Regrowing teeth could be the savior for extraction victims?

[ccc19287]

Japanese scientists are conducting clinical trials for a drug that aims to regrow teeth in humans. The trials began in September 2024 at Kyoto University Hospital and Kitano Hospital in Osaka. The drug targets a protein called USAG-1, which inhibits tooth growth, and aims to stimulate the dormant buds of a third set of teeth hidden beneath human gums. The first phase of the trials involves 30 adult males aged 30 to 64 who are missing at least one molar, and if successful, the drug will be tested on children aged 2 to 7 who are missing at least four teeth.

The researchers hope to have the tooth regrowth medicine available by 2030 for patients with congenital tooth deficiency, and eventually for anyone who has lost a tooth due to cavities, injury, or other reasons.

With the recent labgrown tooth from Kings College i wonder if any of you guys has looked into this solution to potentially reverse the damages of classic orthodontists, also, can any type of tooth be regrown and what if there is no toothgap for it?

Im particularily interested in this information as a victim of full wisdom teeth and premolar removal, could this function as a natural bimaxillary surgery and can a previous bimaxillary surgery mess with the effect of this drug?

For example right where they connect the jaws to the face with metal after moving them there wouldnt be any ability for tooth growth right?

Also if this turns into a new hype where people use it to far exceed human norms and physical limits like boosting height by hyperdosing growth hormone to unnatural levels, could this become another case where instead of 28 teeth people will try and grow sets up to 36 in order to get superhuman like jaws?

 

[Scriggan]

l

Japanese scientists are conducting clinical trials for a drug that aims to regrow teeth in humans. The trials began in September 2024 at Kyoto University Hospital and Kitano Hospital in Osaka. The drug targets a protein called USAG-1, which inhibits tooth growth, and aims to stimulate the dormant buds of a third set of teeth hidden beneath human gums. The first phase of the trials involves 30 adult males aged 30 to 64 who are missing at least one molar, and if successful, the drug will be tested on children aged 2 to 7 who are missing at least four teeth.

The researchers hope to have the tooth regrowth medicine available by 2030 for patients with congenital tooth deficiency, and eventually for anyone who has lost a tooth due to cavities, injury, or other reasons.

With the recent labgrown tooth from Kings College i wonder if any of you guys has looked into this solution to potentially reverse the damages of classic orthodontists, also, can any type of tooth be regrown and what if there is no toothgap for it?

Im particularily interested in this information as a victim of full wisdom teeth and premolar removal, could this function as a natural bimaxillary surgery and can a previous bimaxillary surgery mess with the effect of this drug?

For example right where they connect the jaws to the face with metal after moving them there wouldnt be any ability for tooth growth right?

Also if this turns into a new hype where people use it to far exceed human norms and physical limits like boosting height by hyperdosing growth hormone to unnatural levels, could this become another case where instead of 28 teeth people will try and grow sets up to 36 in order to get superhuman like jaws?

link studio

 

[ccc19287]

l

link studio

https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/261703

 

[Scriggan]

https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/261703

@loyolaxavvierretard

 

[Deleted member 131140]

Study pdf
Yeah it's legit. Let's wait till trials are finished

 

[Scriggan]

Study pdf
Yeah it's legit. Let's wait till trials are finished

jfl i gotta need ts

 

[ccc19287]

jfl i gotta need ts

sounds too good to be true i havent seen anyone else talking about it so i posted this

 

[Deleted member 40105]

no retard.

the roots are already gone.

 

[ccc19287]

no retard.

the roots are already gone.

are u too crippled to click on the study that i linked? go studymaxx and let the smart people talk

 

[mandiblade]

Japanese scientists are conducting clinical trials for a drug that aims to regrow teeth in humans. The trials began in September 2024 at Kyoto University Hospital and Kitano Hospital in Osaka. The drug targets a protein called USAG-1, which inhibits tooth growth, and aims to stimulate the dormant buds of a third set of teeth hidden beneath human gums. The first phase of the trials involves 30 adult males aged 30 to 64 who are missing at least one molar, and if successful, the drug will be tested on children aged 2 to 7 who are missing at least four teeth.

The researchers hope to have the tooth regrowth medicine available by 2030 for patients with congenital tooth deficiency, and eventually for anyone who has lost a tooth due to cavities, injury, or other reasons.

With the recent labgrown tooth from Kings College i wonder if any of you guys has looked into this solution to potentially reverse the damages of classic orthodontists, also, can any type of tooth be regrown and what if there is no toothgap for it?

Im particularily interested in this information as a victim of full wisdom teeth and premolar removal, could this function as a natural bimaxillary surgery and can a previous bimaxillary surgery mess with the effect of this drug?

For example right where they connect the jaws to the face with metal after moving them there wouldnt be any ability for tooth growth right?

Also if this turns into a new hype where people use it to far exceed human norms and physical limits like boosting height by hyperdosing growth hormone to unnatural levels, could this become another case where instead of 28 teeth people will try and grow sets up to 36 in order to get superhuman like jaws?

Tooth extraction due to crowding is kind of a self-fulfilling prophecy, in a way. Although the problem of crowding itself was solved, the underlying issue - lack of spacing/bone - gets worse.

Several authors have provided descriptions of the stages of alveolar ridge resorption following tooth removal [6,7]. Atwood (1971) identified six stages of alveolar ridge resorption after tooth extraction, from mild to severe [6]. Most bone loss occurs within the first year [7]. There is a 25% volume loss in the first year after extraction and a 40% reduction in three years. Prolonged edentulism leads to height deficiencies, while width deficiencies occur early due to the pattern of bone resorption.

