limited. Competing with zinc pause zinc during use. Monitor copper levels with chronic use.
Reconstitution
1ml BAC water on 2mg vial = 2mg/ml. 27-29G needle, 4-6mm, 45°. PBS preferred for copper stability.
Dosage
2mg subcut EOD/ ED.
Timing
Evening after training. Separate site from MT-1.
Cycling
4-week cycles. Zinc paused. After cycle reintroduce zinc.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/1g vial (vendor). Very cost effective per mg.
Evidence Grade
B- — Strong in-vitro/animal. Limited human RCTs for subcut use. Topical human evidence solid.
Synergies
Tretinoin (complementary collagen). Copper supplement 30-60 min before injection.
Warnings
Pause zinc during cycle. Monitor serum copper/ceruloplasmin with extended use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
5/10
10/10
8/10

AHK-CU

Intro
Tripeptide analogue of GHK-Cu with higher affinity for hair follicle receptors. AHK (Ala-His-Lys) specifically promotes hair growth via follicle dermal papilla stimulation.
Mechanism
Activates Wnt/β-catenin pathway in hair follicles. Promotes dermal papilla cell proliferation. Upregulates VEGF in follicle microvasculature. Inhibits DHT-induced apoptosis in follicles.
Benefits
Hair density and thickness improvement. Potentially superior to GHK-Cu for scalp/follicle applications. Can be used topically or subcut. Anti-inflammatory in follicle microenvironment.
Negatives
Less research than GHK-Cu overall. Mostly in-vitro data. Higher cost per mg. Limited human studies specifically.
Reconstitution
1ml BAC water per 10mg = 10mg/ml. Can be used topically (DMSO carrier) or subcut.
Dosage
Topical: 0.01-0.1% solution on scalp. Subcut: 1-2mg/day.
Timing
Evening or post-shower for topical.
Cycling
Continuous or 8-week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$68/1g vial (vendor). Very cost effective per mg.
Evidence Grade
C+ — In-vitro strong. Limited human data. Mechanistically plausible.
Synergies
GHK-Cu (different receptor affinity — complementary). Minoxidil topical.
Warnings
Avoid mixing with acidic solutions. PBS preferred diluent.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
9,5/10
8/10

MELANOTAN-1 (MT-1)

Intro
Synthetic α-MSH analogue with MC1R selectivity. Only melanocortin peptide with EMA approval (Scenesse for EPP). Deep even tan with reduced UV exposure.
Mechanism
MC1R agonism → tyrosinase upregulation → eumelanin synthesis. UV activation required to convert precursors to visible pigment.
Benefits
Deep even tan. Photoprotection. Visually reduces PIE by contrast. EMA-approved safety data. Lower systemic effects vs MT-2.
Negatives
Nausea during loading (reduced by microdosing). Mole changes — document before starting. UV >3 required for activation. MC4R spillover at high doses.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 500mcg = 0.05ml.
Dosage
Loading: 500mcg/day × 14 days. Maintenance: 250-500mcg E2-3D + UV.
Timing
Evening — sleep through initial nausea.

Cycling
Loading → Maintenance. No continuous loading.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$4,5/10mg vial × 10. ~€2-3,5/month maintenance.
Evidence Grade
A- — EMA approved. Phase III trials. Extensive safety data.
Synergies
UV exposure (essential). Tretinoin. Solarium if UV index <3.
Warnings
Photograph all moles before starting. Never combine with MT-2.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
7/10
8/10
9/10
8,5/10

BPC-157

Intro
Synthetic pentadecapeptide from gastric juice. Remarkable healing in animal models across tendons, ligaments, muscles, GI tract. Most promising for injury recovery and post-surgical healing.
Mechanism
Upregulates GH receptor. VEGF angiogenesis. FAK-paxillin wound healing pathway. NF-κB inhibition. Collagen synthesis in tenocytes.
Benefits
Tendon/ligament healing acceleration. GI mucosal protection. Nerve regeneration (animal). Anti-inflammatory. Enhanced training recovery.
Negatives
Virtually ALL data is animal/in-vitro. Zero completed human RCTs. Unknown optimal human dosing. Unknown long-term safety.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
200-500mcg/day subcut or IM. Split morning + evening.
Timing
Morning and/or post-training.
Cycling
4-8 weeks on, 4 off. Or acute injury protocol.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$40 per kit (10×5mg vials). ~€3.5/vial. €40-70/month.
Evidence Grade
C+ — Extensive animal data, consistent results. Zero human RCTs. High translation uncertainty.
Synergies
TB-500 (complementary). GHK-Cu (collagen synergy).
Warnings
Theoretical angiogenesis concern with cancer history (unproven in humans). No known drug interactions.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
8/10
4/10
7/10
6/10

TB-500

Intro
Synthetic fragment of thymosin beta-4. Critical role in cell migration, wound healing, tissue regeneration. Systemic healing reach that BPC-157 lacks.
Mechanism
Binds G-actin → cell migration/differentiation. Integrin-linked kinase activation. Metalloproteinase upregulation for tissue remodeling. Vascular tube formation.
Benefits
Systemic healing (reaches distant injury sites). Muscle fiber regeneration. Flexibility/ROM improvements. Potential cardiac protection.
Negatives
Human RCT data absent for recovery use. Higher MW limits oral bioavailability. More expensive than BPC-157. Overlap with BPC-157.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
Loading: 2-2.5mg 2×/week × 4-6 weeks. Maintenance: 2-2.5mg 1×/week.
Timing
Morning or post-training.
Cycling
6-week loading, then maintenance or off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$75 per kit (10×5mg vials). ~€7/vial. €50-90/month.
Evidence Grade
C+ — Animal data solid. Phase II trial in dry eye disease. Limited systemic recovery data in humans.
Synergies
BPC-157 (most common stack). Post-surgery recovery protocol.
Warnings
Same theoretical angiogenesis concern as BPC-157 with cancer history.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
4/10
6/10
6/10

DSIP

Intro
DSIP is a neuropeptide that modulates sleep architecture by promoting delta-wave (slow-wave) sleep. It was isolated from rabbit thalamic venous blood in 1977. Unlike benzodiazepines, it doesn't cause sedation — it shifts the sleep profile toward restorative deep sleep.
Mechanism
Modulates GABA-B receptors. Reduces nocturnal cortisol. Increases GH secretion during sleep. Normalizes circadian rhythm via hypothalamic-pituitary axis modulation. Antioxidant effects.
Benefits
Improved deep sleep quality (not just duration). GH pulse enhancement during sleep. Reduced cortisol during sleep. Potential nootropic effects via improved sleep. Non-sedating — no morning grogginess.
Negatives
Short plasma half-life (~30 min) — may require specific timing. Most data from 1980s-90s Russian studies. Limited modern replication. Expensive per mg.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100-300mcg = 0.02-0.06ml.
Dosage
100-300mcg subcut 30-60 min before sleep.
Timing
30-60 minutes before bedtime.
Cycling
5-7 day cycles. Short-term use most studied.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €30-60/month.
Evidence Grade
C+ — Russian human trials 1980s. Mechanism plausible. Limited modern replication.
Synergies
Melatonin (circadian complementary). Ipamorelin (synergistic GH pulse during sleep).
Warnings
No known serious interactions. Avoid combining with benzodiazepines (additive sleep effects).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

SS-31 (ELAMIPRETIDE)

Intro
SS-31 (Szeto-Schiller peptide 31) is a tetrapeptide that concentrates in the inner mitochondrial membrane, stabilizing cardiolipin. It is arguably the most promising mitochondria-targeting molecule currently studied, with active Phase II/III trials for Barth syndrome, heart failure, and age-related muscle loss.
Mechanism
Binds cardiolipin in inner mitochondrial membrane → stabilizes electron transport chain structure. Reduces mitochondrial ROS production. Maintains cristae morphology. Improves ATP synthesis efficiency.
Benefits
Mitochondrial function restoration. Reduced oxidative stress. Improved energy efficiency (not stimulant-based). Potential muscle function improvement. Active pharmaceutical development — human safety data exists.
Negatives
Expensive per mg. Mostly disease-state human trials — healthy young male data absent. Injectable only (high MW). Long-term use unknown.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
1-5mg/day subcut. Clinical trials used 0.05-0.25 mg/kg IV.
Timing
Morning.
Cycling
4-12 week cycles. Research ongoing.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$86 per kit (10×10mg vials). ~€8/vial. Expensive but unique mechanism.
Evidence Grade
B- — Phase II human trials in disease states. Mechanism very well characterized. Healthy young use extrapolated.
Synergies
NAD+ precursors (complementary mitochondrial support). MOTS-C.
Warnings
No known serious interactions. Not indicated in healthy young without mitochondrial disease.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
6/10
5/10
5/10
5/10

MOTS-C

Intro
MOTS-C is a peptide encoded in the mitochondrial genome — one of the first mitochondria-derived peptides discovered. It acts as a metabolic regulator, improving insulin sensitivity and exercise capacity. Endogenous levels decline with age and are increased by exercise.
Mechanism
Activates AMPK. Inhibits AICAR (purine synthesis) → folate cycle disruption → metabolic reprogramming. Improves glucose uptake independent of insulin. Regulates ROS homeostasis in mitochondria.
Benefits
Improved insulin sensitivity. Enhanced exercise capacity and metabolic efficiency. Anti-obesity effects. Potential longevity effects. Exercise-mimicking properties.
Negatives
Most data animal studies. Human trial data limited to one small RCT. Age-related benefit unclear in young healthy subjects (endogenous levels already high at 18). Expensive.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 2-5mg per injection.
Dosage
5-10mg subcut 2-3×/week.
Timing
Morning or pre-workout.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$65 per kit (10×10mg vials). ~€6/vial. Moderate.
Evidence Grade
C+ — Strong animal data. One small human RCT (n=40). Mechanism well-established.
Synergies
SS-31 (mitochondrial stack). Exercise potentiation.
Warnings
No known serious interactions. Limited human safety data.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

5-AMINO-1MQ

Intro
5-amino-1-methylquinolinium (5-amino-1MQ) is a small molecule that inhibits CD38, the primary NAD+-degrading enzyme in the body. Unlike taking NAD+ precursors (NMN/NR), which add more NAD+ substrate, 5-amino-1MQ prevents NAD+ from being broken down — potentially more efficient.
Mechanism
Inhibits CD38 (NAD+ glycohydrolase) → NAD+ levels rise. CD38 activity increases dramatically with age and inflammation. Preserves endogenous NAD+ pool without external supplementation.
Benefits
NAD+ preservation. Potential fat loss effects (adipocyte CD38 inhibition). Anti-inflammatory. More targeted mechanism than NMN/NR for NAD+ elevation.
Negatives
Very limited human data. Research peptide status. Long-term safety unknown. Age-appropriateness at 18 unestablished (same issue as NAD+ precursors — you don't need this yet).
Reconstitution
Oral or injectable. 5mg vial with 1ml BAC water = 5mg/ml.
Dosage
5-50mg oral or 1-5mg subcut.
Timing
Morning.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months.
Cost (vendor)
$45 per kit (10×5mg) or $110 per kit (10×50mg). ~€4-10/vial.
Evidence Grade
C — Animal data only. No human RCTs. Mechanism well-established biochemically.
Synergies
SS-31, MOTS-C (mitochondrial stack). More relevant at 35+ years.
Warnings
Not recommended under 35. No established benefit in young healthy subjects.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
7/10
3/10

THYMOSIN ALPHA-1

Intro
Thymosin Alpha-1 (Tα1) is an endogenous peptide originally isolated from thymic tissue. It is FDA-approved in 35+ countries for chronic hepatitis B and C, and used as an immune adjuvant in cancer treatment. Strong immunomodulatory and antiviral properties.
Mechanism
Enhances T-cell, NK cell, and dendritic cell function. Upregulates IL-2, IFN-γ. Activates Toll-like receptors. Promotes antigen presentation. Anti-inflammatory via IL-10 pathway.
Benefits
Immune system enhancement and normalization. Antiviral effects. Used clinically for immunocompromised patients. Strong safety data from approved medical use. Potential benefit post-illness or during intense training phases.
Negatives
Healthy young with normal immune function may see minimal benefit. Expensive. Primary benefit for immunocompromised or sick individuals. Mild injection site reactions.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
1-2mg subcut 2×/week. Clinical dose: 1mg/m² body surface area.
Timing
Any time — immune timing less critical.
Cycling
2-6 week cycles. Or as needed during illness.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$80 per kit (10×5mg vials). ~€7/vial. Moderate.
Evidence Grade
B — Approved in multiple countries for specific indications. Good human safety data. Healthy young use extrapolated.
Synergies
BPC-157 (immune + healing stack during recovery). Useful post-surgery.
Warnings
No significant drug interactions at standard doses. Avoid in autoimmune conditions without medical supervision.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
6/10
6/10
6/10

KPV

Intro
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of α-MSH. It retains the anti-inflammatory properties of the parent molecule without melanocortin receptor agonism. Being 3 amino acids, it has superior bioavailability and can even be taken orally for GI effects.
Mechanism
Inhibits NF-κB signalling. Reduces TNF-α, IL-1β, IL-6 production. Activates MC1R and MC3R locally (anti-inflammatory, not pigmentation). Promotes intestinal epithelial healing.
Benefits
Potent anti-inflammatory for gut, skin, and systemic use. Oral bioavailability for GI-specific effects. No melanocortin pigmentation effects. Excellent safety profile. Can be combined with BPC-157 for enhanced GI healing.
Negatives
Limited human clinical trial data. Research peptide status. Very short half-life requires frequent dosing or oral route.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. Can be taken orally (encapsulate or dissolve in water).
Dosage
500mcg–2mg subcut or 1-5mg oral per day.
Timing
Any time. Oral pre-meals for GI effects.
Cycling
Continuous low-dose or acute 4-week protocols.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$60 per kit (10×10mg vials). ~€5.5/vial. Reasonable.
Evidence Grade
C+ — Strong in-vitro/animal. Human data emerging. Mechanism very well characterized.
Synergies
BPC-157 (GI healing stack). Part of BBG or KLOW80 recovery mix.
Warnings
No known serious interactions. Excellent tolerability profile.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
8/10
4/10
7/10
6/10

CEREBROLYSIN

Intro
Cerebrolysin is a complex mixture of low-molecular-weight peptides derived from porcine brain tissue. It contains BDNF, NGF, CNTF, and other neurotrophins. Used clinically in Eastern Europe and Asia for stroke, traumatic brain injury, and Alzheimer's disease.
Mechanism
Provides exogenous BDNF, NGF, and other neurotrophins directly. Promotes neurogenesis and synaptic plasticity. Neuroprotective against excitotoxicity. Anti-apoptotic in neurons.
Benefits
Direct neurotrophin supplementation (vs Semax which stimulates endogenous production). Established clinical use in stroke recovery. May enhance cognitive recovery after stress or illness. Fast-acting neuroplasticity support.
Negatives
Derived from porcine brain — quality control important. Injectable only (IV preferred clinically, IM used in biohacking). Religious/dietary restrictions for some. Most trials in neurological disease, not healthy subjects. Quality varies by vendor significantly.
Reconstitution
Ready solution typically. Check vendor — should be aqueous solution, not lyophilized.
Dosage
1-5ml IM/subcut. Clinical: 10-30ml IV/day. For cognitive use: 1-2ml IM daily.
Timing
Morning.
Cycling
10-30 day cycles. 2-3× per year.
Storage
Refrigerate 2-8°C. Do not freeze.
Cost (vendor)
$29 per kit (6×60mg vials). ~€4.5/vial. Budget-friendly.
Evidence Grade
B- — Multiple RCTs in stroke/TBI (positive). Healthy cognitive enhancement — limited data.
Synergies
Semax (BDNF endogenous + exogenous). Citicoline.
Warnings
Ensure vendor quality — biological product contamination risk. Do not use if porcine-derived products contraindicated.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
6/10
5/10
8/10
6/10

SNAP-8

Intro
Snap-8 (Acetyl Octapeptide-3) is a synthetic octapeptide that mimics the N-terminal portion of SNAP-25. It competes with the SNARE complex, reducing neurotransmitter release at neuromuscular junctions in facial skin. Often called 'topical Botox' in cosmetic science.
Mechanism
Inhibits SNARE complex formation → reduced acetylcholine release at local neuromuscular junctions → reduced muscle contraction intensity in expression lines → smoother appearance over time.
Benefits
Reduces expression-related fine lines without injection. Can be added to moisturizer or serum. No systemic effects. Safe topical profile.
Negatives
Penetration through skin is very limited for large peptides. Most human evidence industry-funded. Effects subtle vs Botox. Not relevant at 18 — no expression lines yet.
Reconstitution
Typically used as topical — dissolve in DMSO or serum base for penetration.
Dosage
2-10% topical solution, apply 2× daily.
Timing
Morning and evening skincare routine.
Cycling
Continuous — topical peptides require sustained use.
Storage
Lyophilized 12+ months. Solution 1 month refrigerated.
Cost (vendor)
$40 per kit (10×10mg vials). ~€3.5/vial. Very affordable.
Evidence Grade
C+ — One industry-funded human trial showing 52% wrinkle reduction. No independent replication.
Synergies
Tretinoin (different mechanism). GHK-Cu (complementary skin matrix support).
Warnings
Not meaningful at 18 years. Consider at 30+ when expression lines begin. Skin penetration limitations mean topical DMSO carrier needed.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
3/10
9/10
3/10
9/10
4/10

PINEALON

Intro
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by the same Russian group as Epitalon (Khavinson). It is derived from the pineal gland and claimed to regulate circadian rhythms, protect neurons, and enhance cognitive function. More targeted neurological action than Epitalon.
Mechanism
Claimed: regulates melatonin secretion rhythm. Neuroprotective against oxidative stress. Potentially modulates DNA methylation patterns in neurons. Anti-apoptotic in neuronal cell lines.
Benefits
Potential sleep quality improvement. Neuroprotective effects in animal models. Claimed cognitive enhancement. Better age-appropriateness than Epitalon (circadian regulation relevant at any age).
Negatives
All evidence from single Russian research group (Khavinson) — significant conflict of interest. No independent replication. Human data limited to elderly. Mechanism insufficiently characterized.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
5-10mg course over 10 days.
Timing
Evening for circadian effects.
Cycling
10-day courses 2-3× per year.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$55 per kit (10×5mg vials). ~€5/vial. Moderate.
Evidence Grade
C — Single research group. Elderly-only human data. No independent replication.
Synergies
Melatonin (circadian stack). DSIP.
Warnings
Same single-source evidence issue as Epitalon. Verify independently before use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
6/10
4/10

EPITHALON (EPITALON)

Intro
Synthetic tetrapeptide from the pineal gland. Claimed telomerase activator. All positive human evidence in elderly (60+) cohorts. Mismarketed to younger users — fundamentally age-inappropriate under 35.
Mechanism
Activates telomerase (hTERT) in somatic cells. Regulates melatonin secretion. Antioxidant. Regulates hypothalamic-pituitary axis.
Benefits
Telomere elongation in elderly subjects. Normalizes melatonin in aged individuals. Sleep improvement. Antioxidant effects.
Negatives
NOT APPROPRIATE UNDER 35-40 YEARS. Your telomeres are already near peak length at 18. Long telomeres correlated with MORE tumors (Johns Hopkins research). All-cause mortality data shows abnormally long telomeres are harmful. Single research group with patent conflict of interest.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
5-10mg/day × 10-20 days (elderly protocol).
Timing
Evening.
Cycling
2× per year for elderly users.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$48 per kit (10×10mg vials). ~€4.4/vial. Affordable but irrelevant at <35.
Evidence Grade
C+ — Single research group. Human data in elderly only. No independent replication.
Synergies
Melatonin, Pinealon. NOT for young users.
Warnings
DO NOT USE UNDER 35. No benefit. Theoretical cancer risk from telomere overextension at young age.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
7/10
3/10
7/10
2/10

IPAMORELIN

Intro
Selective GHRH receptor agonist. Cleanest GHRP — no cortisol/prolactin elevation. Best used with CJC-1295 no-DAC for synergistic GH pulse. At 18, natural GH is already at peak — use with caution.
Mechanism
GHSR-1a (ghrelin receptor) agonist → pulsatile GH release from pituitary. Highly selective. No ACTH, cortisol, or prolactin stimulation at standard doses.
Benefits
Clean GH stimulation. Improved deep sleep. Recovery enhancement. Lean mass support. Better tolerated than GHRP-2/6.
Negatives
At 17-18, endogenous GH already at lifetime peak. Marginal additional benefit. Potential GH receptor downregulation. Water retention possible. Not FDA approved.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100mcg = 0.02ml.
Dosage
100-300mcg per injection. 1-3×/day. Most useful pre-bed.
Timing
Pre-bed (maximize natural GH pulse). Can stack with CJC-1295 no-DAC.
Cycling
12-week cycles, 4-6 weeks off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €40-80/month.
Evidence Grade
C+ — Phase II human trials in GH deficiency. Mechanism well-established. Off-label recovery use anecdotal.
Synergies
CJC-1295 no-DAC (synergistic GH pulse). DSIP (sleep enhancement stack).
Warnings
Marginal benefit at 17-18. Wait until 21+ for optimal use case. Never fasted training + ipamorelin (hypoglycemia risk).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
5/10
7/10
5/10

NAD+

Intro
NAD+ precursors (NMN/NR) raise intracellular NAD+ levels. NAD+ declines with age, primarily after 40. Every positive human RCT enrolled middle-aged or elderly subjects. Not indicated at 18.
Mechanism
NAD+ precursors → raise NAD+ pool → sirtuin activation → mitochondrial efficiency. Requires CD38 to be low for optimal effect.
Benefits
Mitochondrial function in elderly. DNA repair enhancement. Sirtuin activation. Muscle function support in aged subjects.
Negatives
NOT RECOMMENDED UNDER 35. NAD+ peaks between 15-30. 2025 meta-analysis: no significant benefit for muscle function in young subjects. Your niacinamide 10% topical already supports local NAD+. Waste of money at your age.
Reconstitution
Oral capsules. Injectable NAD+ also available (listed vendor).
Dosage
250-500mg NMN or NR oral. Or 100-500mg IV/IM injectable.
Timing
Morning.
Reconstitution
No established cycle for oral. Injectable courses sometimes 10 days.
Storage
Keep dry. Heat sensitive.
Cost (vendor)
$40 per kit (10×100mg) to $130 per kit (10×1000mg). Pointless at 18.
Evidence Grade
B- (in elderly), C (in young). All positive RCTs in 40+ populations.
Synergies
5-amino-1MQ (CD38 inhibitor — more relevant mechanism). SS-31. All age 35+.
Warnings
NOT RECOMMENDED UNDER 35. No demonstrated benefit. Use money elsewhere.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
9/10
3/10
5/10
2/10

PEPTIDES NOT RECOMMENDED FOR THIS CONTEXT

Do Not Use — Reasons Explained

Semaglutide / Tirzepatide / Retatrutide / Cagrilintide
If you can't get your body fat down to 10% at least once in your life, what can you actually do?
I use Tirzepatide myself
IGF-1 LR3 (Used it myself)
Highly anabolic IGF-1 analogue. Promotes growth in ALL tissues including potential tumor cells. Open growth plates at 17-18 make this particularly concerning. Hypoglycemia risk. Not appropriate under 21+.
Dermorphin
Opioid peptide — 50x more potent than morphine. Extremely high addiction potential. Not appropriate for any looksmaxxing or performance context. High risk of dependence, respiratory depression, death in overdose.
Adipotide
Experimental peptide targeting ANXA2/PROHIBITIN on fat cell vasculature. Causes kidney toxicity in primate studies. Never cleared for human use. Avoid entirely.
Oxytocin
Half-life 3-5 minutes IV. Intranasal slightly longer. No meaningful persistent anxiolytic effect for social situations. Better alternatives available (Etifoxine, Selank, Pregab).
PT-141 (Bremelanotide)
MC3R/MC4R agonist for sexual dysfunction. More systemic side effects than MT-1. Nausea, blood pressure effects. Not a looksmaxxing compound.

STACKING GUIDE

Recommended Stacks by Goal

Cognitive Peak
Semax (1mg/day IN) + Citicoline (250mg/day oral) + Selank (500mcg situational). Semax → focus/BDNF, Citicoline → ACh, Selank → anxiety control.
Skin & PIE
GHK-Cu (2mg subcut EOD) + Tretinoin (topical) + Azelaic Acid 20% (topical) + Niacinamide 10% (topical). Best-evidenced combination.
Post-Surgery
BPC-157 (500mcg/day) + TB-500 (2mg 2×/week) + GHK-Cu (500mcg/day) + KPV (1mg/day). 8-week protocol.
Healing & Recovery
BPC-157 + TB-500 combo vial (BBG or KLOW80 mix). Most cost-effective option. KLOW80 adds KPV for anti-inflammatory.
Sleep Quality
DSIP (200mcg subcut pre-bed) + Ipamorelin (100mcg pre-bed). Synergistic GH pulse + deep sleep architecture.
Mitochondrial Stack
SS-31 (2mg/day) + MOTS-C (5mg 3×/week). Age 30+ optimal. Limited benefit at 18.
Immune Support
Thymosin Alpha-1 (1mg 2×/week) for 4-6 weeks during illness, intense training periods, or post-surgery.
Anxiolysis (Daily)
Selank (400-600mcg/day, cycled 14/14). No dependence, no sedation. Best daily option.
Anxiolysis (Events)
Etifoxine 50mg → Pregabalin 75-150mg (reserve for important only). Never two GABAergics same day.

CRITICAL INTERACTIONS
READ BEFORE STACKING

ABSOLUTE
NEVER: Selank + Etifoxine + Pregabalin same day. Three GABAergics = CNS depression risk.
ABSOLUTE
NEVER: MT-1 + MT-2 simultaneously. Receptor overlap, unpredictable systemic effects.
AVOID
Ipamorelin/CJC-1295 on fasted training days — hypoglycemia risk.
AVOID
Semax + Modafinil daily — both dopaminergic. Limit to exam days only.
SEPARATE
GHK-Cu and Zinc: pause zinc during GHK-Cu cycle. Competition for transporters.
SEPARATE
MT-1 and GHK-Cu injections: different anatomical sites same evening.
NOTE
BPC-157 / TB-500 / GHK-Cu vendor combo mixes (BBG, KLOW80) can be drawn from same vial — convenient and cost-effective.

RECONSTITUTION QUICK REFERENCE

Standard Dilutions
Semax 40mg 4ml BAC water → 10mg/ml → 1mg dose = 0.1ml
Selank 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
GHK-Cu 2mg 1ml BAC water (or PBS) → 2mg/ml → 2mg = 1ml
GHK-Cu 50mg (bulk) 25ml BAC water → 2mg/ml → 2mg = 1ml
MT-1 10mg 1ml BAC water → 10mg/ml → 500mcg = 0.05ml
BPC-157 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
TB-500 5mg 1ml BAC water → 5mg/ml → 2mg = 0.4ml
Ipamorelin 5mg 1ml BAC water → 5mg/ml → 100mcg = 0.02ml
DSIP 5mg 1ml BAC water → 5mg/ml → 200mcg = 0.04ml
Epitalon 10mg 2ml BAC water → 5mg/ml → 5mg = 1ml
Thymosin Alpha-1 5mg 1ml BAC water → 5mg/ml → 1mg = 0.2ml
KPV 10mg 1ml BAC water → 10mg/ml → 1mg = 0.1ml (or oral)
PBS vs BAC Water Use PBS for copper peptides (GHK-Cu, AHK-Cu) — better copper stability. BAC water for all others.

VENDOR PRICE REFERENCE (Chinese Warehouse)
$60 flat worldwide shipping fee. All prices USD per kit of 10 vials (divide by 10 for single vial price). Prices as of April 2026.

Product Price (USD) per kit (10 vials)
Semax 5mg×10 $40
Semax 10mg×10 $50
Selank 5mg×10 $40
GHK-Cu 50mg×10 $30
GHK-Cu 100mg×10 $45
AHK-Cu 100mg×10 $68
MT-1 10mg×10 $45
MT-2 10mg×10 $45
BPC-157 5mg×10 $40
BPC-157 10mg×10 $70
TB-500 5mg×10 $75
TB-500 10mg×10 $140
BPC+TB 5mg+5mg×10 $95
GHK+BPC+TB 50/10/10mg×10 $160
GHK+BPC+TB+KPV 80mg×10 $195
KPV 10mg×10 $60
Ipamorelin 5mg×10 $45
Ipamorelin 10mg×10 $80
CJC-1295 no-DAC 5mg×10 $85
CJC+Ipa combo 10mg×10 $95
DSIP 5mg×10 $45
DSIP 15mg×10 $85
SS-31 10mg×10 $86
SS-31 50mg×10 $285
MOTS-C 10mg×10 $65
MOTS-C 40mg×10 $185
5-amino-1MQ 5mg×10 $45
5-amino-1MQ 50mg×10 $110
Thymosin Alpha-1 5mg×10 $80
TA-1 10mg×10 $145
Epitalon 10mg×10 $48
Epitalon 50mg×10 $150
Cerebrolysin 60mg×6 $29
Pinealon 5mg×10 $55
Pinealon 10mg×10 $70
Snap-8 10mg×10 $40
NAD+ 100mg×10 $40
NAD+ 500mg×10 $80
NAD+ 1000mg×10 $130
L-Carnitine 600mg/ml 10ml×10 $80
Glutathione 1500mg×10 $80
Melatonin 10mg×10 $55
VIP 5mg×10 $75
SLU-PP-322 5mg×10 $100
AICAR 50mg×10 $62
Tesamorelin 5mg×10 $110
ARA-290 10mg×10 $80
BAC Water 10ml×10 $10
PBS 10ml×10 $10
Acetic Acid Water 10ml×10 $10

PEPTIDES

Melanotan-1 subcutaneously, in the evening.

GHK-Cu 2 mg subcutaneously, in the evening.

Tirzepatide 2,5 mg subcutaneously, every week

@reyalsnoom @Jesus_ist_König @tqbiq @greylord @aaronbp

Very helpful troynem

WannabeClavicular · Apr 14, 2026

til<3D said:
Complete Guide to Peptide Protocols — Dosing, Evidence & Stacking

by til<3D
Stand: April 2026

DISCLAIMER

Read First
This guide is for educational purposes only. Peptides are not approved drugs in most countries. Everything here is off label and experimental. Do your own research. You are responsible for your own choices. This is not medical advice.
Age Note
Several peptides are specifically marked as inappropriate for users under 18-20 years old due to ongoing hormonal and neural development. These warnings are clearly flagged throughout.
Sources
Evidence grades reflect actual human clinical trial data, animal studies, and in vitro research. Grade A = multiple human RCTs. Grade B = some human data. Grade C = animal/in vitro only.

PEPTIDES COVERED IN THIS THREAD

1. Semax — ACTH(4-7) Analogue — Nootropic

2. Selank — Tuftsin Analogue — Anxiolytic & Cognitive

3. GHK-Cu — Copper Peptide — Skin & Collagen

4. AHK-Cu — Copper Peptide — Hair Growth

5. Melanotan-1 (MT-1) — MC1R Agonist — Tanning

6. BPC-157 — Body Protection Compound — Healing

7. TB-500 — Thymosin Beta-4 — Recovery & Flexibility

8. DSIP — Delta Sleep-Inducing Peptide — Sleep Architecture

9. SS-31 (Elamipretide) — Mitochondria-Targeting Peptide — Energy & Cardioprotection

10. MOTS-C — Mitochondrial-Derived Peptide — Metabolic

11. 5-amino-1MQ — CD38 Inhibitor — NAD+ Preservation

12. Thymosin Alpha-1 — Immune Modulator — Immune Enhancement

13. KPV — Anti-Inflammatory Tripeptide — Gut & Skin

14. Cerebrolysin — Neuropeptide Mix — Cognitive & Neuroprotection

15. Snap-8 — Neuropeptide — Anti-Wrinkle Topical

16. Pinealon — Pineal Peptide — Neuroprotection & Circadian

17. Epithalon (Epitalon) — Tetrapeptide — Telomere (Age 40+ Only)

18. Ipamorelin — GHRP — GH Secretagogue (Age 20+ Optimal)

19. NAD+ — NAD+ Precursors — Mitochondrial (Age 35+ Only)

QUICK REFERENCE — ALL PEPTIDES

Peptide Effectiveness Evidence Age 17-18 Cost/mo Overall
Semax 8/10 B+ ✓ OK €20–35/vial (40mg) 8/10
Selank 8/10 B ✓ OK €25–40/vial (5mg) 7/10
GHK-Cu 7/10 B- ✓ OK €30/vial (50mg bulk) — much better value 7/10
AHK-Cu 6/10 C+ ✓ OK $68/100mg vial (vendor) 6/10
Melanotan-1 (MT-1) 9/10 A- ✓ OK $45/10mg vial × 10 8/10
BPC-157 7/10 C+ ✓ OK $40/5mg vial × 10 6/10
TB-500 7/10 C+ ✓ OK $75/5mg vial × 10 6/10
DSIP 6/10 C+ ✓ OK $45/5mg vial × 10 5/10
SS-31 (Elamipretide) 6/10 B- ✓ OK $86/10mg vial × 10 5/10
MOTS-C 6/10 C+ ✓ OK $65/10mg vial × 10 5/10
5-amino-1MQ 4/10 C ✓ OK $45/5mg vial or $110/50mg 3/10
Thymosin Alpha-1 7/10 B ✓ OK $80/5mg vial × 10 6/10
KPV 6/10 C+ ✓ OK $60/10mg vial × 10 6/10
Cerebrolysin 7/10 B- ✓ OK $29/60mg × 6 vials (vendor) 6/10
Snap-8 3/10 C+ ✓ OK $40/10mg vial × 10 (vendor) 4/10
Pinealon 4/10 C ✓ OK $55/5mg vial × 10 4/10
Epithalon (Epitalon) 2/10 C+ ✗ Caution $48/10mg × 10 (vendor) 2/10
Ipamorelin 6/10 C+ ✗ Caution $45/5mg vial × 10 5/10
NAD+ 2/10 B- ✗ Caution $40-130 depending on dose 2/10

INDIVIDUAL PEPTIDE PROFILES

SEMAX

Intro
Synthetic heptapeptide analogue of ACTH(4-7), developed in Russia for stroke and cognitive enhancement. Decades of clinical data. Crosses BBB efficiently intranasally. You could also do subq but in my opinion it's unnecessary.
Mechanism
Upregulates BDNF. Modulates dopaminergic/serotonergic transmission. Increases enkephalinase activity. NO signalling enhancement.
Benefits
Enhanced focus, memory, learning. Neuroprotection. Anti anxiety via serotonin. Rapid onset 15-30 min. No physical dependence.
Negatives
Receptor desensitization — cycling required. Mild anxiety at high doses. Most studies Russian literature.
Reconstitution
4ml BAC water on 40mg vial = 10mg/ml. 1mg = 0.1ml = 1 pump.
Dosage
0.5–1mg/day intranasal.
Timing
Morning, fasted or first meal.
Cycling
5 days ON / 2 OFF. Or 3 weeks ON / 1 week OFF.

