Pramipexole, Cabergoline and Bromocriptine

[Bizygomatic]

What do you guys think of these drugs?
Anyone that has experience with them?
@PharmaPhaggot @kdev

 

[Bipolar2Cel]

I tried prami, caber and ropinirole, mostly for depression. Helps a bit but not super useful unless I took very high dosages, then the nausea was too brutal and I stopped those high dosages. As for prolactin and libido I found pramipexole much more effective and cleaner than cabergoline, also caber gave more headaches and feeling hot, but I would say overall cabergoline and pramipexole feels 80-90% the same. You can get very high libido at first but after some weeks or months on them it often goes back to normal or mostly normal, cabergoline's dirty 5HT2 receptor effects felt like they were counteracting its D2/D3 receptor libido increasing effects. As far as muscle gains or improved recovery on pramipexole from its effects on HGH like some bros can try to hype I noticed jack shit, some think it can make a difference but I noticed zero difference. I do feel like it increased stamina a bit when doing cardio weirdly but that was it, MAYBE.

Also yeah you can get a weird mix of feeling tired during the day but also wired and having a hard time to fall asleep. Weird mix of fatigue and sleepy but also being too wired to sleep and like your brain can't turn off. Went away after a while though.

If I were to recommend any dopamine agonist it would be pramipexole, felt cleanest of them all. Cabergoline you can dose only a few times a week which is convenient, but long half-life also means you can suffer from nasty side-effects for longer if you overdose or are not used to the dose increase etc you made, whatever. Anyway you can just split the pills with a knife, take pieces/crumbs lol, or dissolve into alcohol or make a suspension and use a pipette(if you are scared or sensitive to side-effects).

Oh and yeah I have been on and off dopamine agonists for many months to years because I still found them helpful. Stuff like DAWS is pure cope and only applies to people who are already neurologically very dysfunctional and have Parkinson's Disease, young healthy people don't get DAWS from withdrawing from dopamine agonists. Worst case scenario just taper off. These drugs are nowhere near "dangerous" lol, your brain can handle withdrawing from those fine without freaky symptoms unless you are old and have PD or some other serious dopaminergic deficits. Again I forgot dosages, cold-turkeyed after months to years of use and didn't notice anything or maybe felt bit more depressed than usual(even this is hard to say when you are chronically depressed to varying levels lol).


Edit: And ropinirole just felt like a shittier shorter half-life version of pramipexole. But yeah for many purposes these D2-D3 agonists are like 80-90+% interchangeable. Obviously stuff like bromocriptine is even way more dirty, worse long-term for heart etc. Cabergoline has a slight increased risk but requires very high dosages over long periods of time. Also even though cabergoline is described as a D2 agonist it still binds almost as strongly to D3, pramipexole is a D3 agonist but still binds strongly to D2. So they are both strong D2/D3 agonists overall.

 

[Bizygomatic]

I tried prami, caber and ropinirole, mostly for depression. Helps a bit but not super useful unless I took very high dosages, then the nausea was too brutal and I stopped those high dosages. As for prolactin and libido I found pramipexole much more effective and cleaner than cabergoline, also caber gave more headaches and feeling hot, but I would say overall cabergoline and pramipexole feels 80-90% the same. You can get very high libido at first but after some weeks or months on them it often goes back to normal or mostly normal, cabergoline's dirty 5HT2 receptor effects felt like they were counteracting its D2/D3 receptor libido increasing effects. As far as muscle gains or improved recovery on pramipexole from its effects on HGH like some bros can try to hype I noticed jack shit, some think it can make a difference but I noticed zero difference. I do feel like it increased stamina a bit when doing cardio weirdly but that was it, MAYBE.

Also yeah you can get a weird mix of feeling tired during the day but also wired and having a hard time to fall asleep. Weird mix of fatigue and sleepy but also being too wired to sleep and like your brain can't turn off. Went away after a while though.

If I were to recommend any dopamine agonist it would be pramipexole, felt cleanest of them all. Cabergoline you can dose only a few times a week which is convenient, but long half-life also means you can suffer from nasty side-effects for longer if you overdose or are not used to the dose increase etc you made, whatever. Anyway you can just split the pills with a knife, take pieces/crumbs lol, or dissolve into alcohol or make a suspension and use a pipette(if you are scared or sensitive to side-effects).

Oh and yeah I have been on and off dopamine agonists for many months to years because I still found them helpful. Stuff like DAWS is pure cope and only applies to people who are already neurologically very dysfunctional and have Parkinson's Disease, young healthy people don't get DAWS from withdrawing from dopamine agonists. Worst case scenario just taper off. These drugs are nowhere near "dangerous" lol, your brain can handle withdrawing from those fine without freaky symptoms unless you are old and have PD or some other serious dopaminergic deficits. Again I forgot dosages, cold-turkeyed after months to years of use and didn't notice anything or maybe felt bit more depressed than usual(even this is hard to say when you are chronically depressed to varying levels lol).


Edit: And ropinirole just felt like a shittier shorter half-life version of pramipexole. But yeah for many purposes these D2-D3 agonists are like 80-90+% interchangeable. Obviously stuff like bromocriptine is even way more dirty, worse long-term for heart etc. Cabergoline has a slight increased risk but requires very high dosages over long periods of time. Also even though cabergoline is described as a D2 agonist it still binds almost as strongly to D3, pramipexole is a D3 agonist but still binds strongly to D2. So they are both strong D2/D3 agonists overall.

Love the detailed response! Did taking them help you feel more motivated?

 

[slycooperr]

I typed a whole paragraph about this, but I remember you told me to kms in discord so I had to erase it all.