Comprehensive Classification System for Localized Alveolar Bone Deficiencies in Treatment Planning for Dental Implants: A Proposed Classification and Prevalence Study - PMC

Introduction The current classification of alveolar bone defects remains ambiguous. This study aims to classify and evaluate the prevalence of bone deformities using a comprehensive classification system for localized alveolar bone deficiencies in ...

pmc.ncbi.nlm.nih.gov

After a lazy search, I found that citation. Bottom line is that you should know that tooth extraction leads to localized bone resorption, which can misalign parts of your skull(more so functionally than aesthetically) if the extraction was premolar.

Spoiler: Reddit case study w/ explanation

I don't think this is the lifefuel you wanted it to be, unfortunately. Personally, I was thinking of perhaps using this in addition to a myobrace or something to grow new incisors without any bimaxillary protrusion. This beats braces/TADs because of pricing, time, and convenience. I'm also not really time-desparate, so I can wait until 2030.

@Snicket thoughts?

 

[ccc19287]

Tooth extraction due to crowding is kind of a self-fulfilling prophecy, in a way. Although the problem of crowding itself was solved, the underlying issue - lack of spacing/bone - gets worse.

Comprehensive Classification System for Localized Alveolar Bone Deficiencies in Treatment Planning for Dental Implants: A Proposed Classification and Prevalence Study - PMC

Introduction The current classification of alveolar bone defects remains ambiguous. This study aims to classify and evaluate the prevalence of bone deformities using a comprehensive classification system for localized alveolar bone deficiencies in ...

pmc.ncbi.nlm.nih.gov

After a lazy search, I found that citation. Bottom line is that you should know that tooth extraction leads to localized bone resorption, which can misalign parts of your skull(more so functionally than aesthetically) if the extraction was premolar.

Spoiler: Reddit case study w/ explanation

I don't think this is the lifefuel you wanted it to be, unfortunately. Personally, I was thinking of perhaps using this in addition to a myobrace or something to grow new incisors without any bimaxillary protrusion. This beats braces/TADs because of pricing, time, and convenience. I'm also not really time-desparate, so I can wait until 2030.

@Snicket thoughts?

absolutely right, i dont really see this as a lifeline and am just interested in the topic since if this becomes a reallife option in the next 10 years or so i imagine you would not get bimax with current number of teeth but just wait since this wouldnt work on a jaw with metal plates. As of now it seems the best option is still bimaxillary osteotomie/ bimax with teeth implants if you are rich?

 

[ccc19287]

Tooth extraction due to crowding is kind of a self-fulfilling prophecy, in a way. Although the problem of crowding itself was solved, the underlying issue - lack of spacing/bone - gets worse.

Comprehensive Classification System for Localized Alveolar Bone Deficiencies in Treatment Planning for Dental Implants: A Proposed Classification and Prevalence Study - PMC

Introduction The current classification of alveolar bone defects remains ambiguous. This study aims to classify and evaluate the prevalence of bone deformities using a comprehensive classification system for localized alveolar bone deficiencies in ...

pmc.ncbi.nlm.nih.gov

After a lazy search, I found that citation. Bottom line is that you should know that tooth extraction leads to localized bone resorption, which can misalign parts of your skull(more so functionally than aesthetically) if the extraction was premolar.

Spoiler: Reddit case study w/ explanation

I don't think this is the lifefuel you wanted it to be, unfortunately. Personally, I was thinking of perhaps using this in addition to a myobrace or something to grow new incisors without any bimaxillary protrusion. This beats braces/TADs because of pricing, time, and convenience. I'm also not really time-desparate, so I can wait until 2030.

@Snicket thoughts?

tbf they are only testing molars rn which will be done by september and that is obviously the easiest, im not sure i believe the 2030 estimation they state in the study, but another thing ive been thinking about is that if you were to create space for incisors/premolars with braces fully conventional then instead of retrusion since the molars are harder to move than the front teeth, this would cause the front teeth to be pushed farther away that the teeth behind the gap you are looking to create, ultimately the exact reverse of something like premolar removal. Lastly if this thing finally gets available to the public it will probably only be paid for by insurance by people with accidents that lost 1 tooth/obvious deformaties in children because they would go broke if they ever admitted they permanently damaged every single patient they have ever treated

 

[mandiblade]

absolutely right, i dont really see this as a lifeline and am just interested in the topic since if this becomes a reallife option in the next 10 years or so i imagine you would not get bimax with current number of teeth but just wait since this wouldnt work on a jaw with metal plates. As of now it seems the best option is still bimaxillary osteotomie/ bimax with teeth implants if you are rich?

Tooth implants to ensure that the bimax doesn't return to baseline? Never heard of that before. Then again, I know nothing about surgeries since I will never undergo any. Ping surgeryknowledgecels

@thecel @mvp2v1

 

[ccc19287]

Tooth implants to ensure that the bimax doesn't return to baseline? Never heard of that before. Then again, I know nothing about surgeries since I will never undergo any. Ping surgeryknowledgecels

@thecel @mvp2v1

keep in mind thats like the theoretical dreamprocedure that no orthodontist would ever recommend themselves/ any insurence would pay for but yes this would be perfect to make sure you dont lose bone again/ maybe even increase mandible height in previous affected areas by properly distributing pressure to them again