![Tsunayoshi Sawada](/data/avatars/l/4/4465.jpg?1577225870)
Tsunayoshi Sawada
Iron
- Joined
- Dec 23, 2019
- Posts
- 241
- Reputation
- 136
Cancer
http://www.ncbi.nlm.nih.gov/pubmed/3921234
https://www.ncbi.nlm.nih.gov/pubmed/1544140
https://www.ncbi.nlm.nih.gov/pubmed/19267249
Androgens
The average dietary cholesterol consumption was strongly associated (r = 0.448, p =.001) with the change in lean mass, which was further strengthened by adjustments for body mass (r = 0.467, p =.001) and lean mass (r = 0.512, p <.001) (Figure 1A). Although dietary protein (g/kg lean mass/d) was significantly correlated with dietary cholesterol (r = 0.387, p =.004), protein was not significantly correlated with change in lean mass (r = −0.034, p =.802)
The direct association between dietary cholesterol and changes in strength further supports the potential anabolic role of cholesterol.
reducing saturated fat in the diet, and/or replacing saturated fat with what are considered more healthy fats (polyunsaturated and/or monounsaturated fats), results in significant decline in the circulating testosterone concentration. With the well-known anabolic effects of androgens on skeletal muscle, this potentially could provide an additional link between saturated fats and/or cholesterol, resistance exercise, and lean body mass accrual
800mg/kg of coconut, castor, canola, cottonseed, pomegranate, blackseed, sheabutter, olive oil, codliver, sardine, palm, repeatedly heated palm (RHPO), vegetable, repeatedly-heated vegetable (RHVO), sesame, and groundnut oils respectively, daily, for 14 days
blackseed, sheabutter, sardine, vegetable and groundnut oils suppressed the DHT level in the serum, while pomegranate, olive, RHPO reduced DHT level in the prostate
oleic acid would alter testicular endocrine functions in either an estrogenic or antiandrogenic manner at puberty
Estrogenic properties included shortened AGI, decrease in serum LH and T (P<0.001), increase in prolactin level in the organogenesis group. Antiandrogenic properties included delayed pubertal maturation, altered serum LH and T levels (P<0.001), epididymal sperm numbers in all treated groups
http://www.ncbi.nlm.nih.gov/pubmed/3921234
http://cancerres.aacrjournals.org/content/4/3/153.full.pdfRequirement of essential fatty acid for mammary tumorigenesis in the rat.
https://pdfs.semanticscholar.org/b44f/0f82cbb7d9473ac99c386626d22d4200e395.pdfHowever, when the corn oil was replaced by hydrogenated coconut oil the tumor incidence never exceeded 8 percent, while in most groups it was zero.
https://www.ncbi.nlm.nih.gov/pubmed/6704963Thus the substitution of hydrogenated coconut oil for corn oil definitely inhibited tumor induction...
http://www.ncbi.nlm.nih.gov/pubmed/6815624These findings suggest that dietary unsaturated fats have potent cocarcinogenic effects on colon carcinogenesis.
https://link.springer.com/article/10.1007/BF02531379Inhibitory effect of a fat-free diet on mammary carcinogenesis in rats.
https://www.ncbi.nlm.nih.gov/pubmed/7285004Experiments with 10 different fats and oils fed at the 20% level indicated that unsaturated fats enhance the yield of adenocarcinomas more than saturated fats.
https://www.ncbi.nlm.nih.gov/pubmed/817101Thus, diets high in unsaturated fat appear to promote pancreatic carcinogenesis in the azaserine-treated rat while a diet high in saturated fat failed to show a similar degree of enhancement of pancreatic carcinogenesis.
https://www.ncbi.nlm.nih.gov/pubmed/3459924The cumulative incidence of tumor-bearing rats among DMBA-dosed rats was greater when the polyunsaturated fat diet was fed
https://www.ncbi.nlm.nih.gov/pubmed/107358...animals fed the HF safflower and corn oil diets exhibited enhanced mammary tumor yields when compared to animals fed HF olive or coconut oil diets...
https://www.ncbi.nlm.nih.gov/pubmed/6782319These results show that a certain amount of polyunsaturated fat, as well as a high level of dietary fat, is required to promote mammary carcinogenesis.
https://www.ncbi.nlm.nih.gov/pubmed/3476922...the addition of 3% ethyl linoleate (an ethyl ester of a polyunsaturated fatty acid) increased the tumor yield to about twice that in rats fed either the high-saturated fat diet or a low-fat diet.
https://www.ncbi.nlm.nih.gov/pubmed/416226...animals fed HF diets rich in linoleic acid, such as safflower and corn oil, exhibited increased incidence and decreased latent period compared with...animals fed HF diets rich in oleic acid (olive oil) or medium-chain saturated fatty acids (coconut oil).