Storage
Lyophilized 12+ months. Reconstituted 4°C, 4 weeks.
Cost (vendor)
$50/100mg vial (vendor).
Evidence Grade
B+ — Russian Phase II/III trials. Growing Western replication.
Synergies
Citicoline, Selank. Never combine with high dose Modafinil same day.
Warnings
Monitor with Modafinil stack. Avoid MAOIs.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
7/10
8/10
8/10

SELANK

Intro
Synthetic analogue of tuftsin. Official anxiolytic drug status in Russia/Ukraine. Anxiolysis without sedation, tolerance, or withdrawal.
Mechanism
Allosteric GABA-A modulation. Inhibits enkephalinase. Modulates BDNF/NGF. Complements Semax via distinct brain connectivity patterns.
Benefits
Anxiolysis without sedation or dependence. Cognitive enhancement. Anti inflammatory. No BtMG. Low desensitization risk at standard doses.
Negatives
Most evidence Russian studies. Additive CNS depression with other GABAergics — critical interaction. Short half-life ~2h intranasal.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
250–800mcg/day intranasal.
Timing
Morning or 30-60 min before stressful situations.
Cycling
14 days ON / 14 days OFF, or situational.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/100mg vial (vendor). Very cost effective per mg.
Evidence Grade
B — Russian Phase II clinical trials in GAD.
Synergies
Semax (complementary). NEVER with Etifoxine, Pregabalin, or alcohol same day.
Warnings
NEVER combine with Etifoxine, Pregabalin, or benzodiazepines same day. Additive CNS depression.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
6/10
8/10
7/10

GHK-CU

Intro
Naturally occurring copper-binding peptide. Plasma levels decline with age. Gold standard for skin regeneration and wound healing.
Mechanism
Activates fibroblasts → collagen I/III/elastin synthesis. VEGF-driven angiogenesis. Inhibits TGF-β1 (anti-fibrotic). Antioxidant enzyme upregulation.
Benefits
PIE/acne scar remodeling. Skin density improvement. Wound/post-surgery healing. Tendon collagen support. Anti-inflammatory.
Negatives
Systemic human RCT data limited. Competing with zinc pause zinc during use. Monitor copper levels with chronic use.
Reconstitution
1ml BAC water on 2mg vial = 2mg/ml. 27-29G needle, 4-6mm, 45°. PBS preferred for copper stability.
Dosage
2mg subcut EOD/ ED.
Timing
Evening after training. Separate site from MT-1.
Cycling
4-week cycles. Zinc paused. After cycle reintroduce zinc.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/1g vial (vendor). Very cost effective per mg.
Evidence Grade
B- — Strong in-vitro/animal. Limited human RCTs for subcut use. Topical human evidence solid.
Synergies
Tretinoin (complementary collagen). Copper supplement 30-60 min before injection.
Warnings
Pause zinc during cycle. Monitor serum copper/ceruloplasmin with extended use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
5/10
10/10
8/10

AHK-CU

Intro
Tripeptide analogue of GHK-Cu with higher affinity for hair follicle receptors. AHK (Ala-His-Lys) specifically promotes hair growth via follicle dermal papilla stimulation.
Mechanism
Activates Wnt/β-catenin pathway in hair follicles. Promotes dermal papilla cell proliferation. Upregulates VEGF in follicle microvasculature. Inhibits DHT-induced apoptosis in follicles.
Benefits
Hair density and thickness improvement. Potentially superior to GHK-Cu for scalp/follicle applications. Can be used topically or subcut. Anti-inflammatory in follicle microenvironment.
Negatives
Less research than GHK-Cu overall. Mostly in-vitro data. Higher cost per mg. Limited human studies specifically.
Reconstitution
1ml BAC water per 10mg = 10mg/ml. Can be used topically (DMSO carrier) or subcut.
Dosage
Topical: 0.01-0.1% solution on scalp. Subcut: 1-2mg/day.
Timing
Evening or post-shower for topical.
Cycling
Continuous or 8-week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$68/1g vial (vendor). Very cost effective per mg.
Evidence Grade
C+ — In-vitro strong. Limited human data. Mechanistically plausible.
Synergies
GHK-Cu (different receptor affinity — complementary). Minoxidil topical.
Warnings
Avoid mixing with acidic solutions. PBS preferred diluent.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
9,5/10
8/10

MELANOTAN-1 (MT-1)

Intro
Synthetic α-MSH analogue with MC1R selectivity. Only melanocortin peptide with EMA approval (Scenesse for EPP). Deep even tan with reduced UV exposure.
Mechanism
MC1R agonism → tyrosinase upregulation → eumelanin synthesis. UV activation required to convert precursors to visible pigment.
Benefits
Deep even tan. Photoprotection. Visually reduces PIE by contrast. EMA-approved safety data. Lower systemic effects vs MT-2.
Negatives
Nausea during loading (reduced by microdosing). Mole changes — document before starting. UV >3 required for activation. MC4R spillover at high doses.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 500mcg = 0.05ml.
Dosage
Loading: 500mcg/day × 14 days. Maintenance: 250-500mcg E2-3D + UV.
Timing
Evening — sleep through initial nausea.

Cycling
Loading → Maintenance. No continuous loading.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$4,5/10mg vial × 10. ~€2-3,5/month maintenance.
Evidence Grade
A- — EMA approved. Phase III trials. Extensive safety data.
Synergies
UV exposure (essential). Tretinoin. Solarium if UV index <3.
Warnings
Photograph all moles before starting. Never combine with MT-2.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
7/10
8/10
9/10
8,5/10

BPC-157

Intro
Synthetic pentadecapeptide from gastric juice. Remarkable healing in animal models across tendons, ligaments, muscles, GI tract. Most promising for injury recovery and post-surgical healing.
Mechanism
Upregulates GH receptor. VEGF angiogenesis. FAK-paxillin wound healing pathway. NF-κB inhibition. Collagen synthesis in tenocytes.
Benefits
Tendon/ligament healing acceleration. GI mucosal protection. Nerve regeneration (animal). Anti-inflammatory. Enhanced training recovery.
Negatives
Virtually ALL data is animal/in-vitro. Zero completed human RCTs. Unknown optimal human dosing. Unknown long-term safety.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
200-500mcg/day subcut or IM. Split morning + evening.
Timing
Morning and/or post-training.
Cycling
4-8 weeks on, 4 off. Or acute injury protocol.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$40 per kit (10×5mg vials). ~€3.5/vial. €40-70/month.
Evidence Grade
C+ — Extensive animal data, consistent results. Zero human RCTs. High translation uncertainty.
Synergies
TB-500 (complementary). GHK-Cu (collagen synergy).
Warnings
Theoretical angiogenesis concern with cancer history (unproven in humans). No known drug interactions.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
8/10
4/10
7/10
6/10

TB-500

Intro
Synthetic fragment of thymosin beta-4. Critical role in cell migration, wound healing, tissue regeneration. Systemic healing reach that BPC-157 lacks.
Mechanism
Binds G-actin → cell migration/differentiation. Integrin-linked kinase activation. Metalloproteinase upregulation for tissue remodeling. Vascular tube formation.
Benefits
Systemic healing (reaches distant injury sites). Muscle fiber regeneration. Flexibility/ROM improvements. Potential cardiac protection.
Negatives
Human RCT data absent for recovery use. Higher MW limits oral bioavailability. More expensive than BPC-157. Overlap with BPC-157.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
Loading: 2-2.5mg 2×/week × 4-6 weeks. Maintenance: 2-2.5mg 1×/week.
Timing
Morning or post-training.
Cycling
6-week loading, then maintenance or off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$75 per kit (10×5mg vials). ~€7/vial. €50-90/month.
Evidence Grade
C+ — Animal data solid. Phase II trial in dry eye disease. Limited systemic recovery data in humans.
Synergies
BPC-157 (most common stack). Post-surgery recovery protocol.
Warnings
Same theoretical angiogenesis concern as BPC-157 with cancer history.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
4/10
6/10
6/10

DSIP

Intro
DSIP is a neuropeptide that modulates sleep architecture by promoting delta-wave (slow-wave) sleep. It was isolated from rabbit thalamic venous blood in 1977. Unlike benzodiazepines, it doesn't cause sedation — it shifts the sleep profile toward restorative deep sleep.
Mechanism
Modulates GABA-B receptors. Reduces nocturnal cortisol. Increases GH secretion during sleep. Normalizes circadian rhythm via hypothalamic-pituitary axis modulation. Antioxidant effects.
Benefits
Improved deep sleep quality (not just duration). GH pulse enhancement during sleep. Reduced cortisol during sleep. Potential nootropic effects via improved sleep. Non-sedating — no morning grogginess.
Negatives
Short plasma half-life (~30 min) — may require specific timing. Most data from 1980s-90s Russian studies. Limited modern replication. Expensive per mg.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100-300mcg = 0.02-0.06ml.
Dosage
100-300mcg subcut 30-60 min before sleep.
Timing
30-60 minutes before bedtime.
Cycling
5-7 day cycles. Short-term use most studied.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €30-60/month.
Evidence Grade
C+ — Russian human trials 1980s. Mechanism plausible. Limited modern replication.
Synergies
Melatonin (circadian complementary). Ipamorelin (synergistic GH pulse during sleep).
Warnings
No known serious interactions. Avoid combining with benzodiazepines (additive sleep effects).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

SS-31 (ELAMIPRETIDE)

Intro
SS-31 (Szeto-Schiller peptide 31) is a tetrapeptide that concentrates in the inner mitochondrial membrane, stabilizing cardiolipin. It is arguably the most promising mitochondria-targeting molecule currently studied, with active Phase II/III trials for Barth syndrome, heart failure, and age-related muscle loss.
Mechanism
Binds cardiolipin in inner mitochondrial membrane → stabilizes electron transport chain structure. Reduces mitochondrial ROS production. Maintains cristae morphology. Improves ATP synthesis efficiency.
Benefits
Mitochondrial function restoration. Reduced oxidative stress. Improved energy efficiency (not stimulant-based). Potential muscle function improvement. Active pharmaceutical development — human safety data exists.
Negatives
Expensive per mg. Mostly disease-state human trials — healthy young male data absent. Injectable only (high MW). Long-term use unknown.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
1-5mg/day subcut. Clinical trials used 0.05-0.25 mg/kg IV.
Timing
Morning.
Cycling
4-12 week cycles. Research ongoing.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$86 per kit (10×10mg vials). ~€8/vial. Expensive but unique mechanism.
Evidence Grade
B- — Phase II human trials in disease states. Mechanism very well characterized. Healthy young use extrapolated.
Synergies
NAD+ precursors (complementary mitochondrial support). MOTS-C.
Warnings
No known serious interactions. Not indicated in healthy young without mitochondrial disease.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
6/10
5/10
5/10
5/10

MOTS-C

Intro
MOTS-C is a peptide encoded in the mitochondrial genome — one of the first mitochondria-derived peptides discovered. It acts as a metabolic regulator, improving insulin sensitivity and exercise capacity. Endogenous levels decline with age and are increased by exercise.
Mechanism
Activates AMPK. Inhibits AICAR (purine synthesis) → folate cycle disruption → metabolic reprogramming. Improves glucose uptake independent of insulin. Regulates ROS homeostasis in mitochondria.
Benefits
Improved insulin sensitivity. Enhanced exercise capacity and metabolic efficiency. Anti-obesity effects. Potential longevity effects. Exercise-mimicking properties.
Negatives
Most data animal studies. Human trial data limited to one small RCT. Age-related benefit unclear in young healthy subjects (endogenous levels already high at 18). Expensive.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 2-5mg per injection.
Dosage
5-10mg subcut 2-3×/week.
Timing
Morning or pre-workout.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$65 per kit (10×10mg vials). ~€6/vial. Moderate.
Evidence Grade
C+ — Strong animal data. One small human RCT (n=40). Mechanism well-established.
Synergies
SS-31 (mitochondrial stack). Exercise potentiation.
Warnings
No known serious interactions. Limited human safety data.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

5-AMINO-1MQ

Intro
5-amino-1-methylquinolinium (5-amino-1MQ) is a small molecule that inhibits CD38, the primary NAD+-degrading enzyme in the body. Unlike taking NAD+ precursors (NMN/NR), which add more NAD+ substrate, 5-amino-1MQ prevents NAD+ from being broken down — potentially more efficient.
Mechanism
Inhibits CD38 (NAD+ glycohydrolase) → NAD+ levels rise. CD38 activity increases dramatically with age and inflammation. Preserves endogenous NAD+ pool without external supplementation.
Benefits
NAD+ preservation. Potential fat loss effects (adipocyte CD38 inhibition). Anti-inflammatory. More targeted mechanism than NMN/NR for NAD+ elevation.
Negatives
Very limited human data. Research peptide status. Long-term safety unknown. Age-appropriateness at 18 unestablished (same issue as NAD+ precursors — you don't need this yet).
Reconstitution
Oral or injectable. 5mg vial with 1ml BAC water = 5mg/ml.
Dosage
5-50mg oral or 1-5mg subcut.
Timing
Morning.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months.
Cost (vendor)
$45 per kit (10×5mg) or $110 per kit (10×50mg). ~€4-10/vial.
Evidence Grade
C — Animal data only. No human RCTs. Mechanism well-established biochemically.
Synergies
SS-31, MOTS-C (mitochondrial stack). More relevant at 35+ years.
Warnings
Not recommended under 35. No established benefit in young healthy subjects.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
7/10
3/10

THYMOSIN ALPHA-1

Intro
Thymosin Alpha-1 (Tα1) is an endogenous peptide originally isolated from thymic tissue. It is FDA-approved in 35+ countries for chronic hepatitis B and C, and used as an immune adjuvant in cancer treatment. Strong immunomodulatory and antiviral properties.
Mechanism
Enhances T-cell, NK cell, and dendritic cell function. Upregulates IL-2, IFN-γ. Activates Toll-like receptors. Promotes antigen presentation. Anti-inflammatory via IL-10 pathway.
Benefits
Immune system enhancement and normalization. Antiviral effects. Used clinically for immunocompromised patients. Strong safety data from approved medical use. Potential benefit post-illness or during intense training phases.
Negatives
Healthy young with normal immune function may see minimal benefit. Expensive. Primary benefit for immunocompromised or sick individuals. Mild injection site reactions.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
1-2mg subcut 2×/week. Clinical dose: 1mg/m² body surface area.
Timing
Any time — immune timing less critical.
Cycling
2-6 week cycles. Or as needed during illness.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$80 per kit (10×5mg vials). ~€7/vial. Moderate.
Evidence Grade
B — Approved in multiple countries for specific indications. Good human safety data. Healthy young use extrapolated.
Synergies
BPC-157 (immune + healing stack during recovery). Useful post-surgery.
Warnings
No significant drug interactions at standard doses. Avoid in autoimmune conditions without medical supervision.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
6/10
6/10
6/10

KPV

Intro
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of α-MSH. It retains the anti-inflammatory properties of the parent molecule without melanocortin receptor agonism. Being 3 amino acids, it has superior bioavailability and can even be taken orally for GI effects.
Mechanism
Inhibits NF-κB signalling. Reduces TNF-α, IL-1β, IL-6 production. Activates MC1R and MC3R locally (anti-inflammatory, not pigmentation). Promotes intestinal epithelial healing.
Benefits
Potent anti-inflammatory for gut, skin, and systemic use. Oral bioavailability for GI-specific effects. No melanocortin pigmentation effects. Excellent safety profile. Can be combined with BPC-157 for enhanced GI healing.
Negatives
Limited human clinical trial data. Research peptide status. Very short half-life requires frequent dosing or oral route.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. Can be taken orally (encapsulate or dissolve in water).
Dosage
500mcg–2mg subcut or 1-5mg oral per day.
Timing
Any time. Oral pre-meals for GI effects.
Cycling
Continuous low-dose or acute 4-week protocols.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$60 per kit (10×10mg vials). ~€5.5/vial. Reasonable.
Evidence Grade
C+ — Strong in-vitro/animal. Human data emerging. Mechanism very well characterized.
Synergies
BPC-157 (GI healing stack). Part of BBG or KLOW80 recovery mix.
Warnings
No known serious interactions. Excellent tolerability profile.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
8/10
4/10
7/10
6/10

CEREBROLYSIN

Intro
Cerebrolysin is a complex mixture of low-molecular-weight peptides derived from porcine brain tissue. It contains BDNF, NGF, CNTF, and other neurotrophins. Used clinically in Eastern Europe and Asia for stroke, traumatic brain injury, and Alzheimer's disease.
Mechanism
Provides exogenous BDNF, NGF, and other neurotrophins directly. Promotes neurogenesis and synaptic plasticity. Neuroprotective against excitotoxicity. Anti-apoptotic in neurons.
Benefits
Direct neurotrophin supplementation (vs Semax which stimulates endogenous production). Established clinical use in stroke recovery. May enhance cognitive recovery after stress or illness. Fast-acting neuroplasticity support.
Negatives
Derived from porcine brain — quality control important. Injectable only (IV preferred clinically, IM used in biohacking). Religious/dietary restrictions for some. Most trials in neurological disease, not healthy subjects. Quality varies by vendor significantly.
Reconstitution
Ready solution typically. Check vendor — should be aqueous solution, not lyophilized.
Dosage
1-5ml IM/subcut. Clinical: 10-30ml IV/day. For cognitive use: 1-2ml IM daily.
Timing
Morning.
Cycling
10-30 day cycles. 2-3× per year.
Storage
Refrigerate 2-8°C. Do not freeze.
Cost (vendor)
$29 per kit (6×60mg vials). ~€4.5/vial. Budget-friendly.
Evidence Grade
B- — Multiple RCTs in stroke/TBI (positive). Healthy cognitive enhancement — limited data.
Synergies
Semax (BDNF endogenous + exogenous). Citicoline.
Warnings
Ensure vendor quality — biological product contamination risk. Do not use if porcine-derived products contraindicated.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
6/10
5/10
8/10
6/10

SNAP-8

Intro
Snap-8 (Acetyl Octapeptide-3) is a synthetic octapeptide that mimics the N-terminal portion of SNAP-25. It competes with the SNARE complex, reducing neurotransmitter release at neuromuscular junctions in facial skin. Often called 'topical Botox' in cosmetic science.
Mechanism
Inhibits SNARE complex formation → reduced acetylcholine release at local neuromuscular junctions → reduced muscle contraction intensity in expression lines → smoother appearance over time.
Benefits
Reduces expression-related fine lines without injection. Can be added to moisturizer or serum. No systemic effects. Safe topical profile.
Negatives
Penetration through skin is very limited for large peptides. Most human evidence industry-funded. Effects subtle vs Botox. Not relevant at 18 — no expression lines yet.
Reconstitution
Typically used as topical — dissolve in DMSO or serum base for penetration.
Dosage
2-10% topical solution, apply 2× daily.
Timing
Morning and evening skincare routine.
Cycling
Continuous — topical peptides require sustained use.
Storage
Lyophilized 12+ months. Solution 1 month refrigerated.
Cost (vendor)
$40 per kit (10×10mg vials). ~€3.5/vial. Very affordable.
Evidence Grade
C+ — One industry-funded human trial showing 52% wrinkle reduction. No independent replication.
Synergies
Tretinoin (different mechanism). GHK-Cu (complementary skin matrix support).
Warnings
Not meaningful at 18 years. Consider at 30+ when expression lines begin. Skin penetration limitations mean topical DMSO carrier needed.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
3/10
9/10
3/10
9/10
4/10

PINEALON

Intro
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by the same Russian group as Epitalon (Khavinson). It is derived from the pineal gland and claimed to regulate circadian rhythms, protect neurons, and enhance cognitive function. More targeted neurological action than Epitalon.
Mechanism
Claimed: regulates melatonin secretion rhythm. Neuroprotective against oxidative stress. Potentially modulates DNA methylation patterns in neurons. Anti-apoptotic in neuronal cell lines.
Benefits
Potential sleep quality improvement. Neuroprotective effects in animal models. Claimed cognitive enhancement. Better age-appropriateness than Epitalon (circadian regulation relevant at any age).
Negatives
All evidence from single Russian research group (Khavinson) — significant conflict of interest. No independent replication. Human data limited to elderly. Mechanism insufficiently characterized.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
5-10mg course over 10 days.
Timing
Evening for circadian effects.
Cycling
10-day courses 2-3× per year.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$55 per kit (10×5mg vials). ~€5/vial. Moderate.
Evidence Grade
C — Single research group. Elderly-only human data. No independent replication.
Synergies
Melatonin (circadian stack). DSIP.
Warnings
Same single-source evidence issue as Epitalon. Verify independently before use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
6/10
4/10

EPITHALON (EPITALON)

Intro
Synthetic tetrapeptide from the pineal gland. Claimed telomerase activator. All positive human evidence in elderly (60+) cohorts. Mismarketed to younger users — fundamentally age-inappropriate under 35.
Mechanism
Activates telomerase (hTERT) in somatic cells. Regulates melatonin secretion. Antioxidant. Regulates hypothalamic-pituitary axis.
Benefits
Telomere elongation in elderly subjects. Normalizes melatonin in aged individuals. Sleep improvement. Antioxidant effects.
Negatives
NOT APPROPRIATE UNDER 35-40 YEARS. Your telomeres are already near peak length at 18. Long telomeres correlated with MORE tumors (Johns Hopkins research). All-cause mortality data shows abnormally long telomeres are harmful. Single research group with patent conflict of interest.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
5-10mg/day × 10-20 days (elderly protocol).
Timing
Evening.
Cycling
2× per year for elderly users.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$48 per kit (10×10mg vials). ~€4.4/vial. Affordable but irrelevant at <35.
Evidence Grade
C+ — Single research group. Human data in elderly only. No independent replication.
Synergies
Melatonin, Pinealon. NOT for young users.
Warnings
DO NOT USE UNDER 35. No benefit. Theoretical cancer risk from telomere overextension at young age.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
7/10
3/10
7/10
2/10

IPAMORELIN

Intro
Selective GHRH receptor agonist. Cleanest GHRP — no cortisol/prolactin elevation. Best used with CJC-1295 no-DAC for synergistic GH pulse. At 18, natural GH is already at peak — use with caution.
Mechanism
GHSR-1a (ghrelin receptor) agonist → pulsatile GH release from pituitary. Highly selective. No ACTH, cortisol, or prolactin stimulation at standard doses.
Benefits
Clean GH stimulation. Improved deep sleep. Recovery enhancement. Lean mass support. Better tolerated than GHRP-2/6.
Negatives
At 17-18, endogenous GH already at lifetime peak. Marginal additional benefit. Potential GH receptor downregulation. Water retention possible. Not FDA approved.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100mcg = 0.02ml.
Dosage
100-300mcg per injection. 1-3×/day. Most useful pre-bed.
Timing
Pre-bed (maximize natural GH pulse). Can stack with CJC-1295 no-DAC.
Cycling
12-week cycles, 4-6 weeks off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €40-80/month.
Evidence Grade
C+ — Phase II human trials in GH deficiency. Mechanism well-established. Off-label recovery use anecdotal.
Synergies
CJC-1295 no-DAC (synergistic GH pulse). DSIP (sleep enhancement stack).
Warnings
Marginal benefit at 17-18. Wait until 21+ for optimal use case. Never fasted training + ipamorelin (hypoglycemia risk).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
5/10
7/10
5/10

NAD+

Intro
NAD+ precursors (NMN/NR) raise intracellular NAD+ levels. NAD+ declines with age, primarily after 40. Every positive human RCT enrolled middle-aged or elderly subjects. Not indicated at 18.
Mechanism
NAD+ precursors → raise NAD+ pool → sirtuin activation → mitochondrial efficiency. Requires CD38 to be low for optimal effect.
Benefits
Mitochondrial function in elderly. DNA repair enhancement. Sirtuin activation. Muscle function support in aged subjects.
Negatives
NOT RECOMMENDED UNDER 35. NAD+ peaks between 15-30. 2025 meta-analysis: no significant benefit for muscle function in young subjects. Your niacinamide 10% topical already supports local NAD+. Waste of money at your age.
Reconstitution
Oral capsules. Injectable NAD+ also available (listed vendor).
Dosage
250-500mg NMN or NR oral. Or 100-500mg IV/IM injectable.
Timing
Morning.
Reconstitution
No established cycle for oral. Injectable courses sometimes 10 days.
Storage
Keep dry. Heat sensitive.
Cost (vendor)
$40 per kit (10×100mg) to $130 per kit (10×1000mg). Pointless at 18.
Evidence Grade
B- (in elderly), C (in young). All positive RCTs in 40+ populations.
Synergies
5-amino-1MQ (CD38 inhibitor — more relevant mechanism). SS-31. All age 35+.
Warnings
NOT RECOMMENDED UNDER 35. No demonstrated benefit. Use money elsewhere.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
9/10
3/10
5/10
2/10

PEPTIDES NOT RECOMMENDED FOR THIS CONTEXT

Do Not Use — Reasons Explained

Semaglutide / Tirzepatide / Retatrutide / Cagrilintide
If you can't get your body fat down to 10% at least once in your life, what can you actually do?
I use Tirzepatide myself
IGF-1 LR3 (Used it myself)
Highly anabolic IGF-1 analogue. Promotes growth in ALL tissues including potential tumor cells. Open growth plates at 17-18 make this particularly concerning. Hypoglycemia risk. Not appropriate under 21+.
Dermorphin
Opioid peptide — 50x more potent than morphine. Extremely high addiction potential. Not appropriate for any looksmaxxing or performance context. High risk of dependence, respiratory depression, death in overdose.
Adipotide
Experimental peptide targeting ANXA2/PROHIBITIN on fat cell vasculature. Causes kidney toxicity in primate studies. Never cleared for human use. Avoid entirely.
Oxytocin
Half-life 3-5 minutes IV. Intranasal slightly longer. No meaningful persistent anxiolytic effect for social situations. Better alternatives available (Etifoxine, Selank, Pregab).
PT-141 (Bremelanotide)
MC3R/MC4R agonist for sexual dysfunction. More systemic side effects than MT-1. Nausea, blood pressure effects. Not a looksmaxxing compound.

STACKING GUIDE

Recommended Stacks by Goal

Cognitive Peak
Semax (1mg/day IN) + Citicoline (250mg/day oral) + Selank (500mcg situational). Semax → focus/BDNF, Citicoline → ACh, Selank → anxiety control.
Skin & PIE
GHK-Cu (2mg subcut EOD) + Tretinoin (topical) + Azelaic Acid 20% (topical) + Niacinamide 10% (topical). Best-evidenced combination.
Post-Surgery
BPC-157 (500mcg/day) + TB-500 (2mg 2×/week) + GHK-Cu (500mcg/day) + KPV (1mg/day). 8-week protocol.
Healing & Recovery
BPC-157 + TB-500 combo vial (BBG or KLOW80 mix). Most cost-effective option. KLOW80 adds KPV for anti-inflammatory.
Sleep Quality
DSIP (200mcg subcut pre-bed) + Ipamorelin (100mcg pre-bed). Synergistic GH pulse + deep sleep architecture.
Mitochondrial Stack
SS-31 (2mg/day) + MOTS-C (5mg 3×/week). Age 30+ optimal. Limited benefit at 18.
Immune Support
Thymosin Alpha-1 (1mg 2×/week) for 4-6 weeks during illness, intense training periods, or post-surgery.
Anxiolysis (Daily)
Selank (400-600mcg/day, cycled 14/14). No dependence, no sedation. Best daily option.
Anxiolysis (Events)
Etifoxine 50mg → Pregabalin 75-150mg (reserve for important only). Never two GABAergics same day.

CRITICAL INTERACTIONS
READ BEFORE STACKING

ABSOLUTE
NEVER: Selank + Etifoxine + Pregabalin same day. Three GABAergics = CNS depression risk.
ABSOLUTE
NEVER: MT-1 + MT-2 simultaneously. Receptor overlap, unpredictable systemic effects.
AVOID
Ipamorelin/CJC-1295 on fasted training days — hypoglycemia risk.
AVOID
Semax + Modafinil daily — both dopaminergic. Limit to exam days only.
SEPARATE
GHK-Cu and Zinc: pause zinc during GHK-Cu cycle. Competition for transporters.
SEPARATE
MT-1 and GHK-Cu injections: different anatomical sites same evening.
NOTE
BPC-157 / TB-500 / GHK-Cu vendor combo mixes (BBG, KLOW80) can be drawn from same vial — convenient and cost-effective.

RECONSTITUTION QUICK REFERENCE

Standard Dilutions
Semax 40mg 4ml BAC water → 10mg/ml → 1mg dose = 0.1ml
Selank 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
GHK-Cu 2mg 1ml BAC water (or PBS) → 2mg/ml → 2mg = 1ml
GHK-Cu 50mg (bulk) 25ml BAC water → 2mg/ml → 2mg = 1ml
MT-1 10mg 1ml BAC water → 10mg/ml → 500mcg = 0.05ml
BPC-157 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
TB-500 5mg 1ml BAC water → 5mg/ml → 2mg = 0.4ml
Ipamorelin 5mg 1ml BAC water → 5mg/ml → 100mcg = 0.02ml
DSIP 5mg 1ml BAC water → 5mg/ml → 200mcg = 0.04ml
Epitalon 10mg 2ml BAC water → 5mg/ml → 5mg = 1ml
Thymosin Alpha-1 5mg 1ml BAC water → 5mg/ml → 1mg = 0.2ml
KPV 10mg 1ml BAC water → 10mg/ml → 1mg = 0.1ml (or oral)
PBS vs BAC Water Use PBS for copper peptides (GHK-Cu, AHK-Cu) — better copper stability. BAC water for all others.

VENDOR PRICE REFERENCE (Chinese Warehouse)
$60 flat worldwide shipping fee. All prices USD per kit of 10 vials (divide by 10 for single vial price). Prices as of April 2026.

Product Price (USD) per kit (10 vials)
Semax 5mg×10 $40
Semax 10mg×10 $50
Selank 5mg×10 $40
GHK-Cu 50mg×10 $30
GHK-Cu 100mg×10 $45
AHK-Cu 100mg×10 $68
MT-1 10mg×10 $45
MT-2 10mg×10 $45
BPC-157 5mg×10 $40
BPC-157 10mg×10 $70
TB-500 5mg×10 $75
TB-500 10mg×10 $140
BPC+TB 5mg+5mg×10 $95
GHK+BPC+TB 50/10/10mg×10 $160
GHK+BPC+TB+KPV 80mg×10 $195
KPV 10mg×10 $60
Ipamorelin 5mg×10 $45
Ipamorelin 10mg×10 $80
CJC-1295 no-DAC 5mg×10 $85
CJC+Ipa combo 10mg×10 $95
DSIP 5mg×10 $45
DSIP 15mg×10 $85
SS-31 10mg×10 $86
SS-31 50mg×10 $285
MOTS-C 10mg×10 $65
MOTS-C 40mg×10 $185
5-amino-1MQ 5mg×10 $45
5-amino-1MQ 50mg×10 $110
Thymosin Alpha-1 5mg×10 $80
TA-1 10mg×10 $145
Epitalon 10mg×10 $48
Epitalon 50mg×10 $150
Cerebrolysin 60mg×6 $29
Pinealon 5mg×10 $55
Pinealon 10mg×10 $70
Snap-8 10mg×10 $40
NAD+ 100mg×10 $40
NAD+ 500mg×10 $80
NAD+ 1000mg×10 $130
L-Carnitine 600mg/ml 10ml×10 $80
Glutathione 1500mg×10 $80
Melatonin 10mg×10 $55
VIP 5mg×10 $75
SLU-PP-322 5mg×10 $100
AICAR 50mg×10 $62
Tesamorelin 5mg×10 $110
ARA-290 10mg×10 $80
BAC Water 10ml×10 $10
PBS 10ml×10 $10
Acetic Acid Water 10ml×10 $10

PEPTIDES

Melanotan-1 subcutaneously, in the evening.

GHK-Cu 2 mg subcutaneously, in the evening.

Tirzepatide 2,5 mg subcutaneously, every week

@reyalsnoom @Jesus_ist_König @tqbiq @greylord @aaronbp

Genuinely thank you

til<3D · Apr 14, 2026

rowboatski said:
Very helpful troynem

WannabeClavicular said:
Genuinely thank you

appeal_clone · Apr 19, 2026

Eyelet said:
dnr i dont need peps high effort tho

w pfp

julian._win · Apr 19, 2026

til<3D said:
Complete Guide to Peptide Protocols — Dosing, Evidence & Stacking

by til<3D
Stand: April 2026

DISCLAIMER

Read First
This guide is for educational purposes only. Peptides are not approved drugs in most countries. Everything here is off label and experimental. Do your own research. You are responsible for your own choices. This is not medical advice.
Age Note
Several peptides are specifically marked as inappropriate for users under 18-20 years old due to ongoing hormonal and neural development. These warnings are clearly flagged throughout.
Sources
Evidence grades reflect actual human clinical trial data, animal studies, and in vitro research. Grade A = multiple human RCTs. Grade B = some human data. Grade C = animal/in vitro only.

PEPTIDES COVERED IN THIS THREAD

1. Semax — ACTH(4-7) Analogue — Nootropic

2. Selank — Tuftsin Analogue — Anxiolytic & Cognitive

3. GHK-Cu — Copper Peptide — Skin & Collagen

4. AHK-Cu — Copper Peptide — Hair Growth

5. Melanotan-1 (MT-1) — MC1R Agonist — Tanning

6. BPC-157 — Body Protection Compound — Healing

7. TB-500 — Thymosin Beta-4 — Recovery & Flexibility

8. DSIP — Delta Sleep-Inducing Peptide — Sleep Architecture

9. SS-31 (Elamipretide) — Mitochondria-Targeting Peptide — Energy & Cardioprotection

10. MOTS-C — Mitochondrial-Derived Peptide — Metabolic

11. 5-amino-1MQ — CD38 Inhibitor — NAD+ Preservation

12. Thymosin Alpha-1 — Immune Modulator — Immune Enhancement

13. KPV — Anti-Inflammatory Tripeptide — Gut & Skin

14. Cerebrolysin — Neuropeptide Mix — Cognitive & Neuroprotection

15. Snap-8 — Neuropeptide — Anti-Wrinkle Topical

16. Pinealon — Pineal Peptide — Neuroprotection & Circadian

17. Epithalon (Epitalon) — Tetrapeptide — Telomere (Age 40+ Only)

18. Ipamorelin — GHRP — GH Secretagogue (Age 20+ Optimal)

19. NAD+ — NAD+ Precursors — Mitochondrial (Age 35+ Only)

QUICK REFERENCE — ALL PEPTIDES

Peptide Effectiveness Evidence Age 17-18 Cost/mo Overall
Semax 8/10 B+ ✓ OK €20–35/vial (40mg) 8/10
Selank 8/10 B ✓ OK €25–40/vial (5mg) 7/10
GHK-Cu 7/10 B- ✓ OK €30/vial (50mg bulk) — much better value 7/10
AHK-Cu 6/10 C+ ✓ OK $68/100mg vial (vendor) 6/10
Melanotan-1 (MT-1) 9/10 A- ✓ OK $45/10mg vial × 10 8/10
BPC-157 7/10 C+ ✓ OK $40/5mg vial × 10 6/10
TB-500 7/10 C+ ✓ OK $75/5mg vial × 10 6/10
DSIP 6/10 C+ ✓ OK $45/5mg vial × 10 5/10
SS-31 (Elamipretide) 6/10 B- ✓ OK $86/10mg vial × 10 5/10
MOTS-C 6/10 C+ ✓ OK $65/10mg vial × 10 5/10
5-amino-1MQ 4/10 C ✓ OK $45/5mg vial or $110/50mg 3/10
Thymosin Alpha-1 7/10 B ✓ OK $80/5mg vial × 10 6/10
KPV 6/10 C+ ✓ OK $60/10mg vial × 10 6/10
Cerebrolysin 7/10 B- ✓ OK $29/60mg × 6 vials (vendor) 6/10
Snap-8 3/10 C+ ✓ OK $40/10mg vial × 10 (vendor) 4/10
Pinealon 4/10 C ✓ OK $55/5mg vial × 10 4/10
Epithalon (Epitalon) 2/10 C+ ✗ Caution $48/10mg × 10 (vendor) 2/10
Ipamorelin 6/10 C+ ✗ Caution $45/5mg vial × 10 5/10
NAD+ 2/10 B- ✗ Caution $40-130 depending on dose 2/10

INDIVIDUAL PEPTIDE PROFILES

SEMAX

Intro
Synthetic heptapeptide analogue of ACTH(4-7), developed in Russia for stroke and cognitive enhancement. Decades of clinical data. Crosses BBB efficiently intranasally. You could also do subq but in my opinion it's unnecessary.
Mechanism
Upregulates BDNF. Modulates dopaminergic/serotonergic transmission. Increases enkephalinase activity. NO signalling enhancement.
Benefits
Enhanced focus, memory, learning. Neuroprotection. Anti anxiety via serotonin. Rapid onset 15-30 min. No physical dependence.
Negatives
Receptor desensitization — cycling required. Mild anxiety at high doses. Most studies Russian literature.
Reconstitution
4ml BAC water on 40mg vial = 10mg/ml. 1mg = 0.1ml = 1 pump.
Dosage
0.5–1mg/day intranasal.
Timing
Morning, fasted or first meal.
Cycling
5 days ON / 2 OFF. Or 3 weeks ON / 1 week OFF.

