Questions on anti accustoming compounds

[mavJJ]

If you have already grown accustom to a stim like , adderall , vyvanse etc is it to late to implement compounds like;
Mematine
Ketotifen
Magnesium glycinate
9-Me-BC?

And to be able to regain the original unprecedented effect?

 

[tension]

idk

 

[mavJJ]

idk

Thank