Query regarding serum penetration on skin

[scylla]

@edodalic29 i bought matrixyl 3000 after knowing you use it
@enchanted_elixir and after seeing your post recommending it i bought the minimalist one
my question is that i read somewhere that products over 500 daltons don't penetrate and get in the skin and matrixyl is 700-800 daltons so does that mean it's useless?

 

[Micrognathic]

Yes, its efficacy is limited since it's over 500 daltons, you might get passive diffusion, but it’s negligible.


Keep in mind that the palmitoyl fatty acid chain attached to it will enhance its lipophilicity and might improve its penetration

(It won't let me attach an image for some reason, so I advise u to read the study)

Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy - PMC

Among the many aspects that contribute to the wellness of each individual, healthy and younger-looking skin play a relevant role, as clearly shown by the important growth of the skin-care products market observed in recent years. In this scenario, ...

pmc.ncbi.nlm.nih.gov

In addition, there are studies proving that it works

https://dermodality.com/wp-content/uploads/2018/10/POD-Matrixyl-3000-Brochure-1-1.pdf

I wouldn't say it's completely useless, but there are many better options out there that would make it completely redundant

If u need more help, pm me brah

 

[scylla]

i can't pm you myself(my account is new) can you pm me?

Yes, its efficacy is limited since it's over 500 daltons, you might get passive diffusion, but it’s negligible.


Keep in mind that the palmitoyl fatty acid chain attached to it will enhance its lipophilicity and might improve its penetration
View attachment 4486644
(It won't let me attach an image for some reason, so I advise u to read the study)

Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy - PMC

Among the many aspects that contribute to the wellness of each individual, healthy and younger-looking skin play a relevant role, as clearly shown by the important growth of the skin-care products market observed in recent years. In this scenario, ...

pmc.ncbi.nlm.nih.gov

View attachment 4486650
In addition, there are studies proving that it works

https://dermodality.com/wp-content/uploads/2018/10/POD-Matrixyl-3000-Brochure-1-1.pdf

I wouldn't say it's completely useless, but there are many better options out there that would make it completely redundant

If u need more help, pm me bra

 

[Micrognathic]

i can't pm you myself(my account is new) can you pm me?

check pms

 

[enchanted_elixir]

@edodalic29 i bought matrixyl 3000 after knowing you use it
@enchanted_elixir and after seeing your post recommending it i bought the minimalist one
my question is that i read somewhere that products over 500 daltons don't penetrate and get in the skin and matrixyl is 700-800 daltons so does that mean it's useless?

I never knew about the matrixyl thing but I’ve used it over time and it definitely works, but use sunscreen to preserve its effects.

 

[LTNUser]

What was your old account name ?

Yes, its efficacy is limited since it's over 500 better options out there that would make it completely redundant

If u need more help, pm me brah

 

[Micrognathic]

What was your old account name ?

FUCK OFF
GO KYS
I WONT PROLONG THIS ANY FURTHER

 

[LTNUser]

FUCK OFF
GO KYS
I WONT PROLONG THIS ANY FURTHER

Oh damn,just saw you are 13
You are an exception

 

[whodoievenbelieve]

I wouldn't say it's completely useless, but there are many better options out there that would make it completely redundant

If u need more help, pm me brah

What what would u say is the best option for these collagen benefits then? I currently use taz everyday and thinking about adding topical estriol.

 

[Sayori]

Yes, its efficacy is limited since it's over 500 daltons, you might get passive diffusion, but it’s negligible.


Keep in mind that the palmitoyl fatty acid chain attached to it will enhance its lipophilicity and might improve its penetration
View attachment 4486644
(It won't let me attach an image for some reason, so I advise u to read the study)

Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy - PMC

Among the many aspects that contribute to the wellness of each individual, healthy and younger-looking skin play a relevant role, as clearly shown by the important growth of the skin-care products market observed in recent years. In this scenario, ...

pmc.ncbi.nlm.nih.gov

View attachment 4486650
In addition, there are studies proving that it works

https://dermodality.com/wp-content/uploads/2018/10/POD-Matrixyl-3000-Brochure-1-1.pdf

I wouldn't say it's completely useless, but there are many better options out there that would make it completely redundant

If u need more help, pm me brah

mirin the high effort response

 

[Micrognathic]

What what would u say is the best option for these collagen benefits then? I currently use taz everyday and thinking about adding topical estriol.

No need to add estriol since they're not synergistic for collagen production
I'd say just stick with taz
If u want, u can maybe combine it with microneedling

 

[Micrognathic]

mirin the high effort response

Thank you

 

[whodoievenbelieve]

No need to add estriol since they're not synergistic for collagen production
I'd say just stick with taz
If u want, u can maybe combine it with microneedling

Yeah I'll def be doing microneedling. Gonna cop the derminator soon. Does estriol not provide it's own benefits though? I saw it listed on aryan incels skin mega thread with this study listed:

Treatment of skin aging with topical estrogens - PubMed

After treatment for 6 months, elasticity and firmness of the skin had markedly improved and the wrinkle depth and pore sizes had decreased by 61 to 100% in both groups. Furthermore, skin moisture had increased and the measurement of wrinkles using skin profilometry, revealed significant, or even...

pubmed.ncbi.nlm.nih.gov

 

[Micrognathic]

Yeah I'll def be doing microneedling. Gonna cop the derminator soon. Does estriol not provide it's own benefits though? I saw it listed on aryan incels skin mega thread with this study listed:

Treatment of skin aging with topical estrogens - PubMed

After treatment for 6 months, elasticity and firmness of the skin had markedly improved and the wrinkle depth and pore sizes had decreased by 61 to 100% in both groups. Furthermore, skin moisture had increased and the measurement of wrinkles using skin profilometry, revealed significant, or even...

pubmed.ncbi.nlm.nih.gov

Yes, it does, but I don't think it should be combined with Taz in my personal opinion ofc

https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/20600_TAZORAC%200.05%25%20AND%200.1%25_STATR_P1.PDF

If u take a look at this study, it showed that taz was less effective in people who used oral estrogen
Now that does not mean it will make topical estroil less effective
till now, there haven't been any studies testing taz + topical estroil, so we can't be sure if it's effective or not
ig for now, start with taz + microneedling if ur still not happy with the results, then I would suggest u add topical estroil

 

[whodoievenbelieve]

Yes, it does, but I don't think it should be combined with Taz in my personal opinion ofc
View attachment 4487596

https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/20600_TAZORAC%200.05%25%20AND%200.1%25_STATR_P1.PDF

If u take a look at this study, it showed that taz was less effective in people who used oral estrogen
Now that does not mean it will make topical estroil less effective
till now, there haven't been any studies testing taz + topical estroil, so we can't be sure if it's effective or not
ig for now, start with taz + microneedling if ur still not happy with the results, then I would suggest u add topical estroil

Appreciate the detailed response, will def do this

 

[Micrognathic]

Appreciate the detailed response, will def do this

now worries man
Keep me updated with how everything goes, and if u need more help, pm me brah