Storage
Lyophilized 12+ months. Reconstituted 4°C, 4 weeks.
Cost (vendor)
$50/100mg vial (vendor).
Evidence Grade
B+ — Russian Phase II/III trials. Growing Western replication.
Synergies
Citicoline, Selank. Never combine with high dose Modafinil same day.
Warnings
Monitor with Modafinil stack. Avoid MAOIs.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
7/10
8/10
8/10

SELANK

Intro
Synthetic analogue of tuftsin. Official anxiolytic drug status in Russia/Ukraine. Anxiolysis without sedation, tolerance, or withdrawal.
Mechanism
Allosteric GABA-A modulation. Inhibits enkephalinase. Modulates BDNF/NGF. Complements Semax via distinct brain connectivity patterns.
Benefits
Anxiolysis without sedation or dependence. Cognitive enhancement. Anti inflammatory. No BtMG. Low desensitization risk at standard doses.
Negatives
Most evidence Russian studies. Additive CNS depression with other GABAergics — critical interaction. Short half-life ~2h intranasal.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
250–800mcg/day intranasal.
Timing
Morning or 30-60 min before stressful situations.
Cycling
14 days ON / 14 days OFF, or situational.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/100mg vial (vendor). Very cost effective per mg.
Evidence Grade
B — Russian Phase II clinical trials in GAD.
Synergies
Semax (complementary). NEVER with Etifoxine, Pregabalin, or alcohol same day.
Warnings
NEVER combine with Etifoxine, Pregabalin, or benzodiazepines same day. Additive CNS depression.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
6/10
8/10
7/10

GHK-CU

Intro
Naturally occurring copper-binding peptide. Plasma levels decline with age. Gold standard for skin regeneration and wound healing.
Mechanism
Activates fibroblasts → collagen I/III/elastin synthesis. VEGF-driven angiogenesis. Inhibits TGF-β1 (anti-fibrotic). Antioxidant enzyme upregulation.
Benefits
PIE/acne scar remodeling. Skin density improvement. Wound/post-surgery healing. Tendon collagen support. Anti-inflammatory.
Negatives
Systemic human RCT data limited. Competing with zinc pause zinc during use. Monitor copper levels with chronic use.
Reconstitution
1ml BAC water on 2mg vial = 2mg/ml. 27-29G needle, 4-6mm, 45°. PBS preferred for copper stability.
Dosage
2mg subcut EOD/ ED.
Timing
Evening after training. Separate site from MT-1.
Cycling
4-week cycles. Zinc paused. After cycle reintroduce zinc.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/1g vial (vendor). Very cost effective per mg.
Evidence Grade
B- — Strong in-vitro/animal. Limited human RCTs for subcut use. Topical human evidence solid.
Synergies
Tretinoin (complementary collagen). Copper supplement 30-60 min before injection.
Warnings
Pause zinc during cycle. Monitor serum copper/ceruloplasmin with extended use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
5/10
10/10
8/10

AHK-CU

Intro
Tripeptide analogue of GHK-Cu with higher affinity for hair follicle receptors. AHK (Ala-His-Lys) specifically promotes hair growth via follicle dermal papilla stimulation.
Mechanism
Activates Wnt/β-catenin pathway in hair follicles. Promotes dermal papilla cell proliferation. Upregulates VEGF in follicle microvasculature. Inhibits DHT-induced apoptosis in follicles.
Benefits
Hair density and thickness improvement. Potentially superior to GHK-Cu for scalp/follicle applications. Can be used topically or subcut. Anti-inflammatory in follicle microenvironment.
Negatives
Less research than GHK-Cu overall. Mostly in-vitro data. Higher cost per mg. Limited human studies specifically.
Reconstitution
1ml BAC water per 10mg = 10mg/ml. Can be used topically (DMSO carrier) or subcut.
Dosage
Topical: 0.01-0.1% solution on scalp. Subcut: 1-2mg/day.
Timing
Evening or post-shower for topical.
Cycling
Continuous or 8-week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$68/1g vial (vendor). Very cost effective per mg.
Evidence Grade
C+ — In-vitro strong. Limited human data. Mechanistically plausible.
Synergies
GHK-Cu (different receptor affinity — complementary). Minoxidil topical.
Warnings
Avoid mixing with acidic solutions. PBS preferred diluent.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
9,5/10
8/10

MELANOTAN-1 (MT-1)

Intro
Synthetic α-MSH analogue with MC1R selectivity. Only melanocortin peptide with EMA approval (Scenesse for EPP). Deep even tan with reduced UV exposure.
Mechanism
MC1R agonism → tyrosinase upregulation → eumelanin synthesis. UV activation required to convert precursors to visible pigment.
Benefits
Deep even tan. Photoprotection. Visually reduces PIE by contrast. EMA-approved safety data. Lower systemic effects vs MT-2.
Negatives
Nausea during loading (reduced by microdosing). Mole changes — document before starting. UV >3 required for activation. MC4R spillover at high doses.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 500mcg = 0.05ml.
Dosage
Loading: 500mcg/day × 14 days. Maintenance: 250-500mcg E2-3D + UV.
Timing
Evening — sleep through initial nausea.

Cycling
Loading → Maintenance. No continuous loading.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$4,5/10mg vial × 10. ~€2-3,5/month maintenance.
Evidence Grade
A- — EMA approved. Phase III trials. Extensive safety data.
Synergies
UV exposure (essential). Tretinoin. Solarium if UV index <3.
Warnings
Photograph all moles before starting. Never combine with MT-2.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
7/10
8/10
9/10
8,5/10

BPC-157

Intro
Synthetic pentadecapeptide from gastric juice. Remarkable healing in animal models across tendons, ligaments, muscles, GI tract. Most promising for injury recovery and post-surgical healing.
Mechanism
Upregulates GH receptor. VEGF angiogenesis. FAK-paxillin wound healing pathway. NF-κB inhibition. Collagen synthesis in tenocytes.
Benefits
Tendon/ligament healing acceleration. GI mucosal protection. Nerve regeneration (animal). Anti-inflammatory. Enhanced training recovery.
Negatives
Virtually ALL data is animal/in-vitro. Zero completed human RCTs. Unknown optimal human dosing. Unknown long-term safety.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
200-500mcg/day subcut or IM. Split morning + evening.
Timing
Morning and/or post-training.
Cycling
4-8 weeks on, 4 off. Or acute injury protocol.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$40 per kit (10×5mg vials). ~€3.5/vial. €40-70/month.
Evidence Grade
C+ — Extensive animal data, consistent results. Zero human RCTs. High translation uncertainty.
Synergies
TB-500 (complementary). GHK-Cu (collagen synergy).
Warnings
Theoretical angiogenesis concern with cancer history (unproven in humans). No known drug interactions.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
8/10
4/10
7/10
6/10

TB-500

Intro
Synthetic fragment of thymosin beta-4. Critical role in cell migration, wound healing, tissue regeneration. Systemic healing reach that BPC-157 lacks.
Mechanism
Binds G-actin → cell migration/differentiation. Integrin-linked kinase activation. Metalloproteinase upregulation for tissue remodeling. Vascular tube formation.
Benefits
Systemic healing (reaches distant injury sites). Muscle fiber regeneration. Flexibility/ROM improvements. Potential cardiac protection.
Negatives
Human RCT data absent for recovery use. Higher MW limits oral bioavailability. More expensive than BPC-157. Overlap with BPC-157.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
Loading: 2-2.5mg 2×/week × 4-6 weeks. Maintenance: 2-2.5mg 1×/week.
Timing
Morning or post-training.
Cycling
6-week loading, then maintenance or off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$75 per kit (10×5mg vials). ~€7/vial. €50-90/month.
Evidence Grade
C+ — Animal data solid. Phase II trial in dry eye disease. Limited systemic recovery data in humans.
Synergies
BPC-157 (most common stack). Post-surgery recovery protocol.
Warnings
Same theoretical angiogenesis concern as BPC-157 with cancer history.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
4/10
6/10
6/10

DSIP

Intro
DSIP is a neuropeptide that modulates sleep architecture by promoting delta-wave (slow-wave) sleep. It was isolated from rabbit thalamic venous blood in 1977. Unlike benzodiazepines, it doesn't cause sedation — it shifts the sleep profile toward restorative deep sleep.
Mechanism
Modulates GABA-B receptors. Reduces nocturnal cortisol. Increases GH secretion during sleep. Normalizes circadian rhythm via hypothalamic-pituitary axis modulation. Antioxidant effects.
Benefits
Improved deep sleep quality (not just duration). GH pulse enhancement during sleep. Reduced cortisol during sleep. Potential nootropic effects via improved sleep. Non-sedating — no morning grogginess.
Negatives
Short plasma half-life (~30 min) — may require specific timing. Most data from 1980s-90s Russian studies. Limited modern replication. Expensive per mg.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100-300mcg = 0.02-0.06ml.
Dosage
100-300mcg subcut 30-60 min before sleep.
Timing
30-60 minutes before bedtime.
Cycling
5-7 day cycles. Short-term use most studied.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €30-60/month.
Evidence Grade
C+ — Russian human trials 1980s. Mechanism plausible. Limited modern replication.
Synergies
Melatonin (circadian complementary). Ipamorelin (synergistic GH pulse during sleep).
Warnings
No known serious interactions. Avoid combining with benzodiazepines (additive sleep effects).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

SS-31 (ELAMIPRETIDE)

Intro
SS-31 (Szeto-Schiller peptide 31) is a tetrapeptide that concentrates in the inner mitochondrial membrane, stabilizing cardiolipin. It is arguably the most promising mitochondria-targeting molecule currently studied, with active Phase II/III trials for Barth syndrome, heart failure, and age-related muscle loss.
Mechanism
Binds cardiolipin in inner mitochondrial membrane → stabilizes electron transport chain structure. Reduces mitochondrial ROS production. Maintains cristae morphology. Improves ATP synthesis efficiency.
Benefits
Mitochondrial function restoration. Reduced oxidative stress. Improved energy efficiency (not stimulant-based). Potential muscle function improvement. Active pharmaceutical development — human safety data exists.
Negatives
Expensive per mg. Mostly disease-state human trials — healthy young male data absent. Injectable only (high MW). Long-term use unknown.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
1-5mg/day subcut. Clinical trials used 0.05-0.25 mg/kg IV.
Timing
Morning.
Cycling
4-12 week cycles. Research ongoing.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$86 per kit (10×10mg vials). ~€8/vial. Expensive but unique mechanism.
Evidence Grade
B- — Phase II human trials in disease states. Mechanism very well characterized. Healthy young use extrapolated.
Synergies
NAD+ precursors (complementary mitochondrial support). MOTS-C.
Warnings
No known serious interactions. Not indicated in healthy young without mitochondrial disease.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
6/10
5/10
5/10
5/10

MOTS-C

Intro
MOTS-C is a peptide encoded in the mitochondrial genome — one of the first mitochondria-derived peptides discovered. It acts as a metabolic regulator, improving insulin sensitivity and exercise capacity. Endogenous levels decline with age and are increased by exercise.
Mechanism
Activates AMPK. Inhibits AICAR (purine synthesis) → folate cycle disruption → metabolic reprogramming. Improves glucose uptake independent of insulin. Regulates ROS homeostasis in mitochondria.
Benefits
Improved insulin sensitivity. Enhanced exercise capacity and metabolic efficiency. Anti-obesity effects. Potential longevity effects. Exercise-mimicking properties.
Negatives
Most data animal studies. Human trial data limited to one small RCT. Age-related benefit unclear in young healthy subjects (endogenous levels already high at 18). Expensive.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 2-5mg per injection.
Dosage
5-10mg subcut 2-3×/week.
Timing
Morning or pre-workout.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$65 per kit (10×10mg vials). ~€6/vial. Moderate.
Evidence Grade
C+ — Strong animal data. One small human RCT (n=40). Mechanism well-established.
Synergies
SS-31 (mitochondrial stack). Exercise potentiation.
Warnings
No known serious interactions. Limited human safety data.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

5-AMINO-1MQ

Intro
5-amino-1-methylquinolinium (5-amino-1MQ) is a small molecule that inhibits CD38, the primary NAD+-degrading enzyme in the body. Unlike taking NAD+ precursors (NMN/NR), which add more NAD+ substrate, 5-amino-1MQ prevents NAD+ from being broken down — potentially more efficient.
Mechanism
Inhibits CD38 (NAD+ glycohydrolase) → NAD+ levels rise. CD38 activity increases dramatically with age and inflammation. Preserves endogenous NAD+ pool without external supplementation.
Benefits
NAD+ preservation. Potential fat loss effects (adipocyte CD38 inhibition). Anti-inflammatory. More targeted mechanism than NMN/NR for NAD+ elevation.
Negatives
Very limited human data. Research peptide status. Long-term safety unknown. Age-appropriateness at 18 unestablished (same issue as NAD+ precursors — you don't need this yet).
Reconstitution
Oral or injectable. 5mg vial with 1ml BAC water = 5mg/ml.
Dosage
5-50mg oral or 1-5mg subcut.
Timing
Morning.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months.
Cost (vendor)
$45 per kit (10×5mg) or $110 per kit (10×50mg). ~€4-10/vial.
Evidence Grade
C — Animal data only. No human RCTs. Mechanism well-established biochemically.
Synergies
SS-31, MOTS-C (mitochondrial stack). More relevant at 35+ years.
Warnings
Not recommended under 35. No established benefit in young healthy subjects.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
7/10
3/10

THYMOSIN ALPHA-1

Intro
Thymosin Alpha-1 (Tα1) is an endogenous peptide originally isolated from thymic tissue. It is FDA-approved in 35+ countries for chronic hepatitis B and C, and used as an immune adjuvant in cancer treatment. Strong immunomodulatory and antiviral properties.
Mechanism
Enhances T-cell, NK cell, and dendritic cell function. Upregulates IL-2, IFN-γ. Activates Toll-like receptors. Promotes antigen presentation. Anti-inflammatory via IL-10 pathway.
Benefits
Immune system enhancement and normalization. Antiviral effects. Used clinically for immunocompromised patients. Strong safety data from approved medical use. Potential benefit post-illness or during intense training phases.
Negatives
Healthy young with normal immune function may see minimal benefit. Expensive. Primary benefit for immunocompromised or sick individuals. Mild injection site reactions.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
1-2mg subcut 2×/week. Clinical dose: 1mg/m² body surface area.
Timing
Any time — immune timing less critical.
Cycling
2-6 week cycles. Or as needed during illness.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$80 per kit (10×5mg vials). ~€7/vial. Moderate.
Evidence Grade
B — Approved in multiple countries for specific indications. Good human safety data. Healthy young use extrapolated.
Synergies
BPC-157 (immune + healing stack during recovery). Useful post-surgery.
Warnings
No significant drug interactions at standard doses. Avoid in autoimmune conditions without medical supervision.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
6/10
6/10
6/10

KPV

Intro
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of α-MSH. It retains the anti-inflammatory properties of the parent molecule without melanocortin receptor agonism. Being 3 amino acids, it has superior bioavailability and can even be taken orally for GI effects.
Mechanism
Inhibits NF-κB signalling. Reduces TNF-α, IL-1β, IL-6 production. Activates MC1R and MC3R locally (anti-inflammatory, not pigmentation). Promotes intestinal epithelial healing.
Benefits
Potent anti-inflammatory for gut, skin, and systemic use. Oral bioavailability for GI-specific effects. No melanocortin pigmentation effects. Excellent safety profile. Can be combined with BPC-157 for enhanced GI healing.
Negatives
Limited human clinical trial data. Research peptide status. Very short half-life requires frequent dosing or oral route.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. Can be taken orally (encapsulate or dissolve in water).
Dosage
500mcg–2mg subcut or 1-5mg oral per day.
Timing
Any time. Oral pre-meals for GI effects.
Cycling
Continuous low-dose or acute 4-week protocols.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$60 per kit (10×10mg vials). ~€5.5/vial. Reasonable.
Evidence Grade
C+ — Strong in-vitro/animal. Human data emerging. Mechanism very well characterized.
Synergies
BPC-157 (GI healing stack). Part of BBG or KLOW80 recovery mix.
Warnings
No known serious interactions. Excellent tolerability profile.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
8/10
4/10
7/10
6/10

CEREBROLYSIN

Intro
Cerebrolysin is a complex mixture of low-molecular-weight peptides derived from porcine brain tissue. It contains BDNF, NGF, CNTF, and other neurotrophins. Used clinically in Eastern Europe and Asia for stroke, traumatic brain injury, and Alzheimer's disease.
Mechanism
Provides exogenous BDNF, NGF, and other neurotrophins directly. Promotes neurogenesis and synaptic plasticity. Neuroprotective against excitotoxicity. Anti-apoptotic in neurons.
Benefits
Direct neurotrophin supplementation (vs Semax which stimulates endogenous production). Established clinical use in stroke recovery. May enhance cognitive recovery after stress or illness. Fast-acting neuroplasticity support.
Negatives
Derived from porcine brain — quality control important. Injectable only (IV preferred clinically, IM used in biohacking). Religious/dietary restrictions for some. Most trials in neurological disease, not healthy subjects. Quality varies by vendor significantly.
Reconstitution
Ready solution typically. Check vendor — should be aqueous solution, not lyophilized.
Dosage
1-5ml IM/subcut. Clinical: 10-30ml IV/day. For cognitive use: 1-2ml IM daily.
Timing
Morning.
Cycling
10-30 day cycles. 2-3× per year.
Storage
Refrigerate 2-8°C. Do not freeze.
Cost (vendor)
$29 per kit (6×60mg vials). ~€4.5/vial. Budget-friendly.
Evidence Grade
B- — Multiple RCTs in stroke/TBI (positive). Healthy cognitive enhancement — limited data.
Synergies
Semax (BDNF endogenous + exogenous). Citicoline.
Warnings
Ensure vendor quality — biological product contamination risk. Do not use if porcine-derived products contraindicated.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
6/10
5/10
8/10
6/10

SNAP-8

Intro
Snap-8 (Acetyl Octapeptide-3) is a synthetic octapeptide that mimics the N-terminal portion of SNAP-25. It competes with the SNARE complex, reducing neurotransmitter release at neuromuscular junctions in facial skin. Often called 'topical Botox' in cosmetic science.
Mechanism
Inhibits SNARE complex formation → reduced acetylcholine release at local neuromuscular junctions → reduced muscle contraction intensity in expression lines → smoother appearance over time.
Benefits
Reduces expression-related fine lines without injection. Can be added to moisturizer or serum. No systemic effects. Safe topical profile.
Negatives
Penetration through skin is very limited for large peptides. Most human evidence industry-funded. Effects subtle vs Botox. Not relevant at 18 — no expression lines yet.
Reconstitution
Typically used as topical — dissolve in DMSO or serum base for penetration.
Dosage
2-10% topical solution, apply 2× daily.
Timing
Morning and evening skincare routine.
Cycling
Continuous — topical peptides require sustained use.
Storage
Lyophilized 12+ months. Solution 1 month refrigerated.
Cost (vendor)
$40 per kit (10×10mg vials). ~€3.5/vial. Very affordable.
Evidence Grade
C+ — One industry-funded human trial showing 52% wrinkle reduction. No independent replication.
Synergies
Tretinoin (different mechanism). GHK-Cu (complementary skin matrix support).
Warnings
Not meaningful at 18 years. Consider at 30+ when expression lines begin. Skin penetration limitations mean topical DMSO carrier needed.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
3/10
9/10
3/10
9/10
4/10

PINEALON

Intro
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by the same Russian group as Epitalon (Khavinson). It is derived from the pineal gland and claimed to regulate circadian rhythms, protect neurons, and enhance cognitive function. More targeted neurological action than Epitalon.
Mechanism
Claimed: regulates melatonin secretion rhythm. Neuroprotective against oxidative stress. Potentially modulates DNA methylation patterns in neurons. Anti-apoptotic in neuronal cell lines.
Benefits
Potential sleep quality improvement. Neuroprotective effects in animal models. Claimed cognitive enhancement. Better age-appropriateness than Epitalon (circadian regulation relevant at any age).
Negatives
All evidence from single Russian research group (Khavinson) — significant conflict of interest. No independent replication. Human data limited to elderly. Mechanism insufficiently characterized.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
5-10mg course over 10 days.
Timing
Evening for circadian effects.
Cycling
10-day courses 2-3× per year.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$55 per kit (10×5mg vials). ~€5/vial. Moderate.
Evidence Grade
C — Single research group. Elderly-only human data. No independent replication.
Synergies
Melatonin (circadian stack). DSIP.
Warnings
Same single-source evidence issue as Epitalon. Verify independently before use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
6/10
4/10

EPITHALON (EPITALON)

Intro
Synthetic tetrapeptide from the pineal gland. Claimed telomerase activator. All positive human evidence in elderly (60+) cohorts. Mismarketed to younger users — fundamentally age-inappropriate under 35.
Mechanism
Activates telomerase (hTERT) in somatic cells. Regulates melatonin secretion. Antioxidant. Regulates hypothalamic-pituitary axis.
Benefits
Telomere elongation in elderly subjects. Normalizes melatonin in aged individuals. Sleep improvement. Antioxidant effects.
Negatives
NOT APPROPRIATE UNDER 35-40 YEARS. Your telomeres are already near peak length at 18. Long telomeres correlated with MORE tumors (Johns Hopkins research). All-cause mortality data shows abnormally long telomeres are harmful. Single research group with patent conflict of interest.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
5-10mg/day × 10-20 days (elderly protocol).
Timing
Evening.
Cycling
2× per year for elderly users.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$48 per kit (10×10mg vials). ~€4.4/vial. Affordable but irrelevant at <35.
Evidence Grade
C+ — Single research group. Human data in elderly only. No independent replication.
Synergies
Melatonin, Pinealon. NOT for young users.
Warnings
DO NOT USE UNDER 35. No benefit. Theoretical cancer risk from telomere overextension at young age.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
7/10
3/10
7/10
2/10

IPAMORELIN

Intro
Selective GHRH receptor agonist. Cleanest GHRP — no cortisol/prolactin elevation. Best used with CJC-1295 no-DAC for synergistic GH pulse. At 18, natural GH is already at peak — use with caution.
Mechanism
GHSR-1a (ghrelin receptor) agonist → pulsatile GH release from pituitary. Highly selective. No ACTH, cortisol, or prolactin stimulation at standard doses.
Benefits
Clean GH stimulation. Improved deep sleep. Recovery enhancement. Lean mass support. Better tolerated than GHRP-2/6.
Negatives
At 17-18, endogenous GH already at lifetime peak. Marginal additional benefit. Potential GH receptor downregulation. Water retention possible. Not FDA approved.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100mcg = 0.02ml.
Dosage
100-300mcg per injection. 1-3×/day. Most useful pre-bed.
Timing
Pre-bed (maximize natural GH pulse). Can stack with CJC-1295 no-DAC.
Cycling
12-week cycles, 4-6 weeks off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €40-80/month.
Evidence Grade
C+ — Phase II human trials in GH deficiency. Mechanism well-established. Off-label recovery use anecdotal.
Synergies
CJC-1295 no-DAC (synergistic GH pulse). DSIP (sleep enhancement stack).
Warnings
Marginal benefit at 17-18. Wait until 21+ for optimal use case. Never fasted training + ipamorelin (hypoglycemia risk).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
5/10
7/10
5/10

NAD+

Intro
NAD+ precursors (NMN/NR) raise intracellular NAD+ levels. NAD+ declines with age, primarily after 40. Every positive human RCT enrolled middle-aged or elderly subjects. Not indicated at 18.
Mechanism
NAD+ precursors → raise NAD+ pool → sirtuin activation → mitochondrial efficiency. Requires CD38 to be low for optimal effect.
Benefits
Mitochondrial function in elderly. DNA repair enhancement. Sirtuin activation. Muscle function support in aged subjects.
Negatives
NOT RECOMMENDED UNDER 35. NAD+ peaks between 15-30. 2025 meta-analysis: no significant benefit for muscle function in young subjects. Your niacinamide 10% topical already supports local NAD+. Waste of money at your age.
Reconstitution
Oral capsules. Injectable NAD+ also available (listed vendor).
Dosage
250-500mg NMN or NR oral. Or 100-500mg IV/IM injectable.
Timing
Morning.
Reconstitution
No established cycle for oral. Injectable courses sometimes 10 days.
Storage
Keep dry. Heat sensitive.
Cost (vendor)
$40 per kit (10×100mg) to $130 per kit (10×1000mg). Pointless at 18.
Evidence Grade
B- (in elderly), C (in young). All positive RCTs in 40+ populations.
Synergies
5-amino-1MQ (CD38 inhibitor — more relevant mechanism). SS-31. All age 35+.
Warnings
NOT RECOMMENDED UNDER 35. No demonstrated benefit. Use money elsewhere.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
9/10
3/10
5/10
2/10

PEPTIDES NOT RECOMMENDED FOR THIS CONTEXT

Do Not Use — Reasons Explained

Semaglutide / Tirzepatide / Retatrutide / Cagrilintide
If you can't get your body fat down to 10% at least once in your life, what can you actually do?
I use Tirzepatide myself
IGF-1 LR3 (Used it myself)
Highly anabolic IGF-1 analogue. Promotes growth in ALL tissues including potential tumor cells. Open growth plates at 17-18 make this particularly concerning. Hypoglycemia risk. Not appropriate under 21+.
Dermorphin
Opioid peptide — 50x more potent than morphine. Extremely high addiction potential. Not appropriate for any looksmaxxing or performance context. High risk of dependence, respiratory depression, death in overdose.
Adipotide
Experimental peptide targeting ANXA2/PROHIBITIN on fat cell vasculature. Causes kidney toxicity in primate studies. Never cleared for human use. Avoid entirely.
Oxytocin
Half-life 3-5 minutes IV. Intranasal slightly longer. No meaningful persistent anxiolytic effect for social situations. Better alternatives available (Etifoxine, Selank, Pregab).
PT-141 (Bremelanotide)
MC3R/MC4R agonist for sexual dysfunction. More systemic side effects than MT-1. Nausea, blood pressure effects. Not a looksmaxxing compound.

STACKING GUIDE

Recommended Stacks by Goal

Cognitive Peak
Semax (1mg/day IN) + Citicoline (250mg/day oral) + Selank (500mcg situational). Semax → focus/BDNF, Citicoline → ACh, Selank → anxiety control.
Skin & PIE
GHK-Cu (2mg subcut EOD) + Tretinoin (topical) + Azelaic Acid 20% (topical) + Niacinamide 10% (topical). Best-evidenced combination.
Post-Surgery
BPC-157 (500mcg/day) + TB-500 (2mg 2×/week) + GHK-Cu (500mcg/day) + KPV (1mg/day). 8-week protocol.
Healing & Recovery
BPC-157 + TB-500 combo vial (BBG or KLOW80 mix). Most cost-effective option. KLOW80 adds KPV for anti-inflammatory.
Sleep Quality
DSIP (200mcg subcut pre-bed) + Ipamorelin (100mcg pre-bed). Synergistic GH pulse + deep sleep architecture.
Mitochondrial Stack
SS-31 (2mg/day) + MOTS-C (5mg 3×/week). Age 30+ optimal. Limited benefit at 18.
Immune Support
Thymosin Alpha-1 (1mg 2×/week) for 4-6 weeks during illness, intense training periods, or post-surgery.
Anxiolysis (Daily)
Selank (400-600mcg/day, cycled 14/14). No dependence, no sedation. Best daily option.
Anxiolysis (Events)
Etifoxine 50mg → Pregabalin 75-150mg (reserve for important only). Never two GABAergics same day.

CRITICAL INTERACTIONS
READ BEFORE STACKING

ABSOLUTE
NEVER: Selank + Etifoxine + Pregabalin same day. Three GABAergics = CNS depression risk.
ABSOLUTE
NEVER: MT-1 + MT-2 simultaneously. Receptor overlap, unpredictable systemic effects.
AVOID
Ipamorelin/CJC-1295 on fasted training days — hypoglycemia risk.
AVOID
Semax + Modafinil daily — both dopaminergic. Limit to exam days only.
SEPARATE
GHK-Cu and Zinc: pause zinc during GHK-Cu cycle. Competition for transporters.
SEPARATE
MT-1 and GHK-Cu injections: different anatomical sites same evening.
NOTE
BPC-157 / TB-500 / GHK-Cu vendor combo mixes (BBG, KLOW80) can be drawn from same vial — convenient and cost-effective.

RECONSTITUTION QUICK REFERENCE

Standard Dilutions
Semax 40mg 4ml BAC water → 10mg/ml → 1mg dose = 0.1ml
Selank 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
GHK-Cu 2mg 1ml BAC water (or PBS) → 2mg/ml → 2mg = 1ml
GHK-Cu 50mg (bulk) 25ml BAC water → 2mg/ml → 2mg = 1ml
MT-1 10mg 1ml BAC water → 10mg/ml → 500mcg = 0.05ml
BPC-157 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
TB-500 5mg 1ml BAC water → 5mg/ml → 2mg = 0.4ml
Ipamorelin 5mg 1ml BAC water → 5mg/ml → 100mcg = 0.02ml
DSIP 5mg 1ml BAC water → 5mg/ml → 200mcg = 0.04ml
Epitalon 10mg 2ml BAC water → 5mg/ml → 5mg = 1ml
Thymosin Alpha-1 5mg 1ml BAC water → 5mg/ml → 1mg = 0.2ml
KPV 10mg 1ml BAC water → 10mg/ml → 1mg = 0.1ml (or oral)
PBS vs BAC Water Use PBS for copper peptides (GHK-Cu, AHK-Cu) — better copper stability. BAC water for all others.

VENDOR PRICE REFERENCE (Chinese Warehouse)
$60 flat worldwide shipping fee. All prices USD per kit of 10 vials (divide by 10 for single vial price). Prices as of April 2026.

Product Price (USD) per kit (10 vials)
Semax 5mg×10 $40
Semax 10mg×10 $50
Selank 5mg×10 $40
GHK-Cu 50mg×10 $30
GHK-Cu 100mg×10 $45
AHK-Cu 100mg×10 $68
MT-1 10mg×10 $45
MT-2 10mg×10 $45
BPC-157 5mg×10 $40
BPC-157 10mg×10 $70
TB-500 5mg×10 $75
TB-500 10mg×10 $140
BPC+TB 5mg+5mg×10 $95
GHK+BPC+TB 50/10/10mg×10 $160
GHK+BPC+TB+KPV 80mg×10 $195
KPV 10mg×10 $60
Ipamorelin 5mg×10 $45
Ipamorelin 10mg×10 $80
CJC-1295 no-DAC 5mg×10 $85
CJC+Ipa combo 10mg×10 $95
DSIP 5mg×10 $45
DSIP 15mg×10 $85
SS-31 10mg×10 $86
SS-31 50mg×10 $285
MOTS-C 10mg×10 $65
MOTS-C 40mg×10 $185
5-amino-1MQ 5mg×10 $45
5-amino-1MQ 50mg×10 $110
Thymosin Alpha-1 5mg×10 $80
TA-1 10mg×10 $145
Epitalon 10mg×10 $48
Epitalon 50mg×10 $150
Cerebrolysin 60mg×6 $29
Pinealon 5mg×10 $55
Pinealon 10mg×10 $70
Snap-8 10mg×10 $40
NAD+ 100mg×10 $40
NAD+ 500mg×10 $80
NAD+ 1000mg×10 $130
L-Carnitine 600mg/ml 10ml×10 $80
Glutathione 1500mg×10 $80
Melatonin 10mg×10 $55
VIP 5mg×10 $75
SLU-PP-322 5mg×10 $100
AICAR 50mg×10 $62
Tesamorelin 5mg×10 $110
ARA-290 10mg×10 $80
BAC Water 10ml×10 $10
PBS 10ml×10 $10
Acetic Acid Water 10ml×10 $10

PEPTIDES

Melanotan-1 subcutaneously, in the evening.

GHK-Cu 2 mg subcutaneously, in the evening.

Tirzepatide 2,5 mg subcutaneously, every week

@reyalsnoom @Jesus_ist_König @tqbiq @greylord @aaronbp

dnr +bookmarked

thomasjiooo · Apr 21, 2026

til<3D said:
Complete Guide to Peptide Protocols — Dosing, Evidence & Stacking

by til<3D
Stand: April 2026

DISCLAIMER

Read First
This guide is for educational purposes only. Peptides are not approved drugs in most countries. Everything here is off label and experimental. Do your own research. You are responsible for your own choices. This is not medical advice.
Age Note
Several peptides are specifically marked as inappropriate for users under 18-20 years old due to ongoing hormonal and neural development. These warnings are clearly flagged throughout.
Sources
Evidence grades reflect actual human clinical trial data, animal studies, and in vitro research. Grade A = multiple human RCTs. Grade B = some human data. Grade C = animal/in vitro only.

PEPTIDES COVERED IN THIS THREAD

1. Semax — ACTH(4-7) Analogue — Nootropic

2. Selank — Tuftsin Analogue — Anxiolytic & Cognitive

3. GHK-Cu — Copper Peptide — Skin & Collagen

4. AHK-Cu — Copper Peptide — Hair Growth

5. Melanotan-1 (MT-1) — MC1R Agonist — Tanning

6. BPC-157 — Body Protection Compound — Healing

7. TB-500 — Thymosin Beta-4 — Recovery & Flexibility

8. DSIP — Delta Sleep-Inducing Peptide — Sleep Architecture

9. SS-31 (Elamipretide) — Mitochondria-Targeting Peptide — Energy & Cardioprotection

10. MOTS-C — Mitochondrial-Derived Peptide — Metabolic

11. 5-amino-1MQ — CD38 Inhibitor — NAD+ Preservation

12. Thymosin Alpha-1 — Immune Modulator — Immune Enhancement

13. KPV — Anti-Inflammatory Tripeptide — Gut & Skin

14. Cerebrolysin — Neuropeptide Mix — Cognitive & Neuroprotection

15. Snap-8 — Neuropeptide — Anti-Wrinkle Topical

16. Pinealon — Pineal Peptide — Neuroprotection & Circadian

17. Epithalon (Epitalon) — Tetrapeptide — Telomere (Age 40+ Only)

18. Ipamorelin — GHRP — GH Secretagogue (Age 20+ Optimal)

19. NAD+ — NAD+ Precursors — Mitochondrial (Age 35+ Only)

QUICK REFERENCE — ALL PEPTIDES

Peptide Effectiveness Evidence Age 17-18 Cost/mo Overall
Semax 8/10 B+ ✓ OK €20–35/vial (40mg) 8/10
Selank 8/10 B ✓ OK €25–40/vial (5mg) 7/10
GHK-Cu 7/10 B- ✓ OK €30/vial (50mg bulk) — much better value 7/10
AHK-Cu 6/10 C+ ✓ OK $68/100mg vial (vendor) 6/10
Melanotan-1 (MT-1) 9/10 A- ✓ OK $45/10mg vial × 10 8/10
BPC-157 7/10 C+ ✓ OK $40/5mg vial × 10 6/10
TB-500 7/10 C+ ✓ OK $75/5mg vial × 10 6/10
DSIP 6/10 C+ ✓ OK $45/5mg vial × 10 5/10
SS-31 (Elamipretide) 6/10 B- ✓ OK $86/10mg vial × 10 5/10
MOTS-C 6/10 C+ ✓ OK $65/10mg vial × 10 5/10
5-amino-1MQ 4/10 C ✓ OK $45/5mg vial or $110/50mg 3/10
Thymosin Alpha-1 7/10 B ✓ OK $80/5mg vial × 10 6/10
KPV 6/10 C+ ✓ OK $60/10mg vial × 10 6/10
Cerebrolysin 7/10 B- ✓ OK $29/60mg × 6 vials (vendor) 6/10
Snap-8 3/10 C+ ✓ OK $40/10mg vial × 10 (vendor) 4/10
Pinealon 4/10 C ✓ OK $55/5mg vial × 10 4/10
Epithalon (Epitalon) 2/10 C+ ✗ Caution $48/10mg × 10 (vendor) 2/10
Ipamorelin 6/10 C+ ✗ Caution $45/5mg vial × 10 5/10
NAD+ 2/10 B- ✗ Caution $40-130 depending on dose 2/10

INDIVIDUAL PEPTIDE PROFILES

SEMAX

Intro
Synthetic heptapeptide analogue of ACTH(4-7), developed in Russia for stroke and cognitive enhancement. Decades of clinical data. Crosses BBB efficiently intranasally. You could also do subq but in my opinion it's unnecessary.
Mechanism
Upregulates BDNF. Modulates dopaminergic/serotonergic transmission. Increases enkephalinase activity. NO signalling enhancement.
Benefits
Enhanced focus, memory, learning. Neuroprotection. Anti anxiety via serotonin. Rapid onset 15-30 min. No physical dependence.
Negatives
Receptor desensitization — cycling required. Mild anxiety at high doses. Most studies Russian literature.
Reconstitution
4ml BAC water on 40mg vial = 10mg/ml. 1mg = 0.1ml = 1 pump.
Dosage
0.5–1mg/day intranasal.
Timing
Morning, fasted or first meal.
Cycling
5 days ON / 2 OFF. Or 3 weeks ON / 1 week OFF.

