Potential link between GLP-1s (including retatrutide) and thyroid cancer?

[obontw]

Studies in animal models have revealed that the use of GLP-1 RAs causes abnormal alterations in thyroid C cells, with a gradual formation of hyperplasia and adenomas [3]. Despite initial reports of a potential increased risk of thyroid cancer in patients treated with GLP-1 RAs, long-term results from clinical studies have alleviated such concerns.

In this study, GLP-1R expression was observed in primary rat C cells but was not detected in primary human C cells. Stimulation with GLP-1 RAs resulted in a modest increase in calcitonin release and expression in primary rat thyroid cultures; however, no functional response to GLP-1 RAs was observed in human thyroid cultures.

However, it cannot be ruled out that the lack of response to GLP-1 RAs in human primary thyroid cultures is due to the low percentage of C cells and very low calcitonin release, which is not detectable with the methods used in this study.

Implications of GLP-1 Receptor Agonist on Thyroid Function: A Literature Review of Its Effects on Thyroid Volume, Risk of Cancer, Functionality and TSH Levels - PMC

The increasing utilization of Glucagon-like Peptide-1 receptor agonists (GLP-1 RAs) in managing type 2 diabetes mellitus has raised interest regarding their impact on thyroid function. In fact, while these agents are well known for their efficacy in ...

pmc.ncbi.nlm.nih.gov

Has anyone read a lot of studies on this? While most of the research has been done on rats, it seems like there could be a link between GLP-1s and thyroid cancer, though very small. What do you think?

 

[Vulcan57]

Just take reta, you'll be fine