L1G7
Bronze
- Joined
- Dec 15, 2025
- Posts
- 273
- Reputation
- 281
NEW .ORG ACCOUNT I HAVE BEEN ON FORUMS FOR 7 YEARS
V (MY TIKTOK ACCOUNT) V
WOULD LOVE A FOLLOW IF YOU LIKED THIS POST
ABALOPARATIDE
Absorption:
Abaloparatide is injected and enters the bloodstream
Main pathway:
Activates PTH1R signaling which recruits more osteoblasts
existing osteoblasts STAY alive longer and activates previously inactive bone forming surfaces.
Osteoblast effect:
PTH1R signaling increases osteoblast recruitment More osteoblasts become active and deposit osteoid increasing the amount of bone surface undergoing mineralization.
Bone matrix production:
Active osteoblasts deposit type-I collagen and other proteins forming new osteoid.
on the outside surface of cortical bone.
This is the actual material that increases outward bone volume.
Mineralization:
Calcium and phosphate are then deposited into that newly produced matrix converting the soft osteoid into hard mineralized cortical bone.
Chondrocyte effect:
Delayed maturation:
PTH1R signaling keeps those cells in the proliferative state longer and delays their transition into hypertrophic chondrocytes.
Maintained proliferative pool:
This preserves more immature chondrocytes that can continue dividing before they eventually mature.
12.9× increase:
increased periosteal mineralizing surface from 1.3% to 16.3% after 3 months a 12.9× increase in the amount of periosteal surface actively forming bone
studied osteoporotic population HARD
TO COMPARE % TO NON osteoporotic PEOPLE
https://pubmed.ncbi.nlm.nih.gov/33434314/
INCREASED final height and long bone length
(SOURCES)
V (MY TIKTOK ACCOUNT) V
WOULD LOVE A FOLLOW IF YOU LIKED THIS POST
ABALOPARATIDE
Absorption:
Abaloparatide is injected and enters the bloodstream
Main pathway:
Activates PTH1R signaling which recruits more osteoblasts
existing osteoblasts STAY alive longer and activates previously inactive bone forming surfaces.
[U][I]PTH1R activation > [/I][/U][U][I]LOWER osteoblast apoptosis + INCREASED osteoblast recruitment > [/I][/U][U][I]INCREASED active mineralizing surfaces >[/I][/U] INCREASED bone formation rateOsteoblast effect:
PTH1R signaling increases osteoblast recruitment More osteoblasts become active and deposit osteoid increasing the amount of bone surface undergoing mineralization.
Bone matrix production:
Active osteoblasts deposit type-I collagen and other proteins forming new osteoid.
on the outside surface of cortical bone.
This is the actual material that increases outward bone volume.
Mineralization:
Calcium and phosphate are then deposited into that newly produced matrix converting the soft osteoid into hard mineralized cortical bone.
Chondrocyte effect:
Delayed maturation:
PTH1R signaling keeps those cells in the proliferative state longer and delays their transition into hypertrophic chondrocytes.
Maintained proliferative pool:
This preserves more immature chondrocytes that can continue dividing before they eventually mature.
12.9× increase:
increased periosteal mineralizing surface from 1.3% to 16.3% after 3 months a 12.9× increase in the amount of periosteal surface actively forming bone
studied osteoporotic population HARD
TO COMPARE % TO NON osteoporotic PEOPLE
https://pubmed.ncbi.nlm.nih.gov/33434314/
INCREASED final height and long bone length
(SOURCES)
t.https://pubmed.ncbi.nlm.nih.gov/26562265/ ^ Abaloparatide activates PTH1R ^ https://pubmed.ncbi.nlm.nih.gov/17517365/ ^ PTH increases osteoblast survival ^ https://pubmed.ncbi.nlm.nih.gov/33434314/ ^ Activates bone forming surfaces ^ https://pubmed.ncbi.nlm.nih.gov/33434314/ ^ Increases mineralizing surfaces ^ https://pubmed.ncbi.nlm.nih.gov/33434314/ ^ Increases bone formation rate ^ https://pubmed.ncbi.nlm.nih.gov/39349089/ ^ Chondrocytes drive bone lengthening ^ https://pubmed.ncbi.nlm.nih.gov/33434314/ ^ Increases periosteal bone formation ^ https://pubmed.ncbi.nlm.nih.gov/31051317/ ^ Increases periosteal mineralizing surface ^ https://pubmed.ncbi.nlm.nih.gov/16831900/ ^ Delays chondrocyte differentiation ^ https://pubmed.ncbi.nlm.nih.gov/17328886/ ^ Regulates chondrocyte proliferation ^ https://pubmed.ncbi.nlm.nih.gov/10571683/ ^ Maintains proliferative chondrocytes ^ https://pubmed.ncbi.nlm.nih.gov/25196529/[SIZE=15px] ^ PTH1R supports long bone growth ^[/SIZE][SIZE=26px][B]LMK IF YALL WANT AN UPDATED POST WITH DOSING SOURCING AND SIDE EFFECTS/SIDE EFFECT MITIGATION[/B][/SIZE]