Storage
Lyophilized 12+ months. Reconstituted 4°C, 4 weeks.
Cost (vendor)
$50/100mg vial (vendor).
Evidence Grade
B+ — Russian Phase II/III trials. Growing Western replication.
Synergies
Citicoline, Selank. Never combine with high dose Modafinil same day.
Warnings
Monitor with Modafinil stack. Avoid MAOIs.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
7/10
8/10
8/10

SELANK

Intro
Synthetic analogue of tuftsin. Official anxiolytic drug status in Russia/Ukraine. Anxiolysis without sedation, tolerance, or withdrawal.
Mechanism
Allosteric GABA-A modulation. Inhibits enkephalinase. Modulates BDNF/NGF. Complements Semax via distinct brain connectivity patterns.
Benefits
Anxiolysis without sedation or dependence. Cognitive enhancement. Anti inflammatory. No BtMG. Low desensitization risk at standard doses.
Negatives
Most evidence Russian studies. Additive CNS depression with other GABAergics — critical interaction. Short half-life ~2h intranasal.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
250–800mcg/day intranasal.
Timing
Morning or 30-60 min before stressful situations.
Cycling
14 days ON / 14 days OFF, or situational.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/100mg vial (vendor). Very cost effective per mg.
Evidence Grade
B — Russian Phase II clinical trials in GAD.
Synergies
Semax (complementary). NEVER with Etifoxine, Pregabalin, or alcohol same day.
Warnings
NEVER combine with Etifoxine, Pregabalin, or benzodiazepines same day. Additive CNS depression.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
6/10
8/10
7/10

GHK-CU

Intro
Naturally occurring copper-binding peptide. Plasma levels decline with age. Gold standard for skin regeneration and wound healing.
Mechanism
Activates fibroblasts → collagen I/III/elastin synthesis. VEGF-driven angiogenesis. Inhibits TGF-β1 (anti-fibrotic). Antioxidant enzyme upregulation.
Benefits
PIE/acne scar remodeling. Skin density improvement. Wound/post-surgery healing. Tendon collagen support. Anti-inflammatory.
Negatives
Systemic human RCT data limited. Competing with zinc pause zinc during use. Monitor copper levels with chronic use.
Reconstitution
1ml BAC water on 2mg vial = 2mg/ml. 27-29G needle, 4-6mm, 45°. PBS preferred for copper stability.
Dosage
2mg subcut EOD/ ED.
Timing
Evening after training. Separate site from MT-1.
Cycling
4-week cycles. Zinc paused. After cycle reintroduce zinc.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/1g vial (vendor). Very cost effective per mg.
Evidence Grade
B- — Strong in-vitro/animal. Limited human RCTs for subcut use. Topical human evidence solid.
Synergies
Tretinoin (complementary collagen). Copper supplement 30-60 min before injection.
Warnings
Pause zinc during cycle. Monitor serum copper/ceruloplasmin with extended use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
5/10
10/10
8/10

AHK-CU

Intro
Tripeptide analogue of GHK-Cu with higher affinity for hair follicle receptors. AHK (Ala-His-Lys) specifically promotes hair growth via follicle dermal papilla stimulation.
Mechanism
Activates Wnt/β-catenin pathway in hair follicles. Promotes dermal papilla cell proliferation. Upregulates VEGF in follicle microvasculature. Inhibits DHT-induced apoptosis in follicles.
Benefits
Hair density and thickness improvement. Potentially superior to GHK-Cu for scalp/follicle applications. Can be used topically or subcut. Anti-inflammatory in follicle microenvironment.
Negatives
Less research than GHK-Cu overall. Mostly in-vitro data. Higher cost per mg. Limited human studies specifically.
Reconstitution
1ml BAC water per 10mg = 10mg/ml. Can be used topically (DMSO carrier) or subcut.
Dosage
Topical: 0.01-0.1% solution on scalp. Subcut: 1-2mg/day.
Timing
Evening or post-shower for topical.
Cycling
Continuous or 8-week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$68/1g vial (vendor). Very cost effective per mg.
Evidence Grade
C+ — In-vitro strong. Limited human data. Mechanistically plausible.
Synergies
GHK-Cu (different receptor affinity — complementary). Minoxidil topical.
Warnings
Avoid mixing with acidic solutions. PBS preferred diluent.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
9,5/10
8/10

MELANOTAN-1 (MT-1)

Intro
Synthetic α-MSH analogue with MC1R selectivity. Only melanocortin peptide with EMA approval (Scenesse for EPP). Deep even tan with reduced UV exposure.
Mechanism
MC1R agonism → tyrosinase upregulation → eumelanin synthesis. UV activation required to convert precursors to visible pigment.
Benefits
Deep even tan. Photoprotection. Visually reduces PIE by contrast. EMA-approved safety data. Lower systemic effects vs MT-2.
Negatives
Nausea during loading (reduced by microdosing). Mole changes — document before starting. UV >3 required for activation. MC4R spillover at high doses.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 500mcg = 0.05ml.
Dosage
Loading: 500mcg/day × 14 days. Maintenance: 250-500mcg E2-3D + UV.
Timing
Evening — sleep through initial nausea.

Cycling
Loading → Maintenance. No continuous loading.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$4,5/10mg vial × 10. ~€2-3,5/month maintenance.
Evidence Grade
A- — EMA approved. Phase III trials. Extensive safety data.
Synergies
UV exposure (essential). Tretinoin. Solarium if UV index <3.
Warnings
Photograph all moles before starting. Never combine with MT-2.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
7/10
8/10
9/10
8,5/10

BPC-157

Intro
Synthetic pentadecapeptide from gastric juice. Remarkable healing in animal models across tendons, ligaments, muscles, GI tract. Most promising for injury recovery and post-surgical healing.
Mechanism
Upregulates GH receptor. VEGF angiogenesis. FAK-paxillin wound healing pathway. NF-κB inhibition. Collagen synthesis in tenocytes.
Benefits
Tendon/ligament healing acceleration. GI mucosal protection. Nerve regeneration (animal). Anti-inflammatory. Enhanced training recovery.
Negatives
Virtually ALL data is animal/in-vitro. Zero completed human RCTs. Unknown optimal human dosing. Unknown long-term safety.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
200-500mcg/day subcut or IM. Split morning + evening.
Timing
Morning and/or post-training.
Cycling
4-8 weeks on, 4 off. Or acute injury protocol.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$40 per kit (10×5mg vials). ~€3.5/vial. €40-70/month.
Evidence Grade
C+ — Extensive animal data, consistent results. Zero human RCTs. High translation uncertainty.
Synergies
TB-500 (complementary). GHK-Cu (collagen synergy).
Warnings
Theoretical angiogenesis concern with cancer history (unproven in humans). No known drug interactions.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
8/10
4/10
7/10
6/10

TB-500

Intro
Synthetic fragment of thymosin beta-4. Critical role in cell migration, wound healing, tissue regeneration. Systemic healing reach that BPC-157 lacks.
Mechanism
Binds G-actin → cell migration/differentiation. Integrin-linked kinase activation. Metalloproteinase upregulation for tissue remodeling. Vascular tube formation.
Benefits
Systemic healing (reaches distant injury sites). Muscle fiber regeneration. Flexibility/ROM improvements. Potential cardiac protection.
Negatives
Human RCT data absent for recovery use. Higher MW limits oral bioavailability. More expensive than BPC-157. Overlap with BPC-157.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
Loading: 2-2.5mg 2×/week × 4-6 weeks. Maintenance: 2-2.5mg 1×/week.
Timing
Morning or post-training.
Cycling
6-week loading, then maintenance or off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$75 per kit (10×5mg vials). ~€7/vial. €50-90/month.
Evidence Grade
C+ — Animal data solid. Phase II trial in dry eye disease. Limited systemic recovery data in humans.
Synergies
BPC-157 (most common stack). Post-surgery recovery protocol.
Warnings
Same theoretical angiogenesis concern as BPC-157 with cancer history.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
4/10
6/10
6/10

DSIP

Intro
DSIP is a neuropeptide that modulates sleep architecture by promoting delta-wave (slow-wave) sleep. It was isolated from rabbit thalamic venous blood in 1977. Unlike benzodiazepines, it doesn't cause sedation — it shifts the sleep profile toward restorative deep sleep.
Mechanism
Modulates GABA-B receptors. Reduces nocturnal cortisol. Increases GH secretion during sleep. Normalizes circadian rhythm via hypothalamic-pituitary axis modulation. Antioxidant effects.
Benefits
Improved deep sleep quality (not just duration). GH pulse enhancement during sleep. Reduced cortisol during sleep. Potential nootropic effects via improved sleep. Non-sedating — no morning grogginess.
Negatives
Short plasma half-life (~30 min) — may require specific timing. Most data from 1980s-90s Russian studies. Limited modern replication. Expensive per mg.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100-300mcg = 0.02-0.06ml.
Dosage
100-300mcg subcut 30-60 min before sleep.
Timing
30-60 minutes before bedtime.
Cycling
5-7 day cycles. Short-term use most studied.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €30-60/month.
Evidence Grade
C+ — Russian human trials 1980s. Mechanism plausible. Limited modern replication.
Synergies
Melatonin (circadian complementary). Ipamorelin (synergistic GH pulse during sleep).
Warnings
No known serious interactions. Avoid combining with benzodiazepines (additive sleep effects).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

SS-31 (ELAMIPRETIDE)

Intro
SS-31 (Szeto-Schiller peptide 31) is a tetrapeptide that concentrates in the inner mitochondrial membrane, stabilizing cardiolipin. It is arguably the most promising mitochondria-targeting molecule currently studied, with active Phase II/III trials for Barth syndrome, heart failure, and age-related muscle loss.
Mechanism
Binds cardiolipin in inner mitochondrial membrane → stabilizes electron transport chain structure. Reduces mitochondrial ROS production. Maintains cristae morphology. Improves ATP synthesis efficiency.
Benefits
Mitochondrial function restoration. Reduced oxidative stress. Improved energy efficiency (not stimulant-based). Potential muscle function improvement. Active pharmaceutical development — human safety data exists.
Negatives
Expensive per mg. Mostly disease-state human trials — healthy young male data absent. Injectable only (high MW). Long-term use unknown.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
1-5mg/day subcut. Clinical trials used 0.05-0.25 mg/kg IV.
Timing
Morning.
Cycling
4-12 week cycles. Research ongoing.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$86 per kit (10×10mg vials). ~€8/vial. Expensive but unique mechanism.
Evidence Grade
B- — Phase II human trials in disease states. Mechanism very well characterized. Healthy young use extrapolated.
Synergies
NAD+ precursors (complementary mitochondrial support). MOTS-C.
Warnings
No known serious interactions. Not indicated in healthy young without mitochondrial disease.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
6/10
5/10
5/10
5/10

MOTS-C

Intro
MOTS-C is a peptide encoded in the mitochondrial genome — one of the first mitochondria-derived peptides discovered. It acts as a metabolic regulator, improving insulin sensitivity and exercise capacity. Endogenous levels decline with age and are increased by exercise.
Mechanism
Activates AMPK. Inhibits AICAR (purine synthesis) → folate cycle disruption → metabolic reprogramming. Improves glucose uptake independent of insulin. Regulates ROS homeostasis in mitochondria.
Benefits
Improved insulin sensitivity. Enhanced exercise capacity and metabolic efficiency. Anti-obesity effects. Potential longevity effects. Exercise-mimicking properties.
Negatives
Most data animal studies. Human trial data limited to one small RCT. Age-related benefit unclear in young healthy subjects (endogenous levels already high at 18). Expensive.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 2-5mg per injection.
Dosage
5-10mg subcut 2-3×/week.
Timing
Morning or pre-workout.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$65 per kit (10×10mg vials). ~€6/vial. Moderate.
Evidence Grade
C+ — Strong animal data. One small human RCT (n=40). Mechanism well-established.
Synergies
SS-31 (mitochondrial stack). Exercise potentiation.
Warnings
No known serious interactions. Limited human safety data.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

5-AMINO-1MQ

Intro
5-amino-1-methylquinolinium (5-amino-1MQ) is a small molecule that inhibits CD38, the primary NAD+-degrading enzyme in the body. Unlike taking NAD+ precursors (NMN/NR), which add more NAD+ substrate, 5-amino-1MQ prevents NAD+ from being broken down — potentially more efficient.
Mechanism
Inhibits CD38 (NAD+ glycohydrolase) → NAD+ levels rise. CD38 activity increases dramatically with age and inflammation. Preserves endogenous NAD+ pool without external supplementation.
Benefits
NAD+ preservation. Potential fat loss effects (adipocyte CD38 inhibition). Anti-inflammatory. More targeted mechanism than NMN/NR for NAD+ elevation.
Negatives
Very limited human data. Research peptide status. Long-term safety unknown. Age-appropriateness at 18 unestablished (same issue as NAD+ precursors — you don't need this yet).
Reconstitution
Oral or injectable. 5mg vial with 1ml BAC water = 5mg/ml.
Dosage
5-50mg oral or 1-5mg subcut.
Timing
Morning.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months.
Cost (vendor)
$45 per kit (10×5mg) or $110 per kit (10×50mg). ~€4-10/vial.
Evidence Grade
C — Animal data only. No human RCTs. Mechanism well-established biochemically.
Synergies
SS-31, MOTS-C (mitochondrial stack). More relevant at 35+ years.
Warnings
Not recommended under 35. No established benefit in young healthy subjects.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
7/10
3/10

THYMOSIN ALPHA-1

Intro
Thymosin Alpha-1 (Tα1) is an endogenous peptide originally isolated from thymic tissue. It is FDA-approved in 35+ countries for chronic hepatitis B and C, and used as an immune adjuvant in cancer treatment. Strong immunomodulatory and antiviral properties.
Mechanism
Enhances T-cell, NK cell, and dendritic cell function. Upregulates IL-2, IFN-γ. Activates Toll-like receptors. Promotes antigen presentation. Anti-inflammatory via IL-10 pathway.
Benefits
Immune system enhancement and normalization. Antiviral effects. Used clinically for immunocompromised patients. Strong safety data from approved medical use. Potential benefit post-illness or during intense training phases.
Negatives
Healthy young with normal immune function may see minimal benefit. Expensive. Primary benefit for immunocompromised or sick individuals. Mild injection site reactions.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
1-2mg subcut 2×/week. Clinical dose: 1mg/m² body surface area.
Timing
Any time — immune timing less critical.
Cycling
2-6 week cycles. Or as needed during illness.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$80 per kit (10×5mg vials). ~€7/vial. Moderate.
Evidence Grade
B — Approved in multiple countries for specific indications. Good human safety data. Healthy young use extrapolated.
Synergies
BPC-157 (immune + healing stack during recovery). Useful post-surgery.
Warnings
No significant drug interactions at standard doses. Avoid in autoimmune conditions without medical supervision.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
6/10
6/10
6/10

KPV

Intro
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of α-MSH. It retains the anti-inflammatory properties of the parent molecule without melanocortin receptor agonism. Being 3 amino acids, it has superior bioavailability and can even be taken orally for GI effects.
Mechanism
Inhibits NF-κB signalling. Reduces TNF-α, IL-1β, IL-6 production. Activates MC1R and MC3R locally (anti-inflammatory, not pigmentation). Promotes intestinal epithelial healing.
Benefits
Potent anti-inflammatory for gut, skin, and systemic use. Oral bioavailability for GI-specific effects. No melanocortin pigmentation effects. Excellent safety profile. Can be combined with BPC-157 for enhanced GI healing.
Negatives
Limited human clinical trial data. Research peptide status. Very short half-life requires frequent dosing or oral route.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. Can be taken orally (encapsulate or dissolve in water).
Dosage
500mcg–2mg subcut or 1-5mg oral per day.
Timing
Any time. Oral pre-meals for GI effects.
Cycling
Continuous low-dose or acute 4-week protocols.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$60 per kit (10×10mg vials). ~€5.5/vial. Reasonable.
Evidence Grade
C+ — Strong in-vitro/animal. Human data emerging. Mechanism very well characterized.
Synergies
BPC-157 (GI healing stack). Part of BBG or KLOW80 recovery mix.
Warnings
No known serious interactions. Excellent tolerability profile.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
8/10
4/10
7/10
6/10

CEREBROLYSIN

Intro
Cerebrolysin is a complex mixture of low-molecular-weight peptides derived from porcine brain tissue. It contains BDNF, NGF, CNTF, and other neurotrophins. Used clinically in Eastern Europe and Asia for stroke, traumatic brain injury, and Alzheimer's disease.
Mechanism
Provides exogenous BDNF, NGF, and other neurotrophins directly. Promotes neurogenesis and synaptic plasticity. Neuroprotective against excitotoxicity. Anti-apoptotic in neurons.
Benefits
Direct neurotrophin supplementation (vs Semax which stimulates endogenous production). Established clinical use in stroke recovery. May enhance cognitive recovery after stress or illness. Fast-acting neuroplasticity support.
Negatives
Derived from porcine brain — quality control important. Injectable only (IV preferred clinically, IM used in biohacking). Religious/dietary restrictions for some. Most trials in neurological disease, not healthy subjects. Quality varies by vendor significantly.
Reconstitution
Ready solution typically. Check vendor — should be aqueous solution, not lyophilized.
Dosage
1-5ml IM/subcut. Clinical: 10-30ml IV/day. For cognitive use: 1-2ml IM daily.
Timing
Morning.
Cycling
10-30 day cycles. 2-3× per year.
Storage
Refrigerate 2-8°C. Do not freeze.
Cost (vendor)
$29 per kit (6×60mg vials). ~€4.5/vial. Budget-friendly.
Evidence Grade
B- — Multiple RCTs in stroke/TBI (positive). Healthy cognitive enhancement — limited data.
Synergies
Semax (BDNF endogenous + exogenous). Citicoline.
Warnings
Ensure vendor quality — biological product contamination risk. Do not use if porcine-derived products contraindicated.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
6/10
5/10
8/10
6/10

SNAP-8

Intro
Snap-8 (Acetyl Octapeptide-3) is a synthetic octapeptide that mimics the N-terminal portion of SNAP-25. It competes with the SNARE complex, reducing neurotransmitter release at neuromuscular junctions in facial skin. Often called 'topical Botox' in cosmetic science.
Mechanism
Inhibits SNARE complex formation → reduced acetylcholine release at local neuromuscular junctions → reduced muscle contraction intensity in expression lines → smoother appearance over time.
Benefits
Reduces expression-related fine lines without injection. Can be added to moisturizer or serum. No systemic effects. Safe topical profile.
Negatives
Penetration through skin is very limited for large peptides. Most human evidence industry-funded. Effects subtle vs Botox. Not relevant at 18 — no expression lines yet.
Reconstitution
Typically used as topical — dissolve in DMSO or serum base for penetration.
Dosage
2-10% topical solution, apply 2× daily.
Timing
Morning and evening skincare routine.
Cycling
Continuous — topical peptides require sustained use.
Storage
Lyophilized 12+ months. Solution 1 month refrigerated.
Cost (vendor)
$40 per kit (10×10mg vials). ~€3.5/vial. Very affordable.
Evidence Grade
C+ — One industry-funded human trial showing 52% wrinkle reduction. No independent replication.
Synergies
Tretinoin (different mechanism). GHK-Cu (complementary skin matrix support).
Warnings
Not meaningful at 18 years. Consider at 30+ when expression lines begin. Skin penetration limitations mean topical DMSO carrier needed.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
3/10
9/10
3/10
9/10
4/10

PINEALON

Intro
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by the same Russian group as Epitalon (Khavinson). It is derived from the pineal gland and claimed to regulate circadian rhythms, protect neurons, and enhance cognitive function. More targeted neurological action than Epitalon.
Mechanism
Claimed: regulates melatonin secretion rhythm. Neuroprotective against oxidative stress. Potentially modulates DNA methylation patterns in neurons. Anti-apoptotic in neuronal cell lines.
Benefits
Potential sleep quality improvement. Neuroprotective effects in animal models. Claimed cognitive enhancement. Better age-appropriateness than Epitalon (circadian regulation relevant at any age).
Negatives
All evidence from single Russian research group (Khavinson) — significant conflict of interest. No independent replication. Human data limited to elderly. Mechanism insufficiently characterized.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
5-10mg course over 10 days.
Timing
Evening for circadian effects.
Cycling
10-day courses 2-3× per year.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$55 per kit (10×5mg vials). ~€5/vial. Moderate.
Evidence Grade
C — Single research group. Elderly-only human data. No independent replication.
Synergies
Melatonin (circadian stack). DSIP.
Warnings
Same single-source evidence issue as Epitalon. Verify independently before use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
6/10
4/10

EPITHALON (EPITALON)

Intro
Synthetic tetrapeptide from the pineal gland. Claimed telomerase activator. All positive human evidence in elderly (60+) cohorts. Mismarketed to younger users — fundamentally age-inappropriate under 35.
Mechanism
Activates telomerase (hTERT) in somatic cells. Regulates melatonin secretion. Antioxidant. Regulates hypothalamic-pituitary axis.
Benefits
Telomere elongation in elderly subjects. Normalizes melatonin in aged individuals. Sleep improvement. Antioxidant effects.
Negatives
NOT APPROPRIATE UNDER 35-40 YEARS. Your telomeres are already near peak length at 18. Long telomeres correlated with MORE tumors (Johns Hopkins research). All-cause mortality data shows abnormally long telomeres are harmful. Single research group with patent conflict of interest.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
5-10mg/day × 10-20 days (elderly protocol).
Timing
Evening.
Cycling
2× per year for elderly users.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$48 per kit (10×10mg vials). ~€4.4/vial. Affordable but irrelevant at <35.
Evidence Grade
C+ — Single research group. Human data in elderly only. No independent replication.
Synergies
Melatonin, Pinealon. NOT for young users.
Warnings
DO NOT USE UNDER 35. No benefit. Theoretical cancer risk from telomere overextension at young age.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
7/10
3/10
7/10
2/10

IPAMORELIN

Intro
Selective GHRH receptor agonist. Cleanest GHRP — no cortisol/prolactin elevation. Best used with CJC-1295 no-DAC for synergistic GH pulse. At 18, natural GH is already at peak — use with caution.
Mechanism
GHSR-1a (ghrelin receptor) agonist → pulsatile GH release from pituitary. Highly selective. No ACTH, cortisol, or prolactin stimulation at standard doses.
Benefits
Clean GH stimulation. Improved deep sleep. Recovery enhancement. Lean mass support. Better tolerated than GHRP-2/6.
Negatives
At 17-18, endogenous GH already at lifetime peak. Marginal additional benefit. Potential GH receptor downregulation. Water retention possible. Not FDA approved.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100mcg = 0.02ml.
Dosage
100-300mcg per injection. 1-3×/day. Most useful pre-bed.
Timing
Pre-bed (maximize natural GH pulse). Can stack with CJC-1295 no-DAC.
Cycling
12-week cycles, 4-6 weeks off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €40-80/month.
Evidence Grade
C+ — Phase II human trials in GH deficiency. Mechanism well-established. Off-label recovery use anecdotal.
Synergies
CJC-1295 no-DAC (synergistic GH pulse). DSIP (sleep enhancement stack).
Warnings
Marginal benefit at 17-18. Wait until 21+ for optimal use case. Never fasted training + ipamorelin (hypoglycemia risk).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
5/10
7/10
5/10

NAD+

Intro
NAD+ precursors (NMN/NR) raise intracellular NAD+ levels. NAD+ declines with age, primarily after 40. Every positive human RCT enrolled middle-aged or elderly subjects. Not indicated at 18.
Mechanism
NAD+ precursors → raise NAD+ pool → sirtuin activation → mitochondrial efficiency. Requires CD38 to be low for optimal effect.
Benefits
Mitochondrial function in elderly. DNA repair enhancement. Sirtuin activation. Muscle function support in aged subjects.
Negatives
NOT RECOMMENDED UNDER 35. NAD+ peaks between 15-30. 2025 meta-analysis: no significant benefit for muscle function in young subjects. Your niacinamide 10% topical already supports local NAD+. Waste of money at your age.
Reconstitution
Oral capsules. Injectable NAD+ also available (listed vendor).
Dosage
250-500mg NMN or NR oral. Or 100-500mg IV/IM injectable.
Timing
Morning.
Reconstitution
No established cycle for oral. Injectable courses sometimes 10 days.
Storage
Keep dry. Heat sensitive.
Cost (vendor)
$40 per kit (10×100mg) to $130 per kit (10×1000mg). Pointless at 18.
Evidence Grade
B- (in elderly), C (in young). All positive RCTs in 40+ populations.
Synergies
5-amino-1MQ (CD38 inhibitor — more relevant mechanism). SS-31. All age 35+.
Warnings
NOT RECOMMENDED UNDER 35. No demonstrated benefit. Use money elsewhere.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
9/10
3/10
5/10
2/10

PEPTIDES NOT RECOMMENDED FOR THIS CONTEXT

Do Not Use — Reasons Explained

Semaglutide / Tirzepatide / Retatrutide / Cagrilintide
If you can't get your body fat down to 10% at least once in your life, what can you actually do?
I use Tirzepatide myself
IGF-1 LR3 (Used it myself)
Highly anabolic IGF-1 analogue. Promotes growth in ALL tissues including potential tumor cells. Open growth plates at 17-18 make this particularly concerning. Hypoglycemia risk. Not appropriate under 21+.
Dermorphin
Opioid peptide — 50x more potent than morphine. Extremely high addiction potential. Not appropriate for any looksmaxxing or performance context. High risk of dependence, respiratory depression, death in overdose.
Adipotide
Experimental peptide targeting ANXA2/PROHIBITIN on fat cell vasculature. Causes kidney toxicity in primate studies. Never cleared for human use. Avoid entirely.
Oxytocin
Half-life 3-5 minutes IV. Intranasal slightly longer. No meaningful persistent anxiolytic effect for social situations. Better alternatives available (Etifoxine, Selank, Pregab).
PT-141 (Bremelanotide)
MC3R/MC4R agonist for sexual dysfunction. More systemic side effects than MT-1. Nausea, blood pressure effects. Not a looksmaxxing compound.

STACKING GUIDE

Recommended Stacks by Goal

Cognitive Peak
Semax (1mg/day IN) + Citicoline (250mg/day oral) + Selank (500mcg situational). Semax → focus/BDNF, Citicoline → ACh, Selank → anxiety control.
Skin & PIE
GHK-Cu (2mg subcut EOD) + Tretinoin (topical) + Azelaic Acid 20% (topical) + Niacinamide 10% (topical). Best-evidenced combination.
Post-Surgery
BPC-157 (500mcg/day) + TB-500 (2mg 2×/week) + GHK-Cu (500mcg/day) + KPV (1mg/day). 8-week protocol.
Healing & Recovery
BPC-157 + TB-500 combo vial (BBG or KLOW80 mix). Most cost-effective option. KLOW80 adds KPV for anti-inflammatory.
Sleep Quality
DSIP (200mcg subcut pre-bed) + Ipamorelin (100mcg pre-bed). Synergistic GH pulse + deep sleep architecture.
Mitochondrial Stack
SS-31 (2mg/day) + MOTS-C (5mg 3×/week). Age 30+ optimal. Limited benefit at 18.
Immune Support
Thymosin Alpha-1 (1mg 2×/week) for 4-6 weeks during illness, intense training periods, or post-surgery.
Anxiolysis (Daily)
Selank (400-600mcg/day, cycled 14/14). No dependence, no sedation. Best daily option.
Anxiolysis (Events)
Etifoxine 50mg → Pregabalin 75-150mg (reserve for important only). Never two GABAergics same day.

CRITICAL INTERACTIONS
READ BEFORE STACKING

ABSOLUTE
NEVER: Selank + Etifoxine + Pregabalin same day. Three GABAergics = CNS depression risk.
ABSOLUTE
NEVER: MT-1 + MT-2 simultaneously. Receptor overlap, unpredictable systemic effects.
AVOID
Ipamorelin/CJC-1295 on fasted training days — hypoglycemia risk.
AVOID
Semax + Modafinil daily — both dopaminergic. Limit to exam days only.
SEPARATE
GHK-Cu and Zinc: pause zinc during GHK-Cu cycle. Competition for transporters.
SEPARATE
MT-1 and GHK-Cu injections: different anatomical sites same evening.
NOTE
BPC-157 / TB-500 / GHK-Cu vendor combo mixes (BBG, KLOW80) can be drawn from same vial — convenient and cost-effective.

RECONSTITUTION QUICK REFERENCE

Standard Dilutions
Semax 40mg 4ml BAC water → 10mg/ml → 1mg dose = 0.1ml
Selank 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
GHK-Cu 2mg 1ml BAC water (or PBS) → 2mg/ml → 2mg = 1ml
GHK-Cu 50mg (bulk) 25ml BAC water → 2mg/ml → 2mg = 1ml
MT-1 10mg 1ml BAC water → 10mg/ml → 500mcg = 0.05ml
BPC-157 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
TB-500 5mg 1ml BAC water → 5mg/ml → 2mg = 0.4ml
Ipamorelin 5mg 1ml BAC water → 5mg/ml → 100mcg = 0.02ml
DSIP 5mg 1ml BAC water → 5mg/ml → 200mcg = 0.04ml
Epitalon 10mg 2ml BAC water → 5mg/ml → 5mg = 1ml
Thymosin Alpha-1 5mg 1ml BAC water → 5mg/ml → 1mg = 0.2ml
KPV 10mg 1ml BAC water → 10mg/ml → 1mg = 0.1ml (or oral)
PBS vs BAC Water Use PBS for copper peptides (GHK-Cu, AHK-Cu) — better copper stability. BAC water for all others.

VENDOR PRICE REFERENCE (Chinese Warehouse)
$60 flat worldwide shipping fee. All prices USD per kit of 10 vials (divide by 10 for single vial price). Prices as of April 2026.

Product Price (USD) per kit (10 vials)
Semax 5mg×10 $40
Semax 10mg×10 $50
Selank 5mg×10 $40
GHK-Cu 50mg×10 $30
GHK-Cu 100mg×10 $45
AHK-Cu 100mg×10 $68
MT-1 10mg×10 $45
MT-2 10mg×10 $45
BPC-157 5mg×10 $40
BPC-157 10mg×10 $70
TB-500 5mg×10 $75
TB-500 10mg×10 $140
BPC+TB 5mg+5mg×10 $95
GHK+BPC+TB 50/10/10mg×10 $160
GHK+BPC+TB+KPV 80mg×10 $195
KPV 10mg×10 $60
Ipamorelin 5mg×10 $45
Ipamorelin 10mg×10 $80
CJC-1295 no-DAC 5mg×10 $85
CJC+Ipa combo 10mg×10 $95
DSIP 5mg×10 $45
DSIP 15mg×10 $85
SS-31 10mg×10 $86
SS-31 50mg×10 $285
MOTS-C 10mg×10 $65
MOTS-C 40mg×10 $185
5-amino-1MQ 5mg×10 $45
5-amino-1MQ 50mg×10 $110
Thymosin Alpha-1 5mg×10 $80
TA-1 10mg×10 $145
Epitalon 10mg×10 $48
Epitalon 50mg×10 $150
Cerebrolysin 60mg×6 $29
Pinealon 5mg×10 $55
Pinealon 10mg×10 $70
Snap-8 10mg×10 $40
NAD+ 100mg×10 $40
NAD+ 500mg×10 $80
NAD+ 1000mg×10 $130
L-Carnitine 600mg/ml 10ml×10 $80
Glutathione 1500mg×10 $80
Melatonin 10mg×10 $55
VIP 5mg×10 $75
SLU-PP-322 5mg×10 $100
AICAR 50mg×10 $62
Tesamorelin 5mg×10 $110
ARA-290 10mg×10 $80
BAC Water 10ml×10 $10
PBS 10ml×10 $10
Acetic Acid Water 10ml×10 $10

PEPTIDES

Melanotan-1 subcutaneously, in the evening.

GHK-Cu 2 mg subcutaneously, in the evening.

Tirzepatide 2,5 mg subcutaneously, every week

@reyalsnoom @Jesus_ist_König @tqbiq @greylord @aaronbp

Amazing thread love it, im currently on mt1 and reta and occasionally selank, I wanna get ghk and dsip, is ghk actually good? And why don’t u just use topical

til<3D · Apr 22, 2026

thomasjiooo said:
Amazing thread love it, im currently on mt1 and reta and occasionally selank, I wanna get ghk and dsip, is ghk actually good? And why don’t u just use topical

The 2mg daily SC dose is used to activate fibroblasts for collagen and elastin synthesis throughout the tissue
And because I alread use Tret,
Pentoxifylline, Azelaic Acid and Niacinamide I dont see the Point of adding another thing just for my face

thomasjiooo · Apr 22, 2026

til<3D said:
Tret,
Pentoxifylline

Don’t have access to these unfortunately, I use salicylic acid and la Roche posay repair cream for my skin that’s it, I have zinc and niacinimide serum but I dont use it, i could buy ghk (injectable) or azelaic acid, what do u think

seigi · Apr 22, 2026

til<3D said:
Epithalon (Epitalon) 2

Ehy epithalon so low? Doesn't display immediate results?

til<3D · Apr 22, 2026

seigi said:
Ehy epithalon so low? Doesn't display immediate results?

Every Peptide was rated in case of a Young male adult

til<3D · Apr 22, 2026

thomasjiooo said:
Don’t have access to these unfortunately, I use salicylic acid and la Roche posay repair cream for my skin that’s it, I have zinc and niacinimide serum but I dont use it, i could buy ghk (injectable) or azelaic acid, what do u think

What’s your goal

thomasjiooo · Apr 22, 2026

til<3D said:
What’s your goal

shrinking the sebaceous filaments, shiny clear skin, tighter skin would be nice cuz I did aqualyx and when the swelling goes down I want it tight

til<3D · Apr 22, 2026

thomasjiooo said:
shrinking the sebaceous filaments, shiny clear skin, tighter skin would be nice cuz I did aqualyx and when the swelling goes down I want it tight

Then I would suggest Tret

thomasjiooo · Apr 22, 2026

til<3D said:
Then I would suggest Tret

Ireland tho I can’t find a good source, maybe I’ll look harder

What %

seigi · Apr 22, 2026

til<3D said:
Every Peptide was rated in case of a Young male adult

Yea. Epithalon and pinealon pretty good for circadian rhythm. If you wanna say the pineal function is at its peak at this age, so is the GHK-Cu, yet we supplement on top of that from a vial. Pt-141 - Not very outward appearance focused but it gives pretty insane boners, surpassing melanotan. You tried it? Or you just found on gpt it makes you sick? Cause it never does that for me

seigi · Apr 22, 2026

til<3D said:
Cognitive Peak

PE-22-28, DNSP-11, GLYX-13 great for that

thomasjiooo · Apr 22, 2026

til<3D said:
Then I would suggest Tret

I found a source but it also has tazarotene, I heard it’s actually better but harder to source, should I just buy both or?

lolo81 · May 3, 2026

til<3D said:
Complete Guide to Peptide Protocols — Dosing, Evidence & Stacking

by til<3D
Stand: April 2026

DISCLAIMER

Read First
This guide is for educational purposes only. Peptides are not approved drugs in most countries. Everything here is off label and experimental. Do your own research. You are responsible for your own choices. This is not medical advice.
Age Note
Several peptides are specifically marked as inappropriate for users under 18-20 years old due to ongoing hormonal and neural development. These warnings are clearly flagged throughout.
Sources
Evidence grades reflect actual human clinical trial data, animal studies, and in vitro research. Grade A = multiple human RCTs. Grade B = some human data. Grade C = animal/in vitro only.