https://www.ncbi.nlm.nih.gov/pubmed/6488161The differences in tumor incidence suggest that carcinogenesis was enhanced by the polyunsaturated fat diet during the promotion stage of carcinogenesis.
https://www.ncbi.nlm.nih.gov/pubmed/2979798...they suggest an association between promotion of mammary cancer and elevated levels of linoleic acid in serum lipids.
https://www.ncbi.nlm.nih.gov/pubmed/6583457These results suggest that a diet high in unsaturated fat alone, or in combination with 4% cholestyramine, promotes DMBA-induced mammary cancer in Wistar rats.
https://www.ncbi.nlm.nih.gov/pubmed/6778606...effect of dietary corn oil (CO), safflower oil (SO), olive oil (OO), coconut oil (CC), and medium-chain triglycerides (MCT)...The incidence of colon tumors was increased in rats fed diets containing high-CO and high-SO...whereas the diets containing high OO, CC, or MCT had no promoting effect on colon tumor incidence.
https://www.ncbi.nlm.nih.gov/pubmed/9066676...an increase in fat intake was accompanied by an increased tumor incidence when corn oil was used in the diets. A high saturated fat ration, on the other hand, was much less effective in this respect.
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1751-1097.1988.tb02882.xThe promotive tumorigenic effects of the other high-fat diets were associated with their high levels of some polyunsaturated fatty acids...
https://www.ncbi.nlm.nih.gov/pubmed/27033117Mice fed 20% saturated fat were almost completely protected from UV tumorigenesis when compared with mice fed 20% polyunsaturated fat.
https://www.ncbi.nlm.nih.gov/pubmed/7214328...we found an inverse association between SF content and tumor burden...at least in male mice; there was a decrease in mortality in mice consuming the highest concentration of SFAs.
https://www.ncbi.nlm.nih.gov/pubmed/1732055Increased tumor incidence and decreased time to tumor were observed when increasing levels of linoleate (18:2)...Increasing levels of stearate were associated with decreased tumor incidence and increased time to tumor.
The following study found this effect to be tissue-specific:A positive correlation between level of dietary LA and mammary tumor incidence was observed
https://www.ncbi.nlm.nih.gov/pubmed/1544140
Compare this to stearic acid, a saturated fatty acid, which is anticarcinogenic:An inverse correlation...was observed between papilloma number and level of LA; however, there was little difference in tumor incidence...To determine whether this inverse correlation...was due to species differences or organ-model differences, a mammary carcinogenesis experiment was performed...Tumor appearance was delayed in the 0.8% LA diet group, and a positive dose-response relationship between dietary LA and mammary-tumor incidence was observed. These studies suggest that the effect of dietary LA on tumor development is target tissue specific rather than species specific.
https://www.ncbi.nlm.nih.gov/pubmed/19267249
https://www.ncbi.nlm.nih.gov/pubmed/6490204Dietary stearate reduces human breast cancer metastasis burden in athymic nude mice.
https://www.ncbi.nlm.nih.gov/pubmed/21586513These results suggest that dietary stearic acid interferes with the availability of certain PUFA required for tumor production.
Prevention of carcinogenesis and inhibition of breast cancer tumor burden by dietary stearate.
Androgens
The average dietary cholesterol consumption was strongly associated (r = 0.448, p =.001) with the change in lean mass, which was further strengthened by adjustments for body mass (r = 0.467, p =.001) and lean mass (r = 0.512, p <.001) (Figure 1A). Although dietary protein (g/kg lean mass/d) was significantly correlated with dietary cholesterol (r = 0.387, p =.004), protein was not significantly correlated with change in lean mass (r = −0.034, p =.802)
The direct association between dietary cholesterol and changes in strength further supports the potential anabolic role of cholesterol.
reducing saturated fat in the diet, and/or replacing saturated fat with what are considered more healthy fats (polyunsaturated and/or monounsaturated fats), results in significant decline in the circulating testosterone concentration. With the well-known anabolic effects of androgens on skeletal muscle, this potentially could provide an additional link between saturated fats and/or cholesterol, resistance exercise, and lean body mass accrual
800mg/kg of coconut, castor, canola, cottonseed, pomegranate, blackseed, sheabutter, olive oil, codliver, sardine, palm, repeatedly heated palm (RHPO), vegetable, repeatedly-heated vegetable (RHVO), sesame, and groundnut oils respectively, daily, for 14 days
blackseed, sheabutter, sardine, vegetable and groundnut oils suppressed the DHT level in the serum, while pomegranate, olive, RHPO reduced DHT level in the prostate
oleic acid would alter testicular endocrine functions in either an estrogenic or antiandrogenic manner at puberty
Estrogenic properties included shortened AGI, decrease in serum LH and T (P<0.001), increase in prolactin level in the organogenesis group. Antiandrogenic properties included delayed pubertal maturation, altered serum LH and T levels (P<0.001), epididymal sperm numbers in all treated groups