PEPTIDES COVERED IN THIS THREAD

1. Semax — ACTH(4-7) Analogue — Nootropic

2. Selank — Tuftsin Analogue — Anxiolytic & Cognitive

3. GHK-Cu — Copper Peptide — Skin & Collagen

4. AHK-Cu — Copper Peptide — Hair Growth

5. Melanotan-1 (MT-1) — MC1R Agonist — Tanning

6. BPC-157 — Body Protection Compound — Healing

7. TB-500 — Thymosin Beta-4 — Recovery & Flexibility

8. DSIP — Delta Sleep-Inducing Peptide — Sleep Architecture

9. SS-31 (Elamipretide) — Mitochondria-Targeting Peptide — Energy & Cardioprotection

10. MOTS-C — Mitochondrial-Derived Peptide — Metabolic

11. 5-amino-1MQ — CD38 Inhibitor — NAD+ Preservation

12. Thymosin Alpha-1 — Immune Modulator — Immune Enhancement

13. KPV — Anti-Inflammatory Tripeptide — Gut & Skin

14. Cerebrolysin — Neuropeptide Mix — Cognitive & Neuroprotection

15. Snap-8 — Neuropeptide — Anti-Wrinkle Topical

16. Pinealon — Pineal Peptide — Neuroprotection & Circadian

17. Epithalon (Epitalon) — Tetrapeptide — Telomere (Age 40+ Only)

18. Ipamorelin — GHRP — GH Secretagogue (Age 20+ Optimal)

19. NAD+ — NAD+ Precursors — Mitochondrial (Age 35+ Only)

QUICK REFERENCE — ALL PEPTIDES

Peptide Effectiveness Evidence Age 17-18 Cost/mo Overall
Semax 8/10 B+ ✓ OK €20–35/vial (40mg) 8/10
Selank 8/10 B ✓ OK €25–40/vial (5mg) 7/10
GHK-Cu 7/10 B- ✓ OK €30/vial (50mg bulk) — much better value 7/10
AHK-Cu 6/10 C+ ✓ OK $68/100mg vial (vendor) 6/10
Melanotan-1 (MT-1) 9/10 A- ✓ OK $45/10mg vial × 10 8/10
BPC-157 7/10 C+ ✓ OK $40/5mg vial × 10 6/10
TB-500 7/10 C+ ✓ OK $75/5mg vial × 10 6/10
DSIP 6/10 C+ ✓ OK $45/5mg vial × 10 5/10
SS-31 (Elamipretide) 6/10 B- ✓ OK $86/10mg vial × 10 5/10
MOTS-C 6/10 C+ ✓ OK $65/10mg vial × 10 5/10
5-amino-1MQ 4/10 C ✓ OK $45/5mg vial or $110/50mg 3/10
Thymosin Alpha-1 7/10 B ✓ OK $80/5mg vial × 10 6/10
KPV 6/10 C+ ✓ OK $60/10mg vial × 10 6/10
Cerebrolysin 7/10 B- ✓ OK $29/60mg × 6 vials (vendor) 6/10
Snap-8 3/10 C+ ✓ OK $40/10mg vial × 10 (vendor) 4/10
Pinealon 4/10 C ✓ OK $55/5mg vial × 10 4/10
Epithalon (Epitalon) 2/10 C+ ✗ Caution $48/10mg × 10 (vendor) 2/10
Ipamorelin 6/10 C+ ✗ Caution $45/5mg vial × 10 5/10
NAD+ 2/10 B- ✗ Caution $40-130 depending on dose 2/10

INDIVIDUAL PEPTIDE PROFILES

SEMAX

Intro
Synthetic heptapeptide analogue of ACTH(4-7), developed in Russia for stroke and cognitive enhancement. Decades of clinical data. Crosses BBB efficiently intranasally. You could also do subq but in my opinion it's unnecessary.
Mechanism
Upregulates BDNF. Modulates dopaminergic/serotonergic transmission. Increases enkephalinase activity. NO signalling enhancement.
Benefits
Enhanced focus, memory, learning. Neuroprotection. Anti anxiety via serotonin. Rapid onset 15-30 min. No physical dependence.
Negatives
Receptor desensitization — cycling required. Mild anxiety at high doses. Most studies Russian literature.
Reconstitution
4ml BAC water on 40mg vial = 10mg/ml. 1mg = 0.1ml = 1 pump.
Dosage
0.5–1mg/day intranasal.
Timing
Morning, fasted or first meal.
Cycling
5 days ON / 2 OFF. Or 3 weeks ON / 1 week OFF.

Storage
Lyophilized 12+ months. Reconstituted 4°C, 4 weeks.
Cost (vendor)
$50/100mg vial (vendor).
Evidence Grade
B+ — Russian Phase II/III trials. Growing Western replication.
Synergies
Citicoline, Selank. Never combine with high dose Modafinil same day.
Warnings
Monitor with Modafinil stack. Avoid MAOIs.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
7/10
8/10
8/10

SELANK

Intro
Synthetic analogue of tuftsin. Official anxiolytic drug status in Russia/Ukraine. Anxiolysis without sedation, tolerance, or withdrawal.
Mechanism
Allosteric GABA-A modulation. Inhibits enkephalinase. Modulates BDNF/NGF. Complements Semax via distinct brain connectivity patterns.
Benefits
Anxiolysis without sedation or dependence. Cognitive enhancement. Anti inflammatory. No BtMG. Low desensitization risk at standard doses.
Negatives
Most evidence Russian studies. Additive CNS depression with other GABAergics — critical interaction. Short half-life ~2h intranasal.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
250–800mcg/day intranasal.
Timing
Morning or 30-60 min before stressful situations.
Cycling
14 days ON / 14 days OFF, or situational.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/100mg vial (vendor). Very cost effective per mg.
Evidence Grade
B — Russian Phase II clinical trials in GAD.
Synergies
Semax (complementary). NEVER with Etifoxine, Pregabalin, or alcohol same day.
Warnings
NEVER combine with Etifoxine, Pregabalin, or benzodiazepines same day. Additive CNS depression.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
6/10
8/10
7/10

GHK-CU

Intro
Naturally occurring copper-binding peptide. Plasma levels decline with age. Gold standard for skin regeneration and wound healing.
Mechanism
Activates fibroblasts → collagen I/III/elastin synthesis. VEGF-driven angiogenesis. Inhibits TGF-β1 (anti-fibrotic). Antioxidant enzyme upregulation.
Benefits
PIE/acne scar remodeling. Skin density improvement. Wound/post-surgery healing. Tendon collagen support. Anti-inflammatory.
Negatives
Systemic human RCT data limited. Competing with zinc pause zinc during use. Monitor copper levels with chronic use.
Reconstitution
1ml BAC water on 2mg vial = 2mg/ml. 27-29G needle, 4-6mm, 45°. PBS preferred for copper stability.
Dosage
2mg subcut EOD/ ED.
Timing
Evening after training. Separate site from MT-1.
Cycling
4-week cycles. Zinc paused. After cycle reintroduce zinc.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/1g vial (vendor). Very cost effective per mg.
Evidence Grade
B- — Strong in-vitro/animal. Limited human RCTs for subcut use. Topical human evidence solid.
Synergies
Tretinoin (complementary collagen). Copper supplement 30-60 min before injection.
Warnings
Pause zinc during cycle. Monitor serum copper/ceruloplasmin with extended use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
5/10
10/10
8/10

AHK-CU

Intro
Tripeptide analogue of GHK-Cu with higher affinity for hair follicle receptors. AHK (Ala-His-Lys) specifically promotes hair growth via follicle dermal papilla stimulation.
Mechanism
Activates Wnt/β-catenin pathway in hair follicles. Promotes dermal papilla cell proliferation. Upregulates VEGF in follicle microvasculature. Inhibits DHT-induced apoptosis in follicles.
Benefits
Hair density and thickness improvement. Potentially superior to GHK-Cu for scalp/follicle applications. Can be used topically or subcut. Anti-inflammatory in follicle microenvironment.
Negatives
Less research than GHK-Cu overall. Mostly in-vitro data. Higher cost per mg. Limited human studies specifically.
Reconstitution
1ml BAC water per 10mg = 10mg/ml. Can be used topically (DMSO carrier) or subcut.
Dosage
Topical: 0.01-0.1% solution on scalp. Subcut: 1-2mg/day.
Timing
Evening or post-shower for topical.
Cycling
Continuous or 8-week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$68/1g vial (vendor). Very cost effective per mg.
Evidence Grade
C+ — In-vitro strong. Limited human data. Mechanistically plausible.
Synergies
GHK-Cu (different receptor affinity — complementary). Minoxidil topical.
Warnings
Avoid mixing with acidic solutions. PBS preferred diluent.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
9,5/10
8/10

MELANOTAN-1 (MT-1)

Intro
Synthetic α-MSH analogue with MC1R selectivity. Only melanocortin peptide with EMA approval (Scenesse for EPP). Deep even tan with reduced UV exposure.
Mechanism
MC1R agonism → tyrosinase upregulation → eumelanin synthesis. UV activation required to convert precursors to visible pigment.
Benefits
Deep even tan. Photoprotection. Visually reduces PIE by contrast. EMA-approved safety data. Lower systemic effects vs MT-2.
Negatives
Nausea during loading (reduced by microdosing). Mole changes — document before starting. UV >3 required for activation. MC4R spillover at high doses.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 500mcg = 0.05ml.
Dosage
Loading: 500mcg/day × 14 days. Maintenance: 250-500mcg E2-3D + UV.
Timing
Evening — sleep through initial nausea.

Cycling
Loading → Maintenance. No continuous loading.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$4,5/10mg vial × 10. ~€2-3,5/month maintenance.
Evidence Grade
A- — EMA approved. Phase III trials. Extensive safety data.
Synergies
UV exposure (essential). Tretinoin. Solarium if UV index <3.
Warnings
Photograph all moles before starting. Never combine with MT-2.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
7/10
8/10
9/10
8,5/10

BPC-157

Intro
Synthetic pentadecapeptide from gastric juice. Remarkable healing in animal models across tendons, ligaments, muscles, GI tract. Most promising for injury recovery and post-surgical healing.
Mechanism
Upregulates GH receptor. VEGF angiogenesis. FAK-paxillin wound healing pathway. NF-κB inhibition. Collagen synthesis in tenocytes.
Benefits
Tendon/ligament healing acceleration. GI mucosal protection. Nerve regeneration (animal). Anti-inflammatory. Enhanced training recovery.
Negatives
Virtually ALL data is animal/in-vitro. Zero completed human RCTs. Unknown optimal human dosing. Unknown long-term safety.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
200-500mcg/day subcut or IM. Split morning + evening.
Timing
Morning and/or post-training.
Cycling
4-8 weeks on, 4 off. Or acute injury protocol.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$40 per kit (10×5mg vials). ~€3.5/vial. €40-70/month.
Evidence Grade
C+ — Extensive animal data, consistent results. Zero human RCTs. High translation uncertainty.
Synergies
TB-500 (complementary). GHK-Cu (collagen synergy).
Warnings
Theoretical angiogenesis concern with cancer history (unproven in humans). No known drug interactions.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
8/10
4/10
7/10
6/10

TB-500

Intro
Synthetic fragment of thymosin beta-4. Critical role in cell migration, wound healing, tissue regeneration. Systemic healing reach that BPC-157 lacks.
Mechanism
Binds G-actin → cell migration/differentiation. Integrin-linked kinase activation. Metalloproteinase upregulation for tissue remodeling. Vascular tube formation.
Benefits
Systemic healing (reaches distant injury sites). Muscle fiber regeneration. Flexibility/ROM improvements. Potential cardiac protection.
Negatives
Human RCT data absent for recovery use. Higher MW limits oral bioavailability. More expensive than BPC-157. Overlap with BPC-157.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
Loading: 2-2.5mg 2×/week × 4-6 weeks. Maintenance: 2-2.5mg 1×/week.
Timing
Morning or post-training.
Cycling
6-week loading, then maintenance or off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$75 per kit (10×5mg vials). ~€7/vial. €50-90/month.
Evidence Grade
C+ — Animal data solid. Phase II trial in dry eye disease. Limited systemic recovery data in humans.
Synergies
BPC-157 (most common stack). Post-surgery recovery protocol.
Warnings
Same theoretical angiogenesis concern as BPC-157 with cancer history.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
4/10
6/10
6/10

DSIP

Intro
DSIP is a neuropeptide that modulates sleep architecture by promoting delta-wave (slow-wave) sleep. It was isolated from rabbit thalamic venous blood in 1977. Unlike benzodiazepines, it doesn't cause sedation — it shifts the sleep profile toward restorative deep sleep.
Mechanism
Modulates GABA-B receptors. Reduces nocturnal cortisol. Increases GH secretion during sleep. Normalizes circadian rhythm via hypothalamic-pituitary axis modulation. Antioxidant effects.
Benefits
Improved deep sleep quality (not just duration). GH pulse enhancement during sleep. Reduced cortisol during sleep. Potential nootropic effects via improved sleep. Non-sedating — no morning grogginess.
Negatives
Short plasma half-life (~30 min) — may require specific timing. Most data from 1980s-90s Russian studies. Limited modern replication. Expensive per mg.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100-300mcg = 0.02-0.06ml.
Dosage
100-300mcg subcut 30-60 min before sleep.
Timing
30-60 minutes before bedtime.
Cycling
5-7 day cycles. Short-term use most studied.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €30-60/month.
Evidence Grade
C+ — Russian human trials 1980s. Mechanism plausible. Limited modern replication.
Synergies
Melatonin (circadian complementary). Ipamorelin (synergistic GH pulse during sleep).
Warnings
No known serious interactions. Avoid combining with benzodiazepines (additive sleep effects).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

SS-31 (ELAMIPRETIDE)

Intro
SS-31 (Szeto-Schiller peptide 31) is a tetrapeptide that concentrates in the inner mitochondrial membrane, stabilizing cardiolipin. It is arguably the most promising mitochondria-targeting molecule currently studied, with active Phase II/III trials for Barth syndrome, heart failure, and age-related muscle loss.
Mechanism
Binds cardiolipin in inner mitochondrial membrane → stabilizes electron transport chain structure. Reduces mitochondrial ROS production. Maintains cristae morphology. Improves ATP synthesis efficiency.
Benefits
Mitochondrial function restoration. Reduced oxidative stress. Improved energy efficiency (not stimulant-based). Potential muscle function improvement. Active pharmaceutical development — human safety data exists.
Negatives
Expensive per mg. Mostly disease-state human trials — healthy young male data absent. Injectable only (high MW). Long-term use unknown.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
1-5mg/day subcut. Clinical trials used 0.05-0.25 mg/kg IV.
Timing
Morning.
Cycling
4-12 week cycles. Research ongoing.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$86 per kit (10×10mg vials). ~€8/vial. Expensive but unique mechanism.
Evidence Grade
B- — Phase II human trials in disease states. Mechanism very well characterized. Healthy young use extrapolated.
Synergies
NAD+ precursors (complementary mitochondrial support). MOTS-C.
Warnings
No known serious interactions. Not indicated in healthy young without mitochondrial disease.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
6/10
5/10
5/10
5/10

MOTS-C

Intro
MOTS-C is a peptide encoded in the mitochondrial genome — one of the first mitochondria-derived peptides discovered. It acts as a metabolic regulator, improving insulin sensitivity and exercise capacity. Endogenous levels decline with age and are increased by exercise.
Mechanism
Activates AMPK. Inhibits AICAR (purine synthesis) → folate cycle disruption → metabolic reprogramming. Improves glucose uptake independent of insulin. Regulates ROS homeostasis in mitochondria.
Benefits
Improved insulin sensitivity. Enhanced exercise capacity and metabolic efficiency. Anti-obesity effects. Potential longevity effects. Exercise-mimicking properties.
Negatives
Most data animal studies. Human trial data limited to one small RCT. Age-related benefit unclear in young healthy subjects (endogenous levels already high at 18). Expensive.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 2-5mg per injection.
Dosage
5-10mg subcut 2-3×/week.
Timing
Morning or pre-workout.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$65 per kit (10×10mg vials). ~€6/vial. Moderate.
Evidence Grade
C+ — Strong animal data. One small human RCT (n=40). Mechanism well-established.
Synergies
SS-31 (mitochondrial stack). Exercise potentiation.
Warnings
No known serious interactions. Limited human safety data.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

5-AMINO-1MQ

Intro
5-amino-1-methylquinolinium (5-amino-1MQ) is a small molecule that inhibits CD38, the primary NAD+-degrading enzyme in the body. Unlike taking NAD+ precursors (NMN/NR), which add more NAD+ substrate, 5-amino-1MQ prevents NAD+ from being broken down — potentially more efficient.
Mechanism
Inhibits CD38 (NAD+ glycohydrolase) → NAD+ levels rise. CD38 activity increases dramatically with age and inflammation. Preserves endogenous NAD+ pool without external supplementation.
Benefits
NAD+ preservation. Potential fat loss effects (adipocyte CD38 inhibition). Anti-inflammatory. More targeted mechanism than NMN/NR for NAD+ elevation.
Negatives
Very limited human data. Research peptide status. Long-term safety unknown. Age-appropriateness at 18 unestablished (same issue as NAD+ precursors — you don't need this yet).
Reconstitution
Oral or injectable. 5mg vial with 1ml BAC water = 5mg/ml.
Dosage
5-50mg oral or 1-5mg subcut.
Timing
Morning.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months.
Cost (vendor)
$45 per kit (10×5mg) or $110 per kit (10×50mg). ~€4-10/vial.
Evidence Grade
C — Animal data only. No human RCTs. Mechanism well-established biochemically.
Synergies
SS-31, MOTS-C (mitochondrial stack). More relevant at 35+ years.
Warnings
Not recommended under 35. No established benefit in young healthy subjects.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
7/10
3/10

THYMOSIN ALPHA-1

Intro
Thymosin Alpha-1 (Tα1) is an endogenous peptide originally isolated from thymic tissue. It is FDA-approved in 35+ countries for chronic hepatitis B and C, and used as an immune adjuvant in cancer treatment. Strong immunomodulatory and antiviral properties.
Mechanism
Enhances T-cell, NK cell, and dendritic cell function. Upregulates IL-2, IFN-γ. Activates Toll-like receptors. Promotes antigen presentation. Anti-inflammatory via IL-10 pathway.
Benefits
Immune system enhancement and normalization. Antiviral effects. Used clinically for immunocompromised patients. Strong safety data from approved medical use. Potential benefit post-illness or during intense training phases.
Negatives
Healthy young with normal immune function may see minimal benefit. Expensive. Primary benefit for immunocompromised or sick individuals. Mild injection site reactions.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
1-2mg subcut 2×/week. Clinical dose: 1mg/m² body surface area.
Timing
Any time — immune timing less critical.
Cycling
2-6 week cycles. Or as needed during illness.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$80 per kit (10×5mg vials). ~€7/vial. Moderate.
Evidence Grade
B — Approved in multiple countries for specific indications. Good human safety data. Healthy young use extrapolated.
Synergies
BPC-157 (immune + healing stack during recovery). Useful post-surgery.
Warnings
No significant drug interactions at standard doses. Avoid in autoimmune conditions without medical supervision.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
6/10
6/10
6/10

KPV

Intro
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of α-MSH. It retains the anti-inflammatory properties of the parent molecule without melanocortin receptor agonism. Being 3 amino acids, it has superior bioavailability and can even be taken orally for GI effects.
Mechanism
Inhibits NF-κB signalling. Reduces TNF-α, IL-1β, IL-6 production. Activates MC1R and MC3R locally (anti-inflammatory, not pigmentation). Promotes intestinal epithelial healing.
Benefits
Potent anti-inflammatory for gut, skin, and systemic use. Oral bioavailability for GI-specific effects. No melanocortin pigmentation effects. Excellent safety profile. Can be combined with BPC-157 for enhanced GI healing.
Negatives
Limited human clinical trial data. Research peptide status. Very short half-life requires frequent dosing or oral route.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. Can be taken orally (encapsulate or dissolve in water).
Dosage
500mcg–2mg subcut or 1-5mg oral per day.
Timing
Any time. Oral pre-meals for GI effects.
Cycling
Continuous low-dose or acute 4-week protocols.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$60 per kit (10×10mg vials). ~€5.5/vial. Reasonable.
Evidence Grade
C+ — Strong in-vitro/animal. Human data emerging. Mechanism very well characterized.
Synergies
BPC-157 (GI healing stack). Part of BBG or KLOW80 recovery mix.
Warnings
No known serious interactions. Excellent tolerability profile.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
8/10
4/10
7/10
6/10

CEREBROLYSIN

Intro
Cerebrolysin is a complex mixture of low-molecular-weight peptides derived from porcine brain tissue. It contains BDNF, NGF, CNTF, and other neurotrophins. Used clinically in Eastern Europe and Asia for stroke, traumatic brain injury, and Alzheimer's disease.
Mechanism
Provides exogenous BDNF, NGF, and other neurotrophins directly. Promotes neurogenesis and synaptic plasticity. Neuroprotective against excitotoxicity. Anti-apoptotic in neurons.
Benefits
Direct neurotrophin supplementation (vs Semax which stimulates endogenous production). Established clinical use in stroke recovery. May enhance cognitive recovery after stress or illness. Fast-acting neuroplasticity support.
Negatives
Derived from porcine brain — quality control important. Injectable only (IV preferred clinically, IM used in biohacking). Religious/dietary restrictions for some. Most trials in neurological disease, not healthy subjects. Quality varies by vendor significantly.
Reconstitution
Ready solution typically. Check vendor — should be aqueous solution, not lyophilized.
Dosage
1-5ml IM/subcut. Clinical: 10-30ml IV/day. For cognitive use: 1-2ml IM daily.
Timing
Morning.
Cycling
10-30 day cycles. 2-3× per year.
Storage
Refrigerate 2-8°C. Do not freeze.
Cost (vendor)
$29 per kit (6×60mg vials). ~€4.5/vial. Budget-friendly.
Evidence Grade
B- — Multiple RCTs in stroke/TBI (positive). Healthy cognitive enhancement — limited data.
Synergies
Semax (BDNF endogenous + exogenous). Citicoline.
Warnings
Ensure vendor quality — biological product contamination risk. Do not use if porcine-derived products contraindicated.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
6/10
5/10
8/10
6/10

SNAP-8

Intro
Snap-8 (Acetyl Octapeptide-3) is a synthetic octapeptide that mimics the N-terminal portion of SNAP-25. It competes with the SNARE complex, reducing neurotransmitter release at neuromuscular junctions in facial skin. Often called 'topical Botox' in cosmetic science.
Mechanism
Inhibits SNARE complex formation → reduced acetylcholine release at local neuromuscular junctions → reduced muscle contraction intensity in expression lines → smoother appearance over time.
Benefits
Reduces expression-related fine lines without injection. Can be added to moisturizer or serum. No systemic effects. Safe topical profile.
Negatives
Penetration through skin is very limited for large peptides. Most human evidence industry-funded. Effects subtle vs Botox. Not relevant at 18 — no expression lines yet.
Reconstitution
Typically used as topical — dissolve in DMSO or serum base for penetration.
Dosage
2-10% topical solution, apply 2× daily.
Timing
Morning and evening skincare routine.
Cycling
Continuous — topical peptides require sustained use.
Storage
Lyophilized 12+ months. Solution 1 month refrigerated.
Cost (vendor)
$40 per kit (10×10mg vials). ~€3.5/vial. Very affordable.
Evidence Grade
C+ — One industry-funded human trial showing 52% wrinkle reduction. No independent replication.
Synergies
Tretinoin (different mechanism). GHK-Cu (complementary skin matrix support).
Warnings
Not meaningful at 18 years. Consider at 30+ when expression lines begin. Skin penetration limitations mean topical DMSO carrier needed.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
3/10
9/10
3/10
9/10
4/10

PINEALON

Intro
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by the same Russian group as Epitalon (Khavinson). It is derived from the pineal gland and claimed to regulate circadian rhythms, protect neurons, and enhance cognitive function. More targeted neurological action than Epitalon.
Mechanism
Claimed: regulates melatonin secretion rhythm. Neuroprotective against oxidative stress. Potentially modulates DNA methylation patterns in neurons. Anti-apoptotic in neuronal cell lines.
Benefits
Potential sleep quality improvement. Neuroprotective effects in animal models. Claimed cognitive enhancement. Better age-appropriateness than Epitalon (circadian regulation relevant at any age).
Negatives
All evidence from single Russian research group (Khavinson) — significant conflict of interest. No independent replication. Human data limited to elderly. Mechanism insufficiently characterized.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
5-10mg course over 10 days.
Timing
Evening for circadian effects.
Cycling
10-day courses 2-3× per year.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$55 per kit (10×5mg vials). ~€5/vial. Moderate.
Evidence Grade
C — Single research group. Elderly-only human data. No independent replication.
Synergies
Melatonin (circadian stack). DSIP.
Warnings
Same single-source evidence issue as Epitalon. Verify independently before use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
6/10
4/10

EPITHALON (EPITALON)

Intro
Synthetic tetrapeptide from the pineal gland. Claimed telomerase activator. All positive human evidence in elderly (60+) cohorts. Mismarketed to younger users — fundamentally age-inappropriate under 35.
Mechanism
Activates telomerase (hTERT) in somatic cells. Regulates melatonin secretion. Antioxidant. Regulates hypothalamic-pituitary axis.
Benefits
Telomere elongation in elderly subjects. Normalizes melatonin in aged individuals. Sleep improvement. Antioxidant effects.
Negatives
NOT APPROPRIATE UNDER 35-40 YEARS. Your telomeres are already near peak length at 18. Long telomeres correlated with MORE tumors (Johns Hopkins research). All-cause mortality data shows abnormally long telomeres are harmful. Single research group with patent conflict of interest.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
5-10mg/day × 10-20 days (elderly protocol).
Timing
Evening.
Cycling
2× per year for elderly users.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$48 per kit (10×10mg vials). ~€4.4/vial. Affordable but irrelevant at <35.
Evidence Grade
C+ — Single research group. Human data in elderly only. No independent replication.
Synergies
Melatonin, Pinealon. NOT for young users.
Warnings
DO NOT USE UNDER 35. No benefit. Theoretical cancer risk from telomere overextension at young age.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
7/10
3/10
7/10
2/10

IPAMORELIN

Intro
Selective GHRH receptor agonist. Cleanest GHRP — no cortisol/prolactin elevation. Best used with CJC-1295 no-DAC for synergistic GH pulse. At 18, natural GH is already at peak — use with caution.
Mechanism
GHSR-1a (ghrelin receptor) agonist → pulsatile GH release from pituitary. Highly selective. No ACTH, cortisol, or prolactin stimulation at standard doses.
Benefits
Clean GH stimulation. Improved deep sleep. Recovery enhancement. Lean mass support. Better tolerated than GHRP-2/6.
Negatives
At 17-18, endogenous GH already at lifetime peak. Marginal additional benefit. Potential GH receptor downregulation. Water retention possible. Not FDA approved.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100mcg = 0.02ml.
Dosage
100-300mcg per injection. 1-3×/day. Most useful pre-bed.
Timing
Pre-bed (maximize natural GH pulse). Can stack with CJC-1295 no-DAC.
Cycling
12-week cycles, 4-6 weeks off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €40-80/month.
Evidence Grade
C+ — Phase II human trials in GH deficiency. Mechanism well-established. Off-label recovery use anecdotal.
Synergies
CJC-1295 no-DAC (synergistic GH pulse). DSIP (sleep enhancement stack).
Warnings
Marginal benefit at 17-18. Wait until 21+ for optimal use case. Never fasted training + ipamorelin (hypoglycemia risk).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
5/10
7/10
5/10

NAD+

Intro
NAD+ precursors (NMN/NR) raise intracellular NAD+ levels. NAD+ declines with age, primarily after 40. Every positive human RCT enrolled middle-aged or elderly subjects. Not indicated at 18.
Mechanism
NAD+ precursors → raise NAD+ pool → sirtuin activation → mitochondrial efficiency. Requires CD38 to be low for optimal effect.
Benefits
Mitochondrial function in elderly. DNA repair enhancement. Sirtuin activation. Muscle function support in aged subjects.
Negatives
NOT RECOMMENDED UNDER 35. NAD+ peaks between 15-30. 2025 meta-analysis: no significant benefit for muscle function in young subjects. Your niacinamide 10% topical already supports local NAD+. Waste of money at your age.
Reconstitution
Oral capsules. Injectable NAD+ also available (listed vendor).
Dosage
250-500mg NMN or NR oral. Or 100-500mg IV/IM injectable.
Timing
Morning.
Reconstitution
No established cycle for oral. Injectable courses sometimes 10 days.
Storage
Keep dry. Heat sensitive.
Cost (vendor)
$40 per kit (10×100mg) to $130 per kit (10×1000mg). Pointless at 18.
Evidence Grade
B- (in elderly), C (in young). All positive RCTs in 40+ populations.
Synergies
5-amino-1MQ (CD38 inhibitor — more relevant mechanism). SS-31. All age 35+.
Warnings
NOT RECOMMENDED UNDER 35. No demonstrated benefit. Use money elsewhere.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
9/10
3/10
5/10
2/10

PEPTIDES NOT RECOMMENDED FOR THIS CONTEXT

Do Not Use — Reasons Explained

Semaglutide / Tirzepatide / Retatrutide / Cagrilintide
If you can't get your body fat down to 10% at least once in your life, what can you actually do?
I use Tirzepatide myself
IGF-1 LR3 (Used it myself)
Highly anabolic IGF-1 analogue. Promotes growth in ALL tissues including potential tumor cells. Open growth plates at 17-18 make this particularly concerning. Hypoglycemia risk. Not appropriate under 21+.
Dermorphin
Opioid peptide — 50x more potent than morphine. Extremely high addiction potential. Not appropriate for any looksmaxxing or performance context. High risk of dependence, respiratory depression, death in overdose.
Adipotide
Experimental peptide targeting ANXA2/PROHIBITIN on fat cell vasculature. Causes kidney toxicity in primate studies. Never cleared for human use. Avoid entirely.
Oxytocin
Half-life 3-5 minutes IV. Intranasal slightly longer. No meaningful persistent anxiolytic effect for social situations. Better alternatives available (Etifoxine, Selank, Pregab).
PT-141 (Bremelanotide)
MC3R/MC4R agonist for sexual dysfunction. More systemic side effects than MT-1. Nausea, blood pressure effects. Not a looksmaxxing compound.

STACKING GUIDE

Recommended Stacks by Goal

Cognitive Peak
Semax (1mg/day IN) + Citicoline (250mg/day oral) + Selank (500mcg situational). Semax → focus/BDNF, Citicoline → ACh, Selank → anxiety control.
Skin & PIE
GHK-Cu (2mg subcut EOD) + Tretinoin (topical) + Azelaic Acid 20% (topical) + Niacinamide 10% (topical). Best-evidenced combination.
Post-Surgery
BPC-157 (500mcg/day) + TB-500 (2mg 2×/week) + GHK-Cu (500mcg/day) + KPV (1mg/day). 8-week protocol.
Healing & Recovery
BPC-157 + TB-500 combo vial (BBG or KLOW80 mix). Most cost-effective option. KLOW80 adds KPV for anti-inflammatory.
Sleep Quality
DSIP (200mcg subcut pre-bed) + Ipamorelin (100mcg pre-bed). Synergistic GH pulse + deep sleep architecture.
Mitochondrial Stack
SS-31 (2mg/day) + MOTS-C (5mg 3×/week). Age 30+ optimal. Limited benefit at 18.
Immune Support
Thymosin Alpha-1 (1mg 2×/week) for 4-6 weeks during illness, intense training periods, or post-surgery.
Anxiolysis (Daily)
Selank (400-600mcg/day, cycled 14/14). No dependence, no sedation. Best daily option.
Anxiolysis (Events)
Etifoxine 50mg → Pregabalin 75-150mg (reserve for important only). Never two GABAergics same day.

CRITICAL INTERACTIONS
READ BEFORE STACKING

ABSOLUTE
NEVER: Selank + Etifoxine + Pregabalin same day. Three GABAergics = CNS depression risk.
ABSOLUTE
NEVER: MT-1 + MT-2 simultaneously. Receptor overlap, unpredictable systemic effects.
AVOID
Ipamorelin/CJC-1295 on fasted training days — hypoglycemia risk.
AVOID
Semax + Modafinil daily — both dopaminergic. Limit to exam days only.
SEPARATE
GHK-Cu and Zinc: pause zinc during GHK-Cu cycle. Competition for transporters.
SEPARATE
MT-1 and GHK-Cu injections: different anatomical sites same evening.
NOTE
BPC-157 / TB-500 / GHK-Cu vendor combo mixes (BBG, KLOW80) can be drawn from same vial — convenient and cost-effective.

RECONSTITUTION QUICK REFERENCE

Standard Dilutions
Semax 40mg 4ml BAC water → 10mg/ml → 1mg dose = 0.1ml
Selank 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
GHK-Cu 2mg 1ml BAC water (or PBS) → 2mg/ml → 2mg = 1ml
GHK-Cu 50mg (bulk) 25ml BAC water → 2mg/ml → 2mg = 1ml
MT-1 10mg 1ml BAC water → 10mg/ml → 500mcg = 0.05ml
BPC-157 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
TB-500 5mg 1ml BAC water → 5mg/ml → 2mg = 0.4ml
Ipamorelin 5mg 1ml BAC water → 5mg/ml → 100mcg = 0.02ml
DSIP 5mg 1ml BAC water → 5mg/ml → 200mcg = 0.04ml
Epitalon 10mg 2ml BAC water → 5mg/ml → 5mg = 1ml
Thymosin Alpha-1 5mg 1ml BAC water → 5mg/ml → 1mg = 0.2ml
KPV 10mg 1ml BAC water → 10mg/ml → 1mg = 0.1ml (or oral)
PBS vs BAC Water Use PBS for copper peptides (GHK-Cu, AHK-Cu) — better copper stability. BAC water for all others.

VENDOR PRICE REFERENCE (Chinese Warehouse)
$60 flat worldwide shipping fee. All prices USD per kit of 10 vials (divide by 10 for single vial price). Prices as of April 2026.

Product Price (USD) per kit (10 vials)
Semax 5mg×10 $40
Semax 10mg×10 $50
Selank 5mg×10 $40
GHK-Cu 50mg×10 $30
GHK-Cu 100mg×10 $45
AHK-Cu 100mg×10 $68
MT-1 10mg×10 $45
MT-2 10mg×10 $45
BPC-157 5mg×10 $40
BPC-157 10mg×10 $70
TB-500 5mg×10 $75
TB-500 10mg×10 $140
BPC+TB 5mg+5mg×10 $95
GHK+BPC+TB 50/10/10mg×10 $160
GHK+BPC+TB+KPV 80mg×10 $195
KPV 10mg×10 $60
Ipamorelin 5mg×10 $45
Ipamorelin 10mg×10 $80
CJC-1295 no-DAC 5mg×10 $85
CJC+Ipa combo 10mg×10 $95
DSIP 5mg×10 $45
DSIP 15mg×10 $85
SS-31 10mg×10 $86
SS-31 50mg×10 $285
MOTS-C 10mg×10 $65
MOTS-C 40mg×10 $185
5-amino-1MQ 5mg×10 $45
5-amino-1MQ 50mg×10 $110
Thymosin Alpha-1 5mg×10 $80
TA-1 10mg×10 $145
Epitalon 10mg×10 $48
Epitalon 50mg×10 $150
Cerebrolysin 60mg×6 $29
Pinealon 5mg×10 $55
Pinealon 10mg×10 $70
Snap-8 10mg×10 $40
NAD+ 100mg×10 $40
NAD+ 500mg×10 $80
NAD+ 1000mg×10 $130
L-Carnitine 600mg/ml 10ml×10 $80
Glutathione 1500mg×10 $80
Melatonin 10mg×10 $55
VIP 5mg×10 $75
SLU-PP-322 5mg×10 $100
AICAR 50mg×10 $62
Tesamorelin 5mg×10 $110
ARA-290 10mg×10 $80
BAC Water 10ml×10 $10
PBS 10ml×10 $10
Acetic Acid Water 10ml×10 $10

PEPTIDES

Melanotan-1 subcutaneously, in the evening.

GHK-Cu 2 mg subcutaneously, in the evening.

Tirzepatide 2,5 mg subcutaneously, every week

@reyalsnoom @Jesus_ist_König @tqbiq @greylord @aaronbp

Quel est ton fournisseur?

til<3D · May 4, 2026

lolo81 said:
Quel est ton fournisseur?

Nigger speak english

LongForgotten · May 24, 2026

I ordered my Reta from deltirion.eu and have had nothing but good results so far

daranaughton · May 26, 2026

til<3D said:
Complete Guide to Peptide Protocols — Dosing, Evidence & Stacking

by til<3D
Stand: April 2026

DISCLAIMER

Read First
This guide is for educational purposes only. Peptides are not approved drugs in most countries. Everything here is off label and experimental. Do your own research. You are responsible for your own choices. This is not medical advice.
Age Note
Several peptides are specifically marked as inappropriate for users under 18-20 years old due to ongoing hormonal and neural development. These warnings are clearly flagged throughout.
Sources
Evidence grades reflect actual human clinical trial data, animal studies, and in vitro research. Grade A = multiple human RCTs. Grade B = some human data. Grade C = animal/in vitro only.

PEPTIDES COVERED IN THIS THREAD

1. Semax — ACTH(4-7) Analogue — Nootropic

2. Selank — Tuftsin Analogue — Anxiolytic & Cognitive

3. GHK-Cu — Copper Peptide — Skin & Collagen

4. AHK-Cu — Copper Peptide — Hair Growth

5. Melanotan-1 (MT-1) — MC1R Agonist — Tanning

6. BPC-157 — Body Protection Compound — Healing

7. TB-500 — Thymosin Beta-4 — Recovery & Flexibility

8. DSIP — Delta Sleep-Inducing Peptide — Sleep Architecture

9. SS-31 (Elamipretide) — Mitochondria-Targeting Peptide — Energy & Cardioprotection

10. MOTS-C — Mitochondrial-Derived Peptide — Metabolic

11. 5-amino-1MQ — CD38 Inhibitor — NAD+ Preservation

12. Thymosin Alpha-1 — Immune Modulator — Immune Enhancement

13. KPV — Anti-Inflammatory Tripeptide — Gut & Skin

14. Cerebrolysin — Neuropeptide Mix — Cognitive & Neuroprotection

15. Snap-8 — Neuropeptide — Anti-Wrinkle Topical

16. Pinealon — Pineal Peptide — Neuroprotection & Circadian

17. Epithalon (Epitalon) — Tetrapeptide — Telomere (Age 40+ Only)

18. Ipamorelin — GHRP — GH Secretagogue (Age 20+ Optimal)

19. NAD+ — NAD+ Precursors — Mitochondrial (Age 35+ Only)

QUICK REFERENCE — ALL PEPTIDES

Peptide Effectiveness Evidence Age 17-18 Cost/mo Overall
Semax 8/10 B+ ✓ OK €20–35/vial (40mg) 8/10
Selank 8/10 B ✓ OK €25–40/vial (5mg) 7/10
GHK-Cu 7/10 B- ✓ OK €30/vial (50mg bulk) — much better value 7/10
AHK-Cu 6/10 C+ ✓ OK $68/100mg vial (vendor) 6/10
Melanotan-1 (MT-1) 9/10 A- ✓ OK $45/10mg vial × 10 8/10
BPC-157 7/10 C+ ✓ OK $40/5mg vial × 10 6/10
TB-500 7/10 C+ ✓ OK $75/5mg vial × 10 6/10
DSIP 6/10 C+ ✓ OK $45/5mg vial × 10 5/10
SS-31 (Elamipretide) 6/10 B- ✓ OK $86/10mg vial × 10 5/10
MOTS-C 6/10 C+ ✓ OK $65/10mg vial × 10 5/10
5-amino-1MQ 4/10 C ✓ OK $45/5mg vial or $110/50mg 3/10
Thymosin Alpha-1 7/10 B ✓ OK $80/5mg vial × 10 6/10
KPV 6/10 C+ ✓ OK $60/10mg vial × 10 6/10
Cerebrolysin 7/10 B- ✓ OK $29/60mg × 6 vials (vendor) 6/10
Snap-8 3/10 C+ ✓ OK $40/10mg vial × 10 (vendor) 4/10
Pinealon 4/10 C ✓ OK $55/5mg vial × 10 4/10
Epithalon (Epitalon) 2/10 C+ ✗ Caution $48/10mg × 10 (vendor) 2/10
Ipamorelin 6/10 C+ ✗ Caution $45/5mg vial × 10 5/10
NAD+ 2/10 B- ✗ Caution $40-130 depending on dose 2/10

INDIVIDUAL PEPTIDE PROFILES

SEMAX

Intro
Synthetic heptapeptide analogue of ACTH(4-7), developed in Russia for stroke and cognitive enhancement. Decades of clinical data. Crosses BBB efficiently intranasally. You could also do subq but in my opinion it's unnecessary.
Mechanism
Upregulates BDNF. Modulates dopaminergic/serotonergic transmission. Increases enkephalinase activity. NO signalling enhancement.
Benefits
Enhanced focus, memory, learning. Neuroprotection. Anti anxiety via serotonin. Rapid onset 15-30 min. No physical dependence.
Negatives
Receptor desensitization — cycling required. Mild anxiety at high doses. Most studies Russian literature.
Reconstitution
4ml BAC water on 40mg vial = 10mg/ml. 1mg = 0.1ml = 1 pump.
Dosage
0.5–1mg/day intranasal.
Timing
Morning, fasted or first meal.
Cycling
5 days ON / 2 OFF. Or 3 weeks ON / 1 week OFF.

Storage
Lyophilized 12+ months. Reconstituted 4°C, 4 weeks.
Cost (vendor)
$50/100mg vial (vendor).
Evidence Grade
B+ — Russian Phase II/III trials. Growing Western replication.
Synergies
Citicoline, Selank. Never combine with high dose Modafinil same day.
Warnings
Monitor with Modafinil stack. Avoid MAOIs.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
7/10
8/10
8/10

SELANK

Intro
Synthetic analogue of tuftsin. Official anxiolytic drug status in Russia/Ukraine. Anxiolysis without sedation, tolerance, or withdrawal.
Mechanism
Allosteric GABA-A modulation. Inhibits enkephalinase. Modulates BDNF/NGF. Complements Semax via distinct brain connectivity patterns.
Benefits
Anxiolysis without sedation or dependence. Cognitive enhancement. Anti inflammatory. No BtMG. Low desensitization risk at standard doses.
Negatives
Most evidence Russian studies. Additive CNS depression with other GABAergics — critical interaction. Short half-life ~2h intranasal.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
250–800mcg/day intranasal.
Timing
Morning or 30-60 min before stressful situations.
Cycling
14 days ON / 14 days OFF, or situational.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/100mg vial (vendor). Very cost effective per mg.
Evidence Grade
B — Russian Phase II clinical trials in GAD.
Synergies
Semax (complementary). NEVER with Etifoxine, Pregabalin, or alcohol same day.
Warnings
NEVER combine with Etifoxine, Pregabalin, or benzodiazepines same day. Additive CNS depression.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
6/10
8/10
7/10

GHK-CU

Intro
Naturally occurring copper-binding peptide. Plasma levels decline with age. Gold standard for skin regeneration and wound healing.
Mechanism
Activates fibroblasts → collagen I/III/elastin synthesis. VEGF-driven angiogenesis. Inhibits TGF-β1 (anti-fibrotic). Antioxidant enzyme upregulation.
Benefits
PIE/acne scar remodeling. Skin density improvement. Wound/post-surgery healing. Tendon collagen support. Anti-inflammatory.
Negatives
Systemic human RCT data limited. Competing with zinc pause zinc during use. Monitor copper levels with chronic use.
Reconstitution
1ml BAC water on 2mg vial = 2mg/ml. 27-29G needle, 4-6mm, 45°. PBS preferred for copper stability.
Dosage
2mg subcut EOD/ ED.
Timing
Evening after training. Separate site from MT-1.
Cycling
4-week cycles. Zinc paused. After cycle reintroduce zinc.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/1g vial (vendor). Very cost effective per mg.
Evidence Grade
B- — Strong in-vitro/animal. Limited human RCTs for subcut use. Topical human evidence solid.
Synergies
Tretinoin (complementary collagen). Copper supplement 30-60 min before injection.
Warnings
Pause zinc during cycle. Monitor serum copper/ceruloplasmin with extended use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
5/10
10/10
8/10

AHK-CU

Intro
Tripeptide analogue of GHK-Cu with higher affinity for hair follicle receptors. AHK (Ala-His-Lys) specifically promotes hair growth via follicle dermal papilla stimulation.
Mechanism
Activates Wnt/β-catenin pathway in hair follicles. Promotes dermal papilla cell proliferation. Upregulates VEGF in follicle microvasculature. Inhibits DHT-induced apoptosis in follicles.
Benefits
Hair density and thickness improvement. Potentially superior to GHK-Cu for scalp/follicle applications. Can be used topically or subcut. Anti-inflammatory in follicle microenvironment.
Negatives
Less research than GHK-Cu overall. Mostly in-vitro data. Higher cost per mg. Limited human studies specifically.
Reconstitution
1ml BAC water per 10mg = 10mg/ml. Can be used topically (DMSO carrier) or subcut.
Dosage
Topical: 0.01-0.1% solution on scalp. Subcut: 1-2mg/day.
Timing
Evening or post-shower for topical.
Cycling
Continuous or 8-week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$68/1g vial (vendor). Very cost effective per mg.
Evidence Grade
C+ — In-vitro strong. Limited human data. Mechanistically plausible.
Synergies
GHK-Cu (different receptor affinity — complementary). Minoxidil topical.
Warnings
Avoid mixing with acidic solutions. PBS preferred diluent.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
9,5/10
8/10

MELANOTAN-1 (MT-1)

Intro
Synthetic α-MSH analogue with MC1R selectivity. Only melanocortin peptide with EMA approval (Scenesse for EPP). Deep even tan with reduced UV exposure.
Mechanism
MC1R agonism → tyrosinase upregulation → eumelanin synthesis. UV activation required to convert precursors to visible pigment.
Benefits
Deep even tan. Photoprotection. Visually reduces PIE by contrast. EMA-approved safety data. Lower systemic effects vs MT-2.
Negatives
Nausea during loading (reduced by microdosing). Mole changes — document before starting. UV >3 required for activation. MC4R spillover at high doses.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 500mcg = 0.05ml.
Dosage
Loading: 500mcg/day × 14 days. Maintenance: 250-500mcg E2-3D + UV.
Timing
Evening — sleep through initial nausea.

Cycling
Loading → Maintenance. No continuous loading.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$4,5/10mg vial × 10. ~€2-3,5/month maintenance.
Evidence Grade
A- — EMA approved. Phase III trials. Extensive safety data.
Synergies
UV exposure (essential). Tretinoin. Solarium if UV index <3.
Warnings
Photograph all moles before starting. Never combine with MT-2.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
7/10
8/10
9/10
8,5/10

BPC-157

Intro
Synthetic pentadecapeptide from gastric juice. Remarkable healing in animal models across tendons, ligaments, muscles, GI tract. Most promising for injury recovery and post-surgical healing.
Mechanism
Upregulates GH receptor. VEGF angiogenesis. FAK-paxillin wound healing pathway. NF-κB inhibition. Collagen synthesis in tenocytes.
Benefits
Tendon/ligament healing acceleration. GI mucosal protection. Nerve regeneration (animal). Anti-inflammatory. Enhanced training recovery.
Negatives
Virtually ALL data is animal/in-vitro. Zero completed human RCTs. Unknown optimal human dosing. Unknown long-term safety.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
200-500mcg/day subcut or IM. Split morning + evening.
Timing
Morning and/or post-training.
Cycling
4-8 weeks on, 4 off. Or acute injury protocol.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$40 per kit (10×5mg vials). ~€3.5/vial. €40-70/month.
Evidence Grade
C+ — Extensive animal data, consistent results. Zero human RCTs. High translation uncertainty.
Synergies
TB-500 (complementary). GHK-Cu (collagen synergy).
Warnings
Theoretical angiogenesis concern with cancer history (unproven in humans). No known drug interactions.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
8/10
4/10
7/10
6/10

TB-500

Intro
Synthetic fragment of thymosin beta-4. Critical role in cell migration, wound healing, tissue regeneration. Systemic healing reach that BPC-157 lacks.
Mechanism
Binds G-actin → cell migration/differentiation. Integrin-linked kinase activation. Metalloproteinase upregulation for tissue remodeling. Vascular tube formation.
Benefits
Systemic healing (reaches distant injury sites). Muscle fiber regeneration. Flexibility/ROM improvements. Potential cardiac protection.
Negatives
Human RCT data absent for recovery use. Higher MW limits oral bioavailability. More expensive than BPC-157. Overlap with BPC-157.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
Loading: 2-2.5mg 2×/week × 4-6 weeks. Maintenance: 2-2.5mg 1×/week.
Timing
Morning or post-training.
Cycling
6-week loading, then maintenance or off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$75 per kit (10×5mg vials). ~€7/vial. €50-90/month.
Evidence Grade
C+ — Animal data solid. Phase II trial in dry eye disease. Limited systemic recovery data in humans.
Synergies
BPC-157 (most common stack). Post-surgery recovery protocol.
Warnings
Same theoretical angiogenesis concern as BPC-157 with cancer history.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
4/10
6/10
6/10

DSIP

Intro
DSIP is a neuropeptide that modulates sleep architecture by promoting delta-wave (slow-wave) sleep. It was isolated from rabbit thalamic venous blood in 1977. Unlike benzodiazepines, it doesn't cause sedation — it shifts the sleep profile toward restorative deep sleep.
Mechanism
Modulates GABA-B receptors. Reduces nocturnal cortisol. Increases GH secretion during sleep. Normalizes circadian rhythm via hypothalamic-pituitary axis modulation. Antioxidant effects.
Benefits
Improved deep sleep quality (not just duration). GH pulse enhancement during sleep. Reduced cortisol during sleep. Potential nootropic effects via improved sleep. Non-sedating — no morning grogginess.
Negatives
Short plasma half-life (~30 min) — may require specific timing. Most data from 1980s-90s Russian studies. Limited modern replication. Expensive per mg.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100-300mcg = 0.02-0.06ml.
Dosage
100-300mcg subcut 30-60 min before sleep.
Timing
30-60 minutes before bedtime.
Cycling
5-7 day cycles. Short-term use most studied.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €30-60/month.
Evidence Grade
C+ — Russian human trials 1980s. Mechanism plausible. Limited modern replication.
Synergies
Melatonin (circadian complementary). Ipamorelin (synergistic GH pulse during sleep).
Warnings
No known serious interactions. Avoid combining with benzodiazepines (additive sleep effects).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

SS-31 (ELAMIPRETIDE)

Intro
SS-31 (Szeto-Schiller peptide 31) is a tetrapeptide that concentrates in the inner mitochondrial membrane, stabilizing cardiolipin. It is arguably the most promising mitochondria-targeting molecule currently studied, with active Phase II/III trials for Barth syndrome, heart failure, and age-related muscle loss.
Mechanism
Binds cardiolipin in inner mitochondrial membrane → stabilizes electron transport chain structure. Reduces mitochondrial ROS production. Maintains cristae morphology. Improves ATP synthesis efficiency.
Benefits
Mitochondrial function restoration. Reduced oxidative stress. Improved energy efficiency (not stimulant-based). Potential muscle function improvement. Active pharmaceutical development — human safety data exists.
Negatives
Expensive per mg. Mostly disease-state human trials — healthy young male data absent. Injectable only (high MW). Long-term use unknown.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
1-5mg/day subcut. Clinical trials used 0.05-0.25 mg/kg IV.
Timing
Morning.
Cycling
4-12 week cycles. Research ongoing.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$86 per kit (10×10mg vials). ~€8/vial. Expensive but unique mechanism.
Evidence Grade
B- — Phase II human trials in disease states. Mechanism very well characterized. Healthy young use extrapolated.
Synergies
NAD+ precursors (complementary mitochondrial support). MOTS-C.
Warnings
No known serious interactions. Not indicated in healthy young without mitochondrial disease.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
6/10
5/10
5/10
5/10

MOTS-C

Intro
MOTS-C is a peptide encoded in the mitochondrial genome — one of the first mitochondria-derived peptides discovered. It acts as a metabolic regulator, improving insulin sensitivity and exercise capacity. Endogenous levels decline with age and are increased by exercise.
Mechanism
Activates AMPK. Inhibits AICAR (purine synthesis) → folate cycle disruption → metabolic reprogramming. Improves glucose uptake independent of insulin. Regulates ROS homeostasis in mitochondria.
Benefits
Improved insulin sensitivity. Enhanced exercise capacity and metabolic efficiency. Anti-obesity effects. Potential longevity effects. Exercise-mimicking properties.
Negatives
Most data animal studies. Human trial data limited to one small RCT. Age-related benefit unclear in young healthy subjects (endogenous levels already high at 18). Expensive.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 2-5mg per injection.
Dosage
5-10mg subcut 2-3×/week.
Timing
Morning or pre-workout.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$65 per kit (10×10mg vials). ~€6/vial. Moderate.
Evidence Grade
C+ — Strong animal data. One small human RCT (n=40). Mechanism well-established.
Synergies
SS-31 (mitochondrial stack). Exercise potentiation.
Warnings
No known serious interactions. Limited human safety data.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

5-AMINO-1MQ

Intro
5-amino-1-methylquinolinium (5-amino-1MQ) is a small molecule that inhibits CD38, the primary NAD+-degrading enzyme in the body. Unlike taking NAD+ precursors (NMN/NR), which add more NAD+ substrate, 5-amino-1MQ prevents NAD+ from being broken down — potentially more efficient.
Mechanism
Inhibits CD38 (NAD+ glycohydrolase) → NAD+ levels rise. CD38 activity increases dramatically with age and inflammation. Preserves endogenous NAD+ pool without external supplementation.
Benefits
NAD+ preservation. Potential fat loss effects (adipocyte CD38 inhibition). Anti-inflammatory. More targeted mechanism than NMN/NR for NAD+ elevation.
Negatives
Very limited human data. Research peptide status. Long-term safety unknown. Age-appropriateness at 18 unestablished (same issue as NAD+ precursors — you don't need this yet).
Reconstitution
Oral or injectable. 5mg vial with 1ml BAC water = 5mg/ml.
Dosage
5-50mg oral or 1-5mg subcut.
Timing
Morning.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months.
Cost (vendor)
$45 per kit (10×5mg) or $110 per kit (10×50mg). ~€4-10/vial.
Evidence Grade
C — Animal data only. No human RCTs. Mechanism well-established biochemically.
Synergies
SS-31, MOTS-C (mitochondrial stack). More relevant at 35+ years.
Warnings
Not recommended under 35. No established benefit in young healthy subjects.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
7/10
3/10

THYMOSIN ALPHA-1

Intro
Thymosin Alpha-1 (Tα1) is an endogenous peptide originally isolated from thymic tissue. It is FDA-approved in 35+ countries for chronic hepatitis B and C, and used as an immune adjuvant in cancer treatment. Strong immunomodulatory and antiviral properties.
Mechanism
Enhances T-cell, NK cell, and dendritic cell function. Upregulates IL-2, IFN-γ. Activates Toll-like receptors. Promotes antigen presentation. Anti-inflammatory via IL-10 pathway.
Benefits
Immune system enhancement and normalization. Antiviral effects. Used clinically for immunocompromised patients. Strong safety data from approved medical use. Potential benefit post-illness or during intense training phases.
Negatives
Healthy young with normal immune function may see minimal benefit. Expensive. Primary benefit for immunocompromised or sick individuals. Mild injection site reactions.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
1-2mg subcut 2×/week. Clinical dose: 1mg/m² body surface area.
Timing
Any time — immune timing less critical.
Cycling
2-6 week cycles. Or as needed during illness.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$80 per kit (10×5mg vials). ~€7/vial. Moderate.
Evidence Grade
B — Approved in multiple countries for specific indications. Good human safety data. Healthy young use extrapolated.
Synergies
BPC-157 (immune + healing stack during recovery). Useful post-surgery.
Warnings
No significant drug interactions at standard doses. Avoid in autoimmune conditions without medical supervision.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
6/10
6/10
6/10

KPV

Intro
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of α-MSH. It retains the anti-inflammatory properties of the parent molecule without melanocortin receptor agonism. Being 3 amino acids, it has superior bioavailability and can even be taken orally for GI effects.
Mechanism
Inhibits NF-κB signalling. Reduces TNF-α, IL-1β, IL-6 production. Activates MC1R and MC3R locally (anti-inflammatory, not pigmentation). Promotes intestinal epithelial healing.
Benefits
Potent anti-inflammatory for gut, skin, and systemic use. Oral bioavailability for GI-specific effects. No melanocortin pigmentation effects. Excellent safety profile. Can be combined with BPC-157 for enhanced GI healing.
Negatives
Limited human clinical trial data. Research peptide status. Very short half-life requires frequent dosing or oral route.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. Can be taken orally (encapsulate or dissolve in water).
Dosage
500mcg–2mg subcut or 1-5mg oral per day.
Timing
Any time. Oral pre-meals for GI effects.
Cycling
Continuous low-dose or acute 4-week protocols.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$60 per kit (10×10mg vials). ~€5.5/vial. Reasonable.
Evidence Grade
C+ — Strong in-vitro/animal. Human data emerging. Mechanism very well characterized.
Synergies
BPC-157 (GI healing stack). Part of BBG or KLOW80 recovery mix.
Warnings
No known serious interactions. Excellent tolerability profile.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
8/10
4/10
7/10
6/10

CEREBROLYSIN

Intro
Cerebrolysin is a complex mixture of low-molecular-weight peptides derived from porcine brain tissue. It contains BDNF, NGF, CNTF, and other neurotrophins. Used clinically in Eastern Europe and Asia for stroke, traumatic brain injury, and Alzheimer's disease.
Mechanism
Provides exogenous BDNF, NGF, and other neurotrophins directly. Promotes neurogenesis and synaptic plasticity. Neuroprotective against excitotoxicity. Anti-apoptotic in neurons.
Benefits
Direct neurotrophin supplementation (vs Semax which stimulates endogenous production). Established clinical use in stroke recovery. May enhance cognitive recovery after stress or illness. Fast-acting neuroplasticity support.
Negatives
Derived from porcine brain — quality control important. Injectable only (IV preferred clinically, IM used in biohacking). Religious/dietary restrictions for some. Most trials in neurological disease, not healthy subjects. Quality varies by vendor significantly.
Reconstitution
Ready solution typically. Check vendor — should be aqueous solution, not lyophilized.
Dosage
1-5ml IM/subcut. Clinical: 10-30ml IV/day. For cognitive use: 1-2ml IM daily.
Timing
Morning.
Cycling
10-30 day cycles. 2-3× per year.
Storage
Refrigerate 2-8°C. Do not freeze.
Cost (vendor)
$29 per kit (6×60mg vials). ~€4.5/vial. Budget-friendly.
Evidence Grade
B- — Multiple RCTs in stroke/TBI (positive). Healthy cognitive enhancement — limited data.
Synergies
Semax (BDNF endogenous + exogenous). Citicoline.
Warnings
Ensure vendor quality — biological product contamination risk. Do not use if porcine-derived products contraindicated.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
6/10
5/10
8/10
6/10

SNAP-8

Intro
Snap-8 (Acetyl Octapeptide-3) is a synthetic octapeptide that mimics the N-terminal portion of SNAP-25. It competes with the SNARE complex, reducing neurotransmitter release at neuromuscular junctions in facial skin. Often called 'topical Botox' in cosmetic science.
Mechanism
Inhibits SNARE complex formation → reduced acetylcholine release at local neuromuscular junctions → reduced muscle contraction intensity in expression lines → smoother appearance over time.
Benefits
Reduces expression-related fine lines without injection. Can be added to moisturizer or serum. No systemic effects. Safe topical profile.
Negatives
Penetration through skin is very limited for large peptides. Most human evidence industry-funded. Effects subtle vs Botox. Not relevant at 18 — no expression lines yet.
Reconstitution
Typically used as topical — dissolve in DMSO or serum base for penetration.
Dosage
2-10% topical solution, apply 2× daily.
Timing
Morning and evening skincare routine.
Cycling
Continuous — topical peptides require sustained use.
Storage
Lyophilized 12+ months. Solution 1 month refrigerated.
Cost (vendor)
$40 per kit (10×10mg vials). ~€3.5/vial. Very affordable.
Evidence Grade
C+ — One industry-funded human trial showing 52% wrinkle reduction. No independent replication.
Synergies
Tretinoin (different mechanism). GHK-Cu (complementary skin matrix support).
Warnings
Not meaningful at 18 years. Consider at 30+ when expression lines begin. Skin penetration limitations mean topical DMSO carrier needed.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
3/10
9/10
3/10
9/10
4/10

PINEALON

Intro
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by the same Russian group as Epitalon (Khavinson). It is derived from the pineal gland and claimed to regulate circadian rhythms, protect neurons, and enhance cognitive function. More targeted neurological action than Epitalon.
Mechanism
Claimed: regulates melatonin secretion rhythm. Neuroprotective against oxidative stress. Potentially modulates DNA methylation patterns in neurons. Anti-apoptotic in neuronal cell lines.
Benefits
Potential sleep quality improvement. Neuroprotective effects in animal models. Claimed cognitive enhancement. Better age-appropriateness than Epitalon (circadian regulation relevant at any age).
Negatives
All evidence from single Russian research group (Khavinson) — significant conflict of interest. No independent replication. Human data limited to elderly. Mechanism insufficiently characterized.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
5-10mg course over 10 days.
Timing
Evening for circadian effects.
Cycling
10-day courses 2-3× per year.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$55 per kit (10×5mg vials). ~€5/vial. Moderate.
Evidence Grade
C — Single research group. Elderly-only human data. No independent replication.
Synergies
Melatonin (circadian stack). DSIP.
Warnings
Same single-source evidence issue as Epitalon. Verify independently before use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
6/10
4/10

EPITHALON (EPITALON)

Intro
Synthetic tetrapeptide from the pineal gland. Claimed telomerase activator. All positive human evidence in elderly (60+) cohorts. Mismarketed to younger users — fundamentally age-inappropriate under 35.
Mechanism
Activates telomerase (hTERT) in somatic cells. Regulates melatonin secretion. Antioxidant. Regulates hypothalamic-pituitary axis.
Benefits
Telomere elongation in elderly subjects. Normalizes melatonin in aged individuals. Sleep improvement. Antioxidant effects.
Negatives
NOT APPROPRIATE UNDER 35-40 YEARS. Your telomeres are already near peak length at 18. Long telomeres correlated with MORE tumors (Johns Hopkins research). All-cause mortality data shows abnormally long telomeres are harmful. Single research group with patent conflict of interest.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
5-10mg/day × 10-20 days (elderly protocol).
Timing
Evening.
Cycling
2× per year for elderly users.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$48 per kit (10×10mg vials). ~€4.4/vial. Affordable but irrelevant at <35.
Evidence Grade
C+ — Single research group. Human data in elderly only. No independent replication.
Synergies
Melatonin, Pinealon. NOT for young users.
Warnings
DO NOT USE UNDER 35. No benefit. Theoretical cancer risk from telomere overextension at young age.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
7/10
3/10
7/10
2/10

IPAMORELIN

Intro
Selective GHRH receptor agonist. Cleanest GHRP — no cortisol/prolactin elevation. Best used with CJC-1295 no-DAC for synergistic GH pulse. At 18, natural GH is already at peak — use with caution.
Mechanism
GHSR-1a (ghrelin receptor) agonist → pulsatile GH release from pituitary. Highly selective. No ACTH, cortisol, or prolactin stimulation at standard doses.
Benefits
Clean GH stimulation. Improved deep sleep. Recovery enhancement. Lean mass support. Better tolerated than GHRP-2/6.
Negatives
At 17-18, endogenous GH already at lifetime peak. Marginal additional benefit. Potential GH receptor downregulation. Water retention possible. Not FDA approved.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100mcg = 0.02ml.
Dosage
100-300mcg per injection. 1-3×/day. Most useful pre-bed.
Timing
Pre-bed (maximize natural GH pulse). Can stack with CJC-1295 no-DAC.
Cycling
12-week cycles, 4-6 weeks off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €40-80/month.
Evidence Grade
C+ — Phase II human trials in GH deficiency. Mechanism well-established. Off-label recovery use anecdotal.
Synergies
CJC-1295 no-DAC (synergistic GH pulse). DSIP (sleep enhancement stack).
Warnings
Marginal benefit at 17-18. Wait until 21+ for optimal use case. Never fasted training + ipamorelin (hypoglycemia risk).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
5/10
7/10
5/10

NAD+

Intro
NAD+ precursors (NMN/NR) raise intracellular NAD+ levels. NAD+ declines with age, primarily after 40. Every positive human RCT enrolled middle-aged or elderly subjects. Not indicated at 18.
Mechanism
NAD+ precursors → raise NAD+ pool → sirtuin activation → mitochondrial efficiency. Requires CD38 to be low for optimal effect.
Benefits
Mitochondrial function in elderly. DNA repair enhancement. Sirtuin activation. Muscle function support in aged subjects.
Negatives
NOT RECOMMENDED UNDER 35. NAD+ peaks between 15-30. 2025 meta-analysis: no significant benefit for muscle function in young subjects. Your niacinamide 10% topical already supports local NAD+. Waste of money at your age.
Reconstitution
Oral capsules. Injectable NAD+ also available (listed vendor).
Dosage
250-500mg NMN or NR oral. Or 100-500mg IV/IM injectable.
Timing
Morning.
Reconstitution
No established cycle for oral. Injectable courses sometimes 10 days.
Storage
Keep dry. Heat sensitive.
Cost (vendor)
$40 per kit (10×100mg) to $130 per kit (10×1000mg). Pointless at 18.
Evidence Grade
B- (in elderly), C (in young). All positive RCTs in 40+ populations.
Synergies
5-amino-1MQ (CD38 inhibitor — more relevant mechanism). SS-31. All age 35+.
Warnings
NOT RECOMMENDED UNDER 35. No demonstrated benefit. Use money elsewhere.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
9/10
3/10
5/10
2/10

PEPTIDES NOT RECOMMENDED FOR THIS CONTEXT

Do Not Use — Reasons Explained

Semaglutide / Tirzepatide / Retatrutide / Cagrilintide
If you can't get your body fat down to 10% at least once in your life, what can you actually do?
I use Tirzepatide myself
IGF-1 LR3 (Used it myself)
Highly anabolic IGF-1 analogue. Promotes growth in ALL tissues including potential tumor cells. Open growth plates at 17-18 make this particularly concerning. Hypoglycemia risk. Not appropriate under 21+.
Dermorphin
Opioid peptide — 50x more potent than morphine. Extremely high addiction potential. Not appropriate for any looksmaxxing or performance context. High risk of dependence, respiratory depression, death in overdose.
Adipotide
Experimental peptide targeting ANXA2/PROHIBITIN on fat cell vasculature. Causes kidney toxicity in primate studies. Never cleared for human use. Avoid entirely.
Oxytocin
Half-life 3-5 minutes IV. Intranasal slightly longer. No meaningful persistent anxiolytic effect for social situations. Better alternatives available (Etifoxine, Selank, Pregab).
PT-141 (Bremelanotide)
MC3R/MC4R agonist for sexual dysfunction. More systemic side effects than MT-1. Nausea, blood pressure effects. Not a looksmaxxing compound.

STACKING GUIDE

Recommended Stacks by Goal

Cognitive Peak
Semax (1mg/day IN) + Citicoline (250mg/day oral) + Selank (500mcg situational). Semax → focus/BDNF, Citicoline → ACh, Selank → anxiety control.
Skin & PIE
GHK-Cu (2mg subcut EOD) + Tretinoin (topical) + Azelaic Acid 20% (topical) + Niacinamide 10% (topical). Best-evidenced combination.
Post-Surgery
BPC-157 (500mcg/day) + TB-500 (2mg 2×/week) + GHK-Cu (500mcg/day) + KPV (1mg/day). 8-week protocol.
Healing & Recovery
BPC-157 + TB-500 combo vial (BBG or KLOW80 mix). Most cost-effective option. KLOW80 adds KPV for anti-inflammatory.
Sleep Quality
DSIP (200mcg subcut pre-bed) + Ipamorelin (100mcg pre-bed). Synergistic GH pulse + deep sleep architecture.
Mitochondrial Stack
SS-31 (2mg/day) + MOTS-C (5mg 3×/week). Age 30+ optimal. Limited benefit at 18.
Immune Support
Thymosin Alpha-1 (1mg 2×/week) for 4-6 weeks during illness, intense training periods, or post-surgery.
Anxiolysis (Daily)
Selank (400-600mcg/day, cycled 14/14). No dependence, no sedation. Best daily option.
Anxiolysis (Events)
Etifoxine 50mg → Pregabalin 75-150mg (reserve for important only). Never two GABAergics same day.

CRITICAL INTERACTIONS
READ BEFORE STACKING

ABSOLUTE
NEVER: Selank + Etifoxine + Pregabalin same day. Three GABAergics = CNS depression risk.
ABSOLUTE
NEVER: MT-1 + MT-2 simultaneously. Receptor overlap, unpredictable systemic effects.
AVOID
Ipamorelin/CJC-1295 on fasted training days — hypoglycemia risk.
AVOID
Semax + Modafinil daily — both dopaminergic. Limit to exam days only.
SEPARATE
GHK-Cu and Zinc: pause zinc during GHK-Cu cycle. Competition for transporters.
SEPARATE
MT-1 and GHK-Cu injections: different anatomical sites same evening.
NOTE
BPC-157 / TB-500 / GHK-Cu vendor combo mixes (BBG, KLOW80) can be drawn from same vial — convenient and cost-effective.

RECONSTITUTION QUICK REFERENCE

Standard Dilutions
Semax 40mg 4ml BAC water → 10mg/ml → 1mg dose = 0.1ml
Selank 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
GHK-Cu 2mg 1ml BAC water (or PBS) → 2mg/ml → 2mg = 1ml
GHK-Cu 50mg (bulk) 25ml BAC water → 2mg/ml → 2mg = 1ml
MT-1 10mg 1ml BAC water → 10mg/ml → 500mcg = 0.05ml
BPC-157 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
TB-500 5mg 1ml BAC water → 5mg/ml → 2mg = 0.4ml
Ipamorelin 5mg 1ml BAC water → 5mg/ml → 100mcg = 0.02ml
DSIP 5mg 1ml BAC water → 5mg/ml → 200mcg = 0.04ml
Epitalon 10mg 2ml BAC water → 5mg/ml → 5mg = 1ml
Thymosin Alpha-1 5mg 1ml BAC water → 5mg/ml → 1mg = 0.2ml
KPV 10mg 1ml BAC water → 10mg/ml → 1mg = 0.1ml (or oral)
PBS vs BAC Water Use PBS for copper peptides (GHK-Cu, AHK-Cu) — better copper stability. BAC water for all others.

VENDOR PRICE REFERENCE (Chinese Warehouse)
$60 flat worldwide shipping fee. All prices USD per kit of 10 vials (divide by 10 for single vial price). Prices as of April 2026.

Product Price (USD) per kit (10 vials)
Semax 5mg×10 $40
Semax 10mg×10 $50
Selank 5mg×10 $40
GHK-Cu 50mg×10 $30
GHK-Cu 100mg×10 $45
AHK-Cu 100mg×10 $68
MT-1 10mg×10 $45
MT-2 10mg×10 $45
BPC-157 5mg×10 $40
BPC-157 10mg×10 $70
TB-500 5mg×10 $75
TB-500 10mg×10 $140
BPC+TB 5mg+5mg×10 $95
GHK+BPC+TB 50/10/10mg×10 $160
GHK+BPC+TB+KPV 80mg×10 $195
KPV 10mg×10 $60
Ipamorelin 5mg×10 $45
Ipamorelin 10mg×10 $80
CJC-1295 no-DAC 5mg×10 $85
CJC+Ipa combo 10mg×10 $95
DSIP 5mg×10 $45
DSIP 15mg×10 $85
SS-31 10mg×10 $86
SS-31 50mg×10 $285
MOTS-C 10mg×10 $65
MOTS-C 40mg×10 $185
5-amino-1MQ 5mg×10 $45
5-amino-1MQ 50mg×10 $110
Thymosin Alpha-1 5mg×10 $80
TA-1 10mg×10 $145
Epitalon 10mg×10 $48
Epitalon 50mg×10 $150
Cerebrolysin 60mg×6 $29
Pinealon 5mg×10 $55
Pinealon 10mg×10 $70
Snap-8 10mg×10 $40
NAD+ 100mg×10 $40
NAD+ 500mg×10 $80
NAD+ 1000mg×10 $130
L-Carnitine 600mg/ml 10ml×10 $80
Glutathione 1500mg×10 $80
Melatonin 10mg×10 $55
VIP 5mg×10 $75
SLU-PP-322 5mg×10 $100
AICAR 50mg×10 $62
Tesamorelin 5mg×10 $110
ARA-290 10mg×10 $80
BAC Water 10ml×10 $10
PBS 10ml×10 $10
Acetic Acid Water 10ml×10 $10

PEPTIDES

Melanotan-1 subcutaneously, in the evening.

GHK-Cu 2 mg subcutaneously, in the evening.

Tirzepatide 2,5 mg subcutaneously, every week

@reyalsnoom @Jesus_ist_König @tqbiq @greylord @aaronbp

whos the vendor

bluebandz · May 26, 2026

til<3D said:
Complete Guide to Peptide Protocols — Dosing, Evidence & Stacking

by til<3D
Stand: April 2026

DISCLAIMER

Read First
This guide is for educational purposes only. Peptides are not approved drugs in most countries. Everything here is off label and experimental. Do your own research. You are responsible for your own choices. This is not medical advice.
Age Note
Several peptides are specifically marked as inappropriate for users under 18-20 years old due to ongoing hormonal and neural development. These warnings are clearly flagged throughout.
Sources
Evidence grades reflect actual human clinical trial data, animal studies, and in vitro research. Grade A = multiple human RCTs. Grade B = some human data. Grade C = animal/in vitro only.

PEPTIDES COVERED IN THIS THREAD

1. Semax — ACTH(4-7) Analogue — Nootropic

2. Selank — Tuftsin Analogue — Anxiolytic & Cognitive

3. GHK-Cu — Copper Peptide — Skin & Collagen

4. AHK-Cu — Copper Peptide — Hair Growth

5. Melanotan-1 (MT-1) — MC1R Agonist — Tanning

6. BPC-157 — Body Protection Compound — Healing

7. TB-500 — Thymosin Beta-4 — Recovery & Flexibility

8. DSIP — Delta Sleep-Inducing Peptide — Sleep Architecture

9. SS-31 (Elamipretide) — Mitochondria-Targeting Peptide — Energy & Cardioprotection

10. MOTS-C — Mitochondrial-Derived Peptide — Metabolic

11. 5-amino-1MQ — CD38 Inhibitor — NAD+ Preservation

12. Thymosin Alpha-1 — Immune Modulator — Immune Enhancement

13. KPV — Anti-Inflammatory Tripeptide — Gut & Skin

14. Cerebrolysin — Neuropeptide Mix — Cognitive & Neuroprotection

15. Snap-8 — Neuropeptide — Anti-Wrinkle Topical

16. Pinealon — Pineal Peptide — Neuroprotection & Circadian

17. Epithalon (Epitalon) — Tetrapeptide — Telomere (Age 40+ Only)

18. Ipamorelin — GHRP — GH Secretagogue (Age 20+ Optimal)

19. NAD+ — NAD+ Precursors — Mitochondrial (Age 35+ Only)

QUICK REFERENCE — ALL PEPTIDES

Peptide Effectiveness Evidence Age 17-18 Cost/mo Overall
Semax 8/10 B+ ✓ OK €20–35/vial (40mg) 8/10
Selank 8/10 B ✓ OK €25–40/vial (5mg) 7/10
GHK-Cu 7/10 B- ✓ OK €30/vial (50mg bulk) — much better value 7/10
AHK-Cu 6/10 C+ ✓ OK $68/100mg vial (vendor) 6/10
Melanotan-1 (MT-1) 9/10 A- ✓ OK $45/10mg vial × 10 8/10
BPC-157 7/10 C+ ✓ OK $40/5mg vial × 10 6/10
TB-500 7/10 C+ ✓ OK $75/5mg vial × 10 6/10
DSIP 6/10 C+ ✓ OK $45/5mg vial × 10 5/10
SS-31 (Elamipretide) 6/10 B- ✓ OK $86/10mg vial × 10 5/10
MOTS-C 6/10 C+ ✓ OK $65/10mg vial × 10 5/10
5-amino-1MQ 4/10 C ✓ OK $45/5mg vial or $110/50mg 3/10
Thymosin Alpha-1 7/10 B ✓ OK $80/5mg vial × 10 6/10
KPV 6/10 C+ ✓ OK $60/10mg vial × 10 6/10
Cerebrolysin 7/10 B- ✓ OK $29/60mg × 6 vials (vendor) 6/10
Snap-8 3/10 C+ ✓ OK $40/10mg vial × 10 (vendor) 4/10
Pinealon 4/10 C ✓ OK $55/5mg vial × 10 4/10
Epithalon (Epitalon) 2/10 C+ ✗ Caution $48/10mg × 10 (vendor) 2/10
Ipamorelin 6/10 C+ ✗ Caution $45/5mg vial × 10 5/10
NAD+ 2/10 B- ✗ Caution $40-130 depending on dose 2/10

INDIVIDUAL PEPTIDE PROFILES

SEMAX

Intro
Synthetic heptapeptide analogue of ACTH(4-7), developed in Russia for stroke and cognitive enhancement. Decades of clinical data. Crosses BBB efficiently intranasally. You could also do subq but in my opinion it's unnecessary.
Mechanism
Upregulates BDNF. Modulates dopaminergic/serotonergic transmission. Increases enkephalinase activity. NO signalling enhancement.
Benefits
Enhanced focus, memory, learning. Neuroprotection. Anti anxiety via serotonin. Rapid onset 15-30 min. No physical dependence.
Negatives
Receptor desensitization — cycling required. Mild anxiety at high doses. Most studies Russian literature.
Reconstitution
4ml BAC water on 40mg vial = 10mg/ml. 1mg = 0.1ml = 1 pump.
Dosage
0.5–1mg/day intranasal.
Timing
Morning, fasted or first meal.
Cycling
5 days ON / 2 OFF. Or 3 weeks ON / 1 week OFF.

Storage
Lyophilized 12+ months. Reconstituted 4°C, 4 weeks.
Cost (vendor)
$50/100mg vial (vendor).
Evidence Grade
B+ — Russian Phase II/III trials. Growing Western replication.
Synergies
Citicoline, Selank. Never combine with high dose Modafinil same day.
Warnings
Monitor with Modafinil stack. Avoid MAOIs.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
7/10
8/10
8/10

SELANK

Intro
Synthetic analogue of tuftsin. Official anxiolytic drug status in Russia/Ukraine. Anxiolysis without sedation, tolerance, or withdrawal.
Mechanism
Allosteric GABA-A modulation. Inhibits enkephalinase. Modulates BDNF/NGF. Complements Semax via distinct brain connectivity patterns.
Benefits
Anxiolysis without sedation or dependence. Cognitive enhancement. Anti inflammatory. No BtMG. Low desensitization risk at standard doses.
Negatives
Most evidence Russian studies. Additive CNS depression with other GABAergics — critical interaction. Short half-life ~2h intranasal.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
250–800mcg/day intranasal.
Timing
Morning or 30-60 min before stressful situations.
Cycling
14 days ON / 14 days OFF, or situational.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/100mg vial (vendor). Very cost effective per mg.
Evidence Grade
B — Russian Phase II clinical trials in GAD.
Synergies
Semax (complementary). NEVER with Etifoxine, Pregabalin, or alcohol same day.
Warnings
NEVER combine with Etifoxine, Pregabalin, or benzodiazepines same day. Additive CNS depression.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
6/10
8/10
7/10

GHK-CU

Intro
Naturally occurring copper-binding peptide. Plasma levels decline with age. Gold standard for skin regeneration and wound healing.
Mechanism
Activates fibroblasts → collagen I/III/elastin synthesis. VEGF-driven angiogenesis. Inhibits TGF-β1 (anti-fibrotic). Antioxidant enzyme upregulation.
Benefits
PIE/acne scar remodeling. Skin density improvement. Wound/post-surgery healing. Tendon collagen support. Anti-inflammatory.
Negatives
Systemic human RCT data limited. Competing with zinc pause zinc during use. Monitor copper levels with chronic use.
Reconstitution
1ml BAC water on 2mg vial = 2mg/ml. 27-29G needle, 4-6mm, 45°. PBS preferred for copper stability.
Dosage
2mg subcut EOD/ ED.
Timing
Evening after training. Separate site from MT-1.
Cycling
4-week cycles. Zinc paused. After cycle reintroduce zinc.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/1g vial (vendor). Very cost effective per mg.
Evidence Grade
B- — Strong in-vitro/animal. Limited human RCTs for subcut use. Topical human evidence solid.
Synergies
Tretinoin (complementary collagen). Copper supplement 30-60 min before injection.
Warnings
Pause zinc during cycle. Monitor serum copper/ceruloplasmin with extended use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
5/10
10/10
8/10

AHK-CU

Intro
Tripeptide analogue of GHK-Cu with higher affinity for hair follicle receptors. AHK (Ala-His-Lys) specifically promotes hair growth via follicle dermal papilla stimulation.
Mechanism
Activates Wnt/β-catenin pathway in hair follicles. Promotes dermal papilla cell proliferation. Upregulates VEGF in follicle microvasculature. Inhibits DHT-induced apoptosis in follicles.
Benefits
Hair density and thickness improvement. Potentially superior to GHK-Cu for scalp/follicle applications. Can be used topically or subcut. Anti-inflammatory in follicle microenvironment.
Negatives
Less research than GHK-Cu overall. Mostly in-vitro data. Higher cost per mg. Limited human studies specifically.
Reconstitution
1ml BAC water per 10mg = 10mg/ml. Can be used topically (DMSO carrier) or subcut.
Dosage
Topical: 0.01-0.1% solution on scalp. Subcut: 1-2mg/day.
Timing
Evening or post-shower for topical.
Cycling
Continuous or 8-week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$68/1g vial (vendor). Very cost effective per mg.
Evidence Grade
C+ — In-vitro strong. Limited human data. Mechanistically plausible.
Synergies
GHK-Cu (different receptor affinity — complementary). Minoxidil topical.
Warnings
Avoid mixing with acidic solutions. PBS preferred diluent.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
9,5/10
8/10

MELANOTAN-1 (MT-1)

Intro
Synthetic α-MSH analogue with MC1R selectivity. Only melanocortin peptide with EMA approval (Scenesse for EPP). Deep even tan with reduced UV exposure.
Mechanism
MC1R agonism → tyrosinase upregulation → eumelanin synthesis. UV activation required to convert precursors to visible pigment.
Benefits
Deep even tan. Photoprotection. Visually reduces PIE by contrast. EMA-approved safety data. Lower systemic effects vs MT-2.
Negatives
Nausea during loading (reduced by microdosing). Mole changes — document before starting. UV >3 required for activation. MC4R spillover at high doses.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 500mcg = 0.05ml.
Dosage
Loading: 500mcg/day × 14 days. Maintenance: 250-500mcg E2-3D + UV.
Timing
Evening — sleep through initial nausea.

Cycling
Loading → Maintenance. No continuous loading.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$4,5/10mg vial × 10. ~€2-3,5/month maintenance.
Evidence Grade
A- — EMA approved. Phase III trials. Extensive safety data.
Synergies
UV exposure (essential). Tretinoin. Solarium if UV index <3.
Warnings
Photograph all moles before starting. Never combine with MT-2.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
7/10
8/10
9/10
8,5/10

BPC-157

Intro
Synthetic pentadecapeptide from gastric juice. Remarkable healing in animal models across tendons, ligaments, muscles, GI tract. Most promising for injury recovery and post-surgical healing.
Mechanism
Upregulates GH receptor. VEGF angiogenesis. FAK-paxillin wound healing pathway. NF-κB inhibition. Collagen synthesis in tenocytes.
Benefits
Tendon/ligament healing acceleration. GI mucosal protection. Nerve regeneration (animal). Anti-inflammatory. Enhanced training recovery.
Negatives
Virtually ALL data is animal/in-vitro. Zero completed human RCTs. Unknown optimal human dosing. Unknown long-term safety.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
200-500mcg/day subcut or IM. Split morning + evening.
Timing
Morning and/or post-training.
Cycling
4-8 weeks on, 4 off. Or acute injury protocol.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$40 per kit (10×5mg vials). ~€3.5/vial. €40-70/month.
Evidence Grade
C+ — Extensive animal data, consistent results. Zero human RCTs. High translation uncertainty.
Synergies
TB-500 (complementary). GHK-Cu (collagen synergy).
Warnings
Theoretical angiogenesis concern with cancer history (unproven in humans). No known drug interactions.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
8/10
4/10
7/10
6/10

TB-500

Intro
Synthetic fragment of thymosin beta-4. Critical role in cell migration, wound healing, tissue regeneration. Systemic healing reach that BPC-157 lacks.
Mechanism
Binds G-actin → cell migration/differentiation. Integrin-linked kinase activation. Metalloproteinase upregulation for tissue remodeling. Vascular tube formation.
Benefits
Systemic healing (reaches distant injury sites). Muscle fiber regeneration. Flexibility/ROM improvements. Potential cardiac protection.
Negatives
Human RCT data absent for recovery use. Higher MW limits oral bioavailability. More expensive than BPC-157. Overlap with BPC-157.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
Loading: 2-2.5mg 2×/week × 4-6 weeks. Maintenance: 2-2.5mg 1×/week.
Timing
Morning or post-training.
Cycling
6-week loading, then maintenance or off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$75 per kit (10×5mg vials). ~€7/vial. €50-90/month.
Evidence Grade
C+ — Animal data solid. Phase II trial in dry eye disease. Limited systemic recovery data in humans.
Synergies
BPC-157 (most common stack). Post-surgery recovery protocol.
Warnings
Same theoretical angiogenesis concern as BPC-157 with cancer history.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
4/10
6/10
6/10

DSIP

Intro
DSIP is a neuropeptide that modulates sleep architecture by promoting delta-wave (slow-wave) sleep. It was isolated from rabbit thalamic venous blood in 1977. Unlike benzodiazepines, it doesn't cause sedation — it shifts the sleep profile toward restorative deep sleep.
Mechanism
Modulates GABA-B receptors. Reduces nocturnal cortisol. Increases GH secretion during sleep. Normalizes circadian rhythm via hypothalamic-pituitary axis modulation. Antioxidant effects.
Benefits
Improved deep sleep quality (not just duration). GH pulse enhancement during sleep. Reduced cortisol during sleep. Potential nootropic effects via improved sleep. Non-sedating — no morning grogginess.
Negatives
Short plasma half-life (~30 min) — may require specific timing. Most data from 1980s-90s Russian studies. Limited modern replication. Expensive per mg.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100-300mcg = 0.02-0.06ml.
Dosage
100-300mcg subcut 30-60 min before sleep.
Timing
30-60 minutes before bedtime.
Cycling
5-7 day cycles. Short-term use most studied.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €30-60/month.
Evidence Grade
C+ — Russian human trials 1980s. Mechanism plausible. Limited modern replication.
Synergies
Melatonin (circadian complementary). Ipamorelin (synergistic GH pulse during sleep).
Warnings
No known serious interactions. Avoid combining with benzodiazepines (additive sleep effects).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

SS-31 (ELAMIPRETIDE)

Intro
SS-31 (Szeto-Schiller peptide 31) is a tetrapeptide that concentrates in the inner mitochondrial membrane, stabilizing cardiolipin. It is arguably the most promising mitochondria-targeting molecule currently studied, with active Phase II/III trials for Barth syndrome, heart failure, and age-related muscle loss.
Mechanism
Binds cardiolipin in inner mitochondrial membrane → stabilizes electron transport chain structure. Reduces mitochondrial ROS production. Maintains cristae morphology. Improves ATP synthesis efficiency.
Benefits
Mitochondrial function restoration. Reduced oxidative stress. Improved energy efficiency (not stimulant-based). Potential muscle function improvement. Active pharmaceutical development — human safety data exists.
Negatives
Expensive per mg. Mostly disease-state human trials — healthy young male data absent. Injectable only (high MW). Long-term use unknown.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
1-5mg/day subcut. Clinical trials used 0.05-0.25 mg/kg IV.
Timing
Morning.
Cycling
4-12 week cycles. Research ongoing.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$86 per kit (10×10mg vials). ~€8/vial. Expensive but unique mechanism.
Evidence Grade
B- — Phase II human trials in disease states. Mechanism very well characterized. Healthy young use extrapolated.
Synergies
NAD+ precursors (complementary mitochondrial support). MOTS-C.
Warnings
No known serious interactions. Not indicated in healthy young without mitochondrial disease.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
6/10
5/10
5/10
5/10

MOTS-C

Intro
MOTS-C is a peptide encoded in the mitochondrial genome — one of the first mitochondria-derived peptides discovered. It acts as a metabolic regulator, improving insulin sensitivity and exercise capacity. Endogenous levels decline with age and are increased by exercise.
Mechanism
Activates AMPK. Inhibits AICAR (purine synthesis) → folate cycle disruption → metabolic reprogramming. Improves glucose uptake independent of insulin. Regulates ROS homeostasis in mitochondria.
Benefits
Improved insulin sensitivity. Enhanced exercise capacity and metabolic efficiency. Anti-obesity effects. Potential longevity effects. Exercise-mimicking properties.
Negatives
Most data animal studies. Human trial data limited to one small RCT. Age-related benefit unclear in young healthy subjects (endogenous levels already high at 18). Expensive.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 2-5mg per injection.
Dosage
5-10mg subcut 2-3×/week.
Timing
Morning or pre-workout.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$65 per kit (10×10mg vials). ~€6/vial. Moderate.
Evidence Grade
C+ — Strong animal data. One small human RCT (n=40). Mechanism well-established.
Synergies
SS-31 (mitochondrial stack). Exercise potentiation.
Warnings
No known serious interactions. Limited human safety data.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

5-AMINO-1MQ

Intro
5-amino-1-methylquinolinium (5-amino-1MQ) is a small molecule that inhibits CD38, the primary NAD+-degrading enzyme in the body. Unlike taking NAD+ precursors (NMN/NR), which add more NAD+ substrate, 5-amino-1MQ prevents NAD+ from being broken down — potentially more efficient.
Mechanism
Inhibits CD38 (NAD+ glycohydrolase) → NAD+ levels rise. CD38 activity increases dramatically with age and inflammation. Preserves endogenous NAD+ pool without external supplementation.
Benefits
NAD+ preservation. Potential fat loss effects (adipocyte CD38 inhibition). Anti-inflammatory. More targeted mechanism than NMN/NR for NAD+ elevation.
Negatives
Very limited human data. Research peptide status. Long-term safety unknown. Age-appropriateness at 18 unestablished (same issue as NAD+ precursors — you don't need this yet).
Reconstitution
Oral or injectable. 5mg vial with 1ml BAC water = 5mg/ml.
Dosage
5-50mg oral or 1-5mg subcut.
Timing
Morning.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months.
Cost (vendor)
$45 per kit (10×5mg) or $110 per kit (10×50mg). ~€4-10/vial.
Evidence Grade
C — Animal data only. No human RCTs. Mechanism well-established biochemically.
Synergies
SS-31, MOTS-C (mitochondrial stack). More relevant at 35+ years.
Warnings
Not recommended under 35. No established benefit in young healthy subjects.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
7/10
3/10

THYMOSIN ALPHA-1

Intro
Thymosin Alpha-1 (Tα1) is an endogenous peptide originally isolated from thymic tissue. It is FDA-approved in 35+ countries for chronic hepatitis B and C, and used as an immune adjuvant in cancer treatment. Strong immunomodulatory and antiviral properties.
Mechanism
Enhances T-cell, NK cell, and dendritic cell function. Upregulates IL-2, IFN-γ. Activates Toll-like receptors. Promotes antigen presentation. Anti-inflammatory via IL-10 pathway.
Benefits
Immune system enhancement and normalization. Antiviral effects. Used clinically for immunocompromised patients. Strong safety data from approved medical use. Potential benefit post-illness or during intense training phases.
Negatives
Healthy young with normal immune function may see minimal benefit. Expensive. Primary benefit for immunocompromised or sick individuals. Mild injection site reactions.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
1-2mg subcut 2×/week. Clinical dose: 1mg/m² body surface area.
Timing
Any time — immune timing less critical.
Cycling
2-6 week cycles. Or as needed during illness.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$80 per kit (10×5mg vials). ~€7/vial. Moderate.
Evidence Grade
B — Approved in multiple countries for specific indications. Good human safety data. Healthy young use extrapolated.
Synergies
BPC-157 (immune + healing stack during recovery). Useful post-surgery.
Warnings
No significant drug interactions at standard doses. Avoid in autoimmune conditions without medical supervision.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
6/10
6/10
6/10

KPV

Intro
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of α-MSH. It retains the anti-inflammatory properties of the parent molecule without melanocortin receptor agonism. Being 3 amino acids, it has superior bioavailability and can even be taken orally for GI effects.
Mechanism
Inhibits NF-κB signalling. Reduces TNF-α, IL-1β, IL-6 production. Activates MC1R and MC3R locally (anti-inflammatory, not pigmentation). Promotes intestinal epithelial healing.
Benefits
Potent anti-inflammatory for gut, skin, and systemic use. Oral bioavailability for GI-specific effects. No melanocortin pigmentation effects. Excellent safety profile. Can be combined with BPC-157 for enhanced GI healing.
Negatives
Limited human clinical trial data. Research peptide status. Very short half-life requires frequent dosing or oral route.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. Can be taken orally (encapsulate or dissolve in water).
Dosage
500mcg–2mg subcut or 1-5mg oral per day.
Timing
Any time. Oral pre-meals for GI effects.
Cycling
Continuous low-dose or acute 4-week protocols.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$60 per kit (10×10mg vials). ~€5.5/vial. Reasonable.
Evidence Grade
C+ — Strong in-vitro/animal. Human data emerging. Mechanism very well characterized.
Synergies
BPC-157 (GI healing stack). Part of BBG or KLOW80 recovery mix.
Warnings
No known serious interactions. Excellent tolerability profile.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
8/10
4/10
7/10
6/10

CEREBROLYSIN

Intro
Cerebrolysin is a complex mixture of low-molecular-weight peptides derived from porcine brain tissue. It contains BDNF, NGF, CNTF, and other neurotrophins. Used clinically in Eastern Europe and Asia for stroke, traumatic brain injury, and Alzheimer's disease.
Mechanism
Provides exogenous BDNF, NGF, and other neurotrophins directly. Promotes neurogenesis and synaptic plasticity. Neuroprotective against excitotoxicity. Anti-apoptotic in neurons.
Benefits
Direct neurotrophin supplementation (vs Semax which stimulates endogenous production). Established clinical use in stroke recovery. May enhance cognitive recovery after stress or illness. Fast-acting neuroplasticity support.
Negatives
Derived from porcine brain — quality control important. Injectable only (IV preferred clinically, IM used in biohacking). Religious/dietary restrictions for some. Most trials in neurological disease, not healthy subjects. Quality varies by vendor significantly.
Reconstitution
Ready solution typically. Check vendor — should be aqueous solution, not lyophilized.
Dosage
1-5ml IM/subcut. Clinical: 10-30ml IV/day. For cognitive use: 1-2ml IM daily.
Timing
Morning.
Cycling
10-30 day cycles. 2-3× per year.
Storage
Refrigerate 2-8°C. Do not freeze.
Cost (vendor)
$29 per kit (6×60mg vials). ~€4.5/vial. Budget-friendly.
Evidence Grade
B- — Multiple RCTs in stroke/TBI (positive). Healthy cognitive enhancement — limited data.
Synergies
Semax (BDNF endogenous + exogenous). Citicoline.
Warnings
Ensure vendor quality — biological product contamination risk. Do not use if porcine-derived products contraindicated.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
6/10
5/10
8/10
6/10

SNAP-8

Intro
Snap-8 (Acetyl Octapeptide-3) is a synthetic octapeptide that mimics the N-terminal portion of SNAP-25. It competes with the SNARE complex, reducing neurotransmitter release at neuromuscular junctions in facial skin. Often called 'topical Botox' in cosmetic science.
Mechanism
Inhibits SNARE complex formation → reduced acetylcholine release at local neuromuscular junctions → reduced muscle contraction intensity in expression lines → smoother appearance over time.
Benefits
Reduces expression-related fine lines without injection. Can be added to moisturizer or serum. No systemic effects. Safe topical profile.
Negatives
Penetration through skin is very limited for large peptides. Most human evidence industry-funded. Effects subtle vs Botox. Not relevant at 18 — no expression lines yet.
Reconstitution
Typically used as topical — dissolve in DMSO or serum base for penetration.
Dosage
2-10% topical solution, apply 2× daily.
Timing
Morning and evening skincare routine.
Cycling
Continuous — topical peptides require sustained use.
Storage
Lyophilized 12+ months. Solution 1 month refrigerated.
Cost (vendor)
$40 per kit (10×10mg vials). ~€3.5/vial. Very affordable.
Evidence Grade
C+ — One industry-funded human trial showing 52% wrinkle reduction. No independent replication.
Synergies
Tretinoin (different mechanism). GHK-Cu (complementary skin matrix support).
Warnings
Not meaningful at 18 years. Consider at 30+ when expression lines begin. Skin penetration limitations mean topical DMSO carrier needed.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
3/10
9/10
3/10
9/10
4/10

PINEALON

Intro
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by the same Russian group as Epitalon (Khavinson). It is derived from the pineal gland and claimed to regulate circadian rhythms, protect neurons, and enhance cognitive function. More targeted neurological action than Epitalon.
Mechanism
Claimed: regulates melatonin secretion rhythm. Neuroprotective against oxidative stress. Potentially modulates DNA methylation patterns in neurons. Anti-apoptotic in neuronal cell lines.
Benefits
Potential sleep quality improvement. Neuroprotective effects in animal models. Claimed cognitive enhancement. Better age-appropriateness than Epitalon (circadian regulation relevant at any age).
Negatives
All evidence from single Russian research group (Khavinson) — significant conflict of interest. No independent replication. Human data limited to elderly. Mechanism insufficiently characterized.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
5-10mg course over 10 days.
Timing
Evening for circadian effects.
Cycling
10-day courses 2-3× per year.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$55 per kit (10×5mg vials). ~€5/vial. Moderate.
Evidence Grade
C — Single research group. Elderly-only human data. No independent replication.
Synergies
Melatonin (circadian stack). DSIP.
Warnings
Same single-source evidence issue as Epitalon. Verify independently before use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
6/10
4/10

EPITHALON (EPITALON)

Intro
Synthetic tetrapeptide from the pineal gland. Claimed telomerase activator. All positive human evidence in elderly (60+) cohorts. Mismarketed to younger users — fundamentally age-inappropriate under 35.
Mechanism
Activates telomerase (hTERT) in somatic cells. Regulates melatonin secretion. Antioxidant. Regulates hypothalamic-pituitary axis.
Benefits
Telomere elongation in elderly subjects. Normalizes melatonin in aged individuals. Sleep improvement. Antioxidant effects.
Negatives
NOT APPROPRIATE UNDER 35-40 YEARS. Your telomeres are already near peak length at 18. Long telomeres correlated with MORE tumors (Johns Hopkins research). All-cause mortality data shows abnormally long telomeres are harmful. Single research group with patent conflict of interest.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
5-10mg/day × 10-20 days (elderly protocol).
Timing
Evening.
Cycling
2× per year for elderly users.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$48 per kit (10×10mg vials). ~€4.4/vial. Affordable but irrelevant at <35.
Evidence Grade
C+ — Single research group. Human data in elderly only. No independent replication.
Synergies
Melatonin, Pinealon. NOT for young users.
Warnings
DO NOT USE UNDER 35. No benefit. Theoretical cancer risk from telomere overextension at young age.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
7/10
3/10
7/10
2/10

IPAMORELIN

Intro
Selective GHRH receptor agonist. Cleanest GHRP — no cortisol/prolactin elevation. Best used with CJC-1295 no-DAC for synergistic GH pulse. At 18, natural GH is already at peak — use with caution.
Mechanism
GHSR-1a (ghrelin receptor) agonist → pulsatile GH release from pituitary. Highly selective. No ACTH, cortisol, or prolactin stimulation at standard doses.
Benefits
Clean GH stimulation. Improved deep sleep. Recovery enhancement. Lean mass support. Better tolerated than GHRP-2/6.
Negatives
At 17-18, endogenous GH already at lifetime peak. Marginal additional benefit. Potential GH receptor downregulation. Water retention possible. Not FDA approved.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100mcg = 0.02ml.
Dosage
100-300mcg per injection. 1-3×/day. Most useful pre-bed.
Timing
Pre-bed (maximize natural GH pulse). Can stack with CJC-1295 no-DAC.
Cycling
12-week cycles, 4-6 weeks off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €40-80/month.
Evidence Grade
C+ — Phase II human trials in GH deficiency. Mechanism well-established. Off-label recovery use anecdotal.
Synergies
CJC-1295 no-DAC (synergistic GH pulse). DSIP (sleep enhancement stack).
Warnings
Marginal benefit at 17-18. Wait until 21+ for optimal use case. Never fasted training + ipamorelin (hypoglycemia risk).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
5/10
7/10
5/10

NAD+

Intro
NAD+ precursors (NMN/NR) raise intracellular NAD+ levels. NAD+ declines with age, primarily after 40. Every positive human RCT enrolled middle-aged or elderly subjects. Not indicated at 18.
Mechanism
NAD+ precursors → raise NAD+ pool → sirtuin activation → mitochondrial efficiency. Requires CD38 to be low for optimal effect.
Benefits
Mitochondrial function in elderly. DNA repair enhancement. Sirtuin activation. Muscle function support in aged subjects.
Negatives
NOT RECOMMENDED UNDER 35. NAD+ peaks between 15-30. 2025 meta-analysis: no significant benefit for muscle function in young subjects. Your niacinamide 10% topical already supports local NAD+. Waste of money at your age.
Reconstitution
Oral capsules. Injectable NAD+ also available (listed vendor).
Dosage
250-500mg NMN or NR oral. Or 100-500mg IV/IM injectable.
Timing
Morning.
Reconstitution
No established cycle for oral. Injectable courses sometimes 10 days.
Storage
Keep dry. Heat sensitive.
Cost (vendor)
$40 per kit (10×100mg) to $130 per kit (10×1000mg). Pointless at 18.
Evidence Grade
B- (in elderly), C (in young). All positive RCTs in 40+ populations.
Synergies
5-amino-1MQ (CD38 inhibitor — more relevant mechanism). SS-31. All age 35+.
Warnings
NOT RECOMMENDED UNDER 35. No demonstrated benefit. Use money elsewhere.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
9/10
3/10
5/10
2/10

PEPTIDES NOT RECOMMENDED FOR THIS CONTEXT

Do Not Use — Reasons Explained

Semaglutide / Tirzepatide / Retatrutide / Cagrilintide
If you can't get your body fat down to 10% at least once in your life, what can you actually do?
I use Tirzepatide myself
IGF-1 LR3 (Used it myself)
Highly anabolic IGF-1 analogue. Promotes growth in ALL tissues including potential tumor cells. Open growth plates at 17-18 make this particularly concerning. Hypoglycemia risk. Not appropriate under 21+.
Dermorphin
Opioid peptide — 50x more potent than morphine. Extremely high addiction potential. Not appropriate for any looksmaxxing or performance context. High risk of dependence, respiratory depression, death in overdose.
Adipotide
Experimental peptide targeting ANXA2/PROHIBITIN on fat cell vasculature. Causes kidney toxicity in primate studies. Never cleared for human use. Avoid entirely.
Oxytocin
Half-life 3-5 minutes IV. Intranasal slightly longer. No meaningful persistent anxiolytic effect for social situations. Better alternatives available (Etifoxine, Selank, Pregab).
PT-141 (Bremelanotide)
MC3R/MC4R agonist for sexual dysfunction. More systemic side effects than MT-1. Nausea, blood pressure effects. Not a looksmaxxing compound.

STACKING GUIDE

Recommended Stacks by Goal

Cognitive Peak
Semax (1mg/day IN) + Citicoline (250mg/day oral) + Selank (500mcg situational). Semax → focus/BDNF, Citicoline → ACh, Selank → anxiety control.
Skin & PIE
GHK-Cu (2mg subcut EOD) + Tretinoin (topical) + Azelaic Acid 20% (topical) + Niacinamide 10% (topical). Best-evidenced combination.
Post-Surgery
BPC-157 (500mcg/day) + TB-500 (2mg 2×/week) + GHK-Cu (500mcg/day) + KPV (1mg/day). 8-week protocol.
Healing & Recovery
BPC-157 + TB-500 combo vial (BBG or KLOW80 mix). Most cost-effective option. KLOW80 adds KPV for anti-inflammatory.
Sleep Quality
DSIP (200mcg subcut pre-bed) + Ipamorelin (100mcg pre-bed). Synergistic GH pulse + deep sleep architecture.
Mitochondrial Stack
SS-31 (2mg/day) + MOTS-C (5mg 3×/week). Age 30+ optimal. Limited benefit at 18.
Immune Support
Thymosin Alpha-1 (1mg 2×/week) for 4-6 weeks during illness, intense training periods, or post-surgery.
Anxiolysis (Daily)
Selank (400-600mcg/day, cycled 14/14). No dependence, no sedation. Best daily option.
Anxiolysis (Events)
Etifoxine 50mg → Pregabalin 75-150mg (reserve for important only). Never two GABAergics same day.

CRITICAL INTERACTIONS
READ BEFORE STACKING

ABSOLUTE
NEVER: Selank + Etifoxine + Pregabalin same day. Three GABAergics = CNS depression risk.
ABSOLUTE
NEVER: MT-1 + MT-2 simultaneously. Receptor overlap, unpredictable systemic effects.
AVOID
Ipamorelin/CJC-1295 on fasted training days — hypoglycemia risk.
AVOID
Semax + Modafinil daily — both dopaminergic. Limit to exam days only.
SEPARATE
GHK-Cu and Zinc: pause zinc during GHK-Cu cycle. Competition for transporters.
SEPARATE
MT-1 and GHK-Cu injections: different anatomical sites same evening.
NOTE
BPC-157 / TB-500 / GHK-Cu vendor combo mixes (BBG, KLOW80) can be drawn from same vial — convenient and cost-effective.

RECONSTITUTION QUICK REFERENCE

Standard Dilutions
Semax 40mg 4ml BAC water → 10mg/ml → 1mg dose = 0.1ml
Selank 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
GHK-Cu 2mg 1ml BAC water (or PBS) → 2mg/ml → 2mg = 1ml
GHK-Cu 50mg (bulk) 25ml BAC water → 2mg/ml → 2mg = 1ml
MT-1 10mg 1ml BAC water → 10mg/ml → 500mcg = 0.05ml
BPC-157 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
TB-500 5mg 1ml BAC water → 5mg/ml → 2mg = 0.4ml
Ipamorelin 5mg 1ml BAC water → 5mg/ml → 100mcg = 0.02ml
DSIP 5mg 1ml BAC water → 5mg/ml → 200mcg = 0.04ml
Epitalon 10mg 2ml BAC water → 5mg/ml → 5mg = 1ml
Thymosin Alpha-1 5mg 1ml BAC water → 5mg/ml → 1mg = 0.2ml
KPV 10mg 1ml BAC water → 10mg/ml → 1mg = 0.1ml (or oral)
PBS vs BAC Water Use PBS for copper peptides (GHK-Cu, AHK-Cu) — better copper stability. BAC water for all others.

VENDOR PRICE REFERENCE (Chinese Warehouse)
$60 flat worldwide shipping fee. All prices USD per kit of 10 vials (divide by 10 for single vial price). Prices as of April 2026.

Product Price (USD) per kit (10 vials)
Semax 5mg×10 $40
Semax 10mg×10 $50
Selank 5mg×10 $40
GHK-Cu 50mg×10 $30
GHK-Cu 100mg×10 $45
AHK-Cu 100mg×10 $68
MT-1 10mg×10 $45
MT-2 10mg×10 $45
BPC-157 5mg×10 $40
BPC-157 10mg×10 $70
TB-500 5mg×10 $75
TB-500 10mg×10 $140
BPC+TB 5mg+5mg×10 $95
GHK+BPC+TB 50/10/10mg×10 $160
GHK+BPC+TB+KPV 80mg×10 $195
KPV 10mg×10 $60
Ipamorelin 5mg×10 $45
Ipamorelin 10mg×10 $80
CJC-1295 no-DAC 5mg×10 $85
CJC+Ipa combo 10mg×10 $95
DSIP 5mg×10 $45
DSIP 15mg×10 $85
SS-31 10mg×10 $86
SS-31 50mg×10 $285
MOTS-C 10mg×10 $65
MOTS-C 40mg×10 $185
5-amino-1MQ 5mg×10 $45
5-amino-1MQ 50mg×10 $110
Thymosin Alpha-1 5mg×10 $80
TA-1 10mg×10 $145
Epitalon 10mg×10 $48
Epitalon 50mg×10 $150
Cerebrolysin 60mg×6 $29
Pinealon 5mg×10 $55
Pinealon 10mg×10 $70
Snap-8 10mg×10 $40
NAD+ 100mg×10 $40
NAD+ 500mg×10 $80
NAD+ 1000mg×10 $130
L-Carnitine 600mg/ml 10ml×10 $80
Glutathione 1500mg×10 $80
Melatonin 10mg×10 $55
VIP 5mg×10 $75
SLU-PP-322 5mg×10 $100
AICAR 50mg×10 $62
Tesamorelin 5mg×10 $110
ARA-290 10mg×10 $80
BAC Water 10ml×10 $10
PBS 10ml×10 $10
Acetic Acid Water 10ml×10 $10

PEPTIDES

Melanotan-1 subcutaneously, in the evening.

GHK-Cu 2 mg subcutaneously, in the evening.

Tirzepatide 2,5 mg subcutaneously, every week

@reyalsnoom @Jesus_ist_König @tqbiq @greylord @aaronbp

wow mirin

ltn-- · May 26, 2026

til<3D said:
Complete Guide to Peptide Protocols — Dosing, Evidence & Stacking

by til<3D
Stand: April 2026

DISCLAIMER

Read First
This guide is for educational purposes only. Peptides are not approved drugs in most countries. Everything here is off label and experimental. Do your own research. You are responsible for your own choices. This is not medical advice.
Age Note
Several peptides are specifically marked as inappropriate for users under 18-20 years old due to ongoing hormonal and neural development. These warnings are clearly flagged throughout.
Sources
Evidence grades reflect actual human clinical trial data, animal studies, and in vitro research. Grade A = multiple human RCTs. Grade B = some human data. Grade C = animal/in vitro only.

PEPTIDES COVERED IN THIS THREAD

1. Semax — ACTH(4-7) Analogue — Nootropic

2. Selank — Tuftsin Analogue — Anxiolytic & Cognitive

3. GHK-Cu — Copper Peptide — Skin & Collagen

4. AHK-Cu — Copper Peptide — Hair Growth

5. Melanotan-1 (MT-1) — MC1R Agonist — Tanning

6. BPC-157 — Body Protection Compound — Healing

7. TB-500 — Thymosin Beta-4 — Recovery & Flexibility

8. DSIP — Delta Sleep-Inducing Peptide — Sleep Architecture

9. SS-31 (Elamipretide) — Mitochondria-Targeting Peptide — Energy & Cardioprotection

10. MOTS-C — Mitochondrial-Derived Peptide — Metabolic

11. 5-amino-1MQ — CD38 Inhibitor — NAD+ Preservation

12. Thymosin Alpha-1 — Immune Modulator — Immune Enhancement

13. KPV — Anti-Inflammatory Tripeptide — Gut & Skin

14. Cerebrolysin — Neuropeptide Mix — Cognitive & Neuroprotection

15. Snap-8 — Neuropeptide — Anti-Wrinkle Topical

16. Pinealon — Pineal Peptide — Neuroprotection & Circadian

17. Epithalon (Epitalon) — Tetrapeptide — Telomere (Age 40+ Only)

18. Ipamorelin — GHRP — GH Secretagogue (Age 20+ Optimal)

19. NAD+ — NAD+ Precursors — Mitochondrial (Age 35+ Only)

QUICK REFERENCE — ALL PEPTIDES

Peptide Effectiveness Evidence Age 17-18 Cost/mo Overall
Semax 8/10 B+ ✓ OK €20–35/vial (40mg) 8/10
Selank 8/10 B ✓ OK €25–40/vial (5mg) 7/10
GHK-Cu 7/10 B- ✓ OK €30/vial (50mg bulk) — much better value 7/10
AHK-Cu 6/10 C+ ✓ OK $68/100mg vial (vendor) 6/10
Melanotan-1 (MT-1) 9/10 A- ✓ OK $45/10mg vial × 10 8/10
BPC-157 7/10 C+ ✓ OK $40/5mg vial × 10 6/10
TB-500 7/10 C+ ✓ OK $75/5mg vial × 10 6/10
DSIP 6/10 C+ ✓ OK $45/5mg vial × 10 5/10
SS-31 (Elamipretide) 6/10 B- ✓ OK $86/10mg vial × 10 5/10
MOTS-C 6/10 C+ ✓ OK $65/10mg vial × 10 5/10
5-amino-1MQ 4/10 C ✓ OK $45/5mg vial or $110/50mg 3/10
Thymosin Alpha-1 7/10 B ✓ OK $80/5mg vial × 10 6/10
KPV 6/10 C+ ✓ OK $60/10mg vial × 10 6/10
Cerebrolysin 7/10 B- ✓ OK $29/60mg × 6 vials (vendor) 6/10
Snap-8 3/10 C+ ✓ OK $40/10mg vial × 10 (vendor) 4/10
Pinealon 4/10 C ✓ OK $55/5mg vial × 10 4/10
Epithalon (Epitalon) 2/10 C+ ✗ Caution $48/10mg × 10 (vendor) 2/10
Ipamorelin 6/10 C+ ✗ Caution $45/5mg vial × 10 5/10
NAD+ 2/10 B- ✗ Caution $40-130 depending on dose 2/10

INDIVIDUAL PEPTIDE PROFILES

SEMAX

Intro
Synthetic heptapeptide analogue of ACTH(4-7), developed in Russia for stroke and cognitive enhancement. Decades of clinical data. Crosses BBB efficiently intranasally. You could also do subq but in my opinion it's unnecessary.
Mechanism
Upregulates BDNF. Modulates dopaminergic/serotonergic transmission. Increases enkephalinase activity. NO signalling enhancement.
Benefits
Enhanced focus, memory, learning. Neuroprotection. Anti anxiety via serotonin. Rapid onset 15-30 min. No physical dependence.
Negatives
Receptor desensitization — cycling required. Mild anxiety at high doses. Most studies Russian literature.
Reconstitution
4ml BAC water on 40mg vial = 10mg/ml. 1mg = 0.1ml = 1 pump.
Dosage
0.5–1mg/day intranasal.
Timing
Morning, fasted or first meal.
Cycling
5 days ON / 2 OFF. Or 3 weeks ON / 1 week OFF.

Storage
Lyophilized 12+ months. Reconstituted 4°C, 4 weeks.
Cost (vendor)
$50/100mg vial (vendor).
Evidence Grade
B+ — Russian Phase II/III trials. Growing Western replication.
Synergies
Citicoline, Selank. Never combine with high dose Modafinil same day.
Warnings
Monitor with Modafinil stack. Avoid MAOIs.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
9/10
7/10
8/10
8/10

SELANK

Intro
Synthetic analogue of tuftsin. Official anxiolytic drug status in Russia/Ukraine. Anxiolysis without sedation, tolerance, or withdrawal.
Mechanism
Allosteric GABA-A modulation. Inhibits enkephalinase. Modulates BDNF/NGF. Complements Semax via distinct brain connectivity patterns.
Benefits
Anxiolysis without sedation or dependence. Cognitive enhancement. Anti inflammatory. No BtMG. Low desensitization risk at standard doses.
Negatives
Most evidence Russian studies. Additive CNS depression with other GABAergics — critical interaction. Short half-life ~2h intranasal.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
250–800mcg/day intranasal.
Timing
Morning or 30-60 min before stressful situations.
Cycling
14 days ON / 14 days OFF, or situational.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/100mg vial (vendor). Very cost effective per mg.
Evidence Grade
B — Russian Phase II clinical trials in GAD.
Synergies
Semax (complementary). NEVER with Etifoxine, Pregabalin, or alcohol same day.
Warnings
NEVER combine with Etifoxine, Pregabalin, or benzodiazepines same day. Additive CNS depression.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
8/10
8/10
6/10
8/10
7/10

GHK-CU

Intro
Naturally occurring copper-binding peptide. Plasma levels decline with age. Gold standard for skin regeneration and wound healing.
Mechanism
Activates fibroblasts → collagen I/III/elastin synthesis. VEGF-driven angiogenesis. Inhibits TGF-β1 (anti-fibrotic). Antioxidant enzyme upregulation.
Benefits
PIE/acne scar remodeling. Skin density improvement. Wound/post-surgery healing. Tendon collagen support. Anti-inflammatory.
Negatives
Systemic human RCT data limited. Competing with zinc pause zinc during use. Monitor copper levels with chronic use.
Reconstitution
1ml BAC water on 2mg vial = 2mg/ml. 27-29G needle, 4-6mm, 45°. PBS preferred for copper stability.
Dosage
2mg subcut EOD/ ED.
Timing
Evening after training. Separate site from MT-1.
Cycling
4-week cycles. Zinc paused. After cycle reintroduce zinc.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$50/1g vial (vendor). Very cost effective per mg.
Evidence Grade
B- — Strong in-vitro/animal. Limited human RCTs for subcut use. Topical human evidence solid.
Synergies
Tretinoin (complementary collagen). Copper supplement 30-60 min before injection.
Warnings
Pause zinc during cycle. Monitor serum copper/ceruloplasmin with extended use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
5/10
10/10
8/10

AHK-CU

Intro
Tripeptide analogue of GHK-Cu with higher affinity for hair follicle receptors. AHK (Ala-His-Lys) specifically promotes hair growth via follicle dermal papilla stimulation.
Mechanism
Activates Wnt/β-catenin pathway in hair follicles. Promotes dermal papilla cell proliferation. Upregulates VEGF in follicle microvasculature. Inhibits DHT-induced apoptosis in follicles.
Benefits
Hair density and thickness improvement. Potentially superior to GHK-Cu for scalp/follicle applications. Can be used topically or subcut. Anti-inflammatory in follicle microenvironment.
Negatives
Less research than GHK-Cu overall. Mostly in-vitro data. Higher cost per mg. Limited human studies specifically.
Reconstitution
1ml BAC water per 10mg = 10mg/ml. Can be used topically (DMSO carrier) or subcut.
Dosage
Topical: 0.01-0.1% solution on scalp. Subcut: 1-2mg/day.
Timing
Evening or post-shower for topical.
Cycling
Continuous or 8-week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$68/1g vial (vendor). Very cost effective per mg.
Evidence Grade
C+ — In-vitro strong. Limited human data. Mechanistically plausible.
Synergies
GHK-Cu (different receptor affinity — complementary). Minoxidil topical.
Warnings
Avoid mixing with acidic solutions. PBS preferred diluent.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
9,5/10
8/10

MELANOTAN-1 (MT-1)

Intro
Synthetic α-MSH analogue with MC1R selectivity. Only melanocortin peptide with EMA approval (Scenesse for EPP). Deep even tan with reduced UV exposure.
Mechanism
MC1R agonism → tyrosinase upregulation → eumelanin synthesis. UV activation required to convert precursors to visible pigment.
Benefits
Deep even tan. Photoprotection. Visually reduces PIE by contrast. EMA-approved safety data. Lower systemic effects vs MT-2.
Negatives
Nausea during loading (reduced by microdosing). Mole changes — document before starting. UV >3 required for activation. MC4R spillover at high doses.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 500mcg = 0.05ml.
Dosage
Loading: 500mcg/day × 14 days. Maintenance: 250-500mcg E2-3D + UV.
Timing
Evening — sleep through initial nausea.

Cycling
Loading → Maintenance. No continuous loading.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3-4 weeks.
Cost (vendor)
$4,5/10mg vial × 10. ~€2-3,5/month maintenance.
Evidence Grade
A- — EMA approved. Phase III trials. Extensive safety data.
Synergies
UV exposure (essential). Tretinoin. Solarium if UV index <3.
Warnings
Photograph all moles before starting. Never combine with MT-2.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
9/10
7/10
8/10
9/10
8,5/10

BPC-157

Intro
Synthetic pentadecapeptide from gastric juice. Remarkable healing in animal models across tendons, ligaments, muscles, GI tract. Most promising for injury recovery and post-surgical healing.
Mechanism
Upregulates GH receptor. VEGF angiogenesis. FAK-paxillin wound healing pathway. NF-κB inhibition. Collagen synthesis in tenocytes.
Benefits
Tendon/ligament healing acceleration. GI mucosal protection. Nerve regeneration (animal). Anti-inflammatory. Enhanced training recovery.
Negatives
Virtually ALL data is animal/in-vitro. Zero completed human RCTs. Unknown optimal human dosing. Unknown long-term safety.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 250mcg = 0.05ml.
Dosage
200-500mcg/day subcut or IM. Split morning + evening.
Timing
Morning and/or post-training.
Cycling
4-8 weeks on, 4 off. Or acute injury protocol.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$40 per kit (10×5mg vials). ~€3.5/vial. €40-70/month.
Evidence Grade
C+ — Extensive animal data, consistent results. Zero human RCTs. High translation uncertainty.
Synergies
TB-500 (complementary). GHK-Cu (collagen synergy).
Warnings
Theoretical angiogenesis concern with cancer history (unproven in humans). No known drug interactions.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
8/10
4/10
7/10
6/10

TB-500

Intro
Synthetic fragment of thymosin beta-4. Critical role in cell migration, wound healing, tissue regeneration. Systemic healing reach that BPC-157 lacks.
Mechanism
Binds G-actin → cell migration/differentiation. Integrin-linked kinase activation. Metalloproteinase upregulation for tissue remodeling. Vascular tube formation.
Benefits
Systemic healing (reaches distant injury sites). Muscle fiber regeneration. Flexibility/ROM improvements. Potential cardiac protection.
Negatives
Human RCT data absent for recovery use. Higher MW limits oral bioavailability. More expensive than BPC-157. Overlap with BPC-157.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
Loading: 2-2.5mg 2×/week × 4-6 weeks. Maintenance: 2-2.5mg 1×/week.
Timing
Morning or post-training.
Cycling
6-week loading, then maintenance or off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$75 per kit (10×5mg vials). ~€7/vial. €50-90/month.
Evidence Grade
C+ — Animal data solid. Phase II trial in dry eye disease. Limited systemic recovery data in humans.
Synergies
BPC-157 (most common stack). Post-surgery recovery protocol.
Warnings
Same theoretical angiogenesis concern as BPC-157 with cancer history.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
4/10
6/10
6/10

DSIP

Intro
DSIP is a neuropeptide that modulates sleep architecture by promoting delta-wave (slow-wave) sleep. It was isolated from rabbit thalamic venous blood in 1977. Unlike benzodiazepines, it doesn't cause sedation — it shifts the sleep profile toward restorative deep sleep.
Mechanism
Modulates GABA-B receptors. Reduces nocturnal cortisol. Increases GH secretion during sleep. Normalizes circadian rhythm via hypothalamic-pituitary axis modulation. Antioxidant effects.
Benefits
Improved deep sleep quality (not just duration). GH pulse enhancement during sleep. Reduced cortisol during sleep. Potential nootropic effects via improved sleep. Non-sedating — no morning grogginess.
Negatives
Short plasma half-life (~30 min) — may require specific timing. Most data from 1980s-90s Russian studies. Limited modern replication. Expensive per mg.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100-300mcg = 0.02-0.06ml.
Dosage
100-300mcg subcut 30-60 min before sleep.
Timing
30-60 minutes before bedtime.
Cycling
5-7 day cycles. Short-term use most studied.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €30-60/month.
Evidence Grade
C+ — Russian human trials 1980s. Mechanism plausible. Limited modern replication.
Synergies
Melatonin (circadian complementary). Ipamorelin (synergistic GH pulse during sleep).
Warnings
No known serious interactions. Avoid combining with benzodiazepines (additive sleep effects).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

SS-31 (ELAMIPRETIDE)

Intro
SS-31 (Szeto-Schiller peptide 31) is a tetrapeptide that concentrates in the inner mitochondrial membrane, stabilizing cardiolipin. It is arguably the most promising mitochondria-targeting molecule currently studied, with active Phase II/III trials for Barth syndrome, heart failure, and age-related muscle loss.
Mechanism
Binds cardiolipin in inner mitochondrial membrane → stabilizes electron transport chain structure. Reduces mitochondrial ROS production. Maintains cristae morphology. Improves ATP synthesis efficiency.
Benefits
Mitochondrial function restoration. Reduced oxidative stress. Improved energy efficiency (not stimulant-based). Potential muscle function improvement. Active pharmaceutical development — human safety data exists.
Negatives
Expensive per mg. Mostly disease-state human trials — healthy young male data absent. Injectable only (high MW). Long-term use unknown.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
1-5mg/day subcut. Clinical trials used 0.05-0.25 mg/kg IV.
Timing
Morning.
Cycling
4-12 week cycles. Research ongoing.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$86 per kit (10×10mg vials). ~€8/vial. Expensive but unique mechanism.
Evidence Grade
B- — Phase II human trials in disease states. Mechanism very well characterized. Healthy young use extrapolated.
Synergies
NAD+ precursors (complementary mitochondrial support). MOTS-C.
Warnings
No known serious interactions. Not indicated in healthy young without mitochondrial disease.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
6/10
5/10
5/10
5/10

MOTS-C

Intro
MOTS-C is a peptide encoded in the mitochondrial genome — one of the first mitochondria-derived peptides discovered. It acts as a metabolic regulator, improving insulin sensitivity and exercise capacity. Endogenous levels decline with age and are increased by exercise.
Mechanism
Activates AMPK. Inhibits AICAR (purine synthesis) → folate cycle disruption → metabolic reprogramming. Improves glucose uptake independent of insulin. Regulates ROS homeostasis in mitochondria.
Benefits
Improved insulin sensitivity. Enhanced exercise capacity and metabolic efficiency. Anti-obesity effects. Potential longevity effects. Exercise-mimicking properties.
Negatives
Most data animal studies. Human trial data limited to one small RCT. Age-related benefit unclear in young healthy subjects (endogenous levels already high at 18). Expensive.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. 2-5mg per injection.
Dosage
5-10mg subcut 2-3×/week.
Timing
Morning or pre-workout.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2-3 weeks.
Cost (vendor)
$65 per kit (10×10mg vials). ~€6/vial. Moderate.
Evidence Grade
C+ — Strong animal data. One small human RCT (n=40). Mechanism well-established.
Synergies
SS-31 (mitochondrial stack). Exercise potentiation.
Warnings
No known serious interactions. Limited human safety data.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
4/10
6/10
5/10

5-AMINO-1MQ

Intro
5-amino-1-methylquinolinium (5-amino-1MQ) is a small molecule that inhibits CD38, the primary NAD+-degrading enzyme in the body. Unlike taking NAD+ precursors (NMN/NR), which add more NAD+ substrate, 5-amino-1MQ prevents NAD+ from being broken down — potentially more efficient.
Mechanism
Inhibits CD38 (NAD+ glycohydrolase) → NAD+ levels rise. CD38 activity increases dramatically with age and inflammation. Preserves endogenous NAD+ pool without external supplementation.
Benefits
NAD+ preservation. Potential fat loss effects (adipocyte CD38 inhibition). Anti-inflammatory. More targeted mechanism than NMN/NR for NAD+ elevation.
Negatives
Very limited human data. Research peptide status. Long-term safety unknown. Age-appropriateness at 18 unestablished (same issue as NAD+ precursors — you don't need this yet).
Reconstitution
Oral or injectable. 5mg vial with 1ml BAC water = 5mg/ml.
Dosage
5-50mg oral or 1-5mg subcut.
Timing
Morning.
Cycling
4-8 week cycles.
Storage
Lyophilized 12+ months.
Cost (vendor)
$45 per kit (10×5mg) or $110 per kit (10×50mg). ~€4-10/vial.
Evidence Grade
C — Animal data only. No human RCTs. Mechanism well-established biochemically.
Synergies
SS-31, MOTS-C (mitochondrial stack). More relevant at 35+ years.
Warnings
Not recommended under 35. No established benefit in young healthy subjects.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
7/10
3/10

THYMOSIN ALPHA-1

Intro
Thymosin Alpha-1 (Tα1) is an endogenous peptide originally isolated from thymic tissue. It is FDA-approved in 35+ countries for chronic hepatitis B and C, and used as an immune adjuvant in cancer treatment. Strong immunomodulatory and antiviral properties.
Mechanism
Enhances T-cell, NK cell, and dendritic cell function. Upregulates IL-2, IFN-γ. Activates Toll-like receptors. Promotes antigen presentation. Anti-inflammatory via IL-10 pathway.
Benefits
Immune system enhancement and normalization. Antiviral effects. Used clinically for immunocompromised patients. Strong safety data from approved medical use. Potential benefit post-illness or during intense training phases.
Negatives
Healthy young with normal immune function may see minimal benefit. Expensive. Primary benefit for immunocompromised or sick individuals. Mild injection site reactions.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
1-2mg subcut 2×/week. Clinical dose: 1mg/m² body surface area.
Timing
Any time — immune timing less critical.
Cycling
2-6 week cycles. Or as needed during illness.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$80 per kit (10×5mg vials). ~€7/vial. Moderate.
Evidence Grade
B — Approved in multiple countries for specific indications. Good human safety data. Healthy young use extrapolated.
Synergies
BPC-157 (immune + healing stack during recovery). Useful post-surgery.
Warnings
No significant drug interactions at standard doses. Avoid in autoimmune conditions without medical supervision.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
7/10
6/10
6/10
6/10

KPV

Intro
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of α-MSH. It retains the anti-inflammatory properties of the parent molecule without melanocortin receptor agonism. Being 3 amino acids, it has superior bioavailability and can even be taken orally for GI effects.
Mechanism
Inhibits NF-κB signalling. Reduces TNF-α, IL-1β, IL-6 production. Activates MC1R and MC3R locally (anti-inflammatory, not pigmentation). Promotes intestinal epithelial healing.
Benefits
Potent anti-inflammatory for gut, skin, and systemic use. Oral bioavailability for GI-specific effects. No melanocortin pigmentation effects. Excellent safety profile. Can be combined with BPC-157 for enhanced GI healing.
Negatives
Limited human clinical trial data. Research peptide status. Very short half-life requires frequent dosing or oral route.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml. Can be taken orally (encapsulate or dissolve in water).
Dosage
500mcg–2mg subcut or 1-5mg oral per day.
Timing
Any time. Oral pre-meals for GI effects.
Cycling
Continuous low-dose or acute 4-week protocols.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$60 per kit (10×10mg vials). ~€5.5/vial. Reasonable.
Evidence Grade
C+ — Strong in-vitro/animal. Human data emerging. Mechanism very well characterized.
Synergies
BPC-157 (GI healing stack). Part of BBG or KLOW80 recovery mix.
Warnings
No known serious interactions. Excellent tolerability profile.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
8/10
4/10
7/10
6/10

CEREBROLYSIN

Intro
Cerebrolysin is a complex mixture of low-molecular-weight peptides derived from porcine brain tissue. It contains BDNF, NGF, CNTF, and other neurotrophins. Used clinically in Eastern Europe and Asia for stroke, traumatic brain injury, and Alzheimer's disease.
Mechanism
Provides exogenous BDNF, NGF, and other neurotrophins directly. Promotes neurogenesis and synaptic plasticity. Neuroprotective against excitotoxicity. Anti-apoptotic in neurons.
Benefits
Direct neurotrophin supplementation (vs Semax which stimulates endogenous production). Established clinical use in stroke recovery. May enhance cognitive recovery after stress or illness. Fast-acting neuroplasticity support.
Negatives
Derived from porcine brain — quality control important. Injectable only (IV preferred clinically, IM used in biohacking). Religious/dietary restrictions for some. Most trials in neurological disease, not healthy subjects. Quality varies by vendor significantly.
Reconstitution
Ready solution typically. Check vendor — should be aqueous solution, not lyophilized.
Dosage
1-5ml IM/subcut. Clinical: 10-30ml IV/day. For cognitive use: 1-2ml IM daily.
Timing
Morning.
Cycling
10-30 day cycles. 2-3× per year.
Storage
Refrigerate 2-8°C. Do not freeze.
Cost (vendor)
$29 per kit (6×60mg vials). ~€4.5/vial. Budget-friendly.
Evidence Grade
B- — Multiple RCTs in stroke/TBI (positive). Healthy cognitive enhancement — limited data.
Synergies
Semax (BDNF endogenous + exogenous). Citicoline.
Warnings
Ensure vendor quality — biological product contamination risk. Do not use if porcine-derived products contraindicated.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
7/10
6/10
5/10
8/10
6/10

SNAP-8

Intro
Snap-8 (Acetyl Octapeptide-3) is a synthetic octapeptide that mimics the N-terminal portion of SNAP-25. It competes with the SNARE complex, reducing neurotransmitter release at neuromuscular junctions in facial skin. Often called 'topical Botox' in cosmetic science.
Mechanism
Inhibits SNARE complex formation → reduced acetylcholine release at local neuromuscular junctions → reduced muscle contraction intensity in expression lines → smoother appearance over time.
Benefits
Reduces expression-related fine lines without injection. Can be added to moisturizer or serum. No systemic effects. Safe topical profile.
Negatives
Penetration through skin is very limited for large peptides. Most human evidence industry-funded. Effects subtle vs Botox. Not relevant at 18 — no expression lines yet.
Reconstitution
Typically used as topical — dissolve in DMSO or serum base for penetration.
Dosage
2-10% topical solution, apply 2× daily.
Timing
Morning and evening skincare routine.
Cycling
Continuous — topical peptides require sustained use.
Storage
Lyophilized 12+ months. Solution 1 month refrigerated.
Cost (vendor)
$40 per kit (10×10mg vials). ~€3.5/vial. Very affordable.
Evidence Grade
C+ — One industry-funded human trial showing 52% wrinkle reduction. No independent replication.
Synergies
Tretinoin (different mechanism). GHK-Cu (complementary skin matrix support).
Warnings
Not meaningful at 18 years. Consider at 30+ when expression lines begin. Skin penetration limitations mean topical DMSO carrier needed.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
3/10
9/10
3/10
9/10
4/10

PINEALON

Intro
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by the same Russian group as Epitalon (Khavinson). It is derived from the pineal gland and claimed to regulate circadian rhythms, protect neurons, and enhance cognitive function. More targeted neurological action than Epitalon.
Mechanism
Claimed: regulates melatonin secretion rhythm. Neuroprotective against oxidative stress. Potentially modulates DNA methylation patterns in neurons. Anti-apoptotic in neuronal cell lines.
Benefits
Potential sleep quality improvement. Neuroprotective effects in animal models. Claimed cognitive enhancement. Better age-appropriateness than Epitalon (circadian regulation relevant at any age).
Negatives
All evidence from single Russian research group (Khavinson) — significant conflict of interest. No independent replication. Human data limited to elderly. Mechanism insufficiently characterized.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml.
Dosage
5-10mg course over 10 days.
Timing
Evening for circadian effects.
Cycling
10-day courses 2-3× per year.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$55 per kit (10×5mg vials). ~€5/vial. Moderate.
Evidence Grade
C — Single research group. Elderly-only human data. No independent replication.
Synergies
Melatonin (circadian stack). DSIP.
Warnings
Same single-source evidence issue as Epitalon. Verify independently before use.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
4/10
7/10
3/10
6/10
4/10

EPITHALON (EPITALON)

Intro
Synthetic tetrapeptide from the pineal gland. Claimed telomerase activator. All positive human evidence in elderly (60+) cohorts. Mismarketed to younger users — fundamentally age-inappropriate under 35.
Mechanism
Activates telomerase (hTERT) in somatic cells. Regulates melatonin secretion. Antioxidant. Regulates hypothalamic-pituitary axis.
Benefits
Telomere elongation in elderly subjects. Normalizes melatonin in aged individuals. Sleep improvement. Antioxidant effects.
Negatives
NOT APPROPRIATE UNDER 35-40 YEARS. Your telomeres are already near peak length at 18. Long telomeres correlated with MORE tumors (Johns Hopkins research). All-cause mortality data shows abnormally long telomeres are harmful. Single research group with patent conflict of interest.
Reconstitution
1ml BAC water on 10mg vial = 10mg/ml.
Dosage
5-10mg/day × 10-20 days (elderly protocol).
Timing
Evening.
Cycling
2× per year for elderly users.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 2 weeks.
Cost (vendor)
$48 per kit (10×10mg vials). ~€4.4/vial. Affordable but irrelevant at <35.
Evidence Grade
C+ — Single research group. Human data in elderly only. No independent replication.
Synergies
Melatonin, Pinealon. NOT for young users.
Warnings
DO NOT USE UNDER 35. No benefit. Theoretical cancer risk from telomere overextension at young age.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
7/10
3/10
7/10
2/10

IPAMORELIN

Intro
Selective GHRH receptor agonist. Cleanest GHRP — no cortisol/prolactin elevation. Best used with CJC-1295 no-DAC for synergistic GH pulse. At 18, natural GH is already at peak — use with caution.
Mechanism
GHSR-1a (ghrelin receptor) agonist → pulsatile GH release from pituitary. Highly selective. No ACTH, cortisol, or prolactin stimulation at standard doses.
Benefits
Clean GH stimulation. Improved deep sleep. Recovery enhancement. Lean mass support. Better tolerated than GHRP-2/6.
Negatives
At 17-18, endogenous GH already at lifetime peak. Marginal additional benefit. Potential GH receptor downregulation. Water retention possible. Not FDA approved.
Reconstitution
1ml BAC water on 5mg vial = 5mg/ml. 100mcg = 0.02ml.
Dosage
100-300mcg per injection. 1-3×/day. Most useful pre-bed.
Timing
Pre-bed (maximize natural GH pulse). Can stack with CJC-1295 no-DAC.
Cycling
12-week cycles, 4-6 weeks off.
Storage
Lyophilized 12+ months. Reconstituted 4°C, 3 weeks.
Cost (vendor)
$45 per kit (10×5mg vials). ~€4/vial. €40-80/month.
Evidence Grade
C+ — Phase II human trials in GH deficiency. Mechanism well-established. Off-label recovery use anecdotal.
Synergies
CJC-1295 no-DAC (synergistic GH pulse). DSIP (sleep enhancement stack).
Warnings
Marginal benefit at 17-18. Wait until 21+ for optimal use case. Never fasted training + ipamorelin (hypoglycemia risk).

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
6/10
7/10
5/10
7/10
5/10

NAD+

Intro
NAD+ precursors (NMN/NR) raise intracellular NAD+ levels. NAD+ declines with age, primarily after 40. Every positive human RCT enrolled middle-aged or elderly subjects. Not indicated at 18.
Mechanism
NAD+ precursors → raise NAD+ pool → sirtuin activation → mitochondrial efficiency. Requires CD38 to be low for optimal effect.
Benefits
Mitochondrial function in elderly. DNA repair enhancement. Sirtuin activation. Muscle function support in aged subjects.
Negatives
NOT RECOMMENDED UNDER 35. NAD+ peaks between 15-30. 2025 meta-analysis: no significant benefit for muscle function in young subjects. Your niacinamide 10% topical already supports local NAD+. Waste of money at your age.
Reconstitution
Oral capsules. Injectable NAD+ also available (listed vendor).
Dosage
250-500mg NMN or NR oral. Or 100-500mg IV/IM injectable.
Timing
Morning.
Reconstitution
No established cycle for oral. Injectable courses sometimes 10 days.
Storage
Keep dry. Heat sensitive.
Cost (vendor)
$40 per kit (10×100mg) to $130 per kit (10×1000mg). Pointless at 18.
Evidence Grade
B- (in elderly), C (in young). All positive RCTs in 40+ populations.
Synergies
5-amino-1MQ (CD38 inhibitor — more relevant mechanism). SS-31. All age 35+.
Warnings
NOT RECOMMENDED UNDER 35. No demonstrated benefit. Use money elsewhere.

Ratings:

Effectiveness
Ease
Evidence
Cost
Overall
2/10
9/10
3/10
5/10
2/10

PEPTIDES NOT RECOMMENDED FOR THIS CONTEXT

Do Not Use — Reasons Explained

Semaglutide / Tirzepatide / Retatrutide / Cagrilintide
If you can't get your body fat down to 10% at least once in your life, what can you actually do?
I use Tirzepatide myself
IGF-1 LR3 (Used it myself)
Highly anabolic IGF-1 analogue. Promotes growth in ALL tissues including potential tumor cells. Open growth plates at 17-18 make this particularly concerning. Hypoglycemia risk. Not appropriate under 21+.
Dermorphin
Opioid peptide — 50x more potent than morphine. Extremely high addiction potential. Not appropriate for any looksmaxxing or performance context. High risk of dependence, respiratory depression, death in overdose.
Adipotide
Experimental peptide targeting ANXA2/PROHIBITIN on fat cell vasculature. Causes kidney toxicity in primate studies. Never cleared for human use. Avoid entirely.
Oxytocin
Half-life 3-5 minutes IV. Intranasal slightly longer. No meaningful persistent anxiolytic effect for social situations. Better alternatives available (Etifoxine, Selank, Pregab).
PT-141 (Bremelanotide)
MC3R/MC4R agonist for sexual dysfunction. More systemic side effects than MT-1. Nausea, blood pressure effects. Not a looksmaxxing compound.

STACKING GUIDE

Recommended Stacks by Goal

Cognitive Peak
Semax (1mg/day IN) + Citicoline (250mg/day oral) + Selank (500mcg situational). Semax → focus/BDNF, Citicoline → ACh, Selank → anxiety control.
Skin & PIE
GHK-Cu (2mg subcut EOD) + Tretinoin (topical) + Azelaic Acid 20% (topical) + Niacinamide 10% (topical). Best-evidenced combination.
Post-Surgery
BPC-157 (500mcg/day) + TB-500 (2mg 2×/week) + GHK-Cu (500mcg/day) + KPV (1mg/day). 8-week protocol.
Healing & Recovery
BPC-157 + TB-500 combo vial (BBG or KLOW80 mix). Most cost-effective option. KLOW80 adds KPV for anti-inflammatory.
Sleep Quality
DSIP (200mcg subcut pre-bed) + Ipamorelin (100mcg pre-bed). Synergistic GH pulse + deep sleep architecture.
Mitochondrial Stack
SS-31 (2mg/day) + MOTS-C (5mg 3×/week). Age 30+ optimal. Limited benefit at 18.
Immune Support
Thymosin Alpha-1 (1mg 2×/week) for 4-6 weeks during illness, intense training periods, or post-surgery.
Anxiolysis (Daily)
Selank (400-600mcg/day, cycled 14/14). No dependence, no sedation. Best daily option.
Anxiolysis (Events)
Etifoxine 50mg → Pregabalin 75-150mg (reserve for important only). Never two GABAergics same day.

CRITICAL INTERACTIONS
READ BEFORE STACKING

ABSOLUTE
NEVER: Selank + Etifoxine + Pregabalin same day. Three GABAergics = CNS depression risk.
ABSOLUTE
NEVER: MT-1 + MT-2 simultaneously. Receptor overlap, unpredictable systemic effects.
AVOID
Ipamorelin/CJC-1295 on fasted training days — hypoglycemia risk.
AVOID
Semax + Modafinil daily — both dopaminergic. Limit to exam days only.
SEPARATE
GHK-Cu and Zinc: pause zinc during GHK-Cu cycle. Competition for transporters.
SEPARATE
MT-1 and GHK-Cu injections: different anatomical sites same evening.
NOTE
BPC-157 / TB-500 / GHK-Cu vendor combo mixes (BBG, KLOW80) can be drawn from same vial — convenient and cost-effective.

RECONSTITUTION QUICK REFERENCE

Standard Dilutions
Semax 40mg 4ml BAC water → 10mg/ml → 1mg dose = 0.1ml
Selank 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
GHK-Cu 2mg 1ml BAC water (or PBS) → 2mg/ml → 2mg = 1ml
GHK-Cu 50mg (bulk) 25ml BAC water → 2mg/ml → 2mg = 1ml
MT-1 10mg 1ml BAC water → 10mg/ml → 500mcg = 0.05ml
BPC-157 5mg 1ml BAC water → 5mg/ml → 250mcg = 0.05ml
TB-500 5mg 1ml BAC water → 5mg/ml → 2mg = 0.4ml
Ipamorelin 5mg 1ml BAC water → 5mg/ml → 100mcg = 0.02ml
DSIP 5mg 1ml BAC water → 5mg/ml → 200mcg = 0.04ml
Epitalon 10mg 2ml BAC water → 5mg/ml → 5mg = 1ml
Thymosin Alpha-1 5mg 1ml BAC water → 5mg/ml → 1mg = 0.2ml
KPV 10mg 1ml BAC water → 10mg/ml → 1mg = 0.1ml (or oral)
PBS vs BAC Water Use PBS for copper peptides (GHK-Cu, AHK-Cu) — better copper stability. BAC water for all others.

VENDOR PRICE REFERENCE (Chinese Warehouse)
$60 flat worldwide shipping fee. All prices USD per kit of 10 vials (divide by 10 for single vial price). Prices as of April 2026.

Product Price (USD) per kit (10 vials)
Semax 5mg×10 $40
Semax 10mg×10 $50
Selank 5mg×10 $40
GHK-Cu 50mg×10 $30
GHK-Cu 100mg×10 $45
AHK-Cu 100mg×10 $68
MT-1 10mg×10 $45
MT-2 10mg×10 $45
BPC-157 5mg×10 $40
BPC-157 10mg×10 $70
TB-500 5mg×10 $75
TB-500 10mg×10 $140
BPC+TB 5mg+5mg×10 $95
GHK+BPC+TB 50/10/10mg×10 $160
GHK+BPC+TB+KPV 80mg×10 $195
KPV 10mg×10 $60
Ipamorelin 5mg×10 $45
Ipamorelin 10mg×10 $80
CJC-1295 no-DAC 5mg×10 $85
CJC+Ipa combo 10mg×10 $95
DSIP 5mg×10 $45
DSIP 15mg×10 $85
SS-31 10mg×10 $86
SS-31 50mg×10 $285
MOTS-C 10mg×10 $65
MOTS-C 40mg×10 $185
5-amino-1MQ 5mg×10 $45
5-amino-1MQ 50mg×10 $110
Thymosin Alpha-1 5mg×10 $80
TA-1 10mg×10 $145
Epitalon 10mg×10 $48
Epitalon 50mg×10 $150
Cerebrolysin 60mg×6 $29
Pinealon 5mg×10 $55
Pinealon 10mg×10 $70
Snap-8 10mg×10 $40
NAD+ 100mg×10 $40
NAD+ 500mg×10 $80
NAD+ 1000mg×10 $130
L-Carnitine 600mg/ml 10ml×10 $80
Glutathione 1500mg×10 $80
Melatonin 10mg×10 $55
VIP 5mg×10 $75
SLU-PP-322 5mg×10 $100
AICAR 50mg×10 $62
Tesamorelin 5mg×10 $110
ARA-290 10mg×10 $80
BAC Water 10ml×10 $10
PBS 10ml×10 $10
Acetic Acid Water 10ml×10 $10

PEPTIDES

Melanotan-1 subcutaneously, in the evening.

GHK-Cu 2 mg subcutaneously, in the evening.

Tirzepatide 2,5 mg subcutaneously, every week

@reyalsnoom @Jesus_ist_König @tqbiq @greylord @aaronbp

I honestly like what I’ve heard on follistatin. What is your idea on it though?

stigmaboy · May 27, 2026

@aaronbp

aaronbp · May 27, 2026

stigmaboy said:
@aaronbp

What?

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